Patents Examined by Raymond Henley, III
  • Inhibitors of secretion of hepatitis B virus antigens
    Patent number: 9533990
    Abstract: Pharmaceutical compositions of the invention comprise triazolopyrimidines useful for the treatment of hepatitis virus in a patient.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: January 3, 2017
    Assignees: Drexel University, Baruch S. Blumberg Institute, Arbutus Biopharma, Inc.
    Inventors: Xiaodong Xu, Andrea Cuconati, Timothy M. Block, Tong Xiao
  • Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
    Patent number: 9527847
    Abstract: Provided herein are methods, kits, and pharmaceutical compositions that include a PI3 kinase inhibitor for treating lupus, a fibrotic condition, or inflammatory myopathies and other conditions (e.g., skin conditions).
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: December 27, 2016
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Vito J. Palombella, David G. Winkler
  • Diethylammonium salts of phenyl-substituted thiobarbituric acid as anti-diabetic agents
    Patent number: 9527820
    Abstract: The diethylammonium salts of phenyl-substituted thiobarbituric acid as anti-diabetic agents include compounds having the formula: wherein X is: and wherein R1 is selected from the group consisting of a hydrogen, halogen, methyl, trifluoromethyl, methoxy, and nitro, and R2 is either halogen or hydrogen, the R1 and R2 substituents being independently bonded to an ortho-, meta-, or para-carbon of the phenyl substituent.
    Type: Grant
    Filed: May 5, 2016
    Date of Patent: December 27, 2016
    Assignee: KING SAUD UNIVERSITY
    Inventors: Assem Barakat, Mohamed Ali, Abdullah Mohammed Al Majid, Sammer Yousuf, Muhammad Iqbal Choudhary
  • Use of one or a combination of phyto-cannabinoids in the treatment of epilepsy
    Patent number: 9522123
    Abstract: This invention relates to the use of one or more cannabinoids in the treatment of epilepsy and more particularly to the use of one or a combination of cannabinoids in the treatment of generalized or partial seizure. In one embodiment it relates to the use of the cannabinoid THCV, as a pure or isolated compound, or as a plant extract in which significant amounts of any THC naturally present has been selectively removed. In another embodiment the phytocannabinoid is CBD.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: December 20, 2016
    Assignees: GW Pharma Limited, Otsuka Pharmaceutical Co., Limited
    Inventors: Benjamin Whalley, Gary Stephens, Claire Williams, Geoffrey Guy, Stephen Wright, Tetsuro Kikuchi
  • Methods and compositions for treating cancer
    Patent number: 9511050
    Abstract: Methods and compositions provided herein relate to the treatment of cancer. In some embodiments, the compositions have utility in the treatment of cancers including glioblastoma multiforme and lung cancer.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: December 6, 2016
    Assignee: Georgetown University
    Inventors: Jeffrey A. Toretsky, Aykut Uren
  • Method for treating skin cancer
    Patent number: 9504667
    Abstract: A method for treating skin cancer including the steps of applying an isothiocyanate functional surfactant to an area affected by skin cancer, wherein the isothiocyanate functional surfactant comprises at least one isothiocyanate functional group associated with an aliphatic and/or aromatic carbon atom of the isothiocyanate functional surfactant.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: November 29, 2016
    Assignee: The William M. Yarbrough Foundation
    Inventor: Michael E. Silver
  • Use of bethanechol for treatment of Xerostomia
    Patent number: 9492546
    Abstract: A formulation for topical administration, comprises bethanechol and a penetration enhancer. The formulation is preferably used by being maintained in the buccal cavity for a period of time prior to being swallowed.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: November 15, 2016
    Assignee: Acacia Pharma Limited
    Inventors: Ian Walker, Michael Frodsham
  • Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease
    Patent number: 9481671
    Abstract: A method of treating a glomerular disease selected from the group consisting of mesangial proliferative glomerulonephritis, collapsing glomerulopathy, proliferative lupus nephritis, crescentic glomerulonephritis and membranous nephropathy in a subject comprises administering to the subject an effective amount of a glucosylceramide synthase inhibitor.
    Type: Grant
    Filed: April 17, 2014
    Date of Patent: November 1, 2016
    Assignee: Genzyme Corporation
    Inventors: Oxana Ibraghimov-Beskrovnaya, Thomas A. Natoli
  • Cysteamine in the treatment of fibrotic disease
    Patent number: 9468612
    Abstract: Fibrotic diseases are characterized by the replacement of healthy tissue with scar tissue and extracellular matrix in response to tissue damage. Here we describe the reduction of extracellular matrix (ECM) deposition, interstitial fibroblasts, interstitial volume, expression of Collagen I mRNA and protein, expression of profibrotic cytokines and macrophage infiltration by Cysteamine treatment.
    Type: Grant
    Filed: October 26, 2011
    Date of Patent: October 18, 2016
    Assignee: Seattle Children's Hospital
    Inventors: Allison A. Eddy, Daryl M. Okamura
  • Pharmaceutical composition of doxycycline with reduced food effect
    Patent number: 9463196
    Abstract: The present invention relates to a once daily tablet comprising doxycycline at sub-antibiotic dose and one or more pharmaceutically acceptable excipients, wherein the tablet exhibits a reduced food effect. The invention further provides a method of treatment of rosacea by administering to a person in need thereof the doxycycline tablet with or without food. A process of preparing the tablet is also provided.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: October 11, 2016
    Assignee: SUN PHARMACEUTICAL INDUSTRIES LIMITED
    Inventors: Ravish Kumar Sharma, Pulak Kumar Metia, Ravinder Singh, Rajesh Srikrishan Shear, Anuj Kumar Fanda, Satish Kumar Jain, Romi Barat Singh, Swarna Pappu, Prabhakar Konatham, Pruthvipathy Katikaneni, Dileep Jami
  • Compositions and methods for treating schizophrenia
    Patent number: 9458130
    Abstract: The disclosure provides a novel polymorph of Compound (I): 2-((1-(2-(4-Fluorophenyl)-2-oxoethyl)piperidin-4-yl)methyl)isoindolin-1-one monohydrochloride dihydrate, i.e., Form (A) of Compound (I).HCl.2H2O. Pharmaceutical compositions comprising Form (A) of Compound (I).HCl.2H2O and related methods of treatment are also disclosed.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: October 4, 2016
    Assignee: Minerva Neurosciences, Inc.
