Patents Examined by R. Phillips
  • Antimicrobial compounds
    Patent number: 4810777
    Abstract: A new class of broad spectrum antibiotic polypeptides termed "Magainin" have been described. These peptides have a molecular weight of about 2500 or less, are highly water soluble, non-cytolyic to animal cells including red-blood cells and are amphiphilic.
    Type: Grant
    Filed: March 4, 1987
    Date of Patent: March 7, 1989
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventor: Michael A. Zasloff
  • Flavivirus antigen
    Patent number: 4810492
    Abstract: There is disclosed an antigen comprising at least part of an amino acid sence of the antigen of a flavivirus, which part contains at least one of epitopes of the flavivirus antigen. The present antigen can be produced easily and safely at low cost by means of recombinant DNA technique. The present antigen can be used as an effective vaccine and diagnostic for Japanese encephalitis.
    Type: Grant
    Filed: November 19, 1986
    Date of Patent: March 7, 1989
    Assignee: The Research Foundation for Microbial Diseases of Osaka University
    Inventors: Hiroyuki Fujita, Iwao Yoshida, Mitsuo Takagi, Sadao Manabe, Konosuke Fukai
  • Intermediates for preparing 1,6-dicarba-vasopressin compounds
    Patent number: 4810778
    Abstract: New compounds which have potent V.sub.2 -vasopressin antagonistic activity are prepared by a 1,6-cyclization using peptide bond formation. The structures of the compounds are characterized by the Pas.sup.1,6 or Tas.sup.1,6 cyclized unit. Also a chiral synthesis of the optically pure Pas intermediates is described.
    Type: Grant
    Filed: May 9, 1988
    Date of Patent: March 7, 1989
    Assignee: SmithKline Beckman Corporation
    Inventors: James F. Callahan, William F. Huffman, Kenneth A. Newlander, Nelson C. F. Yim
  • Immunosuppressant substances, process for their preparation and pharmaceutical compositions containing them
    Patent number: 4810692
    Abstract: The invention provides two novel immunosuppressant cyclodepsipeptides of formula: ##STR1## in which X is chlorine or hydrogen. These compounds may be made by culturing Streptomyces sp. S-16328 (CBS 162.86). The compound in which X is chlorine may be hydrogenolysed to give the compound in which X is hydrogen.
    Type: Grant
    Filed: May 21, 1987
    Date of Patent: March 7, 1989
    Assignee: Rhone-Poulenc Sante
    Inventors: Maurice Deschamps, Francois Floc'h, Gerard Jung, Rodolphe Margraff
  • Method for inducing biological coverings in wounds
    Patent number: 4810693
    Abstract: Methods are disclosed for (a) enhancing the formation of a natural biological dressing composed primarily of serum proteins; (b) enhancing the reestablishment for free, full-thickness skin grafts in warm-blooded animals; (c) enhancing the establishment of split-thickness skin grafts; and (d) increasing the rate of wound closure in warm-blooded animals. The methods utilize GHL-Cu or a derivative thereof.
    Type: Grant
    Filed: May 11, 1987
    Date of Patent: March 7, 1989
    Assignee: ProCyte Corporation
    Inventor: Loren R. Pickart
  • Decapeptides having hypotensive action and process for their preparation
    Patent number: 4810779
    Abstract: New decapeptides having hypotensive action are disclosed, which can be defined by the formula:GLp-Leu-Trp-Pro-X-Pro-Y-Z-Pro-Pro-OH (I)wherein:X=Arg or OrnY=His or GlnZ=Ile or Valwith the following limitations:whenX=Arg:Y=HisZ=Val;whenX=Orn:Y=GlnZ=Ile;or, whenX=Orn:Y=HisZ=Valand pharmaceutically acceptable salts, amides of alkyl esters thereof.
    Type: Grant
    Filed: June 3, 1986
    Date of Patent: March 7, 1989
    Assignee: Enichem Elastomeri S.p.A.
