Abstract: Described here are prosthetic systems, devices, and methods of use therefor. Generally, a prosthesis may be configured to set a resistance to rotation of a prosthetic joint based on a phase of gait. The prosthesis may include a first cylinder, a first piston slidable within the first cylinder, a fluid sump, and a fluid circuit. The fluid circuit may include a plurality of interconnected fluid channels having a unidirectional variable-resistance valve and a set of check valves that are configured to provide unidirectional flow through the valve during piston compression and extension.

Abstract: A transcatheter heart valve includes a paravalvular seal that is configured for transfemoral delivery. The valve includes an outer frame and the seal is formed from a plurality of outwardly extending fibers.

Abstract: Provided is an intraocular lens including a lens body having a back surface disposed on a retinal side and a front surface disposed on a corneal side, wherein an entire back surface is shaped in such a way as to protrude from a peripheral edge of the back surface toward the retinal side in a direction of an optical axis, in a shape of a truncated cone, and the front surface has any of the following shapes (i) to (iii); (i) the front surface is shaped in such a way as to start to be recessed toward the retinal side in the direction of the optical axis when viewed toward a center from a peripheral edge of the front surface, (ii) the front surface is shaped in such a way that an initial part from the peripheral edge of the front surface toward the center is flat, (iii) the front surface is shaped in such a way as to start to protrude toward the corneal side in the direction of the optical axis when viewed toward the center from the peripheral edge of the front surface, but a rate of rise of a protrusion from

Abstract: A heart valve assembly includes an inner frame comprising a graft covering housing a prosthetic heart valve. The graft covering extends around the prosthetic heart valve for providing sealing to the heart valve, an outer frame formed from a metallic material and defining a gridded configuration, and being secured to the graft covering by a plurality of stitches, and a sealing material positioned externally to the outer frame for providing sealing between the outer frame and a patient's anatomical wall to prevent paravalvular leaks. The sealing material includes a plurality of radially extending fibers that extend outwardly of the outer frame. The graft covering is made of polyester, polytetrafluoroethylene, expanded polytetrafluoroethylene, or a polymer.

Abstract: A self-adjusting device configured to be placed in contact with tissue/organ and apply mechanical force to the tissue/organ to achieve an improvement of functioning of the tissue/organ. The self-adjusting capabilities can be carried out by three functional subsystems that can be packaged either in a single, integrated system or in separate modules. A sensing subsystem senses the tissue/organ and sends at least one type of sensing signal characteristic of functioning of the tissue/organ to a controlling subsystem. The controlling subsystem processes the signal with an algorithm to determine if a configuration of the device needs to be changed or a force applied to the tissue/organ needs to be changed. An actuating subsystem can be controlled by the controlling subsystem to affect the configuration/force change when needed. A feedback loop is provided to keep the controlling subsystem up to date as to the state of the actuating subsystem.

Abstract: The invention relates to a mechanical prosthetic heart valve (10) comprising: an annular support (12) having an internal peripheral wall (14) centered about a longitudinal axis (X) and delimiting an internal passage, and at least two mobile leaflets, preferably three mobile leaflets (40), arranged in such a way as to each be able to effect a rotational movement about an axis of rotation perpendicular to said longitudinal axis (X) so that the valve (10) can pass from a closed configuration to an open configuration and vice versa. Each leaflet (40) comprises a leading edge (42) designed to come against a portion of the internal peripheral wall (14) of the annular support (12) when the valve is in a closed configuration, an internal surface (46b) extending from the leading edge (42), and an external surface (46a) opposite the internal surface (46b) and extending from the leading edge (42).

Abstract: Provided is an intraocular lens affixing device which makes it possible to affix an intraocular lens of any kind with respect to the inside of an eye with a ruptured or deleted lens capsule. The intraocular lens affixing device 1 is provided with a device support portion (A) and an intraocular lens housing portion (B) connected to the device support portion (A). The device support portion (A) includes a frame 2 having a shape matching a ciliary sulcus 36. Also provided is an affixing kit for inserting an intraocular lens, the kit being provided with a) an intraocular lens affixing device; and b) an injector for injecting the affixing device.

