Abstract: Methods and devices for successively advancing a plurality of catheters over a guide element to a body tissue are described. In some of the methods, the guide element may be attached to the body tissue, which may be accessible minimally invasively. In certain variations, the guide element may not be detached from the body tissue after the catheters have been advanced over the guide element. The methods may further comprise deploying at least one implant from at least one of the plurality of catheters. In some variations, a method may comprise advancing a first delivery catheter to a first region of a body tissue, deploying a first anchor from the first delivery catheter, where the first anchor is attached to a guide element, proximally withdrawing the first delivery catheter, advancing a second delivery catheter over the guide element, and deploying a second anchor from the second delivery catheter.

Abstract: A bipolar forceps is provided and includes a housing having a shaft that extends therefrom which defines a longitudinal axis therethrough. The housing including a drive assembly disposed therein and is operable to reciprocate an actuation tube within the shaft. The bipolar forceps includes an end effector assembly operatively connected to a distal end of the shaft and has a pair of first and second jaw members. The first and second jaw members are pivotable about a living hinge and are adapted to connect to an electrosurgical energy source. Each of the jaw members includes a cam slot defined at a proximal end thereof. One or more of the jaw members is operatively connected to a distal end the actuation tube via a cam pin such that distal reciprocation of the actuation tube cams each of the jaw members towards one another about the respective living hinge to grasp tissue.

Abstract: A catheter assembly comprising a first polymer, a second polymer and a first weld region. The first polymer forms a balloon having a first waist. The second polymer forms a catheter shaft. The first waist is positioned about a portion of the catheter shaft thereby forming the first weld region. The first weld region comprises a first weld and a second weld which engage the first waist to the catheter shaft. The first weld has a first longitudinal position and the second weld has a second longitudinal position, where the first longitudinal position is different from the second longitudinal position.

Abstract: An infusion device capable of administering liquid medication at a continuous flow rate, and upon user demand delivers a controlled volume dosage of liquid medication at a higher dosage flow rate. The dosage reservoir remains empty until the user actuates it by selectively and temporarily removing the pressure source, such as a spring. During actuation, fluid rapidly flows from the medication reservoir to fill the dosage reservoir. After actuation, the pressure source exerts a higher pressure on the dosage reservoir than the medication reservoir pressure, which results in a temporary higher bolus flow rate. Thus, two distinct flow rates are achieved with one flow restrictor element.

Abstract: A catheter system including an accelerometer-based sensing assembly is provided. In particular the present teachings relate to an accelerometer based assembly used to determine contact between a catheter and surrounding proximate tissue, such as cardiac tissue. An embodiment of such a system may, for example, be used for visualization, mapping, ablation, or other methods of diagnosis and treatment of tissue and/or surrounding areas.

Abstract: An injection aid for a syringe includes a disk with a central orifice and a flange. The flange is located on the top of the disk, and surrounds the central orifice. The outlet end or needle hub of a syringe or insulin pen fits in the flange, with the syringe needle extending through the orifice, thereby securing the disk to the syringe. The bottom surface of the disk is generally flat. The bottom surface of the disk makes contact with the skin when the needle is inserted to the proper depth. In other words, the needle lies perpendicular to the disk and is arranged to project past the disk's flat bottom surface by a set, pre-determined length. When the disk is pressed flat against a patient's skin, the needle is at the proper depth for the substance being injected.

Abstract: An infusion pump includes: a housing, a pump actuator supported by the housing, electronics configured to control the pump actuator, a pain controlled analgesic (“PCA”) input device, a cord having a remote end connected to the PCA input device and a local end connected to the housing, a remote integrated circuit; and a local integrated circuit in communication with the electronics and the remote integrated circuit so as to provide operational information concerning the PCA input device to the electronics.

Abstract: Medical devices and methods of making medical devices are described. In some embodiments, a medical device includes a member having a first portion with a first wall thickness, and a second portion with a second wall thickness, wherein the first portion is circumferentially rotated.

Abstract: A vascular guidewire introducer device (10) having a needle (52), a bulb (16), and a valve subassembly (100) through which a guidewire (14) is insertable for vascular guidewire insertion into a blood vessel (12) of a patient. The valve subassembly (100) includes a proximal fitting (102), a proximal cap (106), and a valve arrangement (104) disposed within a valve seat (118) defined by one of the fitting and the cap. The valve arrangement includes distal and proximal disc-shaped valve members (122,126) having centered slits (124,128) therethrough, and a spacer (130) disposed between the valve members. A method is disclosed for precisely centering the slits of the valve members during assembly and for retaining the valve members in their precisely centered positions in the valve seat. The valve arrangement permits use with a wide range of guidewire diameters.

Abstract: Methods and devices for perfusing a blood vessel during the entire course of an end-to-side or end-to-end anastomosis procedure. One method can be used to form an end-to-side anastomosis of a saphenous vein graft to a coronary artery during an off-pump, beating heart, coronary artery bypass graft. In this example, the distal end of an elongate tube carrying a saphenous vein graft is advanced into an arteriotomy distal to an occlusion in the coronary artery. Perfusing blood flow is provided through the tube to the coronary artery, the vein graft is advanced over the tube to the arteriotomy and sutured completely to the coronary artery. The elongate tube can be retracted through the now secured vein graft, and the coronary artery supplied again from the proximal end of the vein graft. Some tubular devices include a reversibly expandable distal region, to form a seal between the inserted tube and the coronary artery being perfused, to prevent blood flow into the surgical field.

