Abstract: A method of treating a systemic disease in a patient in need of such treatment is disclosed. The method comprising maintaining the inspiratory flow rate and volume of the patient to a certain value and then administering a medicament aerosol formulation to such patient.

Abstract: A composition for treatment of bacterial infections of the eye is disclosed which comprises a lytic enzyme composition specific for the infecting bacteria, and a carrier for delivering said lytic enzyme. The carrier for delivering at least one lytic enzyme to the eye may be but is not limited to the use of an isotonic solution.

Abstract: The invention relates to a new polymorphic crystalline form of S-fluoromethyl 6&agr;,9&agr;-difluoro-11&bgr;-hydroxy-16&agr;-methyl-3-oxo-17&agr;-propionyloxyandrosta-1,4-diene-17&bgr;-carbothiate (fluticasone propionate). The new polymorphic crystalline form is easily handled and easily fluidised and its particle size and shape can be controlled. The invention also relates to the use of this new material in therapy, particularly in the treatment of respiratory disorders, e.g. asthma.

Abstract: An enteric coated pill for treating bacterial infections of the digestive tract, wherein the bacteria to be treated are selected from the group consisting of Listeria, Salmonella, E. coli, Campylobacter and combinations thereof, said pill comprising an effective amount of at least one lytic enzyme genetically coded by a bacteriophage specific for said bacteria of the digestive tract, whereby said enzyme has the ability to digest the cell wall of said bacteria; and a carrier for said enzyme.

Abstract: The present invention discloses a method for treating baterial dental caries caused by Streptococcus mutans, comprising administering a composition comprising an effective amount of at least one lytic enzyme produced by a bacteriophage specific for Streptococcus mutans, with the lytic enzyme having the ability to exclusively digest a cell wall of the Streptococcus mutans infecting all or part of a mouth or teeth, and a toothpaste for delivering the enzyme to the mouth and teeth.

Abstract: An aqueous non-aerosol hair styling composition having 55% or less VOC content, said composition comprising (i) a water soluble or dispersable fixative polymer of about 10 to about 1000 Kilo Daltons and in an amount ranging from 1% to 40% by weight of the composition; (ii) a neutralizing agent in an amount ranging from 0.1 to 10% by weight and selected from the group consisting of 2-amino, 2-methyl, 1-propanol, dimethyl stearamine, sodium hydroxide, and potassium hydroxide; (iii) a surfactant in an amount ranging from 0.01% to 5% by weight and selected from the group consisting of sodium dioctyl sulfo succinate, sodium dodecyl sulfate, cocoamidopropyl betaine, and sodium laureth sulfate; (iv) a salt ranging from 0.01% to 10% by weight and selected from the group consisting of sodium benzoate, and magnesium acetate; (v) an alcohol ranging from 10% to 90% by weight; and (vi) water ranging from 10% to 90% by weight.

Abstract: A mousse forming hair treatment composition, which is a cleansing and conditioning composition and is totally free of anionic surfactants, wherein said composition consists essentially of: (a) a foamable concentrate consisting essentially of n-methyl glucamide with a chain length of C12-C14 as the nonionic surfactant; (b) an aqueous carrier; (c)an aerosol propellant; (d) a thinner selected from the group consisting of polyethylene glycol and polypropylene glycol; and (e) an anionic styling polymer.

Abstract: A transdermal patch contains an active loratidine metabolite contained with polyacrylate polymer matrix. The transdermal patch provides pharmaceutically useful transdermal flux rates over time.

Abstract: A cosmetic composition for topical application to the skin, the hair, the nails or the eyelashes, which contains at least one soluble protein fraction extracted from the seed of Bambara (Voandzeia subterranea) nut, in admixture with a cosmetologically and dermatologically acceptable excipient.

Abstract: The present invention relates to hair-care compositions comprising aqueous polymer dispersions as film-forming agent. These polymers are obtained by free-radical polymerization of a radical monomer in the interior and/or partially at the surface of already existing polymer particles of polyester type.

Abstract: Multipurpose skin preparations in the form of oil-in-water emulsions are disclosed. The skin preparations are prepared by combining an oil phase and an aqueous phase. The oil phase comprises a siloxane polymer, a cyclic silicone, an anti-oxidant, and an emollient. In a second version of the present invention, the oil phase includes a copolymer comprising PPG-12/SMDI. The aqueous phase comprises at least a humectant, a rheology modifier, a thickener, and water. The inventive preparations are useful in topical application to the skin, are highly water resistant, remain on the skin after multiple washings, form a protective barrier on the skin, and effectively deliver and maintain moisturizing and therapeutic agents on the skin. It is believed that the skin preparations of the present invention also effectively deliver and maintain moisturizing and select therapeutic agents, biological agents, pharmaceutical agents, and the like, which are useful for the treatment of pathologies of the skin.

