Patents Examined by Peter G O'Sullivan
  • Patent number: 8633334
    Abstract: The present invention relates to a method for preparing a highly pure trifluoromethanesulphinic acid. The method of the invention for preparing a highly pure trifluoromethanesulphinic acid, starting from an aqueous mixture comprising a trifluoromethanesulphinic acid salt, a trifluoroacetic acid salt and saline impurities resulting from the method for preparing same, is characterized in that said mixture is subjected to the following operations: —acidification such that the trifluoroacetic acid salt and the triflinic acid salt are released in an acid form, —separation of the trifluoroacetic acid and trifluoromethanesulphinic acid by distillation enabling the trifluoroacetic acid to be recovered at the top of the distillation and the trifluoromethanesulphinic acid to be recovered at the bottom of the distillation, —separation by distillation of the trifluoromethanesulphinic acid present in the distillation residue previously obtained.
    Type: Grant
    Filed: November 25, 2008
    Date of Patent: January 21, 2014
    Assignee: Rhodia Operations
    Inventors: Vincent Schanen, Olivier Buisine, François Metz, Bernard Besson
  • Patent number: 8541619
    Abstract: A method and apparatus is provided for cleaning flue gases from combustion plants. The method includes removing dust and removing nitrogen from flue gases, bringing flue gases into contact with an aqueous ammonia solution in the presence of an oxidizing agent whereby a reaction solution forms which contains at least ammonium carbonate, heating the reaction solution such that ammonium carbonate decomposes and carbon dioxide and ammonia transfer into the gas atmosphere, and reacting the gaseous carbon dioxide and the gaseous ammonia to form urea. The apparatus includes a device for removing nitrogen and removing dust from the flue gases, a washing device downstream of the device for removing nitrogen and removing dust, a stripper downstream of the washing device, and a urea installation downstream of the stripper.
    Type: Grant
    Filed: September 9, 2011
    Date of Patent: September 24, 2013
    Assignee: Steag Energy Services GmbH
    Inventor: Hermann Winkler
  • Patent number: 8513460
    Abstract: The invention provides a process for preparing N-(hydrocarbyl)phosphoric or thiophosphoric triamides with substantially improved yields and purity. Two equivalents of hydrocarbylamine are used in the reaction with phosphoryl or thiophosphoryl chloride and then with ammonia in an aromatic solvent. The invention further relates to N-(hydrocarbyl)phosphopric or thiophosphoric triamides having the purity of at least 98% wherein R is a hydrocarbyl group and X is O or S. (RNH)(NH2)2P=X ??(I).
    Type: Grant
    Filed: September 30, 2009
    Date of Patent: August 20, 2013
    Assignee: Agra Group, A.S.
    Inventors: Vladimir Kysilka, Jiri Kopenec, Jiri Krepelka
  • Patent number: 8501488
    Abstract: The present invention relates to a compound for N-terminal substitution of polypeptides which is used in sequencing and quantifying amino acids and a method for sequencing and quantifying an amino acid sequence using the same. The method for sequencing and quantifying amino acids in accordance with the present invention leads to a relative quantitative analysis of proteins with very high reliability, and can distinctively discriminate between y-type ions and b-type ions on the MS/MS spectra, providing the means for realization of high-reliability protein identification.
    Type: Grant
    Filed: June 29, 2005
    Date of Patent: August 6, 2013
    Assignee: Korea University Industry and Academy Cooperation Foundation
    Inventors: Sang-Won Lee, Yong-Ho Lee
  • Patent number: 8471059
    Abstract: The present invention relates to a method for preparing a salt of trifluoromethanesulphinic acid termed “triflinic acid”. More specifically, the invention relates to a method for preparing a highly pure triflinic acid salt.
    Type: Grant
    Filed: November 25, 2008
    Date of Patent: June 25, 2013
    Assignee: Rhodia Operations
    Inventors: Vincent Schanen, Olivier Buisine, François Metz, Bernard Besson
  • Patent number: 8471067
    Abstract: A process for the stereoselective preparation of a P-chiral four-co-ordinated phosphorus compound, the process comprising reacting a first reactant selected from the group consisting of a chiral alcohol, chiral amine or chiral thiol, with a second reactant comprising a P-chiral three-co-ordinated phosphorus compound, in the presence of an electrophile.
    Type: Grant
    Filed: June 1, 2005
    Date of Patent: June 25, 2013
    Assignee: University College Dublin
    Inventors: Declan Gilheany, Shane B. Robinson, Enda Bergin, Denise M. Walsh, Audrius Rimkus, Eoin F. Clarke, Brian G. Kelly, Eoghan M. McGarrigle, Colm P. O'Mahony, Cormac T. O'Connor
  • Patent number: 8471061
    Abstract: A 5-aminolevulinic acid salt which is useful in fields of microorganisms, fermentation, animals, medicaments, plants and the like; a process for producing the same; a medical composition comprising the same; and a plant activator composition comprising the same.
