Patents Examined by Peter O'Sullivan
  • Patent number: 8642657
    Abstract: 4-(methylsulfonylamino)phenyl analogues as potent vanilloid receptor antagonists and pharmaceutical compositions comprising the same. The compounds are useful as analgesics to prevent, alleviate or treat pain diseases or inflammatory disease including pain, acute pain, chronic pain, neuropathic pain, post-operative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurodegeneration, neurotic skin disorder, stroke, urinary bladder hypersensitiveness, irritable bowel syndrome, a respiratory disorder such as asthma or chronic obstructive pulmonary disease, irritation of skin, eye or mucous membrane, fervescence, stomach-duodenal ulcer, inflammatory bowel disease, inflammatory disease and urgent urinary incontinence.
    Type: Grant
    Filed: July 2, 2004
    Date of Patent: February 4, 2014
    Assignee: Gruenenthal GmbH
    Inventors: Jee Woo Lee, Young Ho Kim, Hee Kim, Hyun Kyung Choi, Hee Jin Ha
  • Patent number: 8198479
    Abstract: This invention relates to the field of heterogeneous catalysis, and more particularly to catalysts including carbon supports having compositions which comprise one or more transition metals in combination with nitrogen and/or carbon formed on or over the surface of the carbon support. The present invention also relates to catalyst combinations comprising catalysts including carbon supports having compositions which comprise one or more transition metals in combination with nitrogen and/or carbon formed on or over the surface of a carbon support and a secondary catalyst or, co-catalyst, including a secondary transition metal. The invention further relates to the field of catalytic oxidation reactions, including the preparation of secondary amines by the catalytic oxidation of tertiary amines.
    Type: Grant
    Filed: February 17, 2006
    Date of Patent: June 12, 2012
    Assignee: Monsanto Technology LLC
    Inventors: Juan P. Arhancet, Fuchen Liu
  • Patent number: 8183231
    Abstract: The present invention relates to a series of substituted 3-aminopropane phosphinic acid derivatives of formula I: wherein R, R1, P1, P2 and P3 are as defined herein. The compounds of this invention are useful in treating a variety of diseases including but not limited to depression, anxiety, certain psychiatric symptoms, cognitive impairment and schizophrenia.
    Type: Grant
    Filed: October 24, 2006
    Date of Patent: May 22, 2012
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Yong Mi Choi-Sledeski, Julian Levell, Gregory Bernard Poli, Mark Czekaj, Alan John Collis, Roy Vaz
  • Patent number: 8173839
    Abstract: A 5-aminolevulinic acid salt which is useful in fields of microorganisms, fermentation, animals, medicaments, plants and the like; a process for producing the same; a medical composition comprising the same; and a plant activator composition comprising the same.
    Type: Grant
    Filed: March 28, 2005
    Date of Patent: May 8, 2012
    Assignee: Cosmo Oil Co., Ltd
    Inventors: Naohisa Tachiya, Seiji Nishikawa, Mai Higo, Tohru Tanaka, Masahiro Ishizuka, Hideki Okada
  • Patent number: 8158824
    Abstract: Process for the production of urea from ammonia and carbon dioxide in a urea plant containing a high-pressure synthesis section comprising two reactor sections, a stripper and a condenser, and a recovery section, wherein in the first reactor section a first synthesis solution is formed that is fed to the second reactor section; fresh carbon dioxide is fed to the second reactor section and in the second reactor section a second synthesis solution is formed that is fed to the stripper, wherein the second synthesis solution is stripped with the use of carbon dioxide as stripping gas and the mixed gas stream obtained in the stripper is sent to the condenser together with fresh ammonia and a carbamate stream, whereafter the condensate that is formed in the condenser is fed to the first reactor section and the urea stream that is obtained in the stripper is further purified in the recovery section, wherein the flow of the first synthesis solution from the first reactor section to the second reactor section, the flo
    Type: Grant
    Filed: May 19, 2009
    Date of Patent: April 17, 2012
    Assignee: Stamicarbon B.V.
    Inventors: Lambertus Wilhelmus Gevers, Jozef Hubert Meessen, Johannes Henricus Mennen
  • Patent number: 8158819
    Abstract: The present invention refers to a process to obtain a highly soluble linear alkylbenzene sulfonate (LAS). Specifically it comprises the addition, prior or after sulfonation of linear alkylbenzene and/or neutralization of linear alkylbenzene sulfonic acid of an hydrotropic composition. It also refers to a hydrotropic composition, to a highly soluble linear alkylbenzene sulfonate, to the use of the hydrotropic composition for making said linear alkylbenzene sulfonate highly soluble and to a cleaning composition comprising said linear alkylbenzene sulfonate.
    Type: Grant
    Filed: April 12, 2005
    Date of Patent: April 17, 2012
    Assignee: Cepsa Quimica S.A.
