Abstract: Metallic dihydroxybenzenedisulfonates are prepared, preferably from alkaline metals, from corresponding dihydroxybenzenedisulfonic acids, by reacting the dihydroxybenzenedisulfonic acid present in a sulfuric medium with an adequate amount of a salt including a sulfate or hydrogenosulfate anion.
Abstract: The invention relates to methods for producing sulfonamides of formula I, wherein the variables have the designations cited in the description, by reacting m-nitro-benzoic acid chlorides of formula II with aminosulfons of formula III, under the influence of B equivalents of base IV. Said method is characterized in that, during step a) the aminosulfon of formula III is reacted with B1 equivalents of base IV, and during step b), the reaction mixture resulting from step a) is reacted with m-nitro-benzoic acid chlorides of formula II and B2 equivalents of base IV; B, B1 and B2 having the designations cited in the description.
Type:
Grant
Filed:
November 23, 2006
Date of Patent:
September 11, 2012
Assignee:
BASF SE
Inventors:
Thomas Schmidt, Joachim Gebhardt, Sandra Löhr, Michael Keil, Jan Hendrik Wevers, Michael Rack, Guido Mayer, Axel Pleschke
Abstract: A process for producing urea is disclosed, wherein liquid ammonia and carbon dioxide are reacted in a high-pressure synthesis section (100), and at least part of the carbon dioxide is fed to said synthesis section (100) in liquid phase. A plant operating according to said process and a method for modernizing existing plants accordingly are also disclosed.
Abstract: The invention provides methods for storing boranes (e.g. B-allyldiisopinocampheylborane). The invention also provides stable compositions comprising boranes, as well as methods for carrying out allylboration at high temperature and/or in the presence of water.
Type:
Grant
Filed:
May 19, 2008
Date of Patent:
September 11, 2012
Assignees:
Regents of the University of Minnesota, Sigma-Aldrich Co. LLC
Inventors:
Venkatram R. MeReddy, Kanth V. B. Josyula
Abstract: Current methods for making polyfluorosulfonamido amines, which involve the use of a diamine reactant, provide low yields and produce an undesirable fluorine containing bis-sulfonamide by-product representing an economic loss. The bis-sulfonamide by-product is particularly undesirable because it shares very similar physical properties with the desired monoamine product thus making isolation of the desired polyfluorosulfonamido amine product difficult and costly. Furthermore, instead of the efficient incorporation of fluorine to make the desired polyfluorosulfonamido amine product, the bis-sulfonamide by-product constitutes a substantial loss of costly fluorinated starting material. The bis-sulfonamide by-product also constitutes an undesirable impurity that can worsen surfactancy, repellency, or other performance characteristics of the desired polyfluorosulfonamido amine product.
Type:
Grant
Filed:
July 10, 2009
Date of Patent:
September 4, 2012
Assignee:
E.I. du Pont de Nemours and Company
Inventors:
Alexander Borisovich Shtarov, Peter Michael Murphy, Brent Ryan Gonska, Stephan James McLain
Abstract: The present invention relates to a conductor having high conductivity and electrochemical stability, which is in a solid state over a practically wide temperature range. Specifically disclosed is a plastic crystal containing a compound represented by Formula (I) or (IA) below: and at least one compound [BF3(CF3)] salt represented by Formula (II): Mn+[BF3(CF3)?]n??(II) wherein M is an alkaline metal, alkaline earth metal, aluminum or H; and when M is an alkaline metal or H, n is 1; when M is an alkaline earth metal, n is 2; and when M is aluminum, n is 3.
Type:
Grant
Filed:
December 26, 2007
Date of Patent:
September 4, 2012
Assignee:
National Institute of Advanced Industrial Science and Technology
Abstract: A new P—N—P ligand is useful in ethylene oligomerizations. In combination with i) a source of chromium and ii) an activator such as methylalumoxane; the ligand of this invention may be used to prepare an oligomer product that contains a mixture of hexenes and octenes. The hexenes and octenes produced with this ligand contain very low levels of internal olefins when produced under preferred reaction conditions.
Type:
Grant
Filed:
September 1, 2009
Date of Patent:
August 28, 2012
Assignee:
NOVA Chemicals (International) S.A.
Inventors:
Xiaoliang Gao, Charles Ashton Garret Carter, Lee Douglas Henderson
Abstract: A new P-N-P ligand in which each phosphorus atom is bonded to two ortho-fluorine substituted phenyl groups is useful in ethylene oligomerizations. In combination with i) a source of chromium and ii) an activator such as methalumoxane; the ligand of this invention may be used to prepare an oligomer product that contains a mixture of hexenes and octenes. The hexenes and octenes produced with this ligand contain very low levels of internal olefins when produced under preferred reaction conditions.
Type:
Grant
Filed:
June 24, 2011
Date of Patent:
August 28, 2012
Assignee:
Nova Chemicals (International) S.A.
Inventors:
Xiaoliang Gao, Charles Ashton Garret Carter, Liangyou Fan, Lee Douglas Henderson
Abstract: Methods are provided for preparing branched alkyl-substituted-anilines, such as 2-(1,3-dimethylbutyl)aniline. Such methods comprise combining aniline, an alkyl-substituted-1-alkene, such as 4-methyl-i-pentene, and an aluminum alkyl catalyst.