    Inventors: Valerio Caciagli, Antonio S. Verdini, Giovanna De Luca, Giovanni Di Stazio, Vincenzo Politi
  • Methods of preparing epitopes of tumor associated antigens
    Patent number: 4810781
    Abstract: Methods are disclosed for preparing (1) a pure, biologically active, immunogenic tumor-associated antigen by forming a soluble pool of membrane proteins from antigenic tissue and, by separating, identifying and characterizing antigenic and/or immunogenic proteins therefrom; (2) an ultrapure, biologically active TAA by further subjecting the pure TAA to isotachophoresis and/or affinity chromatography; and (3) making an epitope from purified TAA by injecting TAA into a host animal to stimulate the production by lymphocytes of antibodies specific to TAA, forming hybridomas capable of secreting monoclonal antibodies reactive with the TAA, dividing the TAA into fragments including epitopes, forming epitope-monoclonal antibody complexes, separating the complexes to recover the epitopes, and thereafter identifying and characterizing the epitopes.
    Type: Grant
    Filed: October 13, 1987
    Date of Patent: March 7, 1989
    Assignee: The George Washington University
    Inventor: Ariel C. Hollinshead
  • Stable formulations of ricin toxin a chain and of RTA-immunoconjugates and stabilizer screening methods therefor
    Patent number: 4808705
    Abstract: Highly stable pharmaceutical compositions suitable for parenteral administration to animals or humans comprising a therapeutically effective amount of an RTA-immunoconjugate dissolved in an inert carrier method comprising a stabilizer are claimed. Screening methods for selecting stabilizers effective in preventing precipitation and aggregation of such compositions are described. Preferred stabilizers includes glycerol at a concentration (v/v) of from about 25 to about 35%; dextran sulfates having molecular weights from about 0.1.times.10.sup.6 to about 2.times.10.sup.6 daltons; and human serum albumin.The invention further comprises such compositions which have been lyophilized and/or reconstituted wherein the stabilizer is non-volatile, and may further comprise a carbohydrate stabilizer.The invention further comprises stabilized RTA compositions.
    Type: Grant
    Filed: December 19, 1986
    Date of Patent: February 28, 1989
    Assignee: Cetus Corporation
    Inventor: Robert Ferris
  • Monoclonal antibodies against melanocytes
    Patent number: 4806628
    Abstract: Monoclonal antibodies were discovered which recognize differentiation antigens on melanocytes and melanoma cells at various stages of differentiation. A system of classification based on these antigens is proposed and their use in the diagnosis and treatment of melanoma is given.
    Type: Grant
    Filed: March 17, 1986
    Date of Patent: February 21, 1989
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Anthony Albino, J. Gregory Cairncross, Magdalena Eisinger, Alan N. Houghton, Lloyd Old
  • Proline-containing renin inhibitors
    Patent number: 4804743
    Abstract: This invention concerns novel renin-inhibitory peptides containing proline which are useful for treating renin associated hypertension and for treating hyperaldosteronism. Intermediates and processes for preparing both the intermediates and the novel peptides, pharmaceutical compositions, and methods of treatment are included. Also included is a method of diagnosis of renin-associated hypertension using the compounds of the invention.
    Type: Grant
    Filed: January 29, 1987
    Date of Patent: February 14, 1989
    Assignee: Warner-Lambert Copmany
    Inventors: James S. Kaltenbronn, Elizabeth A. Lunney, Ernest D. Nicolaides
  • Analogs of atrial natriuretic peptides
    Patent number: 4804650
    Abstract: Compounds and compositions comprising synthetic analogs of Atrial Natriuretic Peptides are provided, together with methods for their production and use as natriuretics, diuretics and/or vasodilators, or as intermediates for or modulators of such useful compounds or of native Atrial Natriuretic Peptides.
    Type: Grant
    Filed: March 16, 1988
    Date of Patent: February 14, 1989
    Assignee: Biotechnology Research Associates, J.V.
