Patents Examined by R. Phillips
  • Amino acid 1,2-diketo derivatives as renin inhibitors
    Patent number: 4820691
    Abstract: Compounds of the formula ##STR1## are disclosed. These compounds interevene in the conversion of angiotensin to angiotensin II by inhibiting renin and thus are useful as anti-hypertensive agents.
    Type: Grant
    Filed: June 24, 1987
    Date of Patent: April 11, 1989
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Dinesh V. Patel
  • Renin inhibitors and aminoacid and aminoaldehyde derivatives
    Patent number: 4818748
    Abstract: Anti-hypertensive compounds of the formula ##STR1## in which A represents hydrogen, C.sub.1 -C.sub.8 -alkyl, C.sub.7 -C.sub.14 -aralkyl, phenylsulphonyl, tolylsulphonyl or C.sub.1 -C.sub.8 -alkylsulfphonyl, or represents an aminoprotective group,B represents a direct bond, or represents sarcosyl, or represents a group of the formula ##STR2## D represents a direct bond, or represents a group of the formula ##STR3## wherein X represents methylene, ethylene or sulphur,E, G, J, K, L and M independently have the same meanings as B,R.sup.1 is an optionally substituted phenyl radical, andQ is a hydroxy, alkoxy or amino group, or a physiologically acceptable salt thereof.
    Type: Grant
    Filed: March 6, 1987
    Date of Patent: April 4, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wolfgang Bender, Rolf Henning, Andreas Knorr, Johannes-Peter Stasch
  • Novel substrate for plasma kallikrein and a method for measuring biological components using the same
    Patent number: 4816562
    Abstract: Novel compounds represented by the following general formula (1) and salts thereof: ##STR1## wherein n represents an integer of 3 to 4, R.sup.1 represents ##STR2## or --SO.sub.2 R.sup.2, and R.sup.2 represents optionally branched lower alkyl group having 1 to 6 carbon atoms, phenyl group, benzyl group or tolyl group, which are useful as substrate for use in the measurement of biological components; a substrate for use in the measurement of biological component which comprises said novel compound or salt thereof; and a method for measuring biological component which comprises using said substrate.
    Type: Grant
    Filed: November 21, 1986
    Date of Patent: March 28, 1989
    Assignee: Nitto Boseki Co., Ltd.
    Inventors: Takeshi Nagasawa, Yoshio Nakamura, Kenji Tani, Katsumasa Kuroiwa
  • Biologically active polypeptides
    Patent number: 4816561
    Abstract: Novel biologically active polypeptides, including a new class of transforming growth factor (TGF) polypeptides, which exhibit cell growth promoting properties are disclosed, as well as a process for isolating the TGF polypeptides from both human and murine cell lines in homogeneous form. Also disclosed are antigenic oligopeptides derived from the TGF polypeptides and antibodies raised therefrom which have application in the detection and treatment of malignancies and oligipeptides which have the ability to bind with cellular growth factor receptors and thus to interfere with transformation of certain cell lines into a cancerous state. Compositions and methods based on the disclosed peptides for detection and treatment of cancer and other proliferative diseases and for cell or tissue growth associated treatment, e.g., wound healing, ulcer therapy and bone loss are also described.
    Type: Grant
    Filed: September 17, 1985
    Date of Patent: March 28, 1989
    Inventor: George J. Todaro
  • Stabilization of growth hormones
    Patent number: 4816568
    Abstract: Growth hormones are admixed with various stabilizers to provide for the decreased formation of insolubles and preservation of the soluble bioactivity of the growth hormone in aqueous environments. Examples of such stabilizers include certain polyols, amino acids, polymers of amino acids having a charged side group at physiological PH, and choline salts.
    Type: Grant
    Filed: May 16, 1986
    Date of Patent: March 28, 1989
    Assignee: International Minerals & Chemical Corp.
    Inventors: Edwin J. Hamilton, Jr., Bruce D. Burleigh
  • Piptides having ANF activity
    Patent number: 4816443
    Abstract: Novel peptides having potent natriuretic activity are disclosed with the following amino acid sequence: ##STR1## wherein Z is H, acetyl, Boc or Ser-Leu, E is Phe, NMP, OMT, ChA, F is Gly or DAl, G is Ala or Gly, H is Arg or DAr, Pro, Lys or Dly, I is Ile, Met, MeO, MO.sub.2, Leu, Nle, or Val, J is Aib, .alpha.MG or .alpha.MA, K is Arg or Lys, L is Ile or Val, M is Aib, Gly, Ala or DAl, N is Ala, NMA, Pro, Phe or NMP, O is Gln, DGl, Ala or DAl, P is Ser, His, Arg or Lys, Q is Gly, Pro, Ala or Dal, R is Leu, Phe or ChA, S is Gly, Ala or Dal, Arg or DAr, T is Asn DAs, Ala or Dal, U is Ser, DSe, Ala or DAl, V is Phe, DPh, Ala or DAl, Y is -OH or -NH.sub.2 and n is 0 or 1. Also included are the lower alkyl esters and the physiologically acceptable metal salts and acid addition salts of the foregoing peptides. Unless indicated otherwise all optically active amino acids have the L-configuration.
