Patents Examined by Peter F. Kulkosky
  • Patent number: 6444221
    Abstract: These and other objects of this invention are achieved by providing a novel method and compositions for the clinical treatment of chronic inflammatory diseases. This invention involves use of systemically administered compositions which include primary amine derivatives of benzoic acid as carbonyl trapping agents. These primary therapeutic agents act by chemically binding to and sequestering the aldehyde and/or ketone products of lipid peroxidation. Increased levels of lipid peroxidation have been repeatedly demonstrated as a part of the non-enzymatic “inflammatory cascade” process which underlies the secondary etiology of chronic inflammatory diseases. p-Aminobenzoic acid (or PABA) is an example of the primary therapeutic agent of the present invention. PABA has a small molecular weight, is water soluble, has a primary amine group that reacts with carbonyl-containing metabolites under physiological conditions and is tolerated by the body in relatively high dosages and for extended periods.
    Type: Grant
    Filed: October 12, 1999
    Date of Patent: September 3, 2002
    Inventor: Howard K. Shapiro
  • Patent number: 6368629
    Abstract: A system for releasing a drug specifically in the colon of the gastrointestinal tract, which comprises a drug (b) coated with an organic acid-soluble polymer material (a), and a saccharide (c) which rapidly generates an organic acid by the action of enterobacteria in the lower part of the gastrointestinal tract; a colon-specific drug release oral preparation, which comprises a composition comprising a drug (b) coated with an organic acid-soluble polymer material (a) and a saccharide (c) which rapidly generates an organic acid by the action of enterobacteria in the lower part of the gastrointestinal tract, said composition being coated with an enteric coating polymer material (d). The invention provides a drug release system and a preparation which utilize enterobacteria, which do not form harmful substances due to the release-starting mechanism, show rapid degradation, and have higher colon specificity.
    Type: Grant
    Filed: October 30, 1998
    Date of Patent: April 9, 2002
    Assignee: Yamanouchi Pharmaceutical Company Ltd.
    Inventors: Shunsuke Watanabe, Hitoshi Kawai, Masataka Katsuma, Muneo Fukui
  • Patent number: 6331295
    Abstract: Skin irritation, such as diaper rash, appearing when the skin is allowed to remain in contact with proteolytic enzymes found in feces is prevented by inactivating the fecal proteolytic enzymes by contact with organophilic clays. The organophilic clays are applied to the skin in areas likely to come into contact with feces or to garments such as diapers. A composition suitable for practicing the method of the invention comprises an amount of an organophilic clay effective to inactivate irritating fecal proteolytic enzymes dispersed in a pharmaceutically acceptable non-toxic dermatological vehicle. A fabric incorporating organophilic clay, preferably dispersed in a matrix of a superabsorbent polymer is useful for preparing diapers for infants that can help to prevent skin irritation by fecal enzymes.
    Type: Grant
    Filed: September 8, 1999
    Date of Patent: December 18, 2001
    Assignee: EnviroDerm Pharmaceuticals, Inc.
    Inventor: Anthony A. Schulz
  • Patent number: 6322813
    Abstract: The invention relates to a compact member comprising a plurality of porous cellulose matrices (PCMs), and providing extended release of an active compound located in the pores of said PCMs together with a release modifying agent. The friability of the compact member is less than 2.1%, and the disintegration time in-vitro of said compact member is less than 240 minutes. The compact member is manufactured by exposing a plurality of PCMs to an active compound and a release modifying agent, in optional sequence or mixture, for a time sufficient for said active compound and release modifying agent to fill the pores in said PCMs to a preselected level. The PCMs are subsequently compacted to a desired shape. The invention further relates to use of the compact members for administration of a drug.
    Type: Grant
    Filed: October 30, 1997
    Date of Patent: November 27, 2001
    Assignee: Pharmacia AB
    Inventors: Torkel Green, Christer Nyström
  • Patent number: 6315991
    Abstract: The present invention is directed to monomeric and polymeric compositions based upon polymeric urethane surfactants which are derived from linear, branched, or aromatic compounds of synthetic or natural origin, preferably from tertiary amines and diisocyanate compounds. The urethane polymers of the present invention may be in the form of betaines, quaternium salts, tertiary amine salts or N-oxides. The compounds of the present invention may be incorporated into personal care formulations such as cosmetics, dental care products and toiletries to improve at least one and preferably two or more characteristics of such formulations.
