Patents Examined by Ralph J. Gitomer
  • Patent number: 11510956
    Abstract: Provided are methods of making and using an antimicrobial composition, optionally including adding one or more enzymes to a suspension of lees, wherein the lees was formed by fermenting fruit with yeast and the one or more optional enzymes comprise a protease, a carbohydrase, or a combination of a protease and a carbohydrase; and forming a dried lees by drying the lees. In some examples the fruit includes chardonnay grapes, pinot noir grapes, cabernet franc grapes, or a combination of any two or more of chardonnay grapes, pinot noir grapes, and cabernet franc grapes; the yeast includes one or more Saccharomyces cerevisiae strains of yeast; and drying the lees by heating it. In some examples, trub made from fermenting a grain such as barley is used instead of lees. An antimicrobial composition made as provided may be administered to an animal to inhibit bacterial growth.
    Type: Grant
    Filed: September 30, 2020
    Date of Patent: November 29, 2022
    Inventor: James Nocek
  • Patent number: 11510408
    Abstract: The present invention aims to provide a device for cryopreservation which enables easy and reliable cryopreservation of a cell or tissue. The device for cryopreservation of a cell or tissue of the present invention includes a deposition part on which a cell or tissue is to be deposited together with a preservation solution, wherein a surface of the deposition part includes a protrusion for holding a cell or tissue and a recess for storing a preservation solution.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: November 29, 2022
    Inventors: Kakeru Yoshida, Atsushi Matsuzawa, Yukio Tokunaga
  • Patent number: 11510951
    Abstract: The present invention is a cannabidiol oral dosage form including predominantly or exclusively hemp pomace that has been co-fermented with a complex fungi, compounded as a tablet or formulated within a capsule. The dosage forms contain dietary fiber, important to activity as the desired delivery system, having a ratio of at least one part soluble dietary fiber to 30 parts insoluble dietary fiber, and delivers desirable/non hallucinogenic cannabinoids (CBD, CBG) in a ratio of 60:1 up to 120:1 to hallucinogenic cannabinoids (THC).
    Type: Grant
    Filed: February 28, 2020
    Date of Patent: November 29, 2022
    Assignee: Fermented Farmer, LLC
    Inventor: Jordan Seth Rubin
  • Patent number: 11497760
    Abstract: The present invention relates to a method for solubilizing poorly water-soluble dietary supplements and pharmaceutically active agents, to the solubilisate produced by this method and respective uses as a dietary supplement or pharmaceutical dosage form. A phosphatidylcholine-based solubilization method is disclosed.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: November 15, 2022
    Assignee: Athenion AG
    Inventors: Ingo Saar, Wolfgang Brysch, Jörg Von Wegerer
  • Patent number: 11497206
    Abstract: The present application relates to a cell cryopreservation protective composition, the use of the composition, and a cell cryopreservation method. The cell cryopreservation protective composition comprises a zwitterionic molecule having the general formula R1—N+(CH3)2—(CH2)n—R2, wherein R1 is a linear or branched alkyl having 1 to 10 carbon atoms, and is optionally substituted with a substituent; R2 is any negatively charged group selected from the group consisting of —COO?, —SO4?, —SO3?, and (I); and R3 is a group selected from the group consisting of (methyl)acryloyloxyalkyl, alkyl and alkenyl; and the zwitterionic molecule having general formula R1—N+(CH3)2—(CH2)n—R2 is preferably a betaine compound. The cell cryopreservation protective composition can carry out cell cryopreservation in a non-toxic and efficient manner, and results in an extremely high post-thaw cell survival rate and does not require stepwise cryopreservation.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: November 15, 2022
    Assignee: Tianjin University
    Inventors: Lei Zhang, Jing Yang
  • Patent number: 11484551
    Abstract: Methods and compositions for treating aging-related diseases as well as liver regeneration, prevention of liver degeneration, and maintenance of liver are described. The compositions used in the methods include blood plasma and blood plasma fractions derived from blood plasma with efficacy in treating and/or preventing disease.
    Type: Grant
    Filed: May 19, 2021
    Date of Patent: November 1, 2022
    Assignee: Alkahest, Inc.
