Patents Examined by Patricia L. Morris
  • Salt forms of 4-cyano-N-(4,4-dimethylcyclohex-1-en-1-yl)-6-(2,2,6,6-Tetr amethyltetrahydro-2H-pyran-4-yl)pyridin-3-yl)-1H-imidazole-2-carboximide
    Patent number: 10858348
    Abstract: The present disclosure discusses salt forms of 4-cyano-N-[2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yl)pyridin-3-yl]-1H-imidazole-2-carboxamide.
    Type: Grant
    Filed: January 8, 2020
    Date of Patent: December 8, 2020
    Assignee: Janssen Pharmaceutica NV
    Inventors: Nagy E. Fawzy, David Breslin
  • Method for purifying crude 2,5-furandicarboxylic acid composition
    Patent number: 10858332
    Abstract: A method for purifying a crude 2,5-furandicarboxylic acid composition including 2,5-furandicarboxylic acid and 5-formylfuran-2-carboxylic acid is disclosed. The method includes the steps of: (a) subjecting the crude 2,5-furandicarboxylic acid composition to complete dissolution in a solvent solution to obtain a mixture, the solvent solution including an organic solvent and water; (b) subjecting 5-formylfuran-2-carboxylic acid in the mixture to an addition reaction with sodium hydrogen sulfite to obtain an addition product; and (c) subjecting 2,5-furandicarboxylic acid to precipitation after step (b) to obtain purified 2,5-furandicarboxylic acid.
    Type: Grant
    Filed: January 7, 2020
    Date of Patent: December 8, 2020
    Assignee: FAR EASTERN NEW CENTURY CORPORATION
    Inventors: Shu-Wei Liu, Ruey-Fen Liao, Xin-An Lu
  • Aromatic sulfonamide derivatives
    Patent number: 10844016
    Abstract: Substituted aromatic sulfonamides of formula (I) pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: November 24, 2020
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Stefan Werner, Stefanie Mesch, Arwed Cleve, Nico Bräuer, Simon Anthony Herbert, Markus Koch, Henrik Dahllöf, Maren Osmers, Elizabeth Hardaker, Anton Lishchynskyi
  • Process for producing pyrrole compound
    Patent number: 10844011
    Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: November 24, 2020
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Toshiaki Nagata, Naohiro Fukuda, Tomomi Ikemoto
  • Crystal forms of lenvatinib
    Patent number: 10836727
    Abstract: The present invention provides novel crystalline forms of 4-[3-Chloro-4-(N?-cyclopropylureido)phenoxy]-7-methoxyquinoline-6-carboxamide methanesulfonate, as well as methods for their preparation.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: November 17, 2020
    Assignee: Indena S.P.A.
    Inventors: Nicola Sardone, Stefano Luca Giaffreda, Andrea Gambini, Alex Petrolati, Pietro Allegrini, Enrico Modena
  • Cocrystal, production method thereof, and medicament containing cocrystal
    Patent number: 10836745
    Abstract: The present invention provides a cocrystal of (S)-3-(1-((1-acryloylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-1H-1,2,4-triazol-5(4H)-one and an organic acid capable of forming a cocrystal with the compound.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: November 17, 2020
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Koya Kimoto, Mitsuo Yamamoto, Masato Kitayama, Yasuhiro Sawai, Miyuki Hohokabe, Kentaro Iwata
  • Method for synthesizing sodium 2,2,6,6-tetramethylpiperidides
    Patent number: 10836723
    Abstract: There is a demand for the development of a technique according to which sodium 2,2,6,6-tetramethylpiperidides (Na-TMPs) can be economically and efficiently synthesized through simple operations including a small number of steps under mild conditions in a short period of time. Also, there is a demand for the development of a technique according to which high-quality Na-TMPs that do not contain lithium or lithium compounds such as Li-TMP can be synthesized. The method for synthesizing sodium 2,2,6,6-tetramethylpiperidides includes a step of obtaining sodium 2,2,6,6-tetramethylpiperidides by reacting, in a reaction solvent, 2,2,6,6-tetramethylpiperidines with a dispersion product obtained by dispersing sodium in a dispersion solvent or an organosodium compound having an aromatic ring obtained through a reaction with a dispersion product obtained by dispersing sodium in a dispersion solvent.
    Type: Grant
    Filed: January 24, 2018
    Date of Patent: November 17, 2020
    Assignee: KOBELCO ECO-SOLUTIONS CO., LTD.
    Inventors: Yoshiaki Murakami, Miyuki Fukushima, Kazuhiko Takai, Sobi Asako
  • Diaryl substituted 6,5-fused ring compounds as C5aR inhibitors
    Patent number: 10828285
    Abstract: The present disclosure provides, inter alia, Compounds of Formula (I) or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: November 10, 2020
    Assignee: ChemoCentryx, Inc.
    Inventors: Pingchen Fan, Christopher W. Lange, Viengkham Malathong, Venkat Reddy Mali, Sreenivas Punna, Hiroko Tanaka, Yibin Zeng, Penglie Zhang
  • Crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione hemihydrate, compositions and methods of use thereof
    Patent number: 10829472
    Abstract: Provided herein is a crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione hemihydrate. Pharmaceutical compositions comprising the crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione hemihydrate are also disclosed.
    Type: Grant
    Filed: October 31, 2019
    Date of Patent: November 10, 2020
    Assignee: Celgene Corporation
    Inventor: Jerry Lee Atwood
  • Process for the preparation of ivacaftor
    Patent number: 10815202
    Abstract: The present invention provides processes for the preparation of ivacaftor using novel intermediates and a process for its preparation.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: October 27, 2020
    Assignee: Laurus Labs Limited
    Inventors: Suresh Thatipally, Venkata Krishna Reddy, Venkata Lakshmi Narasimha Rao Dammalapati, Satyanarayana Chava
  • Compounds for treatment of immune inflammatory disorders
    Patent number: 10807952
    Abstract: Compounds, methods of use, and processes for making inhibitors of complement Factor D are provided comprising Formula I, I? and I?? or a pharmaceutically acceptable salt or composition thereof. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein reduces the excessive activation of complement.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: October 20, 2020
    Assignee: Achillion Pharmaceuticals, Inc.
