Patents Examined by Paul A. Zucker
  • Patent number: 10774026
    Abstract: A method for producing esters of an alpha, beta-unsaturated carboxylic acid are disclosed, the method includes reacting a three or four carbon beta-hydroxyalkanoate composition or mixtures thereof with a mono-alcohol under heating conditions to form a reaction product and distilling the reaction product to recover a composition containing at least fifty percent by weight of the ester of the alpha, beta-unsaturated carboxylic acid.
    Type: Grant
    Filed: April 1, 2020
    Date of Patent: September 15, 2020
    Inventors: Timothy Walter Abraham, Ravi R. Gokarn
  • Patent number: 10774025
    Abstract: The present invention provides a production method of a multifunctional acrylate with a reduced tin content which includes adding an acid to a mixture containing an organotin compound and a multifunctional acrylate and distilling the mixture containing the acid.
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: September 15, 2020
    Inventors: Keisuke Ito, Shigeaki Matsumoto, Keita Shigematsu
  • Patent number: 10766845
    Abstract: The present invention generally relates to processes for converting acrylate esters or a derivative thereof to difluoropropionic acid or a derivative thereof. This process is generally performed using fluorine gas in a hydrofluorocarbon solvent.
    Type: Grant
    Filed: March 9, 2020
    Date of Patent: September 8, 2020
    Assignee: Vifor (International) Ltd.
    Inventor: YongQi Mu
  • Patent number: 10759731
    Abstract: There is provided a method for producing a C2-C20 fluorine-containing organic acid with reduced fluorine-free organic compound. A method for producing a C2-C20 fluorine-containing organic acid, the method including contacting a mixture containing a C2-C20 fluorine-containing organic acid and a fluorine-free organic compound with a concentrated sulfuric acid and then separating a C2-C20 fluorine-containing organic acid phase from a concentrated sulfuric acid phase. The contacting is conducted such that an amount of water present in the concentrated sulfuric acid phase is 10% by mass or less, and the C2-C20 fluorine-containing organic acid is obtained in the form of the C2-C20 fluorinated organic acid phase having a reduced content ratio of the fluorine-free organic compound compared with said mixture.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: September 1, 2020
    Inventors: Shuuji Itatani, Mihoko Ohashi
  • Patent number: 10739330
    Abstract: Described herein are fluorescent compounds and methods and comprising these compounds. The compounds disclosed herein are carbopyronine reagents that fluoresce in the red portion of the UV/VIS spectrum and provide bright fluorescence intensity, uniform cell staining, and good retention within live cells as well as low toxicity toward cells.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: August 11, 2020
    Assignee: Life Technologies Corporation
    Inventors: Kyle Gee, Hee Chol Kang, Wenjun Zhou, Bradley Dubbels, Michael Olszowy, Michael O'Grady
  • Patent number: 10730821
    Abstract: Methods for preparing isotopically modified 1,4-diene systems from non-isotopically modified 1,4-dienes involve selective oxidation of one or more bis-allylic position(s), or the preparation of isotopically modified 1,4-diene systems via trapping pi-allylic complexes with a source of deuterium or tritium. Such methods are useful for preparing isotopically modified polyunsaturated lipid including polyunsaturated fatty acids and polyunsaturated fatty acid derivatives.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: August 4, 2020
    Assignee: Retrotope, Inc.
    Inventors: Dragoslav Vidovic, Mikhail Sergeevich Shchepinov
  • Patent number: 10729778
    Abstract: Prodrugs or a pharmaceutically acceptable salt thereof which comprise a covalent treprostinil carrier conjugate, as well as their pharmaceutical composition, may be used as medicaments, especially for diseases or disorders which can be treated by treprostinil, such as pulmonary arterial hypertension (PAH).
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: August 4, 2020
    Assignee: Ascendis Pharma A/S
    Inventors: Ulrich Hersel, Harald Rau, Torben Lessmann, Nicola Bisek, Guillaume Maitro, Kennett Sprogøe, Thomas Wegge, Oliver Keil, Joachim Zettler
  • Patent number: 10730827
    Abstract: A process for purifying alkanesulfonic anhydride that includes feeding a stream containing alkanesulfonic anhydride, sulfuric acid, high boilers and residual low boilers into a melt crystallization to form crystals of the alkanesulfonic anhydride suspended in mother liquor, and solid-liquid separation to remove the crystals from the mother liquor.