    Type: Grant
    Filed: March 24, 1999
    Date of Patent: November 13, 2001
    Assignee: Fleet Bank, National Association
    Inventors: Albert Zofchak, Madeline Kenney, John Obeji, Michael Mosquera
  • Patent number: 6316016
    Abstract: A method for creating a barrier to protect wood materials for house construction or wooden structures such as houses from humidity, moisture and/or biological attacks, such as wood decaying fungi and termites, is disclosed. The method is to treat wood itself or, preferably, the ground surface under the floor with a liquid containing a synthetic resin emulsion and an anti-fungal and wood preservative agent and/or a pesticide such as termite-controlling agent, and further, a foaming agent. The barrier contains a selected copolymer of vinyl acetate and a polyurethane polymer.
    Type: Grant
    Filed: May 3, 1999
    Date of Patent: November 13, 2001
    Assignee: Nippon Eisei Center Co., Ltd.
    Inventor: Toru Iwakawa
  • Patent number: 6312726
    Abstract: A gastric remaining preparation having a configuration entirely different from that of the conventional ones. It comprises a swollen molding having a mesh-like cross-section and an apparent density of less than 1, containing an acid-resistant polymer compound as a predominant component as well as at least an auxiliary blowing agent and a drug substance. The molding can be produced by using a multi-screw extruder.
    Type: Grant
    Filed: February 20, 1996
    Date of Patent: November 6, 2001
    Assignee: Nippon Shinyaku Co., Ltd.
    Inventors: Kouichi Nakamichi, Shougo Izumi, Hiroyuki Yasuura
  • Patent number: 6309628
    Abstract: A pearlescent composition containing: (a) a dialkyl ether corresponding to formula (I): R1—O—R2 wherein R1 and R2, independently of one another, represent linear or branched alkyl and/or alkenyl groups having from 12 to 22 carbon atoms; (b) a silicone compound; and (c) an emulsifier selected from the group consisting of alkyl oligoglycosides, alkenyl oligoglycosides, fatty acid-N-alkyl polyhydroxyalkylamides, alkyl ether sulfates, betaines, and mixtures thereof.
    Type: Grant
    Filed: May 12, 1999
    Date of Patent: October 30, 2001
    Assignee: Henkel Kommanditgesellschaft auf Aktien
    Inventors: Achim Ansmann, Bernd Fabry
  • Patent number: 6309630
    Abstract: Compositions for topical ophthalmic application comprising an aqueous mixture of a non-steroidal anti-inflammatory agent. The compositions are formulated with a pH and concentration of agent chosen to maintain at least some of the therapeutic agent of the formulation in suspension.
    Type: Grant
    Filed: May 24, 1994
    Date of Patent: October 30, 2001
    Assignee: Insite Vision Incorporated
    Inventors: Rajesh Patel, Lyle M. Bowman, Peng Shen
  • Patent number: 6306422
    Abstract: A method for the controlled release of a biologically active agent wherein the agent is released from a hydrophobic, pH-sensitive polymer matrix is disclosed and claimed. In one embodiment, the polymer matrix swells when the environment reaches pH 8.5, releasing the active agent. A polymer of hydrophobic and weakly acidic comonomers is disclosed for use in the controlled release system. In another embodiment, weakly basic comonomers are used and the active agent is released as the pH drops. Further disclosed is a specific embodiment in which the controlled release system may be used. The pH-sensitive polymer is coated onto a latex catheter used in ureteral catheterization. A common problem with catheterized patients is the infection of the urinary tract with urease-producing bacteria. In addition to the irritation caused by the presence of the bacteria, urease produced by these bacteria degrade urea in the urine, forming carbon dioxide and ammonia. The ammonia causes an increase in the pH of the urine.
    Type: Grant
    Filed: August 3, 1998
    Date of Patent: October 23, 2001
    Assignee: CApHCO, Inc.
    Inventors: Christopher D. Batich, Marc S. Cohen, Kirk Foster, William Toreki, III
  • Patent number: 6306413
    Abstract: Stable aqueous dispersions of 1,2-benzisothiazolin-3-one containing Xanthan gum which is substantially free from organic solvents.
    Type: Grant
    Filed: December 18, 1995
    Date of Patent: October 23, 2001
    Assignee: Zeneca Limited
    Inventor: John David Payne
  • Patent number: 6306382
    Abstract: A keratotic plug remover composition comprising a polymer compound having a salt forming group is disclosed. The composition according to the invention can effectively remove keratotic plugs in the skin pores, so that the conspicuousness of the skin pores is mitigated and clean and healthy skin pores can be maintained. The composition does not hurt the skin.
    Type: Grant
    Filed: November 12, 1996
    Date of Patent: October 23, 2001
    Assignee: Kao Corporation
    Inventors: Tomohiro Uemura, Masanori Tanahashi, Yoshinao Kono
  • Patent number: 6303134
    Abstract: Methods and compositions are disclosed for providing prolonged release of therapeutic agents by way of in situ stereotaxic implantation in specific loci, including pathways, to treat known disorders. One or more microstructures comprising therapeutic agents and pharmaceutically acceptable carriers are implanted, for example, through a cannula. The microstructures are of a sufficient size and shape to prevent dispersion from the implant site.
