Patents Examined by Peter O'Sullivan
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Patent number: 8067468Abstract: Salts of L-carnitine and alkanoyl L-carnitines with phytic acid of general formula (I), and the process of preparing the same, wherein the mole ratio between the L-carnitine or its alkanoyl derivatives cation and phytic acid anion be within the range of 1:1 to 6:1, wherein: n=1-6; R1 is the phytate anion; R is either hydrogen, a straight alkanoyl group having 2-12 carbon atoms or a branched-chain alkanoyl group having 2-12 carbon atoms.Type: GrantFiled: September 12, 2009Date of Patent: November 29, 2011Inventor: Jian Chen
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Patent number: 8063245Abstract: Disclosed is a phosphazene compound and a photosensitive resin composition. The phosphazene compound is obtained by reacting a phenoxyphosphazene compound (A-1) having a phenolic hydroxyl group and/or a cross-linked phenoxyphosphazene compound (A-2) obtained by cross-linking the phenoxyphosphazene compound (A-1) with an epoxy compound (B) having an unsaturated double bond and/or an isocyanate compound (C), wherein the phosphazene compound has an unsaturated double bond in its molecule.Type: GrantFiled: June 3, 2004Date of Patent: November 22, 2011Assignee: Kaneka CorporationInventors: Koji Okada, Toshio Yamanaka
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Patent number: 8058474Abstract: A process for preparing a compound (C) represented by the following formula: wherein R1 represents hydrogen, C1-6 alkyl or C3-8 cycloalkyl, and R2 represents hydrogen or methoxy, characterized by reacting a compound (A-1) represented by the following formula: wherein R1 has the same definition as above, with a compound (B) represented by the following formula: wherein R2 has the same definition as above, and L represents a leaving group, is provided. Compound (C) is effective for prevention or treatment of various diseases associated with angiogenesis neoplasia.Type: GrantFiled: March 9, 2009Date of Patent: November 15, 2011Assignee: Eisai R&D Management Co., Ltd.Inventor: Toshihiko Naito
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Patent number: 8053596Abstract: A process for preparing alkyl glyceryl sulfonate includes fractionally distilling an alkyl glyceryl epoxide mixture to afford alkyl glyceryl epoxide of formula IV: where R is a C4-12 alkyl, in at least about 98.0% purity by weight with respect to epoxidized compounds, the epoxidized compounds comprising the alkyl glyceryl epoxide of formula IV, dimer alkyl glyceryl epoxide of formula V, and trimer alkyl glyceryl epoxide of formula VI: where R is a C4-12 alkyl; and reacting the at least about 98.0% alkyl glyceryl epoxide of formula IV with a mixture of an alkali bisulfite and an alkali sulfite in a sulfonation reaction at a temperature, to afford the alkyl glyceryl sulfonate of formula I: where R is a C4-12 alkyl and M is an alkali metal.Type: GrantFiled: November 2, 2009Date of Patent: November 8, 2011Assignee: Third Stream Bioscience, Inc.Inventors: Dennis Neigel, Michael Calhoun, Ed Richman
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Patent number: 8049026Abstract: Ionic compounds which are liquids at room temperature are formed by the method of mixing a neutral organic ligand with the salt of a metal cation and its conjugate anion. The liquids are hydrophobic, conductive and stable and have uses as solvents and in electrochemical devices.Type: GrantFiled: January 10, 2008Date of Patent: November 1, 2011Assignee: UT-Battelle, LLCInventors: Sheng Dai, Huimin Luo
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Patent number: 8049033Abstract: Provided are a dendrimer solid acid and a polymer electrolyte membrane using the same. The polymer electrolyte membrane includes a macromolecule of a dendrimer solid acid having ionically conductive terminal groups at the surface thereof and a minimum amount of ionically conductive terminal groups required for ionic conduction, thus suppressing swelling and allowing a uniform distribution of the dendrimer solid acid, thereby improving ionic conductivity. Since the number of ionically conductive terminal groups in the polymer electrolyte membrane is minimized and the polymer matrix in which swelling is suppressed is used, methanol crossover and difficulties of outflow due to a large volume may be reduced, and a macromolecule of the dendrimer solid acid having the ionically conductive terminal groups on the surface thereof is uniformly distributed. Accordingly, ionic conductivity is high and thus, the polymer electrolyte membrane shows good ionic conductivity even in non-humidified conditions.Type: GrantFiled: October 10, 2006Date of Patent: November 1, 2011Assignee: Samsung SDI Co., Ltd.Inventors: Myung-sup Jung, Jin-gyu Lee, Sang-kook Mah, Jae-jun Lee