    Type: Grant
    Filed: April 18, 2018
    Date of Patent: August 4, 2020
    Assignee: BASF SE
    Inventors: Juergen Wortmann, Jan Spielmann, Katharina Federsel, Feelly Ruether
  • Patent number: 10730823
    Abstract: A process for isolating pure tert-butyl (meth)acrylate from crude tert-butyl (meth)acrylate by distillation, wherein the process is carried out in a dividing wall column having separation-active internals and a vaporizer and in which a dividing wall is arranged in the longitudinal direction of the column to form an upper joint column region, a lower joint column region, an inflow section having a side feed point, and an offtake section having a side offtake point, where the column has from 20-80 theoretical plates and the ratio of the amount of liquid at the upper end of the dividing wall going to the enrichment section and the stripping section of the column is set in the range from 1:0.2 to 1:5.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: August 4, 2020
    Assignee: BASF SE
    Inventors: Ortmund Lang, Bernd Metzen, Claus Hechler
  • Patent number: 10717751
    Abstract: The present disclosure provides polymerizable luminescent dyes useful for incorporation into polymers. The dyes and the polymers can be used in sensing and imaging applications, for example, to provide accurate and optionally long term measurements of glucose in vivo. The present disclosure also provides sensors including the polymers described herein. The sensors can be implanted into a tissue of a subject and used for long-term or short-term continuous and semi-continuous collection of data of various biochemical analytes, optionally without the use of implantable hardware of any type and/or enzymatic and electrochemical detection methods.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: July 21, 2020
    Assignee: Profusa, Inc.
    Inventors: Soya Gamsey, Viachaslau Bernat, Alex Kutyavin, Jacob William Clary, Sulolit Pradhan
  • Patent number: 10717698
    Abstract: The present invention relates to compounds of ester derivative of resveratrol, compositions comprising ester derivatives of resveratrol, processes for synthesizing an ester of resveratrol, and use thereof.
    Type: Grant
    Filed: March 6, 2017
    Date of Patent: July 21, 2020
    Assignee: ELC Management LLC
    Inventors: Fatemeh Mohammadi, Elham Tavasoli
  • Patent number: 10711030
    Abstract: A method for the purification of allopregnanolone is disclosed. Allopregnanolone prepared from isopregnanolone contains impurities such as triphenylphosphine oxide and other unknown impurities. To remove these impurities and purify allopregnanolone, the allopregananolone is dissolved in acetonitrile, and crystallized from the acetonitrile. The resulting crystallized allopregnanolone may then be re-crystallized from acetonitrile to further purify the allopregnanolone.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: July 14, 2020
    Assignee: FARMABIOS S.P.S.
    Inventors: Enrico Torregrossa, Marco Brusasca, Cristina Manfrotto
  • Patent number: 10710952
    Abstract: A process for producing acetic acid is disclosed in which the methyl iodide concentration is maintained in the vapor product stream formed in a flashing step. The methyl iodide concentration in the vapor product stream ranges from 24 to less than 36 wt. % methyl iodide, based on the weight of the vapor product stream. In addition, the acetaldehyde concentration is maintained within the range from 0.005 to 1 wt. % in the vapor product stream. The vapor product stream is distilled in a first column to obtain an acetic acid product stream comprising acetic acid and up to 300 wppm hydrogen iodide and/or from 0.1 to 6 wt. % methyl iodide and an overhead stream comprising methyl iodide, water and methyl acetate.