Abstract: To provide an amino phosphate derivative having an excellent sphingosine-1-phosphate (S1P) receptor modulatory action. As a result of continued intensive research to create a highly safe compound which has an S1P receptor modulatory action, is has been discovered that an amino phosphate derivative represented by the following general formula (1), has a strong S1P receptor modulatory action.
Abstract: The present invention provides a nitrogen-containing carbon material characterized in that it satisfies a specific relational expression between the number ratio of nitrogen atoms to carbon atoms and the number ratio of hydrogen atoms to carbon atoms and has peaks in specific regions in the X-ray diffraction and in the laser Raman spectrum. The nitrogen-containing carbon material of the present invention can be produced by carbonizing azulmic acid in an inert gas atmosphere, and it is useful as an electrode material or the like because it has a high nitrogen content and a low hydrogen content.
Abstract: The present invention provides cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compounds, which may be substituted in the 1-position with amino, amido, ether or ester groups, e.g., a 1-OH cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) compound. The cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) compounds of the present invention are potent ocular hypotensives, and are particularly suitable for the management of glaucoma. Moreover, the cyclopentane heptanoic, 2-(cycloalkyl or arylalkyl) compounds of this invention are smooth muscle relaxants with broad application in systemic hypertensive and pulmonary diseases; smooth muscle relaxants with application in gastrointestinal disease, reproduction, fertility, incontinence, shock, etc.
Type:
Grant
Filed:
December 19, 2008
Date of Patent:
September 13, 2011
Assignee:
Allergan, Inc.
Inventors:
David F. Woodward, Steven W. Andrews, Robert M. Burk, Michael E. Garst
Abstract: The invention relates to novel indole derivatives of the general formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
Abstract: Substituted and pyridines and pyridazines having angiogenesis inhibiting activity and the generalized structural formula wherein the ring containing A, B, D, E, and L is phenyl or a nitrogen-containing heterocycle; groups X and Y may be any of a variety of defined linking units; R1 and R2 may be defined independent substituents or together may be a ring-defining bridge; ring J may be an aryl, pyridyl, or cycloalkyl group; and G groups may be any of a variety of defined substituents. Pharmaceutical compositions containing these materials, and methods of treating a mammal having a condition characterized by abnormal angiogenesis or hyperpermiability processes using these materials are also disclosed.
Type:
Grant
Filed:
November 24, 2003
Date of Patent:
July 12, 2011
Assignee:
Bayer Healthcare LLC
Inventors:
Jacques P. Dumas, Stephen J. Boyer, Julie A. Dixon, Teddy K. Joe, Harold C. E. Kluender, Wendy Lee, Dhanapalan Nagarathnam, Robert N. Sibley, Ning Su
Abstract: A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
Type:
Grant
Filed:
February 27, 2007
Date of Patent:
June 28, 2011
Assignee:
Abbott Laboratories
Inventors:
Hing Leung Sham, Daniel W. Norbeck, Xiaoqi Chen, David A. Betebenner, Dale J. Kempf, Thomas R. Herrin, Gondi N. Kumar, Stephen L. Condon, Arthur J. Cooper, Daniel A. Dickman, Steven M. Hannick, Lawrence Kolaczkowski, Patricia A. Oliver, Daniel J. Plata, Peter J. Stengel, Eric J. Stoner, Jieh-Heh J. Tien, Jih-Hua Liu, Ketan M. Patel
Abstract: The invention relates to compounds of formula (I), wherein R, R1, R2, X and n are as defined in the description, and their use for the preparation of pharmaceutical compositions for the treatment of inflammatory states.
Type:
Grant
Filed:
June 16, 2005
Date of Patent:
June 21, 2011
Assignee:
Pharmeste S.R.L.
Inventors:
Pier Giovanni Baraldi, Pier Andrea Borea, Pierangelo Geppetti
Abstract: Crystalline form III of the compound of formula (I): characterised by its powder X-ray diffraction diagram. Medicinal products containing the same which are useful in the treatment of melatoninergic disorders.
Abstract: Sulfonate salts have the formula: HOCH2CH2CF2CF2SO3?M+ wherein M+ is a Li, Na, K, ammonium or tetramethylammonium ion. Onium salts, oxime sulfonates and sulfonyloxyimides derived from these salts are effective photoacid generators in chemically amplified resist compositions.
Abstract: A process for manufacture of hydrofluoroalkanesulfonic acid with at least one hydrogen bonded to the carbon atom adjacent to the carbon atom bonded to the sulfonic acid group comprising: contacting a fluoroolefin with sulfite in an aqueous solution adjusted to about pH 4 to pH 12; removing water from the solution to form a solid; directly treating the solid with oleum; and distilling the hydrofluoroalkanesulfonic acid therefrom. Also a process for manufacture of potassium hydrofluoroalkanesulfonate in high purity is described.
Type:
Grant
Filed:
February 22, 2010
Date of Patent:
March 1, 2011
Assignee:
E. I. du Pont de Nemours and Company
Inventors:
Mark Andrew Harmer, Christopher P. Junk, Zoe Schnepp
Abstract: Novel biaromatic compounds having the general formula (I): and cosmetic/pharmaceutical compositions comprised thereof are useful in human or veterinary medicine (in dermatology and also in the fields of cardiovascular diseases, of immune diseases and/or of diseases related to the metabolism of lipids) or, alternatively, in cosmetic compositions.