Abstract: The invention is related to a flavorant composition containing 1′-acetoxychavicol acetate and 1′-acetoxyeugenol acetate derivatives thereof as well as a flavorant acceptable carrier. The flavorant composition may be used for flavoring foods, beverages or healthcare products with warm/hot, spicy and pungent sensations related to Galangal.
Type:
Grant
Filed:
August 8, 2000
Date of Patent:
November 5, 2002
Assignee:
Givaudan Roure (International) SA
Inventors:
Jean-Pierre Bachmann, Markus Gautschi, Bernhard Hostettler, Xiaogen Yang
Abstract: Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis.
Type:
Grant
Filed:
April 3, 2001
Date of Patent:
November 5, 2002
Assignees:
Elan Pharmaceuticals, Inc., Eli Lilly Company
Inventors:
Jing Wu, Jay S. Tung, Eugene D. Thorsett, Jon K. Reel, Warren J. Porter, Jeffrey S. Nissen, Thomas E. Mabry, Lee H. Latimer, Varghese John, Beverly K. Folmer, James J. Droste, Thomas C. Britton, James E. Audia
Abstract: A process for the manufacture of an alkyl ester of an aliphatic carboxylic acid comprises the steps of supplying a first feed stream comprising carbon monoxide and an alkene of formula CnH2n to a reactor, supplying a second feed stream comprising an alkyl alcohol, having a formula R—OH where R is an optionally substituted alkyl group, to the reactor, and reacting together said first and second feed streams in the reactor in the presence of a carbonylation catalyst, which catalyses the carbonylation reaction between carbon monoxide and the alkene, to form a product comprising an alkyl alkanoate having the formula CnH2n+1COOR, such that the ratio of alkyl alcohol to alkyl alkanoate present in the reactor is greater than the ratio of alkyl alcohol to alkyl alkanoate present in an azeotropic mixture of the alkyl alcohol and alkyl alkanoate. The process is particularly useful for the manufacture of methyl propionate by the methoxycarbonylation of ethylene.
Abstract: The present invention relates to a process for preparing monoacetylated hydroquinone compounds of the formula I,
to the novel final products of the process and to a process for preparing the precursors.
Type:
Grant
Filed:
October 3, 2000
Date of Patent:
November 5, 2002
Assignee:
BASF Aktiengesellschaft
Inventors:
Karin Schein, Kai-Uwe Baldenius, Wolfgang Siegel, Rainer Stürmer, Detlef Ruff, Hagen Jaedicke
Abstract: The invention relates to a method for oxidizing primary alcohols in order to obtain aldehydes and/or carboxylic acids. The reaction takes place in the presence of a catalyst supported on aluminium oxides or aluminium silicates and containing palladium, platinum, cobalt, rhodium, ruthenium, iridium, rhenium, optionally with co-catalysts.
Type:
Grant
Filed:
May 31, 2000
Date of Patent:
November 5, 2002
Assignee:
RWE-DEA Aktiengesellschraft fur Mineraloel und Chemie
Abstract: Perfluorinated esters of alkanoyl-L-carnitine of the formula (I):
are useful as cationic lipids for the intracellular delivery of pharmacologically active compounds.
Abstract: A process for producing high quality TPA suitable for PET feedstock material from recycled polyester. The process includes the steps of depolymerizing the polyester to form DMT; separating the DMT from secondary materials; and hydrolyzing the DMT to form TPA. In a preferred embodiment of the invention the recycled polyester is contacted with a component monomer or oligomer thereof to liquefy the polyester prior to depolymerizing the polyester.
Type:
Grant
Filed:
November 12, 1999
Date of Patent:
October 29, 2002
Assignee:
Eastman Chemical Company
Inventors:
Thomas Michael Pell, Jr., Michael Paul Ekart, David Dunlap Cornell, Damon Brian Shackelford, Donald Lee Carver
Abstract: A process for the production of acetic acid by reacting carbon monoxide with methanol and/or a reactive derivative thereof in a liquid reaction composition comprising an iridium carbonylation catalyst, methyl iodide, methyl acetate, water and acetic acid characterized in that there is also present in the reaction composition a polydentate phosphine oxide compound in an amount of less than 10 mol per gram atom of iridium.
Abstract: Antiatherosclerotic compounds are provided which have the following structure:
wherein
R is lower alkyl;
R1 is hydroxy, amino, or lower alkoxy,
R2 and R3 are each independently hydrogen, alkyl or aryl;
Ar is phenyl, indanyl, benzhydryl, or phenyl substituted with one or more member selected from the group consisting of halogen, lower alkyl, perfluoroalkyl, lower alkoxy, perfluoroalkylalkoxy, dialkylamino, and aryloxy; or pharmaceutically acceptable salts thereof.
Type:
Grant
Filed:
September 28, 2001
Date of Patent:
October 29, 2002
Inventors:
Hassan M. Elokdah, Theodore S. Sulkowski
Abstract: There is disclosed chiral copper complex catalyst composition, which is obtained by contacting an optically active N-salicylideneaminoalcohol compound of formula (1):
with a mono-valent or di-valent copper compound in an inert solvent,
wherein R1 and R2 represent an alkyl group and the like,
X1 and X2 represent a hydrogen atom, a halogen atom, a nitro group, an alkyl group, an alkoxy group, a cyano group or the like, and
the amount of the mono-valent or di-valent copper compound is less than 1 mole per 1 mole of the optically active N-salicylideneaminoalcohol compound of formula (1), and a process for producing an optically active cylopropane-carboxylic acid ester using the same.