    Type: Grant
    Filed: March 13, 2012
    Date of Patent: June 25, 2013
    Assignee: Cosmo Oil Co., Ltd.
    Inventors: Naohisa Tachiya, Seiji Nishikawa, Mai Higo, Tohru Tanaka, Masahiro Ishizuka, Hideki Okada
  • Patent number: 8431735
    Abstract: A four stage inexpensive method of preparing pharmaceutical grade Melphalans of Melphalan 2-HCl, Melphalan HCl and Melphalan by: reacting N-phthaloyl-4-[bis(2-hydroxyethyl)amino]-phenylalanine ethyl ester with phosphorous oxychloride, reacting the chlorinated product with HCl and alkali hydroxide and purifying, and lyophilizing to obtain Melphalans.
    Type: Grant
    Filed: February 23, 2009
    Date of Patent: April 30, 2013
    Assignee: ChemPacific Corporation
    Inventor: Chen Zhou
  • Patent number: 8426635
    Abstract: A process for preparing solid alkaline earth metal salts of secondary paraffinsulphonic acids is claimed. This process comprises converting an aqueous solution of a secondary paraffinsulphonic acid and an alkaline earth metal hydroxide into solid form by spray drying.
    Type: Grant
    Filed: March 4, 2009
    Date of Patent: April 23, 2013
    Assignee: Clariant Finance (BVI) Limited
    Inventors: Gerd Reinhardt, Peter Naumann, Georg Borchers, Mathias Groeschen
  • Patent number: 8426642
    Abstract: The invention relates to a method for isolating concentrated paraffin sulfonic acids from reaction mixtures that are produced during the sulfoxidation of n-paraffins, from which a major part of the sulfuric acid and the paraffin was removed by phase separation and which contain, in addition to the free paraffin sulfonic acids, n-paraffins, water and optionally minor amounts of sulfuric acids. The method according to the invention is characterized by removing paraffin and optionally residual water by vacuum distillation. The paraffin sulfonic acids obtained by distillation have a content of more than 85% by weight of the active substance. The material is pale, odorless and low in sulfuric acid and paraffin.
    Type: Grant
    Filed: April 29, 2008
    Date of Patent: April 23, 2013
    Assignee: Clariant Finance (BVI) Limited
    Inventors: Gerd Reinhardt, Peter Naumann, Lars Cuypers
  • Patent number: 8394995
    Abstract: The invention provides a process for the preparation of a carbonyl compound in high efficiency by oxidizing an alcohol. The process for the preparation of a carbonyl compound of the present invention includes a step of oxidizing an alcohol in the presence of a compound of the formula (I) or a derivative or a salt thereof, and an oxidant, wherein R1 and R2 independently represent hydrogen, a halogen, a nitro or acidic group, or an alkyl or alkoxy group, each of which optionally has a substituent, or R1 and R2 combine the two carbon atoms to which they are boned to form an aromatic ring.
    Type: Grant
    Filed: August 29, 2008
    Date of Patent: March 12, 2013
    Assignee: National University Corporation Nagoya University
    Inventors: Kazuaki Ishihara, Muhammet Uyanik, Yukihiro Isogai, Suguru Ohara
  • Patent number: 8367867
    Abstract: A process for producing urea is disclosed, wherein liquid ammonia and carbon dioxide are reacted in a high-pressure synthesis section (100), and at least part of the carbon dioxide is fed to said synthesis section (100) in liquid phase. A plant operating according to said process and a method for modernizing existing plants accordingly are also disclosed.
    Type: Grant
    Filed: October 4, 2007
    Date of Patent: February 5, 2013
    Assignee: Urea Casale S.A.
    Inventors: Federico Zardi, Sergio Debernardi
  • Patent number: 8304395
    Abstract: The invention relates to methods of use for compounds in treating, reducing the incidence, reducing the severity or pathogenesis of an intestinal disease or condition in a subject, including, inter alia, inflammatory bowel disease, Crohn's disease, ulcerative colitis, or a combination thereof.
    Type: Grant
    Filed: July 5, 2007
    Date of Patent: November 6, 2012
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventor: Saul Yedgar
  • Patent number: 8299294
    Abstract: The subject invention provides: a method for producing vinyl sulfonic acid, comprising conducting demetallation of vinyl sulfonate salt, wherein the demetallation rate is not less than 95% according to the following formula: Demetallation rate(%)={(acid value after demetallation)/(acid value before demetallation)}×100; a method for producing vinyl sulfonic acid, comprising conducting demetallation of vinyl sulfonate salt, wherein demetallation is carried out using a strongly acidic ion exchange resin; and said method further comprising the step of purifying a product of the demetallation using a thin film evaporator.
    Type: Grant
    Filed: December 26, 2007
    Date of Patent: October 30, 2012
    Assignee: Asahi Kasei Finechem Co., Ltd.
