Patents Examined by Raj Bawa
  • Multi-stage drug delivery system
    Patent number: 6207191
    Abstract: A drug delivery system (10) includes a first capsule half (12) having an inner chamber (16) containing a drug (18) therein. A plug (28) is disposed in a passageway (26) of the capsule half (12) for plugging the opening (24) thereof. The plug (28) is releasable from the passageway opening (24) upon the application of pressure from within the inner chamber (16). A pump mechanism, reactive with the external environment of the capsule half (12), causes an increase in pressure within the inner chamber (16) and forces the plug (28) out of the passageway (26) to release the drug (18) from the inner chamber (16) and out of the passageway (26). Thusly, after initial release of drug from a second capsule half (14) releasably mounted on the first capsule half (12), the first capsule half (12) provides a second pulse of drug release at a predetermined time after initial ingestion of the capsule.
    Type: Grant
    Filed: August 12, 1999
    Date of Patent: March 27, 2001
    Assignee: Port Systems, L.L.C.
    Inventors: John R. Crison, Gordon L. Amidon
  • Controlled delay release device
    Patent number: 6200600
    Abstract: Novel devices for the controlled release of active materials especially pharmaceuticals comprise a capsule formed from two separable pieces at least part of the capsule walls is water permeable. The capsule contains a water sensitive material which on contact with water causes the two pieces to separate. In the preferred embodiment the devices comprise a generally cylindrical tube closed at one or both ends by a water swellable plug. The devices find particular application as oral dosage forms for use in man.
    Type: Grant
    Filed: December 15, 1994
    Date of Patent: March 13, 2001
    Assignee: BTG International Limited
    Inventor: Abdul Rashid
  • Method of treating HIV by a topical composition
    Patent number: 6200557
    Abstract: A solution or gel composition containing activated stabilized chlorine dioxide and phosphates, such as disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, and sodium monofluorophosphate, is disclosed for destroying HIV. The preferred concentration ranges are between about 0.005%-2.0% chlorine dioxide, and between about 0.02%-3.0% phosphate. The phosphate compound retards escape of chlorine dioxide in the pH range of 6.0 to 7.4, at which pH stabilized chlorine dioxide becomes activated and releases sufficient chlorine dioxide to reduce motility and become lethal to the involved micro-organisms. Using a lubricant as a vehicle for the chlorine dioxide/phosphate composition; development of vaginal itching due to Candida Albicans will be stopped.
    Type: Grant
    Filed: October 14, 1999
    Date of Patent: March 13, 2001
    Inventor: Perry A. Ratcliff
  • Aerosol formulation containing P134a and particulate medicament
    Patent number: 6200549
    Abstract: A pharmaceutical formulation comprising (i) one or more particulate medicaments, and (ii) 1,1,1,2-tetrafluoroethane as propellant, which formulation contains less than 0.0001% w/w surfactant based upon the weight of medicament, particulate medicament being present in an amount from 0.005 to 5% w/w relative to the total weight of the formulation and having a particle size of less than 100 microns, with the proviso that said medicament is other than salmeterol, salbutamol, fluticasone propionate, beclomethasone dipropionate or a physiologically acceptable salt or solvate thereof and with the proviso that when said formulation consists of betamethasone, ergotamine tartrate or sodium cromoglycate and 1,1,1,2-tetrafluoroethane the weight to weight ratio of medicament to propellant is other than 69:7900 or 0.866% w/w.
    Type: Grant
    Filed: March 9, 1999
    Date of Patent: March 13, 2001
    Assignee: Glaxo Group Limited
    Inventors: Rachel Ann Akehurst, Anthony James Taylor, David Andrew Wyatt
  • Thickening latex, manufacturing process and cosmetic applications
    Patent number: 6197287
    Abstract: Composition comprising an oil phase, an aqueous phase, at least one emulsifier of water-in-oil (W/O) type, at least one emulsifier of oil-in-water (O/W) type, characterized in that the composition is an inverted latex comprising from 20% to 60% by weight, and preferably from 25% to 45% by weight, of a branched or crosslinked anionic polyelectrolyte based on at least one monomer possessing a strongly acidic function, copolymerized either with at least one monomer possessing a weakly acidic function or with at least one neutral monomer. The compositions have cosmetic applications.
