Abstract: The present invention relates to a care and/or make-up anhydrous composition, in particular a cosmetic, dermatological, hygienic or pharmaceutical composition, for the skin, which may be provided in the form of a cast product or a gel comprising at least one, in particular pulverulent, coloring matter and a dispersion of non-film-forming polymer particles which are surface-stabilized in a partially nonvolatile liquid fatty phase. Depending on the quantity of polymer and of nonvolatile oil, it is possible to obtain, on the lips or the skin, a nonfatty soft film having remarkable transfer-free properties, while imparting a very high degree of comfort. The invention also relates to the use of this dispersion in such a composition.

Abstract: A method for treatment of bacterial infections of the digestive tract is disclosed which comprises administering a lytic enzyme specific for the infecting bacteria. The lytic enzyme is preferably in a carrier for delivering said lytic enzyme. The bacteria to be treated is selected from the group consisting of Listeria, Salmonella, E. coli, Campylobacter, and combinations thereof. The carrier for delivering at least one lytic enzyme to the digestive tract is selected from the group consisting of suppository enemas, syrups, or enteric coated pills.

Abstract: Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a biodegradable material and have a mass density less than 0.4 g/cm3/. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear &agr;-hydroxy-acid polyester backbone having at least one amino acid group incorporated therein and at least one poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, porous particles having a relatively large mean diameter, for example greater than 5 &mgr;m, can be used for enhanced delivery of a therapeutic agent to the alveolar region of the lung.

Abstract: Disclosed are compositions for cleaning and conditioning of hair and/or skin comprising a mixture preparable by transesterification of a triglyceride with sucrose. These compositions typically further comprise various surfactants and optional ingredients depending on the specific composition desired.

Abstract: A composition suitable for topical application, comprising a liquid fatty phase, at least one dye, and at least 2% by weight, relative to the total weight of the composition, of polymer particles which are dispersed and stabilized at the surface by at least one stabilizer in the liquid fatty phase. The present invention also provides a composition suitable for topical application, comprising a cosmetic, dermatological, hygiene or pharmaceutical liquid fatty phase, at least one active agent selected from the group consisting of cosmetic, dermatological, hygiene and pharmaceutical active agents, and at least 2% by weight, relative to the total weight of the composition, of polymer particles which are dispersed and stabilized at the surface by at least one stabilizer in the liquid fatty phase.

Abstract: A pharmaceutical aerosol formulation which comprises particulate medicament selected from the group consisting of salmeterol, salbutamol, fluticasone propionate, beclomethasone dipropionate and physiologically acceptable salts and solvates thereof and a fluorocarbon or hydrogen-containing chlorofluorocarbon propellant, which formulation is substantially free of surfactant is disclosed. Also disclosed is a method of treating respiratory disorders which comprises administration by inhalation of an effective amount of the, pharmaceutical aerosol formulation which may be contained in a canister.

Abstract: Methods and pharmaceutical compositions employing norastemizole and a leukotriene inhibitor for the treatment or prevention of inflammation or allergic disorders, such as asthma or the symptoms thereof. Also included are methods and compositions employing norastemizole and a decongestant for the treatment or prevention of inflammation or allergic disorders, such as asthma or the symptoms thereof.

Abstract: The present invention discloses a composition for dermatological infections by the use of a lytic enzyme in a carrier suitable for topical application to dermal tissues. The method for the treatment of dermatological infections comprises administering a composition comprising effective amount of a therapeutic agent, with the therapeutic agent comprising a lytic enzyme produced by infecting a bacteria with phage specific for that bacteria.

Abstract: Compositions and methods for the prophylactic and therapeutic treatment of bacterial infections are disclosed which comprise administering to an individual an effective amount of a composition comprising an effective amount of lytic enzyme and a carrier for delivering the lytic enzyme. This method and composition can be used for the treatment of upper respiratory infections, skin infections, wounds, burns, vaginal infections, eye infections, intestinal disorders and dental problems.

Abstract: This invention relates to aerosol formulations of use for the administration of medicaments by inhalation, in particular a pharmaceutical aerosol formulation which comprises particulate salbutamol and physiologically acceptable salts and solvates thereof and a fluorocarbon or hydrogen-containing chlorofluorocarbon propellant, which formulation is substantially free of surfactant. A method of treating respiratory disorders which comprises administration by inhalation of an effective amount of a pharmaceutical aerosol formulation as defined is also described.

Abstract: Aqueous aerosol compositions are produced particularly for the delivery of an atomized oil, such as a fragrance oil, insecticidal oil or medicinal oil. The water based system, which includes a water soluble propellant and a dispersed oil phase in water with a polymeric emulsion, does not need shaking before use, is not flammable, and leaves no deposition on surfaces.