    Type: Grant
    Filed: May 19, 1987
    Date of Patent: March 28, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Stephen F. Brady, Ruth F. Nutt
  • The use of human growth hormone for the treatment of intoxicated individuals
    Patent number: 4816439
    Abstract: Human growth hormone is used for the treatment of individuals who are intoxicated with poisonous substances of the type which is degraded in the liver by microsomal enzymes, such as hexobarbiturates or alcohol.
    Type: Grant
    Filed: March 27, 1987
    Date of Patent: March 28, 1989
    Assignee: Nordiske Gentofte A/S
    Inventor: Karin D. Jorgensen
  • Peptides and compositions
    Patent number: 4816441
    Abstract: Peptides of the formula R.sup.1 -His-Asp-Glu-Ala-R wherein R.sup.1 is Ala-Gln, and R is a polypeptide residue with up to 50 amino acid residues, and wherein one, more or all of the amino acid residues in R.sup.1 and/or R independently may be omitted, can be used to augment cell mediated cytotoxicity and thereby to treat cancers and viral infections. These peptides may be prepared by proteolytic digestion of Staphylococcus aureus protein A, as well as by protein synthesis, recombinant DNA methods or any other methods known in the art.
    Type: Grant
    Filed: November 14, 1986
    Date of Patent: March 28, 1989
    Assignee: Novo Industri A/S
    Inventors: Jesper Zeuthen, Lars Thim, Niels P. H. Moller
  • Immunotherapeutic anti-inflammatory peptide agents
    Patent number: 4816449
    Abstract: Anti-inflammatory peptides of the formula A-B-C-D-E, useful in treating allergies, autoimmune diseases, and other disorders, and methods for using them are described.
    Type: Grant
    Filed: December 9, 1986
    Date of Patent: March 28, 1989
    Assignee: Immunetech Pharmaceuticals
    Inventor: Gary S. Hahn
  • Partially retro-inverted tuftsin analogues, method for the preparation thereof and pharmaceutical compositions containing them
    Patent number: 4816560
    Abstract: New partially retro-inverted tuftsin analogues of general formula I ##STR1## wherein R represents the side-chain of the amino acids threonine, methionine or leucineR.sup.1 represents the side-chain of the amino acids lysine or arginineR.sup.2 is hydrogen or a metabolically labile acyl group,all the asymmetric carbon atoms are either of the S- or R-configuration, or, alternatively, the first, third, and fourth asymmetric carbons, starting from the N-terminal residue, are of the S-configuration while the second one is of the R- or (R,S)-configuration, and the corresponding pharmacologically acceptable salts, esters and amides. The new compounds which share the same pharmacological properties of tuftsin, are much more stable toward the enzymatic degradation than the parent molecule.
    Type: Grant
    Filed: July 16, 1987
    Date of Patent: March 28, 1989
    Assignees: Eniricerche S.p.A., Sclavo S.p.A.
    Inventors: Antonio S. Verdini, Fabio Bonelli, Antonello Pessi, Franco Cardinali, Diana Boraschi, Stefano Censini, Romano Di Trapani
  • Insulin-selective somatostatin analogs
    Patent number: 4816438
    Abstract: Anglerfish somatostatin-28 has the formula: ##STR1## Anglerfish somatostation-28 is insulin-selective when administered in vivo and is useful for the treatment of insulinoma. The 14-residue C-terminal peptide may also be used.
    Type: Grant
    Filed: April 1, 1987
    Date of Patent: March 28, 1989
    Assignee: The Salk Institute for Biological Studies
    Inventors: Joachim Spiess, Bryan D. Noe
  • Biologically active peptides TAN-866
    Patent number: 4816559
    Abstract: The iron-containing biologically active peptide TAN-866 produced by microorganisms belonging to the genus Pseudomonas and its iron free compounds have antibacterial activity mainly against gram-negative bacteria. These peptides can be used as a therepeutic agent for bacterial infections in mammals, domestic fowl, etc., caused by Pseudomonas aeruginosa. Further, TAN-866 and its deacyl compounds are also promising as the starting materials and intermediates for the synthesis of novel products.