    Type: Grant
    Filed: January 19, 1999
    Date of Patent: March 6, 2001
    Assignee: Societe d'Exploitation de Produits pour les Industries Chimiques Seppic
    Inventors: Paul Mallo, Guy Tabacchi, Jean-Pierre Boiteux
  • Pharmaceutical compositions for treating late phase allergic reactions and inflammatory diseases
    Patent number: 6193957
    Abstract: A method of treating a mammalian patient suffering from or prone to a condition characterized by late phase allergic reactions, airway hyperresponsiveness or inflammatory reactions, e.g., asthma, allergic rhinitis, allergic dermatitis, allergic conjunctivitis, inflammatory bowel disease or rheumatoid arthritis, comprising the administration to the patient of an oral, parenteral, intrabronchial, topical, intranasal or intraocular pharmaceutical composition containing in each dose about 0.005 to about 1.0 mg per kilogram of patient body weight of ultra-low molecular weight heparins (ULMWH) or other sulfated polysaccharides having average molecular weights of about 1,000-3,000 daltons. Suitable inhalant and other pharmaceutical compositions for use in the novel treatment method are also disclosed.
    Type: Grant
    Filed: May 4, 1999
    Date of Patent: February 27, 2001
    Assignee: Baker Norton Pharmaceuticals, Inc.
    Inventor: Tahir Ahmed
  • Topical compositions
    Patent number: 6193956
    Abstract: The present invention relates to a two-part container containing an outer container and an inner container for use in containing skin care compositions.
    Type: Grant
    Filed: April 6, 1999
    Date of Patent: February 27, 2001
    Assignee: Johnson & Johnson Consumer Companies, Inc.
    Inventors: Jue-Chen Liu, Jonas C. T. Wang, Mohammed Yusuf, Norihiro Yamamoto, Satoshi Kazama, Christopher R. Stahl, Jean P. Holland, Kamran Mather, Margaret A. Aleles, Sachio Hamada, Curtis A. Cole
  • Physiologically acceptable foamable formulation and foam
    Patent number: 6187290
    Abstract: There is described a foamable formulation comprising a foamable carrier and an active ingredient which may be admixed with the carrier or packaged separately and dispersed into the carrier during the foaming process. Alginate gel is a preferred foamable carrier. The foam produced from such a formulation, and a foam sheet produced by drying the foam, also form part of the invention. The formulation, foam and foam sheet are especially useful for medical applications, for example in treating burns. As apparatus to store the components of the formulation and to generate the foam is also described.
    Type: Grant
    Filed: May 7, 1997
    Date of Patent: February 13, 2001
    Assignee: Giltech Limited
    Inventors: Thomas Gilchrist, Eilidh Gilchrist
  • Cosmetic product for removal of keratotic plugs from skin pores
    Patent number: 6174536
    Abstract: A cosmetic product is provided for removing keratotic skin plugs. The product includes a flexible non-occlusive substrate sheet onto which a composition containing an anionic or nonionic polymer is deposited. The composition is treated to become dry non-tacky to the touch yet upon being wetted for use the composition again turns tacky and mobile. The method of application involves either directly moistening the product or indirectly moistening by first wetting a consumer's face in an area where the product is applied. Thereafter, water is allowed to evaporate leaving a film to which the keratotic plugs are bonded. The film is then peeled away concommittingly removing the plugs.
    Type: Grant
    Filed: January 22, 1999
    Date of Patent: January 16, 2001
    Assignee: Chesebrough-Pond's USA Co., division of Conopco, Inc.
    Inventors: Brian Andrew Crotty, Philip Edward Miner, Anthony Johnson, Alexander Paul Znaiden
  • Transdermal preparation containing a loratidine metabolite with antihistaminic activity
    Patent number: 6165498
    Abstract: A transdermal patch contains an active loratidine metabolite contained with a polyacrylate polymer matrix. The transdermal patch provides pharmaceutically useful transdermal flux rates over time.