    Type: Grant
    Filed: September 13, 2018
    Date of Patent: July 14, 2020
    Assignee: Celanese International Corporation
    Inventors: Ronald D. Shaver, Yaw-Hwa Liu, Mark O. Scates
  • Patent number: 10710955
    Abstract: Methods and systems for producing alkyl hydroxyalkanoate from hydroxy carboxylic acid recovery bottoms. The methods generally comprise the steps of obtaining a hydroxy carboxylic acid recovery bottom, adding a mono-alcohol to the hydroxy carboxylic acid recovery bottom to obtain a first mixture, heating the first mixture in the presence of a catalyst to form a reaction product, distilling the reaction product, and recovering an alkyl hydroxyalkanoate fraction.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: July 14, 2020
    Inventors: Timothy Walter Abraham, Anthony Louis Duran, Stephen C. Edgar, Ravi R. Gokarn
  • Patent number: 10711031
    Abstract: A method for extracting phytosterols from tall oil pitch. The method involves saponifying tall oil pitch using an alkali in a polyatomic alcohol, extracting unsaponified matter from the alkali-alcohol solution using a hydrocarbon solvent, subsequently removing the solvent by distillation, and concentrating the phytosterols, wherein a mixture of paraffin hydrocarbons is used as said hydrocarbon solvent, and, following extraction from the extraction solution, betulin is isolated by crystallization and the phytosterols are then concentrated by means of rectification. This method enables an increase in the extraction rate of phytosterols from a saponified tall oil pitch up to 95%, producing the end product with phytosterol content of at least 65% with unwanted betulin impurities at no more than 0.3%.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: July 14, 2020
    Inventors: Ilia Nikolaevich Chernov, Alexey Olegovich Korshunov, Taras Ivanovich Dolinskiy, Mikhail Alekseevich Lazarev, Ekaterina Aleksandrovna Mavrina, Ilia Sergeevich Ilichev, Arkadiy Benyuminovich Radbil
  • Patent number: 10707424
    Abstract: A method of making a chemical product includes reacting a compound represented by Chemical Formula 1 with a metal alkyl chalcogenide using a palladium catalyst and a tertiary phosphine catalyst to obtain a first intermediate represented by Chemical Formula 2, obtaining a second intermediate represented by Chemical Formula 3 from the first intermediate, obtaining a third intermediate from the second intermediate and a compound represented by Chemical Formula 4, obtaining a fourth intermediate including a chalcogen-containing ring from the third intermediate, and performing a cyclization reaction of the fourth intermediate to obtain a fused heteroaromatic compound. A fused heteroaromatic compound obtained by the method, an intermediate thereof, and a synthetic method of the intermediate are disclosed.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: July 7, 2020
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Eun Kyung Lee, Eigo Miyazaki, Jeong Il Park, Hyun Bum Kang
  • Patent number: 10696617
    Abstract: Provided is a method for the alcoholysis of an amide. The method comprises subjecting an amide-containing compound to alcoholysis under alkaline conditions using an epoxy compound as an accelerant of alcoholysis, the method comprising: mixing the amide-containing compound, the epoxy compound, a pH adjuster and a solvent to form an alkaline reaction system, the pH of the alkaline reaction system being 7.5-9.5; reacting the alkaline reaction system at 50° C. ˜150° C. to subject the amide-containing compound to alcoholysis.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: June 30, 2020
    Inventors: Jiangping Lu, Qinglan Pei, Jinquan Yu, Enxuan Zhang
  • Patent number: 10689338
    Abstract: Novel amisulpride derivatives and pharmaceutical compositions thereof are disclosed. The amisulpride derivative disclosed herein or a pharmaceutical composition thereof may have better membrane permeability compared to amisulpride. The amisulpride derivative disclosed herein or a pharmaceutical composition thereof may be used for antagonizing dopamine and/or serotonin (e.g., 5-HT2a) and/or ?2 receptor in a subject, either individually or in combination with other CNS active agents. The amisulpride derivative disclosed herein or a pharmaceutical composition thereof may be used for treating one or more conditions responsive to modulation of dopamine and/or serotonin (e.g., 5-HT2a) and/or ?2 receptor in a subject, either individually or in combination with other CNS active agents.
    Type: Grant
    Filed: September 5, 2019
    Date of Patent: June 23, 2020
    Assignee: LB Pharmaceuticals Inc.
    Inventors: Andrew R. Vaino, Vincent T. Grattan, Zachary Prensky
  • Patent number: 10683265
    Abstract: The present invention relates to a cannabidiol-3-sulfonic acid, a preparation method and application thereof, and a cannabidiol derivative. The present invention introduces a sulfonic acid group in a molecular structure of cannabidiol, and the sulfonic acid group as a polar group can increase the polarity of cannabidiol, thereby improving the water solubility thereof. The cannabidiol-3-sulfonic acid can be subjected to a salt forming reaction with an inorganic base or an organic base, so that the water solubility of the cannabidiol is further improved, and the druggability of a drug based on a parent nucleus and physiological activity of the CBD structure can be enhanced. The newly introduced sulfonic acid group in the cannabidiol-3-sulfonic acid provided by the present invention can be used as a new action site to react with a specific group, and the research and application range of the cannabidiol-3-sulfonic acid is further broadened.
    Type: Grant
    Filed: October 7, 2019
    Date of Patent: June 16, 2020
    Inventors: Guiwu Qu, Ming Cui
  • Patent number: 10676500
    Abstract: The present invention relates to processes for preparing compounds of Formula (I) and compounds of Formula (II): These compounds are useful as FXR or TGR5 modulators.
    Type: Grant
    Filed: April 9, 2018
    Date of Patent: June 9, 2020
    Assignee: Enanta Pharmaceuticals, Inc.
    Inventors: Guoqiang Wang, Yong He, Brett Granger, Xuechao Xing, Yat Sun Or