    Inventors: Jason Allan Wiles, Avinash S. Phadke, Milind Deshpande, Atul Agarwal, Dawei Chen, Venkat Rao Gadhachanda, Akihiro Hashimoto, Godwin Pais, Qiuping Wang, Xiangzhu Wang, William Greenlee
  • Processes and intermediates for the preparation of Pimavanserin
    Patent number: 10807953
    Abstract: The present disclosure relates to novel, safe and efficient processes for the synthesis of Pimavanserin and salts thereof, as well as novel intermediates that can be used in these processes.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: October 20, 2020
    Assignee: Pliva Hrvatska D.O.O.
    Inventors: Tomislav Biljan, Jasna Dogan, Leonid Metsger, Sara Morasi Pipercic, Marina Ratkaj, Maja Matanovic Skugor, Yi Wang
  • Method for preparing tyrosine kinase inhibitor and derivative thereof
    Patent number: 10793548
    Abstract: The present invention relates to a method for preparing a tyrosine kinase inhibitor and a derivative thereof. The present method has a short synthesis route, low costs, easy operation, and is suitable for large-scale production.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: October 6, 2020
    Assignee: Jiangsu Hengrui Medicine Co., Ltd.
    Inventors: Guaili Wu, Quanliang Zhang, Yongxing Cao
  • Selective C-KIT kinase inhibitor
    Patent number: 10793543
    Abstract: The present invention provides a compound represented by formula (I), or a pharmaceutically acceptable salt, a solvate, an ester, an acid, a metabolite or a prodrug thereof. The compound itself in the present invention or in combination with at least one therapeutic agent can be used for preventing or treating diseases, disorders or symptoms caused by the adjustment of the activity of tyrosine kinase C-KIT, or affected by the activity of the tyrosine kinase C-KIT or involving in the activity of the tyrosine kinase C-KIT, especially cancers or other cell proliferation diseases.
    Type: Grant
    Filed: March 28, 2017
    Date of Patent: October 6, 2020
    Assignees: PRECEDO PHARMACEUTICALS CO., LTD, HEFEI GRACEVO BIO-MEDICINE CO., LTD
    Inventors: Qingsong Liu, Jing Liu, Qiang Wang, Beilei Wang, Feiyang Liu, Shuang Qi, Ziping Qi, Fengming Zou, Cheng Chen, Wenchao Wang, Chen Hu, Xiaochuan Liu, Wei Wang, Aoli Wang, Li Wang, Zhenquan Hu, Tao Ren
  • N-[(pyridyloxy)propanyl]benzamides
    Patent number: 10787432
    Abstract: This invention relates to compounds of formula (I), a process for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions having an association with the orexin sub-type 1 receptor. Ar, R1, R2, R3, R4, R5, R6 and R7 have meanings given in the description.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: September 29, 2020
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Doris Riether, Marco Ferrara, Niklas Heine, Uta Lessel, Janet Rachel Nicholson, Anton Pekcec
  • 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-mercapto-1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation
    Patent number: 10787431
    Abstract: Provided herein is a process for the preparation of 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-mercapto-1H-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: September 29, 2020
    Assignee: Dow AgroSciences LLC
    Inventors: Nicholas R. Babij, Qiang Yang, Sarah Ryan, Yan Hao, Gary Roth, Kaitlyn Gray
  • Crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione dihydrate, compositions and methods of use thereof
    Patent number: 10781199
    Abstract: Provided herein is a crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione dihydrate. Pharmaceutical compositions comprising the crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione dihydrate are also disclosed.
    Type: Grant
    Filed: October 31, 2019
    Date of Patent: September 22, 2020
    Assignee: Celgene Corporation
    Inventor: Jerry Lee Atwood
  • Cocrystal, production method thereof, and medicament containing cocrystal
    Patent number: 10766876
    Abstract: The present invention provides a cocrystal of (S)-3-(1-((1-acryloylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-1H-1,2,4-triazol-5(4H)-one and an organic acid capable of forming a cocrystal with the compound.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: September 8, 2020
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Koya Kimoto, Mitsuo Yamamoto, Masato Kitayama, Yasuhiro Sawai, Miyuki Hohokabe, Kentaro Iwata
  • Crystalline forms of an androgen receptor modulator
    Patent number: 10766875
    Abstract: Described herein are amorphous and crystalline forms of the androgen receptor modulator 4-[7-(6-cyano-5-trifluoromethylpyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-N-methylbenzamide. Also described are pharmaceutical compositions suitable for administration to a mammal that include the androgen receptor modulator, and methods of using the androgen receptor modulator, alone and in combination with other compounds, for treating diseases or conditions that are associated with androgen receptor activity.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: September 8, 2020
    Assignees: Aragon Pharmaceuticals, Inc., Sloan-Kettering Institute for Cancer Research
    Inventors: Anna Dihas, Mark R. Herbert, Ouathek Ouerfelli, Nicholas D. Smith
  • Lysyl oxidase-like 2 inhibitors and uses thereof
    Patent number: 10766860
    Abstract: Described herein are compounds that are LOXL2 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with LOXL2 activity.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: September 8, 2020
    Assignee: PHARMAKEA, INC.
    Inventors: Martin W. Rowbottom, John Howard Hutchinson, David Lonergan