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Patent number: 8049032Abstract: A solid acid having a core of calixarene or calix resorcinarene. The solid acid is an ion conducting compound in which at least one of the hydroxyl groups is substituted by an organic group having a cation exchange group at a terminal end, a polymer electrolyte membrane including the same, and a fuel cell using the polymer electrolyte membrane. The polymer electrolyte membrane can provide low methanol crossover and high ionic conductivity. Accordingly, a fuel cell having high efficiency can be obtained by using the polymer electrolyte membrane.Type: GrantFiled: October 12, 2006Date of Patent: November 1, 2011Assignee: Samsung SDI Co., Ltd.Inventors: Jae-jun Lee, Myung-sup Jung, Do-yun Kim, Jin-gyu Lee, Sang-kook Mah
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Patent number: 8044239Abstract: One aspect of the invention is a compound of formula (I) Ro-[L-(CqH2qS)pCrH2rRf]2??(I) wherein Ro is a divalent organic group having 2 to 40 carbon atoms; L is a linking group selected from —NHC(O)NH— or —C(O)NH— wherein the left side of the linking group is bonded to Ro; p is an integer of 0 or 1; q is an integer of 2 to 10; r is an integer of 1 to 10; and Rf is a linear or branched C1-C6 perfluoroalkyl group. Other aspects of the invention are a composite structure comprising a porous support and a porous nanoweb comprising fibrous structures comprised of one or more compositions of formula (I) and a method for making said composite structures.Type: GrantFiled: August 13, 2007Date of Patent: October 25, 2011Assignee: E. I. du Pont de Nemours and CompanyInventors: Keith Ward Hutchenson, Anilkumar Raghavanpillai, Stefan Reinartz
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Patent number: 8039666Abstract: A method for preparing an amine borane from an alkali metal borohydride and an amine salt. The alkali metal borohydride is allowed to react with 0.95 to 1.05 equivalents of the amine salt in a solvent which contains water and an amine.Type: GrantFiled: November 20, 2009Date of Patent: October 18, 2011Assignees: Rohm and Haas Company, Air Products and Chemicals, Inc.Inventors: Anthony Rocco Cartolano, Sergei Vladimirovich Ivanov, Cheryl Irene Teich, John Hiroshi Yamamoto
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Patent number: 8034973Abstract: The present invention relates to a process for obtaining a highly soluble linear alkylbenzene sulfonate with an adjustable 2-phenyl isomer content and an extremely low sulfonation color, in which a catalytic system based on highly stable solid catalysts and with a high selectivity for linear monoalkylated compounds is used.Type: GrantFiled: March 16, 2006Date of Patent: October 11, 2011Assignee: Cepsa Quimica, S.A.Inventors: José Luis Goncalvez De Almeida, José Luis Berna Tejero
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Patent number: 8030513Abstract: The present invention provides for a rheology control agent that includes a following compound represented by the following formula: wherein A, B, C and D equal CH2, CHR, NH, or O, and A, B, C and D may be the same or different and at least one of A and B equals NH and at least one of C and D equals NH; and wherein R1, R2, and R3 may be the same or different and represent a linear, branched, hyper-branched, or dendritic ether, polyether or hydrocarbon based chain, optionally forming at least one carbon-based ring, being saturated or unsaturated and R2 represents linear or branched alkylenes, ethers, polyethers, or polyester linkages and at least one of R1, R2, and R3 comprises an ester group or an amide group which is branched off from the main chain; excluded from Formula (1) is a compound wherein R2 is CH2—CH2—CH2—CH2—CH(C(O)OCH3), A, B, C, and D are equal to NH and R1 and R3 are both equal to a linear octyl hydrocarbon chain; the rheology control agent is suitable for solvent-borne and water-borne coatType: GrantFiled: April 13, 2010Date of Patent: October 4, 2011Assignee: E. I. du Pont de Nemours and CompanyInventors: Christian Peter Lenges, Yanhui Niu, Yu-Ling Hsiao, Jiang Ding, Robert John Barsotti, Renee J. Kelly, Robert James Butera, Young H. Kim
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Patent number: 8030356Abstract: The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.Type: GrantFiled: March 16, 2007Date of Patent: October 4, 2011Assignees: Cardioxyl Pharmaceuticals, Inc., The Johns Hopkins UniversityInventors: John P. Toscano, Frederick Arthur Brookfield, Andrew D. Cohen, Stephen Martin Courtney, Lisa Marie Frost, Vincent Jacob Kalish
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Patent number: 8030515Abstract: Sulfonate salts have the formula: HOCH2CH2CF2CF2SO3?M+ wherein M+ is a Li, Na, K, ammonium or tetramethylammonium ion. Onium salts, oxime sulfonates and sulfonyloxyimides derived from these salts are effective photoacid generators in chemically amplified resist compositions.Type: GrantFiled: March 9, 2011Date of Patent: October 4, 2011Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Katsuhiro Kobayashi, Youichi Ohsawa, Takeshi Kinsho, Takeru Watanabe