    Inventors: John A. Lewicki, Robert M. Scarborough, Jr., Lorin K. Johnson
  • Method for synthesizing a peptide containing a non-peptide
    Patent number: 4803261
    Abstract: This invention features a method for the solid phase synthesis of non-peptide bonds (CH.sub.2 --NH) in polypeptide chains. These polypeptides are synthesized by standard procedures and the non-peptide bond synthesized by reacting an amino aldehyde and an amino acid in the presence of NaCNBH.sub.3.This invention also features somatostatin analogs with non-peptide bonds.This invention further features a solid phase method of chemically modifying a peptide. The method involves synthesizing .alpha.-N-R and side group N-R analogs of peptides, where R is an alkyl or aryl group, by reacting a carbonyl-containing compound and an amino acid in the presence of NaCNBH.sub.3.
    Type: Grant
    Filed: June 27, 1986
    Date of Patent: February 7, 1989
    Assignee: The Administrators of the Tulane Educational Fund
    Inventors: David H. Coy, Simon J. Hocart
  • Process for using endogenous enkephalins and endorphins to inhibit growth of tumerous cells
    Patent number: 4801614
    Abstract: A process for the therapeutic treatment of cancer patients involving stimulation and promotion of the natural immune system (both T cell and NK cell activity) resisting and inhibiting tumorous growth (cancer) as well as resisting infections (viral, bacterial and fungal) by administering an effective dosage (e.g., 0.25 mg per kilogram of body weight to as low as about 10.sup.-14 mg/kg) of an endogenous endorphin (e.g., leucine-enkephalin and methionine-enkephalin).
    Type: Grant
    Filed: October 1, 1987
    Date of Patent: January 31, 1989
    Assignee: TNI Pharmaceuticals, Inc.
    Inventor: Nicholas P. Plotnikoff
  • Growth hormone-releasing factor analogs
    Patent number: 4801456
    Abstract: Human Growth Hormone-Releasing Factor (hGRF) analogs having the sequence [X.sup.3, Y.sup.8, Z.sup.25, Nle.sup.27 ]-hGRF(1-A)--B, wherein X, Y, and Z are selected from the group consisting of Asn and Asp, A has a value from 29-44, and B is NH.sub.2 or OH are synthesized and administered to animals to stimulate the release of Growth Hormone (GH).
    Type: Grant
    Filed: July 9, 1987
    Date of Patent: January 31, 1989
    Assignee: International Minerals & Chemical Corp.
    Inventor: Keith A. Drengler
  • Method of inhibiting inflammatory response
    Patent number: 4801612
    Abstract: Many malignant neoplasias are treated by radiation therapy which can result in painful inflammation of the covering skin and/or mucosal membranes. Similarly, skin disorder patients receiving U.V. treatment may experience an inflammatory response.Certain neuropeptides have been discovered to have the unusual properties of preventing, or inhibiting, the edema and protein extravasation of skin and mucosal membrane injuries due to thermal or radiation assault or exposure to trauma or noxious agents. A method for inhibiting an inflammatory response in the skin or mucosal membranes of a patient is provided in which a therapeutically effective amount of a neuropeptide, such as Corticotropin Releasing Factor ("CRF") or its analogs, is administered.
    Type: Grant
    Filed: July 3, 1986
    Date of Patent: January 31, 1989
    Assignee: Regents of the University of California
    Inventors: Edward T. Wei, Juliann G. Kiang
  • Peptide, process for preparation thereof and use thereof
    Patent number: 4801580
    Abstract: The invention relates to novel peptides, of pharmacological activity, of the formula: ##STR1## wherein R.sup.1 is hydrogen,R.sub.b.sup.1 is methyl,R.sup.2 is carboxy, carboxymethylcarbamoyl, 1-carboxyethylcarbamoyl or ethoxycarbonylmethylcarbamoyl,R.sup.q is carboxy or 3-t-butoxycarbonylcarbazoyl,R.sup.p is carboxy or methoxycarbonyl,R.sup.r is hydrogen, t-butoxycarbonyl or benzyloxycarbonyl,m is the integer 2, andn is the integer 1, or its pharmaceutically acceptable salt.
