Abstract: A double-sided aspheric diffractive multifocal lens and methods of manufacturing and design of such lenses in the field of ophthalmology. The lens can include an optic comprising an aspheric anterior surface and an aspheric posterior surface. On one of the two surfaces a plurality of concentric diffractive multifocal zones can be designed. The other surface can include a toric component. The double-sided aspheric surface design results in improvement of the modulation transfer function (MTF) of the lens-eye combination by aberration reduction and vision contrast enhancement as compared to one-sided aspheric lens. The surface having a plurality of concentric diffractive multifocal zones produces a near focus, an intermediate focus, and a distance focus.

Abstract: An artificial cornea and an associated manufacturing method are disclosed. The artificial cornea has two sides, each of which has an associated microstructure. In an embodiment, microlines can be provided on an anterior side, and a posterior side can have micropores. Both the geometry of the microstructures and their dimensions can be customized for an individual patient. The geometry of the artificial cornea itself and its dimensions can also be customized as such. In addition, the lifetime of the artificial cornea can be significantly enhanced by adding co-polymer(s) into the hydrogel to strengthen its mechanical properties. Patient recovery can be aided by adding peptides into the artificial cornea surfaces to improve cell growth post-operation.

Abstract: An endoprosthesis may include an expandable framework configured to shift between a delivery configuration and a deployed configuration, and a covering including a plurality of polymeric cover segments disposed about at least a portion of the expandable framework. A portion of each of the plurality of polymeric cover segments may be fixedly attached to the expandable framework. The plurality of polymeric cover segments is longitudinally spaced apart from each other in the delivery configuration. The plurality of polymeric cover segments longitudinally overlaps each other in the deployed configuration.

Abstract: Systems and methods for improving vision of a subject implanted with an intraocular lens (IOL). In some embodiments, a method includes determining at least one modification to be made to an IOL implanted in a subject to improve the vision of the subject, wherein the IOL has a first index of refraction; and based on the determination, applying laser radiation to at least one selected area of the IOL to form, within the IOL, at least one additional layer having a different index of refraction than the first index of refraction and a particular shape within the IOL configured to improve the vision of the subject.

Abstract: A two-step delivery method, system and device is disclosed comprising, in various embodiments, a self-expanding frame. A self-expanding frame is delivered and expanded within a heart chamber followed by delivery of a prosthetic valve comprising prosthetic valves thereon into the expanded self-expanding frame, which is in turn connected to a valve connection region defined on and by the delivered and expanded frame.

Abstract: Described herein are intraocular lenses and methods of implantation. In one aspect, the lens includes a shape changing optical element; a force translation element having a first end region coupled to the optical element and a second end region extending towards a ciliary structure, and an attachment portion coupled to the second end region of the force translation element and configured to contact the ciliary structure. The force translation element is configured to functionally transmit movements of the ciliary structure into a force exerted upon the optical element to effect an accommodating and a disaccommodating change of the optical element.

Abstract: An artificial heart valve includes a frame, one or more struts attached to the frame, and a leaflet configured to open and close a fluid flow path through the frame by moving in response to heartbeats. Movement of the leaflet is restricted by the one or more struts. The leaflet includes an inner leaflet body having a negative Poisson's ratio, and an outer leaflet body at least partially surrounding the inner leaflet body, the outer leaflet body having a positive Poisson's ratio.

Abstract: An ophthalmic implant including an intraocular lens (IOL) and at least one drug delivery device. The IOL including an anterior side, a posterior side, a lens, and at least one haptic extending outwardly from the lens and including a first haptic extending from the lens at a first optic-haptic junction. The at least one drug delivery device including a first drug delivery device including a pad and a fixation portion extending from the pad. The pad including at least one therapeutic agent contained therein, an anterior surface, a posterior surface, and a sidewall extending around the pad and between the anterior surface and the posterior surface. The drug delivery device configured for attachment to the IOL via the fixation portion. In an assembled state of the implant, the first drug delivery device is attached to the IOL and the pad overlays the first optic-haptic junction.

Abstract: The present disclosure relates generally to the field of medical devices. In particular, the present disclosure relates to delivery systems configured to position a distal portion of a medical device within a restricted anatomical area. In one example, a delivery system may include a flexible elongate member with an inner member within a lumen of the flexible elongate member. A stent may be constrained therebetween. The stent may be configured to move between a first configuration to a second deployed configuration when unconstrained from the flexible elongate member. When the stent moves from the first configuration to the second configuration, the inner member may change from a first length to a second, shorter length. Other embodiments are contemplated.

Abstract: A prosthetic heart valve reinforcement ring is disclosed for reinforcing a natural heart valve with leaflets. The prosthetic ring includes a ring body sized and dimensioned to fit around the annulus of the heart valve. The ring body has an inner surface with a plurality of grooves on the inner surface of the ring body, where each of grooves is configured to grasp a suture. A method of reinforcing a natural heart valve is also disclosed. Sutures are provided around an annulus of a natural heart valve with leaflets. A prosthetic ring is selected that is sized to fit around the annulus. The prosthetic ring is attached to the annulus by inserting sutures into the grooves until the leaflets are properly closed. The fit of the prosthetic ring is adjusted by individually manipulating the sutures in the grooves. The sutures are tied, securing the prosthetic ring in place.