    Inventors: José Luis Berna Tejero, José Luis Goncalvez De Almeida, Ignacio López Serrano
  • Patent number: 8153840
    Abstract: Disclosed is an optimized process and apparatus for more efficiently and economically carrying out the liquid-phase oxidation of an oxidizable compound. Such liquid-phase oxidation is carried out in a bubble column reactor that provides for a highly efficient reaction at relatively low temperatures. When the oxidized compound is para-xylene and the product from the oxidation reaction is crude terephthalic acid (CTA), such CTA product can be purified and separated by more economical techniques than could be employed if the CTA were formed by a conventional high-temperature oxidation process.
    Type: Grant
    Filed: February 22, 2010
    Date of Patent: April 10, 2012
    Assignee: Grupo Petrotemex, S.A. de C.V.
    Inventors: Thomas Earl Woodruff, Alan George Wonders
  • Patent number: 8138210
    Abstract: The present invention refers to new indanyl sulphonamide compounds with general formula (I), as well as to their preparation procedure, their application as medicine and the pharmaceuticals composition which they are made up of. The new compounds of formula I show affinity for 5-HT6 receptors and are, therefore, effective for treating diseases mediated by these receptors.
    Type: Grant
    Filed: August 18, 2006
    Date of Patent: March 20, 2012
    Assignee: Laboratorios Del Dr. Esteve, S.A.
    Inventors: Maria De Las Ermitas Alcalde-Pais, Maria De Les Neus Mesquida-Estevez, Sara Lopez-Perez, Jordi Frigola-Constansa, Joerg Holenz, Ramon Merce-Vidal
  • Patent number: 8129565
    Abstract: A process and a related plant layout for producing urea are disclosed, wherein the high-pressure loop (1) comprises a synthesis reactor (2), a thermal stripper (3), a condenser (4), and an adiabatic CO2 stripper (10) disposed upstream said thermal stripper, separating a vapour phase (13) containing ammonia from the urea solution (9) discharged from the reactor, and recycling said vapour phase to the reactor. The adiabatic stripper (10) can be incorporated in a reactor (200) having a top reaction zone and a bottom adiabatic stripping zone. A revamping method for a conventional urea plant in accordance with the inventive process is also disclosed.
    Type: Grant
    Filed: November 17, 2009
    Date of Patent: March 6, 2012
    Assignee: Urea Casale S.A.
    Inventors: Federico Zardi, Andrea Scotto
  • Patent number: 8119842
    Abstract: Methods for producing a compound of formula k1 or k2 by reducing a dihydronapthalene amide compound of formula i with hydrogen gas in the presence of a ruthenium catalyst of formula j1 or j2 Ru(Z)2(L)??j1; Ru(E)(E?)(L)(D)??j2; wherein m, n, Ar, Y, R1 E, E?, D, Z and L are as defined herein.
    Type: Grant
    Filed: December 14, 2009
    Date of Patent: February 21, 2012
    Assignee: Roche Palo Alto LLP
    Inventors: Kieran Durkin, Lawrence Emerson Fisher, Arthur Meili, Michaelangelo Scalone, Xianqing Shi, Justin Vitale
  • Patent number: 8119833
    Abstract: Provided are a dendrimer solid acid and a polymer electrolyte membrane using the same. The polymer electrolyte membrane includes a macromolecule of a dendrimer solid acid having ionically conductive terminal groups at the surface thereof and a minimum amount of ionically conductive terminal groups required for ionic conduction, thus suppressing swelling and allowing a uniform distribution of the dendrimer solid acid, thereby improving ionic conductivity. Since the number of ionically conductive terminal groups in the polymer electrolyte membrane is minimized and the polymer matrix in which swelling is suppressed is used, methanol crossover and difficulties of outflow due to a large volume may be reduced, and a macromolecule of the dendrimer solid acid having the ionically conductive terminal groups on the surface thereof is uniformly distributed. Accordingly, ionic conductivity is high and thus, the polymer electrolyte membrane shows good ionic conductivity even in non-humidified conditions.
    Type: Grant
    Filed: July 5, 2011
    Date of Patent: February 21, 2012
    Assignee: Samsung SDI Co., Ltd.
    Inventors: Myung-sup Jung, Jin-gyu Lee, Sang-kook Mah, Jae-jun Lee
  • Patent number: 8119804
    Abstract: An organic semiconducting layer formulation containing an organic binder which has a permittivity, ?, at 1,000 Hz of 3.3 or less and a polyacene compound of Formula A: and processes for the preparation thereof and uses thereof in various electronic devices.
    Type: Grant
    Filed: March 8, 2010
    Date of Patent: February 21, 2012
    Assignee: Merck Patent GmbH
    Inventors: Beverley Anne Brown, Janos Veres, Remi Manouk Anemian, Richard Williams, Simon Dominic Ogier, Stephen William Leeming
  • Patent number: 8106241
    Abstract: An enhanced process is described for the synthesis of urea from ammonia and carbon dioxide, at a high pressure and temperature, with the formation of ammonium carbamate as intermediate, which includes a high pressure synthesis section, comprising at least one separation step by decomposition-stripping with ammonia of the non-converted ammonium carbamate, carried out in a vertical apparatus, commonly called stripper, characterized in that said step also comprises a feeding, in the lower part of said stripper, of a stream of CO2, heated to a temperature ranging from 130 to 230° C., in a quantity of 1 to 15% by weight with respect to the total weight of the fresh CO2 fed to the process, containing a passivating agent in such a quantity that its equivalent content of O2 in moles varies from 0.05% to 0.80% with respect to the moles of CO2 of said stream.