    Type: Grant
    Filed: March 23, 1998
    Date of Patent: December 26, 2000
    Assignee: Hexal AG
    Inventors: Karin Klokkers, Wilfried Fischer, Daniel Bracher
  • Pigmented water-in-oil emulsion cosmetic sticks
    Patent number: 6162421
    Abstract: A pigmented water-in-oil emulsion cosmetic stick composition comprising, by weight of the total composition, 0.5-50% water, 0.5-70% of a volatile solvent having a viscosity of 0.2 to 20 centipoise at 25.degree. C., 0.5-40% of a hydrocarbon wax, and 0.5-40% of a fluorinated oil.
    Type: Grant
    Filed: November 5, 1998
    Date of Patent: December 19, 2000
    Assignee: Revlon Consumer Products Corporation
    Inventors: Renee Joan Ordino, Natividad Jose, Robert Walter Sandewicz, Ann Marshall Ureneck
  • Orally administrable time release drug containing products
    Patent number: 6156340
    Abstract: A time release orally administrable drug containing product comprising a core, a drug layer attached to the core, and first and second coating layers is disclosed. The first coating layer is directly adjacent to the drug layer, and has a limited permeability to water. The second coating layer is directly adjacent to the first coating, and is more permeable to water than the first layer. A method for using this drug in the treatment of a patient is also disclosed.
    Type: Grant
    Filed: March 29, 1996
    Date of Patent: December 5, 2000
    Assignee: Duquesne University of the Holy Ghost
    Inventors: Christianah Moji Adeyeye, Hideki Ichikawa, Yoshinobu Fukumori
  • Cosmetic compositions comprising a combination of UV absorbers
    Patent number: 6153174
    Abstract: The present invention relates to cosmetic compositions comprising a combination of sunscreen filters of the formula ##STR1## with other sunscreen filters.
    Type: Grant
    Filed: October 9, 1997
    Date of Patent: November 28, 2000
    Assignee: BASF Aktiengesellschaft
    Inventors: Karin Sperling, Thomas Wunsch, Horst Westenfelder, Beate Trentmann
  • Uridine 5'-diphosphate and analogs useful for treating lung diseases
    Patent number: 6143279
    Abstract: Compounds of Formula I: ##STR1## wherein: X.sub.1, and X.sub.2 are each independently either O.sup.- or S.sup.- ;X.sub.3 and X.sub.4 are each independently either --H or --OH, with the proviso that X.sub.3 and X.sub.4 are not simultaneously --H;R.sub.1 is selected from the group consisting of O, imido, methylene and dihalomethylene;R.sub.2 is selected from the group consisting of H, halo, alkyl, substituted alkyl, alkoxyl, nitro and azido;R.sub.3 is selected from the group consisting of H, alkyl, acyl, aryl, and arylalkyl; andR.sub.4 is selected from the group consisting of --OR', --SR', --NR', and --NR'R", wherein R' and R" are independently selected from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, alkoxyl, and aryloxyl, with the proviso that R' is absent when R.sub.
    Type: Grant
    Filed: August 28, 1998
    Date of Patent: November 7, 2000
    Assignees: The University of North Carolina at Chapel Hill, Inspire Pharmaceuticals, Inc.
    Inventors: Richard C. Boucher, Jr., Sammy Ray Shaver, William Pendergast, Benjamin Yerxa, Janet L. Rideout, Robert Dougherty, Dallas Croom
  • Glossy transfer resistant lipstick compositions
    Patent number: 6143283
    Abstract: A cosmetic composition having improved transfer resistance comprising:a) from about 0.1-60% of a copolymer which is an adhesive at room temperature,b) from about 0.1-60% by weight of a volatile solvent having a viscosity of 0.5 to 20 centipoise at 25.degree. C.,c) 0.1-60% by weight of a nonvolatile oil.d) 0.1-80% dry particulate matter.
