Patents Examined by Ralph J. Gitomer
  • Patent number: 10660336
    Abstract: A method for controlling plant viruses comprising treating plant or soil with a composition for controlling plant viruses comprising Trichodermin wherein the composition has antiviral activity against plant viruses when applied to a plant or to soil. In some embodiments, the Trichodermin is isolated from a Trichoderma albolutescens strain.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: May 26, 2020
    Assignees: SEOUL WOMEN'S UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION, KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
    Inventors: Dong Ho Lee, Jae Jin Kim, Ki Hyun Ryu, Beom Seok Kim, Seung Mok Ryu
  • Patent number: 10653754
    Abstract: The present invention relates to a process for preparing a highly pure neurotoxic component of a botulinum toxin by cultivating Clostridium botulinum under conditions that allow production of a botulinum toxin, and isolating the neurotoxic component from the botulinum toxin. In addition, the present invention relates to a highly pure neurotoxic component of a botulinum toxin obtainable by the process of the present invention and uses thereof.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: May 19, 2020
    Assignee: Merz Pharmaceuticals GmbH
    Inventors: Michael Pfeil, Andreas Wiesenburg
  • Patent number: 10646537
    Abstract: The present disclosure relates to the field of health food technology, in particular to a traditional Chinese medicine composition, preparation method and use thereof. The traditional Chinese medicine composition is made from Coicis Semen, Hippophae Fructus, Citri Rubrum Exocarpium and Glycyrrhizae Radix et Rhizoma. The traditional Chinese medicine composition uses less species of Chinese herbs and has significant effect on reducing the circumference of waist and abdomen, reducing the weight of visceral fat and anti-inflammation by reasonable combination, and does not have side effects.
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: May 12, 2020
    Assignee: INFINITUS (CHINA) COMPANY LTD.
    Inventors: Renhuai Cong, Fangli Ma, Chung Wah Ma, Xiaoling Wang, Lingyun Xiao
  • Patent number: 10646531
    Abstract: A method for at least one of inhibiting growth of myeloma cells, inhibiting myeloma cell-induced activation or formation of osteoclasts, and inhibiting inflammation is provided, wherein the method comprises administering to a subject in need an effective amount of grapefruit essential oil.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: May 12, 2020
    Assignee: TCI Co., Ltd.
    Inventor: Yung-Hsiang Lin
  • Patent number: 10646476
    Abstract: The present invention concerns compositions for the increase in the humoral secretion comprising imidazole peptides or extracts containing them, as well as the use of said compositions for the prevention and/or treatment of secretarial dysfunctions of the body mucosa.
    Type: Grant
    Filed: July 26, 2016
    Date of Patent: May 12, 2020
    Assignee: Metis Healthcare S.r.l.
    Inventors: Cristiano Umberto Rumio, Francesco Palladini
  • Patent number: 10639343
    Abstract: A preparation method of Gynostemma Pentaphyllus leaves extracts with increased amount of small molecular effective saponin and decreased benzopyrene includes the steps of drying fresh Gynostemma Pentaphyllus leaves after heating, treating the dried Gynostemma Pentaphyllus leaves with steam, adding water of 1 to 100-fold volume to the above Gynostemma Pentaphyllus leaves and then preparing a hot water extract by carrying out a hot water extraction at 100-180 V, 0.5-10 atm for 1-120 hours, adding C1-C4 lower alcohol of 1 to 100-fold volume to the residual remained after the hot water extraction and then preparing an alcohol extract of the residual from the hot water extract by carrying out an alcohol extraction at 50-100° C. for 1-4 hours, and mixing the hot water extract and the alcohol extract, and then filtering and concentrating the mixture.