    Inventors: Viktoria Kheifets, Benson Lu
  • Patent number: 11478008
    Abstract: The present disclosure provides compositions comprising a supercritical rosemary extract and a lipid system comprising raffish liver oil or the product of an enzymatic or chemical glycerolysis processing of ratfish liver oil. The present disclosure also provides use of said compositions for immunotherapy potentiators or adjuvants for patients with cancer or immunological disorders; treatment of autoimmune-based immunological disorder selected from the group consisting of: rheumatoid arthritis, type I diabetes, psoriasis, celiac disease and multiple sclerosis; treatment of tumor growth, chronic lymphocytic choriomeningitis virus infection, hepatitis (B and C) virus infection, or human immunodeficiency virus infection; or prevention of kidney damage.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: October 25, 2022
    Inventors: Carlos Torres Olivares, Luis Vázquez De Frutos, Marta Corzo, Pablo Arranz, Ana Ramírez De Molina, Guillermo Reglero Rada, Viviana Loria Kohen, Marta Gómez De Cedrón, Juan Moreno Rubio, José Moisés Laparra Llopis, Enrique Casado Sáenz
  • Patent number: 11471493
    Abstract: The invention relates to use of a mesenchymoangioblast-derived mesenchymal stem cell (MSC-MSC) for treating allergic airway disease (AAD)/asthma in a subject.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: October 18, 2022
    Inventors: Chrishan Samuel, Simon Royce
  • Patent number: 11471433
    Abstract: Disclosed herein are compositions and methods for increasing the fitness of insects for agriculture or commerce, wherein the composition includes a postbiotic agent (e.g., a short chain fatty acid).
    Type: Grant
    Filed: July 31, 2020
    Date of Patent: October 18, 2022
    Assignee: Flagship Pioneering Innovations V, Inc.
    Inventors: Ignacio Martinez, Maier Steve Avendano Amado, Thomas Michael Malvar, Emily Michelle Mallick
  • Patent number: 11458170
    Abstract: The invention relates to a pharmaceutical composition containing a PLP-dependent enzyme and optionally its cofactor, pyridoxal phosphate (PLP), and/or a phosphate or non-phosphate precursor of PLP, its use as a drug, its production method and a therapeutic treatment method related to it. The pharmaceutical composition comprises erythrocytes and a pharmaceutically acceptable vehicle, the erythrocytes encapsulating the PLP-dependent enzyme. The PLP-dependent enzyme may be methioninase, tyrosine phenol-lyase, tyrosine aminotransferase or cystathionine beta-synthase.
    Type: Grant
    Filed: September 22, 2020
    Date of Patent: October 4, 2022
    Assignee: ERYTECH PHARMA
    Inventors: Yann Godfrin, Vanessa Bourgeaux, Fabien Gay, Thomas Cortese
  • Patent number: 11458178
    Abstract: The present invention provides a novel IL-1? and/or IL-6 expression inhibitor and use thereof. The IL-1? and/or IL-6 expression inhibitor in accordance with an aspect of the present invention contains a component derived from alcoholic fermentation lees.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: October 4, 2022
    Inventors: Masanori Yamato, Yosky Kataoka, Yasuhisa Tamura, Satoshi Kume, Toshitaka Minetoki, Kazuhisa Hizume, Satoshi Okazaki, Miyo Hirata, Shinya Okuda, Takayuki Bogaki
  • Patent number: 11453857
    Abstract: The present disclosure relates to a novel strain of Lactobacillus fermentum LM1016 (KCCM12468P). The disclosed strain can be useful for treating or preventing cardiovascular diseases, obesity, fatty liver and/or diabetes. The present disclosure also relates to compositions comprising the strain. The compositions can be useful for medicines, health-functional foods, dairy products, fermented products, food additives, animal feeds, etc.
    Type: Grant
    Filed: March 25, 2019
    Date of Patent: September 27, 2022
    Assignees: Genome and Company, Lactomason Co., Ltd.
    Inventor: Han Soo Park
  • Patent number: 11452764
    Abstract: Methods and compositions are described herein that inhibit FAK/ATK interactions. Such methods and compositions are useful for inhibiting cell adhesion and cancer metastasis.