    Type: Grant
    Filed: May 19, 2008
    Date of Patent: January 31, 2012
    Assignee: Saipem S.p.A.
    Inventors: Lino Carlessi, Alessandro Gianazza
  • Patent number: 8088763
    Abstract: Novel cyclohexyl-1,4-diamine compounds corresponding to formula I, processes for the production thereof, pharmaceutical compositions containing these compounds, methods of producing pharmaceutical compositions including these compounds and related methods of treating or inhibiting certain diseases or conditions.
    Type: Grant
    Filed: November 9, 2006
    Date of Patent: January 3, 2012
    Assignee: Gruenenthal GmbH
    Inventors: Corinna Sundermann, Bernd Sundermann
  • Patent number: 8088950
    Abstract: The invention relates to a process for the preparation of triamides from ammonia and amido-dichlorides.
    Type: Grant
    Filed: March 26, 2009
    Date of Patent: January 3, 2012
    Assignee: BASF SE
    Inventors: Michael Bock, Oliver Huttenloch, Patrick Deck, Oliver Bey, Heiner Schelling, Markus Siegert
  • Patent number: 8084641
    Abstract: The present invention is directed to compositions comprising organocatalysts that facilitate stereo-selective reactions and the method of their synthesis and use. Particularly, the invention relates to metal-free organocatalysts for facilitation of stereo-selective reactions, and the method of their synthesis and use.
    Type: Grant
    Filed: October 11, 2006
    Date of Patent: December 27, 2011
    Assignee: STC.UNM
    Inventor: Wei Wang
  • Patent number: 8084638
    Abstract: The present application relates to sulfanyl derivatives of formula (I) and to their use as synthesis intermediates, especially for the preparation of the pharmaceutically active compound mesna. Formula (I), wherein X is O or N—C(NH)NH2; M+ is hydrogen, sodium, disodium, potassium, dipotassium, ammonium (NH4)+, diammonium, quaternary ammonium, calcium or magnesium.
    Type: Grant
    Filed: July 17, 2008
    Date of Patent: December 27, 2011
    Assignee: UCB Pharma, S.A.
    Inventors: Julien Leveque, Nicolas Barbarin, Magali Palacio
  • Patent number: 8080687
    Abstract: The invention relates to a process for the granulation of a concentrated urea solution whereas the granulation produces a urea granulate and a dust laden air, which is then fed into a dust scrubber which removes the coarser dust with a less concentrated urea solution and which releases a residual air comprising air with ammonia, carbon dioxide water and an aerosol comprising mainly ammonium isocyanate and a part of very fine urea sublimate, whereas the aerosol is then separated off and fed into a isomerisation unit which comprises a stripping where the ammonium isocyanate reacts with steam to form urea which is then redirected into the dust scrubber as a less concentrated urea solution, and the residual air is directed into an acidic scrubber which releases clean air into the atmosphere which finally leads to a recycling of the aerosol of ammonium isocyanate into urea. The invention also relates to a device for carrying out the related process.
    Type: Grant
    Filed: May 4, 2009
    Date of Patent: December 20, 2011
    Assignee: Uhde Fertilizer Technology B.V.
    Inventors: Paul Niehues, Harald Franzrahe, Matthias Potthoff, Roland Monstrey
  • Patent number: 8076376
    Abstract: Aniline sulfonamide derivatives according to formula I have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders: where R1, R2, R3, R4, R5, R6, and L are set forth in the description.
    Type: Grant
    Filed: July 21, 2006
    Date of Patent: December 13, 2011
    Inventors: Jay P. Powers, Xiao He, Dustin McMinn, Yosup Rew, Daqing Sun
  • Patent number: 8071650
    Abstract: The present invention relates to novel thiourea derivatives as a modulator for vanilloid receptor (VR) and the pharmaceutical compositions containing the same. As diseases associated with the activity of vanilloid receptor, pain acute pain, chronic pain, neuropathic pain, post-operative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurodegeneration, neurotic skin disorder, stroke, urinary bladder hypersensitiveness, irritable bowel syndrome, a respiratory disorder such as asthma or chronic obstructive pulmonary disease, irritation of skin, eye or mucous membrane, fervescence, stomach-duodenal ulcer, inflammatory bowel disease and inflammatory diseases can be enumerated. The present invention provides a pharmaceutical composition for prevention or treatment of these diseases.
    Type: Grant
    Filed: March 26, 2007
    Date of Patent: December 6, 2011
    Assignee: Pacific Corporation
    Inventors: Young Ger Suh, Uh Taek Oh, Hee Doo Kim, Jee Woo Lee, Hyeung Geun Park, Ok Hui Park, Yong Sil Lee, Young Ho Park, Yung Hyup Joo, Jin Kyu Choi, Kyung Min Lim, Sun Young Kim, Jin Kwan Kim, Hyun Ju Koh, Joo Hyun Moh, Yeon Su Jeong, Jung Bum Yi, Young Im Oh