Abstract: A cosmetic composition pressurized as an aerosol in the presence of a propellant and forming a mousse, comprising, in a cosmetically acceptable medium, at least one associative polyurethane and at least one anionic polymer, and to the use of an associative polyurethane in order to improve the properties of mousses based on anionic polymer and propellant.

Abstract: Dental composition, product and process using a silicon containing abrasion resistant material. The dental products formed are abrasion resistant and self-lubricating across their entire cross sections. Dental compositions useful for forming dental products in accordance with the invention preferably includes an ethylenically unsaturated silane. The composition is formed into a dental prosthesis, such as an artificial tooth, inlay, onlay, facing, crown or bridge.

Abstract: The present invention is directed to a pharmaceutical composition including a hydrophobic therapeutic agent having at least one ionizable functional group, and a carrier. The carrier includes an ionizing agent capable of ionizing the functional group, a surfactant, and optionally solubilizers, triglycerides, and neutralizing agents. The invention further relates to a method of preparing such compositions by providing a composition of an ionizable hydrophobic therapeutic agent, an ionizing agent, and a surfactant, and neutralizing a portion of the ionizing agent with a neutralizing agent. The compositions of the invention are particularly suitable for use in oral dosage forms.

Abstract: A hair cosmetic composition having an excellent hair setting property, and which imparts to hair good flexibility and a good finish feeling. The hair cosmetic composition comprises (a) a water-soluble amine-oxide-containing polymer having a weight-average molecular weight of 10,000 to 500,000 and (b) a water-soluble polymer selected from the group consisting of nonionic, cationic, anionic and amphoteric polymers. The weight ratio of component (a) to component (b) falls within a range of from 1:10 to 10:1. Components (a) and (b) are incorporated in a total amount of from 0.1 to 10 wt. % based on the hair cosmetic composition.

Abstract: According to the subject invention, dispersible dry powder pharmaceutical-based compositions are provided, including methods for their manufacture and dry powder dispersion devices. A dispersible dry powder pharmaceutical-based composition is one having a moisture content of less than about 10% by weight (% w) water, usually below about 5% w and preferably less than about 3% w; a particle size of about 1.0-5.0 &mgr;m mass median diameter (MMD), usually 1.0-4.0 &mgr;m MMD, and preferably 1.0-3.0 &mgr;m MMD; a delivered dose of about >30%, usually >40%, preferably >50%, and most preferred >60%; and an aerosol particle size distribution of about 1.0-5.0 &mgr;m mass median aerodynamic diameter (MMAD), usually 1.5-4.5 &mgr;m MMAD, and preferably 1.5-4.0 MMAD. Such composition are of pharmaceutical grade purity.

Abstract: Wounds involving minor lesions such as cuts, excoriations, burns, scalds and various kinds of open efflorescence require rapid covering to arrest bleeding, to disinfect the wound area and to suppress secondary microbial contamination. The present invention is a hemostatically active aerosol composition comprised of microdispersed polyanhydroglucuronic acid and salts thereof and from 0.75 to 0.995 parts by weight of a dispergating/propellant system. The system includes compounds which are nonpolar or of low polarity with a surface tension of less than 30 mN/M and a permitivity of 10 kilohertz of less than 10 and at least one compound selected from the group consisting of a fluorinated or perfluorinated alkane, a C3 to C8 cycloalkane and a fluorinated or perfluorinated aliphatic ether.

Abstract: Stable microdispersed polyanhydroglucuronic acid and salts thereof contain in their polymeric chain from 8 to 30 per cent by weight of carboxyl groups, at least 80 per cent by weight of these groups being of the uronic type, at most 5 per cent by weight of carbonyl groups including intra- and inter-molecular 2,6 and 3,6 hemiacetals, 2,4-hemialdals and C2-C3 aldehydes. The molecular mass of the polymeric chain is from 1×103 to 3×105 Daltons. The microdispersed products are prepared by subjecting a polyanhydroglucuronic acid-containing material to partial or complete hydrolysis and neutralisation in an oxidative environment.

Abstract: Melt processable, flushable polymer fibers and methods of making melt processable, flushable polymer fibers are disclosed. The fibers comprise poly(ethylene oxide). Preferably, the poly(ethylene oxide) is modified by grafting polar vinyl monomers, such as poly(ethylene glycol) methacrylate and 2-hydroxyethyl methacrylate, onto poly(ethylene oxide). The modified poly(ethylene oxide) has improved melt processability and can be used to melt process poly(ethylene oxide) fibers of thinner diameters.

Abstract: A method for improving the corrosion resistance of aerosol or foam hair spray formulations in metal containers is disclosed. In particular, the present invention involves the use of phosphate ester emulsifiers in the preparation of the emulsion polymer hair fixative resins to provide corrosion resistance of the hair styling composition in metal containers without negatively affecting the performance of the hair styling product itself. Use of the selected emulsifiers is particularly useful in non-corrosive aqueous hair styling compositions containing low (80% or less) volatile organic compound (VOC) concentrations.