Abstract: A prosthetic valve for implantation within a native mitral valve may be provided. The prosthetic valve may include an annular valve body and a plurality of atrial anchoring arms and a plurality of ventricular anchoring legs configured to extend radially outward from the annular valve body. The prosthetic valve may also include a blood-inflatable cuff situated between the arms and legs and fastened to at least one arm. The cuff may be configured to extend radially outward beyond a terminal end of at least one arm when fully inflated with blood.

Abstract: An expandable stent (1) to enhance the supply of blood to downstream tissue which is being supplied with blood through a diseased intracranial artery (100) with a stenosis (102) formed therein by plaque with a bore (103) therethrough. The expandable stent (1) comprises first and second end portions (3,4) joined by a central portion (5). The central portion (5) is configured in the expanded state of the stent (1) to be located in the bore (103) of the stenosis (102) with the first and second end portions (3,4) abutting non-diseased parts (104,106) of the artery (100) adjacent the proximal and distal ends (105,107) of the stenosis (102) for anchoring the stent (1) in the artery (100). The central portion (5) with the stent (1) in the expanded state is configured to apply a radial outward pressure to the stenosis (102) such that the diameter of the bore (103) of the stenosis (102) is maintained at its current diameter or increased to approximately 50% of the non-diseased parts (104,106) of the artery (100).

Abstract: A leaflet positioning and fixing clip and a narrow-environment orientation system thereof are provided. The clip includes a fixing element, a lower gripping arm assembly sleeved outside the fixing element, an upper gripping arm assembly sleeved outside the lower gripping arm assembly, a pull rope controlling the upper gripping arm assembly to move, and an occlusive film attached below the lower gripping arm assembly. The upper gripping arm assembly includes an upper central fixing plate and upper gripping arms radially distributed around the upper central fixing plate. The lower gripping arm assembly includes a lower central fixing plate and lower gripping arms. There are at least two upper gripping arms mated with at least two lower gripping arms to form grippers for gripping a tricuspid valve. The occlusive film is stably positioned in a center of the tricuspid valve through the grippers.

Abstract: Disclosed herein are methods, implants and systems for treatment of mitral valve prolapse by subannular fixation of the prolapsed mitral valve. The disclosure relates generally to the field of heart valve repair devices, methods and kits and more specifically to trans catheter methods and devices for insertion of tethers and anchors to the mitral valve leaflets for reduction the prolapsed mitral valve and subannular fixation of the prolapsed leaflet to treat mitral valve regurgitation.

Abstract: Devices and methods are disclosed for managing and/or treating body tissues obstructing a hollow body lumen, including the prostatic lobe tissues obstructing the urethra, for example conditions including benign prostatic hyperplasia (BPH), bladder outlet obstruction (BOO), benign prostatic obstruction (BPO) and associated lower urinary tract symptoms (LUTS). A retrieval sheath having an elongated shaft member with at least one region of modified flexibility that is configured compress the implant to a reduced profile for removal from the patient's body.

Abstract: A diametric adjustment mechanism for an implantable medical device including a track defining a series of diametric setpoints, including a first diametric setpoint and a second diametric setpoint, a rider engaged with the track such that the rider is selectively movable along the track from the first diametric setpoint to the second diametric setpoint and from the second diametric setpoint to the first diametric setpoint, and a biasing element biasing the rider toward the first diametric setpoint when the rider is at the second diametric setpoint.

Abstract: An interstitial fluid accumulation chamber is configured to be implanted in a mammal for use as a protective environment for transplanted cells. The interstitial fluid accumulation chamber includes opposed first and second members, a cell isolation chamber, and a plurality of spaced-apart members. The opposed first and second members are disposed in spaced-apart relation. The cell isolation chamber is disposed within and in-between the opposed first and second members. The cell isolation chamber includes a filter which contains pores sized to allow interstitial fluid to enter the cell isolation chamber while preventing cells within the cell isolation chamber from leaving the cell isolation chamber. The plurality of spaced-apart members are disposed within and between the opposed first and second members. The plurality of spaced-apart members form a tortuous path which is configured to prevent tissue from growing within the interstitial fluid accumulation chamber.