Abstract: A method for making a peritoneal dialysis therapy machine having a tubing set includes: packaging an end of each of a plurality of the tubes of the set in a body; arranging the tubes according to a sequence of steps of a dialysis treatment set-up so that a user is urged to remove the tubes from the single body in a desired order; and configuring the body to plug connectors attached to each of the ends of the tubes.

Abstract: This invention relates to an accessory for attaching to a needle to prevent needle stick injuries. The safety needle accessory is suitable for use with a hollow needle and comprises a needle hub surrounding the needle and a slidable sleeve slidably mounted on the needle hub. The slidable sleeve bears resiliently on the needle hub such that, in use, as the slidable sleeve is caused to move into a retracted position. A restoring force is generated within the slidable sleeve and on removal of the needle from the patient the restoring force causes the slidable sleeve to move into an extended position covering the needle tip. The safety needle locks in this position after removal of the needle from the patient.

Abstract: Some embodiments of a portable infusion pump system can be configured to can be configured to adjust the sensitivity of particular detectors or alert systems based (at least in part) on information received from a monitoring device. For example, a glucose monitoring device can communication with an infusion pump assembly used to supply insulin or another medication to a user. In such circumstances, the data received from the monitoring device can be used to adjust the sensitivity of an occlusion detection system.

Abstract: An augmented, adaptive algorithm utilizing model predictive control (MPC) is developed for closed-loop glucose control in type 1 diabetes. A linear empirical input-output subject model is used with an MPC algorithm to regulate blood glucose online, where the subject model is recursively adapted, and the control signal for delivery of insulin and a counter-regulatory agent such as glucagon is based solely on online glucose concentration measurements. The MPC signal is synthesized by optimizing an augmented objective function that minimizes local insulin accumulation in the subcutaneous depot and control signal aggressiveness, while simultaneously regulating glucose concentration to a preset reference set point. The mathematical formulation governing the subcutaneous accumulation of administered insulin is derived based on nominal temporal values pertaining to the pharmacokinetics (time-course of activity) of insulin in human, in terms of its absorption rate, peak absorption time, and overall time of action.

Abstract: A co-axial catheter assembly including a first lumen having a first distal end and a first proximal end, and a second lumen having a second distal end and a second proximal end. The second lumen extends co-axially with the first lumen, wherein the second lumen is at least partially disposed within the first lumen and the second distal end extends distally of the first distal end. A catheter hub provides for fluid connections of the inner and outer lumens with respective extension tubes, and includes spacers that maintain the proximal end of the inner lumen concentrically within the proximal end of the outer lumen and the distal end of the inner lumen concentrically within the distal end of the outer lumen, respectively. Methods of manufacturing and of inserting the catheter are also disclosed.

Abstract: An application or an attachment device for attaching a medical device includes a base layer and an adhesive layer on a rearward side of the base layer. The adhesive layer is adapted to removably attach the base layer. The adhesive layer can be adapted to removably attach the base layer to a patient (either a human patient or a lower animal patient). The device also includes a medical device attachment mechanism on a forward side of the base layer, The attachment mechanism is adapted to attach the medical device to the base layer. The medical device can, for example, be a sensor. The medical device attachment mechanism can, for example, include a mechanical attachment mechanism. The medical device attachment mechanism can additionally or alternatively include at least one adhesive layer on the base layer. The adhesive layer can, for example, be positioned on the base layer so that it does not extend beyond a footprint of the medical device when the medical device is attached to the base layer.

Abstract: A co-axial catheter assembly (100), including a first lumen (110) having a first distal end (114) and a first proximal end (112), and a second lumen (120) having a second distal end (124) and a second proximal end (122). The second lumen (120) extends co-axially with the first lumen (110), wherein the second lumen is at least partially disposed within the first lumen and the second distal end extends distally of the first distal end. A method of manufacturing the catheter is also disclosed.

Abstract: A vibrational catheter for disrupting obstructions in lumens such as blood vessels includes an elongate flexible catheter body having a proximal end, a distal end and at least one lumen extending longitudinally therethrough, a vibrational transmission member extending longitudinally through the lumen of the catheter body and having a proximal end and a distal end, and a transition connector attached to the proximal end of the vibrational transmission member for coupling the transmission member with a vibrational energy source. The transition connector includes a bore into which the proximal end of the vibrational transmission member extends. The proximal end of the vibrational transmission member is attached within the bore of the transition connector with variable attachment forces such that the transition connector exerts a lowest amount of attachment force on an attached distal-most portion of the vibrational transmission member housed within the bore.

Abstract: Implantable drug infusion devices, systems and methods for delivering therapeutic substance to a subject that include a bulkhead and an attached reservoir formed by an elastic bladder are disclosed. When filled with therapeutic substance, the elastic bladder is elastically expanded such that the therapeutic substance is held at a pressure above ambient pressure. As the therapeutic substance is removed from the reservoir, the bladder collapses and may conform to the shape of the bulkhead surface over which it is located.

Abstract: A cassette insertable into an irrigation or aspiration machine for endoscopy includes an irrigation or an aspiration tube and a support provided with one or two inlet plugs and one or two outlet plugs where two tubes form an elbow to be connectable to the inlet or outlet plugs in an input and output direction of motion, respectively and to form an irrigation or aspiration pumping area in the input and output direction of motion. The support includes a T-shaped guide according to the head of the T for protecting the elbow of each tube and according to the length of the T body in a slot guiding the tube in the output direction. The T-shaped guide extends between one or two inlet plugs to form the irrigation or aspiration pumping area on both sides of the slot between each inlet plug and the head of the T.