    Type: Grant
    Filed: February 22, 1999
    Date of Patent: October 16, 2001
    Assignee: Advanced Research and Technology Institute, Inc.
    Inventor: Michael J. Kubek
  • Patent number: 6300427
    Abstract: Disclosed is a method of inhibiting the formation of scale on reactor surfaces in contact with a polymerizing vinyl monomer comprising contacting said monomer with a terpolymer which comprises the condensation reaction product of (A) an aromatic compound that contains the group where Q is OR or SR and R is hydrogen, alkyl from C1 to C15, or aryl, alkaryl, or aralkyl from C6 to C15: (B) about 0.1 to about 10 moles of a carbonyl compound per mole of said aromatic compound; and (C) about 0.1 to about 10 moles of a thiourea per mole of said aromatic compound.
    Type: Grant
    Filed: January 4, 2000
    Date of Patent: October 9, 2001
    Assignee: Occidental Chemical Corporation
    Inventors: Ramesh Krishnamurti, Sandor Nagy, Qi Wang, Bib Hichri
  • Patent number: 6299892
    Abstract: Particles of coordinated complex comprising a basic, hydrous polymer and a capacitance adding compound, as well as methods for their production, are described. These complexes exhibit a high degree of bioactivity making them suitable for a broad range of applications through their incorporation into conventional vehicles benefiting from antimicrobial and similar properties.
    Type: Grant
    Filed: February 20, 1992
    Date of Patent: October 9, 2001
    Inventor: Robert A. Schmitz
  • Patent number: 6296865
    Abstract: The present invention relates to insecticidal compositions based on polymers, processes for their preparation and their use for controlling insects which occur in interior rooms.
    Type: Grant
    Filed: August 7, 1998
    Date of Patent: October 2, 2001
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ralf Dujardin, Mike-Dirk Bublitz, Hermann Neumann
  • Patent number: 6294163
    Abstract: The present invention relates to a method for sequestering bile acids in a patient and to particular polymers for use in the method. The method comprises administering a therapeutically effective amount of a guanidinium moiety-containing polymer composition to a mammal, such as a human, whereby bile acids are sequestered. The polymers of the invention comprise guanidinium moieties and optionally, additional substituents such as a hydrophobic group, a quaternary ammonium-containing group or a combination thereof.
    Type: Grant
    Filed: October 2, 1998
    Date of Patent: September 25, 2001
    Assignee: GelTex Pharmaceuticals, Inc.
    Inventors: Pradeep K. Dhal, Stephen R. Holmes-Farley, John S. Petersen
  • Patent number: 6294162
    Abstract: A transparent gel air freshener and method of preparing the same. The gel composition comprises an aqueous gel, a fragrance, a surfactant and a co-solvent. The gel is transparent and free from visible particles and inhomogeneities, has a uniform texture and a continuous structure, and includes volatile scented components. The gel is capable of suspending solids such as botanicals therein for decorative effect. The method provides for preparation of a such a gel air freshener, including the suspension of botanicals therein, while maintaining the clarity, texture, and structure of the gel. The method includes the steps of preparing a gel composition and cooling the gel composition. Botanicals may be added to the gel composition when it has gelled enough to support die botanical on the gel surface.
    Type: Grant
    Filed: April 21, 2000
    Date of Patent: September 25, 2001
    Assignee: Bath & Body Works, Inc.
    Inventors: Steven Semoff, Rueven Sarraf
  • Patent number: 6290981
    Abstract: A method of treatment for impotency is provided. The method involves the administration of nitric oxide by a nitric oxide-releasing agent capable of providing a penile erection-inducing amount of nitric oxide to the corpus cavernosum of the penis of an impotent male animal. Also provided is a nitric oxide delivery means for use in the method.
    Type: Grant
    Filed: April 9, 1999
    Date of Patent: September 18, 2001
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Larry K. Keefer, Joseph E. Saavedra, Paul C. Doherty, Mark S. Hanamoto, Virgil A. Place
  • Patent number: 6284280
    Abstract: The invention relates to new microparticles containing active ingredients, which contain at least one gas or a gaseous phase in addition to the active ingredient(s), agents containing these particles (microparticulate systems), their use for ultrasound-controlled in vivo release of active ingredients, as well as a process for the production of particles and agents.
    Type: Grant
    Filed: December 13, 1999
    Date of Patent: September 4, 2001
    Assignee: Schering Aktiengesellschaft
    Inventors: Werner Weitschies, Dieter Heldmann, Peter Hauff, Thomas Fritzsch, Harald Stahl