Abstract: A method of altering a refractive property of a crosslinked acrylic polymer material by irradiating the material with a high energy pulsed laser beam to change its refractive index. The method is used to alter the refractive property, and hence the optical power, of an implantable intraocular lens after implantation in the patient's eye. In some examples, the wavelength of the laser beam is in the far red and near IR range and the light is absorbed by the crosslinked acrylic polymer via two-photon absorption at high laser pulse energy. The method also includes designing laser beam scan patterns that compensate for effects of multiphone absorption such as a shift in the depth of the laser pulse absorption location, and compensate for effects caused by high laser pulse energy such as thermal lensing. The method can be used to form a Fresnel lens in the optical zone.

Abstract: Features for a powered prosthetic thumb are described. The thumb provides for rotation of a digit that mimics the natural movement possible with a sound thumb. The thumb may attach to a full or partial prosthetic hand or socket on a residual limb. The thumb may include an upper assembly, including a prosthetic thumb digit, rotatably attached to a mount about a pinch axis and a lateral axis. The digit may rotate about only the pinch axis, only the lateral axis, or both the pinch and lateral axes simultaneously. A first actuator may actuate to cause rotation of the digit about the pinch axis. A second actuator may actuate to cause rotation of the digit about the lateral axis. The first and second actuators may be actuated together at appropriate speeds to cause rotation about both the pinch and lateral axes simultaneously. A swaying chassis may be rotatably connected with the upper assembly and a lower assembly about various offset axes to provide for rotation about the lateral axis.

Abstract: A docking device includes a hollow cylindrical body portion having an internal surface and an outer surface. The hollow cylindrical body portion is formed of a three-dimensional (3D) woven fabric comprising a plurality of different types of fibers.

Abstract: The invention relates to a mechanical prosthetic heart valve (10) comprising an annular support (12) having an internal peripheral wall (14) centered about a longitudinal axis (X) and delimiting an internal passage, and at least two mobile leaflets (40), preferably three leaflets (40), arranged in such a way as to each be able to effect a rotational movement about an axis of rotation perpendicular to said longitudinal axis (X) so that the valve (10) can pass from a closed configuration to an open configuration and vice versa. Each leaflet comprises a central part (46), and two lateral winglets (48a, 48b) flanking the central part (46) symmetrically with respect to a plane of symmetry (Z) of the leaflet. Each winglet (48a, 48b) comprises one of two terminal portions (49a, 49b).

Abstract: A stent-deployment assembly for use with a guidewire comprises a biliary stent and an elongated stent-conveyance tube comprising a guidewire-retaining segment that includes respective distal and proximal apertures defining a guidewire-path therethrough, and a lengthways laterally-breachable portion. In a stent-advancement configuration, the guidewire passes through the respective apertures so as to interiorly traverse the guidewire-retaining segment, and the stent is arranged to surround a stent-conveyance tube segment that is proximally displaced from the guidewire-retaining segment, for advancement of the stent together with the stent-conveyance tube along the guidewire into a body lumen of a human subject.

Abstract: A method of treating an aortic aneurysm of a patient with an endovascular graft system and mitigating post implant syndrome associated therewith comprises placing at least one prosthesis across an aneurysmal space. The prosthesis comprises a double-walled filling structure and a stent-graft. The stent graft is radially expanded at a first pressure and the filing structure is filled with a first filing agent to contact a thrombus in the aortic aneurysmal space. After the first filling agent is removed, the filling structure is filled with a second filling agent to contact the thrombus. Next the stent-graft is expanded at a second pressure causing the filing structure to place an effective amount of pressure on the thrombus and substantially mitigating the effects of post implant syndrome associated with the prosthesis.