    Type: Grant
    Filed: July 19, 2018
    Date of Patent: September 27, 2022
    Assignees: University of North Dakota, Board of Trustees of Michigan State University
    Inventors: Marc D. Basson, Leslie A. Kuhn, Sebastian Raschka
  • Patent number: 11445722
    Abstract: A kit, including: a first solution, a second solution, and a metal mesh. The first solution includes: dulbecco's modified eagle medium (DMEM), 65-95 V/V %; dimethyl sulfoxide (DMSO), 5.5-20 V/V %; ethylene glycol (EG), 3.5-15 V/V %; bovine serum albumin (BSA), 0.5-4 W/V %; sucrose 1-5 W/V %; methylcellulose with a viscosity of 4000 centipoise (cP), 0.05-0.8 W/V %; hetastarch 0.25-0.6 W/V %; and glucose 15-35 W/V %. The second solution includes: DMEM, 65-95 V/V %; DMSO, 5.5-20 V/V %; EG, 8-20 V/V %; BSA, 0.5-4 W/V %; sucrose, 10-20 W/V %; methylcellulose with a viscosity of 4000 centipoise (cP), 0.05-0.8 W/V %; polyvinyl pyrrolidone (PVP), 0.25-0.6 W/V %; and glucose 15-35 W/V %. The metal mesh has a thickness of 0.15-0.2 mm and includes a plurality of square holes. The side length of the square holes is 2.0-3.0 mm, and the spacing between adjacent holes is 0.5-2.0 mm.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: September 20, 2022
    Inventors: Hongping Wu, Min Zeng, Xu Zhou, Xiaofang Jin, Qiurui Yang
  • Patent number: 11446241
    Abstract: Embodiments of the invention involve treating ophthalmology conditions by the topical or oral use of acetylcholinesterase inhibitors. By effectively reducing or eliminating the population of Demodex mites in affected areas and areas where Demodex mites may exist, this treatment achieves a more complete remission of clinical signs and symptoms of the ophthalmological afflictions than any previously described method. Embodiments of the invention are useful for treating ocular afflictions caused by Demodex-induced inflammatory eye conditions, including meibomian gland dysfunction, conjunctivitis, keratoconjunctivitis, hyperemia, blepharitis and dry eye disease.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: September 20, 2022
    Assignee: Attillaps Holdings Inc.
    Inventor: Frank Anthony Spallitta
  • Patent number: 11439676
    Abstract: Embodiments of a method and supplement for preventing and/or treating gastrointestinal distress, including ulcer conditions, in animals such as humans are disclosed. The supplement is in a gel or other form and comprises mastic gum and an emulsifying agent such as lecithin. The supplement may also comprise B vitamins, one or more prebiotics or probiotics, and one or more minerals as well as, pH buffers and flavoring. A disclosed method of preventing and/or treating gastrointestinal distress comprises orally dosing an animal such as a human with the supplement at least once daily.
    Type: Grant
    Filed: September 1, 2020
    Date of Patent: September 13, 2022
    Assignee: KAECO Group, Inc.
    Inventors: Kelly Terry, Leon Kratochvil, James Harless, Tom Kratochvil
  • Patent number: 11419910
    Abstract: The present invention relates to a composition and use thereof directed towards treating various health ailments, such as skin and respiratory problems and various infections. More particularly, the present invention relates to a lime sulfur solution and use thereof, of varying percentages, directed towards improving vision and treating various skin problems and infections, such as toenail fungus, athlete's foot, jock itch, skin psoriasis, eczema, vaginal yeast infections, head or beard dandruff, respiratory infections, itching of the skin (particularly of the hands), acne (facial and/or body acne), poison ivy, insect bites, head and body lice, crabs, cuts, treating wounds infected by staff and/or MRSA (methicillin-resistant Staphylococcus aureus) bacteria, tongue thrush, ringworm, penis foreskin infections, skin tags, and is also directed towards treating various respiratory infections (such as pneumonia, chronic obstructive pulmonary disease (COPD), asthma, and Covid-19 infections).
    Type: Grant
    Filed: May 11, 2020
    Date of Patent: August 23, 2022
    Inventor: Guy J. Guidry
  • Patent number: 11413328
    Abstract: The present invention relates to methods for treatment or prevention of asthma, mild intermittent asthma, mild persistent asthma, moderate persistent asthma, severe persistent asthma, eosinophilic asthma, neutrophilic asthma, steroid refractory asthma, status asthmaticus, pneumonia, bronchiectasis, COPD, sarcoidosis, and lung cancer based on reducing airway hyper responsiveness, increasing pulmonary compliance, reducing lung inflammation, reducing inflammatory cell count in bronchoalveolar fluid and reducing cytokine production by administration of a mammalian ?- and/or ?-defensin.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: August 16, 2022
    Assignee: NOVOZYMES A/S
    Inventors: Peter Nordkild, Søren Kjærulff
  • Patent number: 11413312
    Abstract: The present invention provides a method of treating a subject suffering from dry eye syndrome, comprising: administering to said subject a pharmaceutical composition for treating dry eye syndrome, comprising an effective amount of adipose-derived mesenchymal stem cells and the pharmaceutical composition is administered to the eye topically in the form of eye drops.
    Type: Grant
    Filed: December 4, 2019
    Date of Patent: August 16, 2022
    Assignee: National Taiwan University
    Inventors: I-Hsuan Liu, Chung-Tien Lin
  • Patent number: 11406680
    Abstract: The present invention relates to a health functional food for inhibiting a rise of blood glucose containing coffee and tagatose.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: August 9, 2022
    Inventors: Byung Gyu Park, Young Mi Lee, Seong Bo Kim, Seung Won Park