Abstract: Disclosed is a process for the preparation of trifluoromethanesulfonic acid anhydride by the steps of (1) forming a mixed anhydride comprising a trifluoromethanesulfonyl acyl residue and a carboxyl residue by contacting trifluoromethanesulfonic acid or a derivative thereof with a carboxyl compound selected from ketene, dialkyl ketenes, carboxylic acids, and derivatives of carboxylic acids and (2) subjecting the mixed anhydride to reactive distillation wherein the mixed anhydride undergoes disproportionation to produce triflic anhydride and a higher boiling carboxylic acid anhydride.
Abstract: 2-Phenoxyphenylacetic acid derivatives of the formula I
where the substituents and the index have the following meanings:
A is
where
R1 is halogen, C1-C4-alkyl, C1-C4-alkoxy, CF3, C1-C4-haloalkoxy, formyl, C(═O)NRaRb or C(Ra)═NORb;
Ra is hydrogen or C1-C4-alkyl;
Rb is C1-C4-alkyl;
n is 1, 2, 3 or 4, where the groups R1 may be different if n is not 1;
R2 is halogen, CH3 or CF3;
m is 0 or 1; and
X is OCH3 or NHCH3;
processes and intermediates for preparing the compounds I and the use of the compounds I for controlling harmful fungi are described.
Type:
Grant
Filed:
April 25, 2001
Date of Patent:
October 22, 2002
Assignee:
BASF Aktiengesellschaft
Inventors:
Wassilios Grammenos, Hubert Sauter, Andreas Gypser, Oliver Cullmann, Markus Gewehr, Bernd Müller, Arne Ptock, Norbert Götz, Roland Götz, Thorsten Volk, Eberhard Ammermann, Thomas Grote, Gisela Lorenz, Siegfried Strathmann
Abstract: Trifluoromethyl-substituted biphenylcarboxylic acids are prepared by converting methyl-substituted biphenylcarbonitriles into the corresponding trichloromethyl-substituted biphenylcarbonitriles, converting the trichloromethyl group thereof to a trifluoromethyl group and thus obtaining trifluoromethyl-substituted biphenylcarbonitriles, and preparing the corresponding carboxylic acids therefrom by hydrolysis. A number of intermediates arising during this are novel compounds.
Type:
Grant
Filed:
January 8, 2002
Date of Patent:
October 15, 2002
Assignee:
Bayer Aktiengesellschaft
Inventors:
Peter Müller, Albrecht Marhold, Karen Peilstöcker
Abstract: A process for preparing a malonic acid monoester or &bgr;-ketoester from an epoxide includes the steps of reacting an epoxide with carbon monoxide and an alcohol in the presence of a catalytic amount of a cobalt compound and at least one promoter to produce a &bgr;-hydroxyester, separating the &bgr;-hydroxyester from the cobalt compound and the promoter, and oxidizing the &bgr;-hydroxyester to produce a malonic acid monoester or &bgr;-ketoester.
Type:
Grant
Filed:
June 20, 2001
Date of Patent:
October 15, 2002
Assignee:
Samsung Electronics Co., Ltd.
Inventors:
Byeong No Lee, In-Sun Jung, Eun Joo Jang
Abstract: Novel thyroid receptor ligands are provided which have the general formula (I)
where R1 is alkyl of 1 to 4 carbons or cycloalkyl of 3 to 7 carbons; R2 and R3 are the same or different and are hydrogen, halogen, alkyl of 1 to 3 carbons or cycloalkyl of 3 to 5 carbons, at least one of R2 and R3 being other than hydrogen; n is an integer from 0 to 4; R4 is an aliphatic hydrocarbon, an aromatic hydrocarbon, carboxylic acid ester thereof, alkenyl carboxylic acid or ester thereof, hydroxy, halogen, cyano, or a phosphonic acid or an ester thereof, or a pharmaceutically acceptible salt thereof. A method for treating diseases associated with metabolism dysfunction or which are dependent on the expression of a T3 regulated gene, such as obesity, hypercholesterolemia, osteoporosis, hypothyroidism, and goiter, is also provided.
Type:
Grant
Filed:
March 20, 2000
Date of Patent:
October 15, 2002
Assignee:
Karo Bio AB
Inventors:
Yi-Lin Li, Ye Liu, Asa Hedfors, Johan Malm, Charlotta Mellin, Minsheng Zhang
Abstract: The synthesis of N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester via conversion under reducing conditions of novel imidazolidinone(s) is disclosed.
Type:
Grant
Filed:
November 17, 1999
Date of Patent:
October 15, 2002
Assignee:
The NutraSweet Company
Inventors:
Vladislav Orlovski, Indra Prakash, Mike G. Scaros, Christine M. V. Moore
Abstract: Novel 2-substituted 7-haloindenes and methods for synthesizing such indenes are described. The 2-substituted 7-haloindenes may be coupled with any aryl group to produce a metallocene catalyst intermediate.