    Type: Grant
    Filed: January 4, 2018
    Date of Patent: May 5, 2020
    Assignee: BTC CORPORATION
    Inventors: Tae Young Kim, Joo Myung Moon, Su Hyun Kyong, Yoon Hee Kim
  • Patent number: 10640728
    Abstract: The invention discloses a method for preparing rapeseed oil by a semi-solid aqueous enzymatic process, belonging to the field of functional foods and health care products. The present invention first prepares a semi-solid rapeseed paste with 3.5-4.5% moisture content, which is hydrolyzed by a mixture of pectinase, cellulase and alkaline protease to extract rapeseed oil. The resulting rapeseed oil contains high levels of active ingredients including totaxin, sterol, phenols and beta-carotene. The rapeseed oil of the invention can be added into animal feeds, which helps to reduce animal blood lipid levels and body weight. It can significantly reduce the contents of total triglyceride, total cholesterol and LDC-C in the blood, and, at the same time, increases the level of HDL-C in the blood. In addition, the rapeseed oil prepared by the present invention can relieve hepatic steatosis in hyperlipemia rats.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: May 5, 2020
    Assignee: Jiangnan University
    Inventors: Yuanfa Liu, Peirang Cao, Jinwei Li, Liang Zhang
  • Patent number: 10632063
    Abstract: This invention relates to kits that allow the user to apply cosmetic products such as creams and serums to be mixed with a subject's own platelet rich plasma (PRP) and applied to the skin for several days.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: April 28, 2020
    Assignee: PPLUS SKIN CARE LIMITED
    Inventor: Mitra Najafi
  • Patent number: 10633688
    Abstract: Methods, processes, systems, and apparatuses are disclosed for predicting minoxidil response in the treatment of androgenetic alopecia based on colorimetric assay for sulfotransferase activity. In particular, SULT1A1 activity may be used as an indicator of minoxidil response. A genetic test for alleles of the SULT1A1 gene may be performed to provide a more personalized therapy.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: April 28, 2020
    Assignee: Follea International
    Inventors: Ofer A. Goren, John McCoy, Philip Y. Tam
  • Patent number: 10626370
    Abstract: Process for carrying out an in vitro biochemical reaction for preparing a cell suspension suitable for application to the skin of a patient.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: April 21, 2020
    Assignee: LABORATOIRES GENEVRIER
    Inventors: Dominique Vacher, Jean-Noel Gouze
  • Patent number: 10617634
    Abstract: Implementations of a topical homeopathic formulation may include an active portion including a plurality of active ingredients and a base including a plurality of inactive ingredients. The plurality of active ingredients may include one of tinctures and homeopathic preparations of Apis mellifica, Arnica montana, Atropa belladonna, Bellis perennis, Bryonia alba, Cactus grandifloras, Caulophyllum thalictroides, Cimicifuga racemose, Citrullus colocynthis, Cyclamen europaeum, Gelsemium Sempervirens, Gnaphalium polycephalum, Jonesia asoca, Juniperus Sabina, Kali carbonicum, Lilium tigrinum, Rhamnus californica, Tilia europaea, Viburnum opulus, and any combination thereof.
    Type: Grant
    Filed: March 2, 2018
    Date of Patent: April 14, 2020
    Assignee: Biolyte Laboratories, LLC
    Inventor: Daniel Kaline
  • Patent number: 10617745
    Abstract: A method for preventing bleeding, blood-brain barrier disruption, brain injury, or a combination thereof in a subject destined for cardiac surgery is disclosed. The method involves administering to the subject prior to cardiac surgery a therapeutically effective amount of alpha-1 antitrypsin (AAT-1), or functional variant thereof. The result is that it prevents bleeding, blood-brain barrier disruption, or a combination thereof in a subject destined for cardiac surgery.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: April 14, 2020
    Assignee: Mor Research Applications Ltd.
    Inventor: Dan Abrahamov
  • Patent number: 10619181
    Abstract: A method of detecting a Shigella or Cronobacter microorganism. The method comprises providing a culture device with a selective culture medium and a detection article comprising a first indicator system.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: April 14, 2020
    Assignee: 3M Innovative Properties Company
    Inventors: Takatoshi Moriyama, Patrick A. Mach, Akio Kitahara, Henry J. Lubrant
  • Patent number: 10617734
    Abstract: The present invention relates to a chemical and pharmaceutical technology, and in particular to a STAT3 and ERK signal pathway inhibitor and a use thereof. The present invention provides a STAT3 and ERK signal pathway inhibitor. The inhibitor mainly consists of a mogroside and/or an analog thereof. The mogroside and the analog thereof inhibit the phosphorylation of a transcription factor STAT3 and the phosphorylation of an ERK. The method for preparing the mogroside and the analog has the characteristics of simpleness, strong operability and high purity of products. The present invention further provides a use of the STAT3 and ERK signal pathway inhibitor in the preparation of drugs for treating tumors, which realizes the purposes of inhibiting the proliferation of cancer cells and promoting the apoptosis of cancer cells and has a very good inhibition effect on cancers.
