Abstract: The invention discloses a methodology for the biomimetic culture of urothelial cells from mammalian bladders, including murine, porcine, bovine and human sources to isolate and expand urothelial cells for use in various applications, such as intravesical urothelial cell therapy to treat cystitis and bladder cancer.

Abstract: Compositions for treating a sleep disorder or modifying or improving the sleep-wake cycle in a subject are disclosed herein. In some examples, the composition can comprise one or more sleep promoting active agents, one or more sleep quality active agents, one or more sleep recovery active agents, and optionally one or more next day active agents. The composition can provide an immediate burst release of the one or more sleep promoting active agents, a delayed burst or delayed sustained release of the one or more sleep quality active agents, a delayed burst or delayed sustained release of the one or more sleep recovery active agents, and a delayed burnt or delayed sustained release of the one or more next day active agents. The composition can be provided as a daily oral uni-dosage form. Methods of making and using the compositions are also provided.

Abstract: A composition for treating skin disorders including a mixture of herbal extracts of Azadirachta indica, Acacia catechu, Hemidesmus indicus, Phyllanthus emblica, Terminalia bellirica, Terminalia chebula and optionally Tinospora cordifolia and use thereof. A method for treating skin disorders using the composition is also disclosed.

Abstract: The present disclosure relates to materials and methods for extracellular vesicle (e.g., exosome)-mediated delivery of cargo (e.g., endogenous and/or exogenous) to non-bovine mammalian (e.g., human) cells. For example, exosomes isolated from bovine milk for delivering cargo to non-bovine mammalian (e.g., human) cells are provided.

Abstract: Disclosed is a method of improving a condition or appearance of skin. The method can include applying to skin an effective amount of a topical skin composition comprising tetrahexyldecyl ascorbate, Phyllanthus emblica fruit extract, and tocopherol or tocopherol acetate.

Abstract: Crystalline forms of 4-acetoxy-N,N-dimethyltryptamine (psilacetin), compositions containing that crystalline form, and their methods of use are disclosed. The crystalline forms of 4-acetoxy-N,N-dimethyltryptamine (psilacetin) according to the disclosure include crystalline 4-acetoxy-N,N-dimethyltryptammonium hydrofumarate, the fumarate salt of psilacetin, and/or crystalline bis(4-acetoxy-N,N-dimethyltryptammonium) fumarate, and pharmaceutical compositions containing a crystalline form of psilacetin.

Abstract: Dietary supplements, nutraceutical compositions, medical foods, animal feeds, and pharmaceutical compositions for treating osteoarthritis and other osteo-articular conditions involving neuropathy and associated symptoms. A synergistic composition containing a high dose range of agmatine and acceptable salts thereof and in combination with other active ingredients having salutary effects in treating osteoarthritis and other osteo-articular conditions involving neuropathy and associated symptoms. The composition prepared with excipients and compatible carriers, including but not limited to, powders, tablets, capsules, controlled release carriers, lozenges and chewable preparations, liquid suspensions, suspensions in an edible supporting matrix or foodstuff and oral rehydration solution to facilitate consumption.

Abstract: A method for obtaining an aqueous extract of Clitoria ternatea flowers, as well as the aqueous extract itself, are provided. The aqueous extract can be used for promoting growth of Achillea sp. grown under saline conditions.

Abstract: An oil extract from Gardenia jasminoides flowers obtained by extraction from powder of Gardenia jasminoides flowers with supercritical CO2, and the process of obtaining such an extract. Also, cosmetic composition including such an oil extract from Gardenia jasminoides flowers having in particular an antiaging effect for the skin, and method for preventing and/or treating changes to the skin due to aging or photoaging using such an extract.

Abstract: Described herein is a system, methods, processes and nutrient-rich products-by-process, which are generated by the conversion of winery derivatives into nutrient-rich products in an ecological manner. Integration of this system into a winery assists the winery to manage its previously-considered waste nutrient-rich products in an ecological manner, which can also optionally provide them with a novel revenue stream. The system, methods, and processes are used to convert winemaking derivatives into bioactive nutrient-rich products comprising antioxidants and other bioactive molecules that reside within the marc and lees. These nutrient-rich products can be used as natural flavour, texture and color enhancers, in addition to nutritional ingredients to fortify processed foods and consumer recipes. They can also be used as health supplements and in the cosmetic industry.

Abstract: A therapeutic treatment for the treatment of COVID-19 disease, the treatment to be initiated soon after and preferably within approximately twenty four hours after the patient develops the first signs of symptoms comprising but not limited to individually or in combination thereof fever, headache, sore joints, cough, fatigue, chills. The treatment consists of the oral administration of the herb thyme, also know as common thyme (Thymus vulgaris). The treatment is thought to inhibit the replication and activity of the virus allowing the patient to regain normal health and assist in developing immunity to the virus. The treatment is not known to completely eliminate the virus from the patient therefore resulting in the patient possibly developing the same or different symptoms of the disease a second, or more times requiring additional treatments of the disclosed thyme therapeutic treatment.

Abstract: A method of whitening skin or evening out skin tone is disclosed. The method can include topically applying to skin in need of treatment a composition comprising an effective amount of an extract of white navy bean, wherein topical application of the composition whitens skin or evens out skin tone.

Abstract: Disclosed herein are compositions for treating, ameliorating, preventing, or reducing the symptoms associated with menopause and/or hot flashes. The compositions disclosed herein comprise a curcumin composition, a green tea extract composition, and a phycocyanin composition that act as neurokinin 3 receptor antagonists. Also described herein are methods utilizing the aforementioned compositions.

Abstract: Use of a lentil product to increase the bioavailability of non-haem iron in a composition comprising one or more anti-nutritional factors.

Abstract: A heptane composition obtained from a plant source is described, wherein the plant source comprises Commiphora wildii and wherein the heptane composition is obtained by a process of extraction comprising hydrodistilling or steam distilling a resin of Commiphora wildii to obtain an essential oil. A method of using the heptane composition as a solvent for extracting one or more natural products is also described.

Abstract: The present invention relates to a water resistant wound cover with high comfort and good air permeability. In particular, the present invention relates to an aqueous wound healing formulation comprising a water-soluble or a water-dispersible polymeric material that does not sting when applied to a minor injury to the skin.

Abstract: A freeze-dried nipa palm powder obtainted by mixing (75-100) part of a sap of inflorescence stalk with (0-25) part other ingredients, then freezing said sap of inflorescence stalk with said other ingredients in frozen molds using an individual quick freezer (IQF) at temperature from ?25° C. to ?29° C. to obtain frozen sap of inflorescence stalk blocks, and freeze drying frozen sap of inflorescence stalk molds at a pressure of 7.8948×10?4?1.3158×10?3 atm for 48 hours. The freeze-dried nipa palm powder such as multi-purpose food products that can be used not only as directly, or dissolved in water such as a beverage, but also as a health-promoting functional food, improve immunity, skin care, and beauty for users.

Abstract: The invention relates to a pet food composition comprising at least one natural antioxidant and at least one synthetic antioxidant and at least one acidity regulator component to regulate the pH, wherein the pet food composition does not contain 1,2-dihydro-6-ethoxy-2,2,4-trimethylquinoline. Further, the invention comprises a method of producing the pet food composition as well as the use of the pet food composition.

Abstract: A crystalline pigment or colorant composition having high color intensity and/or low sugar content, and methods and processes of preparation. The composition may comprise purified fruit and/or vegetable color juices.

Abstract: The present invention relates to methods of treating overweight or obesity, reducing fat, sugar, and food intake, and reducing body weight or body weight gain in a subject using geranium oil or orlistat mouthwash, or a combination of both.