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Patent number: 8026391Abstract: This method for producing a potassium perfluoroalkanesulfonate includes an electrochemical fluorination step in which an alkanesulfonyl halide compound is subjected to electrochemical fluorination in anhydrous hydrogen fluoride, thereby to generate a production gas containing perfluoroalkanesulfonyl fluoride as the main component. In addition, for example, the methods may include a gas absorption step in which the production gas is reacted with an aqueous solution of potassium hydroxide, thereby to generate a gas absorbed solution containing potassium perfluoroalkanesulfonate, a purification step in which impurities such as potassium fluoride, potassium hydroxide, and potassium sulfate, are removed, and a concentration and collection step in which the aqueous solution from which the impurities are removed is concentrated and dried.Type: GrantFiled: September 29, 2006Date of Patent: September 27, 2011Assignees: Mitsubishi Materials Corporation, Mitsubishi Materials Electronic Chemicals Co., Ltd.Inventors: Masakazu Uotani, Hiroyuki Yatsuyanagi, Tsunetoshi Honda
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Patent number: 8026389Abstract: The present invention provides active ingredients and herbicide formulations, as well as the production processes therefor. The active ingredient of the invention is a dry, solid ammonium salt of glyphosate, having high purity (95 to 100%) and low humidity (<1.0% m/m), and is useful as “technical salt” for the preparation of dry, solid, and water-soluble herbicide formulations of the invention. The production process of said active ingredient comprises a solid/liquid/solid reaction between a solid ammonium salt and solid glyphosate acid, both solid being dispersed in an organic liquid medium. The products of the invention are highly water-soluble and are useful for controlling crop weeds.Type: GrantFiled: December 17, 2007Date of Patent: September 27, 2011Inventor: Ricardo Amaral Remer
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Patent number: 8026384Abstract: The present invention relates to a new process for the synthesis of alkyl phosphinic acids, and more particularly to a coupling reaction between an alkylhalide and a hypophosphorous acid derivative in the presence of an amine and an amineoxide.Type: GrantFiled: April 30, 2008Date of Patent: September 27, 2011Assignee: AstraZeneca ABInventors: Daniel Finnhult, Roger Sohlberg, Fredrik Stalfors, Carina Svensson, Johanna Wachtmeister, Thomas Wannman
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Patent number: 8026388Abstract: Synthesis of biphosphonate compounds can be advantageously carried out in a solvent/diluent comprising a compound of formula (3) wherein R is hydrogen or a C1-C6 alkyl group; each of R1 is a C1-C6 alkyl group or both R1 groups are linked to form a C1-C3 alkylene group; and R2 is hydrogen, a C1-C6 alkyl group, a C1-C6 alkoxy group, or is linked together with R to form a C3-C7 carbon ring.Type: GrantFiled: July 10, 2009Date of Patent: September 27, 2011Assignee: Synthon BVInventor: Jiri Bartl
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Patent number: 8026394Abstract: A main object of the present invention is to provide a lithium salt which can improve its lithium transference number when used as a supporting salt of an electrolyte solution or the like. To attain the object, the present invention provides a lithium salt comprising a chemical structure represented by the following general formula (1): in which R1 to R3 may be same or different from each other and denote a fluoroalkyl group, an alkyl group or a phenyl group.Type: GrantFiled: December 4, 2007Date of Patent: September 27, 2011Assignee: Toyota Jidosha Kabushiki KaishaInventors: Hisashi Yamamoto, Masaki Matsui
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Patent number: 8017797Abstract: A method for efficiently producing 4-(hydroxymethylphosphinyl)-2-oxobutanoic acid, useful as a production intermediate of herbicide L-AMPB. The method comprises using a compound represented by the below formula (4): (4) where R1 represents a C1-4 alkyl group, arylmethyl group, or substituted arylmethyl group.Type: GrantFiled: March 21, 2008Date of Patent: September 13, 2011Assignee: Meiji Seika Kaisha Ltd.Inventors: Nobuto Minowa, Nozomu Nakanishi, Masaaki Mitomi
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Patent number: 8017803Abstract: A process for producing tamsulosin of formula I and pharmaceutically acceptable addition salts, thereof comprises the steps of: a) Reacting compound R,R-[2-(4-methoxy-phenyl)-1-methyl-ethyl]-(1-phenyl-ethyl)-amine of formula II or a salt thereof ?with chlorosulfonic acid with or without an organic solvent, to obtain compound R,R-2-methoxy-5-[2-(1-phenyl-ethylamino)-propyl]-benzenesulfonic acid of formula III b) Hydrogenolysis of compound R,R-2-methoxy-5-[2-(1-phenyl-ethylamino)-propyl]-benzenesulfonic acid of formula III or a salt thereof carried out in an alcohol in the presence of a palladium catalyst using hydrogen or a source of hydrogen, to obtain compound R-(?)-5-(2-amino-propyl)-2-methoxy-benzenesulfonic acid of formula IV c) Reacting primary amine R-(?)-5-(2-amino-propyl)-2-methoxy-benzenesulfonic acid of formula IV, or a salt thereof, with a compound of formula V ?wherein X represents an halogen atom selected from the group consisting of Cl; Br and I, to obtain 5-{(2R)-2-Type: GrantFiled: January 18, 2005Date of Patent: September 13, 2011Assignee: Hovione Inter Ltd.Inventors: Zita Mendes, Joana Baptista, Dionisio Martin, William Heggie