Abstract: Evaporative coolants suitable for use as cold spray topical anesthetics containing hydrofluorocarbons and/or hydrochlorofluorocarbons, preferably 1,1,1,3,3-pentafluoropropane, either alone or in combination with other hydrofluorocarbon and/or hydrochlorofluorocarbon components. The invention includes a system for cooling skin using the coolant and a device for spraying the coolant, as well as a method of cooling or topically anesthetizing the skin comprising spraying such evaporative coolants thereon.

Abstract: Cosmetic foaming compositions and hair mousse compositions employ a foaming agent comprising a mixture of first and second nonionic surfactants and having a total HLB as measured by the Griffin method of at least 12. The first nonionic surfactant is selected from defined polyoxyethylene alkyl ether surfactants, polyoxyethylene alkenyl ether surfactants, polyoxypropylene polyoxyethylene ether surfactants, and mixtures thereof; and the second nonionic surfactant is selected from defined polyoxyethylene long chain alkyl fatty acid or benzene ether surfactants, polyoxyethylene ether surfactants, polyoxypropylene ether surfactants, and mixtures thereof.

Abstract: An aerosol preparation for skin-cooling which coagulates sherbet-like on the applied site when sprayed, comprising a liquefied gas and a concentrate containing a C1-3 lower alcohol and a C10-22 straight chain monocarboxylic acid can contain drugs labile in water of which the incorporation has been difficult in the previous aerosol preparations, gives a good feeling when used, and have a durable cooling effect. Accordingly, it is effective on quick calming the pain caused by contusion, sprain, muscular fatigue, etc. or the itch caused by athlete's foot, insect bite, etc.

Abstract: An emulsifier mixture for use in the production of phase inversion temperature (PIT) emulsions is provided. The emulsifier mixture comprises fatty acid ethoxylates and partial glycerides which enable PIT emulsions to be produced at a given phase inversion temperature irrespective of the polarity of the oils, allowing for the emulsifying of a broad range of oils irrespective of their character, under the same conditions.

Abstract: The present invention describes formulations of nanoparticulate HIV protease inhibitors comprising a cellulosic surface stabilizer. The nanoparticulate formulations have an increased rate of dissolution in vitro, an increased rate of absorption in vivo, a decreased fed/fasted ratio variability, and a decreased variability in absorption. The present invention is also directed to methods of making the novel formulations. In particular, nanoparticulate formulations of HIV type 1 (HIV-1) and type 2 (HIV-2) protease inhibitors are described.

Abstract: The invention relates to a cosmetic cleansing and skin care preparation which is particularly suitable for extremely greasy pubertal skin and exhibits very good sebostatic effectiveness. The preparation contains 0.25-5 wt. % of a combination comprising 5-40 wt. % of an alga laminaria saccharina extract; 10-60 wt. % of lilium candidum root extract; 10-50 wt. % glycyrrehetinic acid as a natural extract of glycyrrhiza glabra. The preparation also contains 99.75 to 95 wt. % cosmetic auxiliary agents and carriers, optionally mixed with additional active substances.

Abstract: The aqueous-alcoholic hair fixing composition contains from 0.1 to 10 percent by weight of shellac, neutralized from 50 to 100%; from 0.01 to 20 percent by weight of at least one film-forming hair fixing synthetic polymer, advantageously a terpolymer made from octylacrylamide, t-butylamino-ethylmethacrylate and at least two monomers selected from the group consisting of methacrylic acid, esters of acrylic acid and esters of methacrylic acid; from 30 to 70 percent by weight of at least one alcohol containing from 1 to 4 carbon atoms; from 30 to 70 percent by weight water; and, for compositions to be sprayed by means of a propellant, from 15 to 85% by weight of a propellant, advantageously dimethylether, an alkane, N2, N2O or CO2. The combination of the shellac and the synthetic hair fixing polymer causes a synergistic viscosity lowering which advantageously promotes rinsibility without impairing fixing performance.

Abstract: Aerosol compositions are provided that enhance the therapeutic action of ointments by producing, upon topical application thereof, a sustained cooling effect that provides fast relief form pain and itching as well as a tendency to shrink swollen, inflamed tissue. The compositions contain oils, thickening agents for the oils, and propellant. Aqueous solutions, therapeutic ingredients and various adjuvants may also be present. The specific propellant and the proportion used are selected to provide a deposit with a temperature of about −5° C. to about +5° C. In this temperature range, the deposit is cold enough for the required therapeutic effect, but not so cold as to cause pain or tissue damage. The choice and proportion of thickening agents used are selected to provide a deposit that does not flow or spread. Were the deposit to spread, it would present a large surface area from which propellant present in the deposit would evaporate rapidly.

Abstract: A simulated capsule-like medicament comprising a subcoating of a mixture of a water-soluble, film-forming polymer, e.g. hydroxypropylmethyl cellulose and a hydrophobic plasticizer, e.g. castor oil, which promotes a smooth uniform and substantially bubble free outer coating, e.g. gelatin, for the capsule-like medicament; capsule-like medicaments which are slightly bowed in shape; and a process of making such medicaments.