    Type: Grant
    Filed: May 13, 1982
    Date of Patent: January 31, 1989
    Assignee: Fujisawa Pharmaceutical Company, Ltd.
    Inventors: Yoshihiko Kitaura, Osamu Nakaguchi, Keiji Hemmi, Matsuhiko Aratani, Hidekazu Takeno, Satoshi Okada, Hirokazu Tanaka, Masashi Hashimoto, Yoshio Kuroda, Eiko Iguchi, Masanobu Kohsaka, Hatsuo Aoki, Hiroshi Imanaka
  • Bradykinin antagonist peptides
    Patent number: 4801613
    Abstract: The substitution of the L-Pro at the 7-position of the peptide hormone bradykinin or other substituted analogs of bradykinin with an aromatic amino acid or the D-configuration converts bradykinin agonists into a bradykinin antagonist. The invention further includes additional modifications at other positions within the novel 7-position modified bradykinin antagonists which increase enzyme resistance, antagonist potency and/or specificity of the new bradykinin antagonists. The analogs produced are useful in treating conditions and diseases of the mammal and human body in which an excess of bradykinin or related kinins are produced or injected as by bites into the body.
    Type: Grant
    Filed: June 17, 1987
    Date of Patent: January 31, 1989
    Assignee: Nova Technology Limited Partnership
    Inventors: John M. Stewart, Raymond J. Vavrek
  • Stereospecific synthesis of carboxyalkyl peptides
    Patent number: 4801721
    Abstract: Methods for the alkylation of substituted amines with trifluorate esters is disclosed.
    Type: Grant
    Filed: December 19, 1986
    Date of Patent: January 31, 1989
    Inventors: James W. Ryan, Alfred Chung
  • LHRH antagonists
    Patent number: 4800191
    Abstract: The present invention deals with LHRH antagonists which possess improved water solubility and while having the high antagonist potency of the basic peptides, are free of the edematogenic effects. These compounds are highly potent in inhibiting the release of gonadotropins from the pituitary gland in mammals, including humans.The compounds of this invention are represented by the formulaX-R.sup.1 -R.sup.2 -R.sup.3 -Ser-Tyr-R.sup.6 -Leu-Arg-Pro-R.sup.10 -NH.sub.2whereinX is an acyl group derived from straight or branched chain aliphatic or alicyclic carboxylic acids having from 1 to 7 carbon atoms,R.sup.1 is D- or L-Pro, D- or L- .DELTA. .sup.3 -Pro, D-Phe, D-Phe(4-H1), D-Ser, D-Thr, D-Ala, D-Nal (1) or D-Nal (2),R.sup.2 is D-Phe or D-Phe(4-H1)R.sup.3 is D-Trp, D-Phe, D-Pal, D-Nal(1) or D-Nal (2),R.sup.6 is D-Cit, D-Hci, D-Cit(Q) or D-Hci(Q) andR.sup.
    Type: Grant
    Filed: July 17, 1987
    Date of Patent: January 24, 1989
    Inventors: Andrew V. Schally, Sandor Bajusz
  • Compositions of hormonally active human and porcine inhibin containing an .alpha. chain and 62 chain
    Patent number: 4798885
    Abstract: DNA encoding the prepro inhibin .alpha. and .beta. chains has been isolated. This DNA is ligated into expression vectors and used to transform host cells for the preparation of inhibin or activin. Also provided are prohormone domains and other inhibin .alpha. or .beta. chain derivatives having therapeutic or diagnostic interest. The compositions provided herein are useful in the manipulation of fertility in animals.
    Type: Grant
    Filed: December 31, 1986
    Date of Patent: January 17, 1989
    Assignee: Genentech, Inc.
    Inventors: Anthony J. Mason, Peter H. Seeburg