Abstract: A prosthetic heart valve includes an annular frame that has an inflow end and an outflow end and is radially compressible and expandable between a radially compressed configuration and a radially expanded configuration. The prosthetic heart valve further includes a leaflet structure positioned within the frame and secured thereto, and an outer sealing member mounted outside of the frame and adapted to seal against surrounding tissue when the prosthetic heart valve is implanted within a native heart valve annulus of a patient. The sealing member can include a mesh layer and pile layer comprising a plurality of pile yarns extending outwardly from the mesh layer.

Abstract: Cardiac valve repair devices with coaptation members and multiple clip mechanisms and associated systems and methods are disclosed herein. A cardiac valve repair device configured in accordance with embodiments of the present technology can include, for example, an optional fixation member configured to engage tissue within a left atrium proximate to a native mitral valve, a coaptation member depending from the fixation member, and a plurality of clip mechanisms extending from a downstream portion of the coaptation member. The coaptation member can be positioned between the native leaflets and at least partially fill a space between the native leaflets. A first clip mechanism can engage a first portion of one of the native leaflets, and a second clip mechanism can engage another portion of the same native leaflet or an opposing native leaflet.

Abstract: The present technology is a prosthetic heart valve device, and related systems and methods, for treating a native valve of a human heart having a native annulus and native leaflets. One embodiment comprises a valve support, a prosthetic valve assembly within the valve support, and an anchoring member having an upstream portion and a downstream portion. The device further includes an extension member coupled to the fixation frame and extending radially outward therefrom. The extension member includes a plurality of wires, at least a portion of which include an inner core surrounded by an outer material. The wires include a plurality of recesses extending through at least a portion of the thickness of the outer material, and a therapeutic agent in the recesses for delivery to the anatomy when the prosthetic heart valve device is positioned at a native annulus.

Abstract: A two-step delivery method, system and device is disclosed comprising, in various embodiments, a self-expanding frame. A self-expanding frame is delivered and expanded within a heart chamber followed by delivery of a prosthetic valve comprising prosthetic valves thereon into the expanded self-expanding frame, which is in turn connected to a valve connection region defined on and by the delivered and expanded frame.

Abstract: Medical Implant (100), comprising a microbial cellulose tube (1), comprising a wall (2) having an inner surface (3) and an outer surface (4), wherein the wall comprises several layers (5, 6, 7) of microbial cellulose, wherein said layers are concentric or substantially concentric to a longitudinal axis (L) of the tube, a stent (9) which placed inside of the microbial cellulose tube (1), wherein an outer surface (10) of the stent contacts the inner surface (3) of the microbial cellulose tube (1), and method for producing such implant. The implant can be covered with newly created bile duct epithelium, thereby creating a new bile duct from body cells. The implant can be removed after completion of creation of the new bile duct. So, the implant as suitable as a temporary implant. The implant can be used for surgery, such as surgery of gall bladder, bile duct and/or liver, e.g. gall bladder removal, hepatobiliary malignancy surgery or liver transplantation.

Abstract: A valve repair device for repairing a native valve of a patient includes a spacer element, a pair of paddles, and a pair of gripping members. The pair of paddles is coupled to the spacer element. The pair of gripping members is disposed between the pair of paddles. The paddles and the gripping members are configured to attach to leaflets of a heart valve. The spacer element extends past side edges of the gripping members, extends past side edges of the paddles, or extends past the side edges of both the gripping members and the paddles.

Abstract: Described here are prosthetic systems, devices, and methods of use therefor. Generally, a prosthesis may be configured to set a resistance to rotation of a prosthetic joint based on a phase of gait. The prosthesis may include a first cylinder, a first piston slidable within the first cylinder, a fluid sump, and a fluid circuit. The fluid circuit may include a plurality of interconnected fluid channels having a unidirectional variable-resistance valve and a set of check valves that are configured to provide unidirectional flow through the valve during piston compression and extension.

Abstract: The invention relates to an expandable vascular implant for implantation into vessels of a patient, the vascular implant being convertible from a compressed state to an expanded state, and the vascular implant comprising the following: a hollow cylindrical main body having a longitudinal direction and a proximal end and a distal end, and a main body lumen which extends from the proximal to the distal end. The hollow cylindrical main body is formed by a tubular lattice structure, the tubular lattice structure having at least one first and at least one second region, the first region being fixedly connected to the second region, the first region being designed to be self-expandable, and the second region is designed to be balloon-dilatable.

Abstract: An intraocular implant device for comprehensive intraocular vision advancement includes an intraocular implant body shaped for positioning inside a lens chamber of an eye. In some embodiments, the implant includes an optical adjustable base accommodating lens configured to provide both base adjustment and accommodation. In further embodiments, the implant includes a photoelectric sensor operable to receive incident light through the cornea and to convert the received light into electrical energy for use with one or more circuit components disposed on the body, and wherein the photoelectric sensor is also operable to convert the received light into image data. The ocular implant device may include a projector for projecting the an image representative of the image data onto the retina of a user.

Abstract: A transcatheter heart valve includes a paravalvular seal that is configured for transfemoral delivery. The valve includes an outer frame and the seal is formed from a plurality of outwardly extending fibers.