    Type: Grant
    Filed: August 27, 1998
    Date of Patent: November 7, 2000
    Assignee: Revlon Consumer Products Corporation
    Inventors: Joseph Frank Calello, Anjali Abhimanyu Patil, Salvatore Joseph Barone, Ann Marshall Krog
  • Metered dose inhaler for salmeterol
    Patent number: 6143277
    Abstract: A metered dose inhaler having part or all of its internal metallic surfaces coated with one or more fluorocarbon polymers, in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising salmeterol, or a salt thereof, and a fluorocarbon propellant, optionally in combination with one or more other pharmacologically active agents and one or more excipients.
    Type: Grant
    Filed: December 19, 1996
    Date of Patent: November 7, 2000
    Assignees: Glaxo Wellcome Inc., Glaxo Group Limited
    Inventors: Ian C. Ashurst, Craig S. Herman, Li Li, Michael T. Riebe
  • Structured water in cosmetic compositions
    Patent number: 6139855
    Abstract: The invention relates to composition having enhanced biological activity, the compositions comprising at least one structured water. In particular, the compositions contain a combination of I and S waters and a biologically active agent, in which the activity of the agent is increased relative to its activity in a non-structured water composition.
    Type: Grant
    Filed: February 1, 1999
    Date of Patent: October 31, 2000
    Assignee: Color Access, Inc.
    Inventors: Gheorghe Cioca, Joseph Gubernick, Andrew J. Bevacqua, Nicolae Vrabie, Daniel H. Maes, Kenneth D. Marenus, Edward Pelle, Neelam Muizzuddin, Vasile Ionita-Manzatu, Mirela Cristina Ionita-Manzatu
  • Flash flow processing of thermoplastic polymers and products made therefrom
    Patent number: 6129926
    Abstract: A method of producing a solid thermoplastic-containing matrix by flash flow processing thermoplastic polymers as well as the products produced by such method is provided. The method involves subjecting a feedstock of a thermoplastic polymer to flash flow melt spin processing at a temperature of about 200-430.degree. F. and shear imposed by centrifugal force from an operating speed of about 3600-3800 rpm. The matrix thus prepared is in the form of a floss, fiber, flake, filament, ribbon, spicule and mixtures thereof A guest material such as a dye, a fragrance, a comestible, an oil, a photographic reducer and developer, an organism, an antioxidant and a medicament may further be incorporated into the feedstock prior to processing.
    Type: Grant
    Filed: October 29, 1993
    Date of Patent: October 10, 2000
    Assignee: Fuisz Technologies Ltd.
    Inventor: Richard C. Fuisz
  • Medicinal aerosol products containing formulations of ciclesonide and related steroids
    Patent number: 6120752
    Abstract: A pharmaceutical aerosol formulation suitable for oral and/or nasal inhalation including an anti-inflammatory steroid of the formula ##STR1## in which: R.sub.1 is 1-butyl, 2-butyl, cyclohexyl or phenyl andR.sub.2 is acetyl or isobutanoyl, in particular ciclesonide. The formulations also include hydrofluorocarbon propellants such as HFC 134a and/or 227, and cosolvent such as ethanol in an amount sufficient to solubilize the ciclesonide or related steroid (and various optional ingredients, such as surfactant). The formulations exhibit very desirable physical and chemical stability, as well as excellent delivery characteristics.
    Type: Grant
    Filed: May 13, 1998
    Date of Patent: September 19, 2000
    Assignees: 3M Innovative Properties Company, Byk Gulden Lomberg Chemische Fabrik GmbH
    Inventors: Martin J. Oliver, Kanu M. Fatania, John S. Scott, Helgert Muller
  • Subcoated simulated capsule-like medicament
    Patent number: 6120801
    Abstract: A simulated capsule-like medicament comprising a subcoating of a mixture of a water-soluble, film-forming polymer, e.g. hydroxypropylmethyl cellulose and a hydrophobic plasticizer, e.g. castor oil, which promotes a smooth uniform and substantially bubble free outer coating, e.g. gelatin, for the capsule-like medicament; capsule-like medicaments which are slightly bowed in shape; and a process of making such medicaments.
    Type: Grant
    Filed: April 15, 1999
    Date of Patent: September 19, 2000
    Assignee: McNeil-PPC, Inc.
    Inventors: Kishor B. Parekh, Dennis C. Wieand, Jean B. Leasure