    Type: Grant
    Filed: December 23, 2015
    Date of Patent: April 14, 2020
    Assignee: BEIJING UNIVERSITY OF AGRICULTURE
    Inventors: Can Liu, Lanqing Ma, Dequan Dou, Yuanxia Sun, Long Rong, Xiaomeng Zhao, Juntao Li, Yan Wang, Zhengzi Bi, Xiaozhu Bi, Haiwen Hu
  • Patent number: 10612000
    Abstract: The disclosure provides methods of making a cell-containing product having a uniform amount of cells therein. The method comprises pooling red blood cells from a plurality of blood units, and inactivating any pathogen contained therein. A storage solution added to the cellular component results in a cell-containing product that is essentially pathogen and white blood cell free and has an extended shelf life of about 42 to about 100 days. The cell-containing product is further divided into units which comprise a uniform dose of RBCs per unit.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: April 7, 2020
    Assignee: New York Blood Center, Inc.
    Inventors: Beth H. Shaz, Christopher D. Hillyer
  • Patent number: 10609929
    Abstract: The invention concerns a plant conditioning preparation comprising a (i) water based extract of plant A, especially belonging to the genus Urtica, (ii) an oil based extract of plant B, especially belonging to the genus Salix, and (iii) an emulsifier. The invention further comprises a process for the production of the said plant conditioning preparation and a method for using such a preparation. In addition, a plant conditioning preparation obtainable by said process as well as a method and a use of a plant conditioning preparation for enhancing the immune system of a plant are also disclosed.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: April 7, 2020
    Assignee: OGET INNOVATIONS GMBH
    Inventor: András Horváth
  • Patent number: 10605707
    Abstract: A method of removing a floatation liquid from between a microscope slide and a paraffin embedded biological specimen including position the microscope slide with the paraffin embedded biological specimen floated thereon onto a slide support element. The slide support element is rotated to cause the microscope slide and the paraffin embedded biological specimen to move in a way that causes the floatation liquid disposed between the microscope slide and the paraffin embedded biological specimen to be removed from between the microscope slide and the paraffin embedded biological specimen.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: March 31, 2020
    Inventor: Lee H. Angros
  • Patent number: 10596217
    Abstract: The invention relates to a composition containing a Withania somnifera extract, obtained by fermentation by incubating the Withania somnifera extract with a filamentous fungus of the Beauveria genus. The composition can be used to treat or prevent ?-synucleinopathies in a subject.
    Type: Grant
    Filed: April 13, 2015
    Date of Patent: March 24, 2020
    Assignees: Ethnodyne, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Chérif Rabhi, Léon Cariel, Jamal Ouazzani, Guillaume Arcile
  • Patent number: 10596102
    Abstract: The present invention relates to an emollient composition comprising emu oil, jojoba oil, a dermatological base and a metal or metalloid oxide, hydroxide or carbonate. The composition has efficacy in the prevention or treatment of a range of skin conditions.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: March 24, 2020
    Assignee: EUPHARMA PTY LTD.
    Inventor: Alec Eutick
  • Patent number: 10596201
    Abstract: An acellular soft tissue-derived matrix includes a collagenous tissue that has been delipidated and decellularized. Adipose tissue is among the soft tissues suitable for manufacturing an acellular soft tissue-derived matrix. Exogenous tissuegenic cells and other biologically-active factors may be added to the acellular matrix. The acellular matrix may be provided as particles, a slurry, a paste, a gel, or in some other form. The acellular matrix may be provided as a three-dimensional scaffold that has been reconstituted from particles of the three-dimensional tissue. The three-dimensional scaffold may have the shape of an anatomical feature and serve as a template for tissue repair or replacement. A method of making an acellular soft tissue-derived matrix includes steps of removing lipid from the soft tissue by solvent extraction and chemical decellularization of the soft tissue.
    Type: Grant
    Filed: September 5, 2018
    Date of Patent: March 24, 2020
    Assignee: Musculoskeletal Transplant Foundation
    Inventors: Yen-Chen Huang, Asia Ivery, Bryan Choi, Benjamin Schilling, Manh-Dan Ngo