    Inventors: Hiroshi Akikaze, Takehiko Miyai
  • Patent number: 8283492
    Abstract: A process for manufacture of hydrofluoroalkanesulfonic acid with at least one hydrogen bonded to the carbon atom adjacent to the carbon atom bonded to the sulfonic acid group comprising: contacting a fluoroolefin with sulfite in an aqueous solution adjusted to about pH 4 to pH 12; removing water from the solution to form a solid; directly treating the solid with oleum; and distilling the hydrofluoroalkanesulfonic acid therefrom. Also a process for manufacture of potassium hydrofluoroalkanesulfonate in high purity is described.
    Type: Grant
    Filed: January 20, 2011
    Date of Patent: October 9, 2012
    Assignee: E I du Pont de Nemours and Company
    Inventors: Mark Andrew Harmer, Christopher P. Junk, Zoe Schnepp
  • Patent number: 8283494
    Abstract: Process for the preparation of urea from ammonia and carbon dioxide in a urea production process comprising, in a high-pressure synthesis section: a. a reactor, wherein ammonia and carbon dioxide react to form a urea-comprising synthesis solution; b. a stripper, wherein the urea-comprising synthesis solution is heated and stripped, optionally in counter-current with a stripping agent; c. a submerged condenser, wherein the gas leaving the top of the stripper is, at least partially, condensed to form a condensate solution and d. an ejector, in the line connecting the submerged condenser and the reactor, supporting the transport of the condensate solution from the submerged condenser to the reactor, wherein a gas stream leaving the top of the submerged condenser is controlled by one or more controlling elements.
    Type: Grant
    Filed: December 3, 2007
    Date of Patent: October 9, 2012
    Assignee: Stamicarbon B.V.
    Inventors: Stephen Rudolf Alexander Zwart, Johannes Henricus Mennen
  • Patent number: 8278488
    Abstract: The present invention relates to a process for producing a tertiary amine in the presence of a catalyst containing copper and at least one element selected from the group consisting of elements belonging to Groups 2, 3, 7 and 12 of the Periodic Table (long form of the periodic table), said process including the steps of (a) reducing an amide compound in a hydrogen atmosphere; and (b) introducing a dialkyl amine containing a linear or branched alkyl group having 1 to 6 carbon atoms into a reaction product obtained in the step (a), and treating the reaction product with the dialkyl amine. The present invention provides a process for producing high-purity aliphatic tertiary amines containing a less amount of by-products by reducing aliphatic acid amides under moderate conditions using a chromium-free catalyst, as well as a process for producing amine derivatives such as amine oxide by using the aliphatic tertiary amines, with a good productivity in an economical manner.
    Type: Grant
    Filed: August 7, 2008
    Date of Patent: October 2, 2012
    Assignee: Kao Corporation
    Inventors: Michio Terasaka, Tetsuaki Fukushima, Hideki Taniguchi, Masaharu Jono
  • Patent number: 8273918
    Abstract: The invention relates to an process for preparing Tamsulosin hydrochloride of Formula (I) which comprises (i) reacting (R)-(?)-5-(2-amino-propyl)-2-methoxybenzenesulfonamide of Formula (II) with substituted phenoxy compound of Formula (III), wherein Z represents a removing group, such as —OSO2CH3, —OSO2C6H4CH3, —F, —Br, —Cl, or —I, in a solvent in the presence of an alkaline earth metal oxide to obtain Tamsulosin base and (ii) converting Tamsulosin base into hydrochloride salt in a solvent by addition of aqueous hydrochloric acid.
    Type: Grant
    Filed: August 10, 2006
    Date of Patent: September 25, 2012
    Assignee: Avrobindo Pharma Ltd.
    Inventors: Anand Gopalkrishna Kamat, Narsimha Reddy Penthala, Sivakumaran Meenakshisunderam
  • Patent number: 8269041
    Abstract: The present invention relates to salts having thiouronium or uronium cations, to processes for the preparation thereof, and to the use thereof as ionic liquids.
    Type: Grant
    Filed: May 28, 2004
    Date of Patent: September 18, 2012
    Assignee: Merl Patent GmbH
    Inventors: Nikolai (Myloka) Ignatyev, Urs Welz-Biermann, German Bissky, Helge Willner, Andriy Kucheryna
  • Patent number: 8268885
    Abstract: The present invention relates to small molecules as entry inhibitors of the HIV virus, processes for their preparation as well as pharmaceutical compositions, their use as medicines, and diagnostic kits comprising them. The present invention also concerns combinations of the present entry inhibitors with other anti-retroviral agents. It further relates to their use in assays as reference compounds or as reagents. The compounds of the present invention are useful for preventing or treating infection by HIV and for treating AIDS.
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: September 18, 2012
    Assignee: Janssen R&D Ireland
    Inventors: Koenraad Lodewijk August Van Acker, Piet Tom Bert Paul Wigerinck, Lieve Emma Jan Michiels, Abdellah Tahri