    Type: Grant
    Filed: July 8, 1987
    Date of Patent: March 28, 1989
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Setsuo Harada, Hideo Ono, Nozomi Katayama
  • Method for producing hepatitis B virus proteins in yeast
    Patent number: 4816564
    Abstract: The entire hepatitis B Virus pre-S antigen gene linked in one contiguous reading frame to the hepatitis B virus surface antigen gene has been expressed in Saccharomyces cerevisiae. The expressed protein aggregates into a particulate form which displays the major antigenic sites encoded by both domains, thereby highlighting the utility of yeast as a host for the expression of pre-S domains. This protein is useful in in vitro diagnostic systems and as a vaccine for the treatment and prevention of hepatitis B virus-induced diseases and/or infections.
    Type: Grant
    Filed: January 31, 1986
    Date of Patent: March 28, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Ronald W. Ellis, Arpi Hagopian, Peter J. Kniskern
  • Process for the treatment and the prevention of AIDS and other disorders induced by the LAV/HTLV III virus
    Patent number: 4814323
    Abstract: The invention relates to a process for the treatment and the prevention of the acquired immunodeficiency syndrome (AIDS) and AIDS related complex (ARC) induced by the LAV/HTLV III virus in a patient infected with said virus, comprising administering to said patient an effective amount of a compound selected from cyclosporins.
    Type: Grant
    Filed: March 25, 1986
    Date of Patent: March 21, 1989
    Inventors: J. M. Andrieu, P. Even, Alain Venet
  • Nor-statine and nor-cyclostatine polypeptides
    Patent number: 4814342
    Abstract: Polypeptides and derivatives thereof containing nor-statine and nor-cyclostatine are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin.
    Type: Grant
    Filed: October 23, 1987
    Date of Patent: March 21, 1989
    Assignee: Pfizer Inc.
    Inventors: Dennis J. Hoover, Robert L. Rosati, Ronald T. Wester
  • Inducer of T-suppressor cells
    Patent number: 4814434
    Abstract: A biologically active composition extracted from thymus tissue, capable of inducing immature bone marrow cells to differentiate into competent suppressor T-cells.
    Type: Grant
    Filed: November 15, 1984
    Date of Patent: March 21, 1989
    Assignee: Ventres Laboratories, Inc.
    Inventor: Marcia F. Goldfarb
  • Synthetic peptide antigen for the detection of HIV-2 infection
    Patent number: 4812556
    Abstract: A synthetic peptide antigen corresponding to a region of the glycoprotein gp41 encoded by the env gene of HIV-2 is provided. The peptide which is immunologically reactive with HIV-2 specific antibodies is useful in assays for detection of HIV-2 infection or exposure and in compositions to elicit the production of antibodies against HIV-2 in animals including man.
    Type: Grant
    Filed: May 18, 1987
    Date of Patent: March 14, 1989
    Assignee: Virovahl
    Inventors: Anders Vahlne, Bo Svennerholm, Lars Rymo, Stig Jeansson, Peter Horal
  • Tripeptide renin inhibitors
    Patent number: 4812442
    Abstract: Enzyme tripeptides of the formula: ##STR1## and analogs thereof which inhibit renin and are useful for treating various forms of renin-associated hypertension, hyperaldosteronism and congestive heart failure; compositions containing these renin-inhibitory peptides, optionally with other antihypertensive agents; and methods of treating hypertension, hyperaldosteronism or congestive heart failure or of establishing renin as a causative factor in these problems employing the novel tripeptides.
    Type: Grant
    Filed: May 4, 1987
    Date of Patent: March 14, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Joshua S. Boger, Ben E. Evans, Mark G. Bock
  • Polypeptides useful in vaccination against enteroviruses
    Patent number: 4810491
    Abstract: A synthetic polypeptide, suitable for use in vaccination against or diagnosis of a disease caused by an enterovirus, is an octapeptide coded for by codons 93-100 in the RNA sequence coded for the structural capsid protein VP1 for poliovirus type 3 Sabin strain or by equivalent codons of another enterovirus or is an antigenic equivalent of such an octapeptide, the numbers of the codons being counted from the 5'-terminus of the nucleotide sequence for the VP1 capsid protein.
    Type: Grant
    Filed: July 2, 1987
    Date of Patent: March 7, 1989
    Assignee: National Research Development Corporation
    Inventors: Philip D. Minor, David M. A. Evans, Geoffrey C. Schild, Jeffrey W. Almond
  • Solubilized lignosulfonate derivatives
    Patent number: RE32895
    Abstract: Valuable new and widely used compositions of matter are comprised of products having enhanced solubility and increased dispersant and the like surfactant activity which products are resulfonated units of alkaline oxidized, hydrolyzed, partially desulfonated lignosulfonates.
    Type: Grant
    Filed: September 17, 1981
    Date of Patent: March 28, 1989
    Assignee: Reed Lignin, Inc.
    Inventors: William J. Detroit, Michael E. Sanford