    Inventor: Remy Luthringer
  • Aqueous composition comprising dicamba and a drift control agent
    Patent number: 9451767
    Abstract: The present invention relates to an aqueous composition comprising dicamba and a drift control agent; to a method for preparing a tank mix, which comprises the step of contacting water and said composition, and optionally further pesticides; to a method of controlling phytopathogenic fungi and/or undesired vegetation and/or unde-sired insect or mite attack and/or for regulating the growth of plants, wherein the composition is allowed to act on the respective pests, their environment or the plants to be protected from the respective pest, on the soil and/or on undesired plants and/or the crop plants and/or their environment; and finally to a use of the alkoxylate of the formula (I) as defined below for reducing the wind drift of an aqueous composition comprising a pesticide.
    Type: Grant
    Filed: June 11, 2013
    Date of Patent: September 27, 2016
    Assignee: BASF SE
    Inventors: Marc Nolte, Wen Xu, Steven Bowe, Maarten Staal, Terrance M. Cannan
  • Methods for the treatment of parkinson's disease psychosis using pimavanserin
    Patent number: 9446037
    Abstract: Methods for the treatment of Parkinson's disease psychosis which comprise the administration of pimavanserin.
    Type: Grant
    Filed: November 26, 2013
    Date of Patent: September 20, 2016
    Assignee: ACADIA Pharmaceuticals Inc.
    Inventors: Roger Mills, Hilde Williams
  • Crystalline pharmaceutical and methods of preparation and use thereof
    Patent number: 9447077
    Abstract: Novel crystalline polymorphic forms, Forms A, B, C, D, and E of a compound of Formula I, which has been found to be a potent inhibitor of LFA-1, are disclosed. Methods of preparation and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed in this invention.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: September 20, 2016
    Assignee: SARcode Bioscience Inc.
    Inventors: John Burnier, Thomas Gadek, Frederic Naud
  • Pharmaceutical composition
    Patent number: 9447065
    Abstract: The present invention provides a pharmaceutical composition which prevents from decreasing the blood exposure of the third generation coxib-drugs, a process for preparing the said pharmaceutical composition and its use. It has been founded in this invention that adding a basic amine or a basic amino acid, or a cyclodextrin to the third generation coxib-drug can afford a pharmaceutical composition which can prevent from decreasing the blood exposure, AUC and bioavailability. The pharmaceutical composition of the present invention has also good stability, which is useful for drugs. Namely, the technological thought that adding a basic amine or a basic amino acid, or a cyclodextrin to the third generation coxib-drug can prevent from decreasing the blood exposure, AUC and bioavailability has been established in this invention.
    Type: Grant
    Filed: October 18, 2012
    Date of Patent: September 20, 2016
    Assignee: RaQualia Pharma Inc.
    Inventors: Yasuhiro Iwata, Kaoru Shimada, Yoshiyuki Okumura, Mayumi Kashino, Hiromitsu Yoshida
  • Pharmaceutical formulations comprising high purity cangrelor and methods for preparing and using the same
    Patent number: 9439921
    Abstract: The present invention relates to high purity cangrelor, pharmaceutical formulations comprising high purity cangrelor as an active ingredient, methods for preparing such compounds and formulations, and methods for using the pharmaceutical formulations in the inhibition of platelet activation and aggregation.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: September 13, 2016
    Assignee: THE MEDICINES COMPANY
    Inventors: Panna Dutta, Adel Rafai Far, Min Ding, Rajeshwar Motheram
  • Nanoparticles of a metal and a biguanide
    Patent number: 9433591
    Abstract: A process for making nanoparticles of biocompatible materials is described, wherein an aqueous reaction mixture comprising a metal ion, a biguanide, an oxidant, and water; optionally further comprising an alpha-amino acid or a nucleobase; is provided along with temperature conditions to directly form within the reaction mixture, a stable dispersion of metal-containing nanoparticles. Biocompatible nanoparticles comprised of cerium and a biguanide, and optionally containing an alpha-amino acid or a nucleobase, are also described. The use of metal oxide nanoparticles comprising a biguanide as a nanoparticle core/corona in the preparation of nanoscale ionic (liquid) material compositions is disclosed.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: September 6, 2016
    Assignee: CERION, LLC
    Inventors: Kenneth Joseph Reed, Ashley Renée Versaggi, Wendi Ann Costanzo
  • Injectable pharmaceutical compositions comprising adrenaline and citric acid
    Patent number: 9433589
    Abstract: The present invention relates to injectable pharmaceutical compositions showing improved storage stability said compositions comprising adrenaline and citric acid showing improved storage stability.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: September 6, 2016
    Assignee: Rigshospitalet
    Inventors: Philip Hansen, Pär Johansson, Jens Kindtler
  • Foaming alcohol compositions with selected dimethicone surfactants
    Patent number: 9414586
    Abstract: Foaming alcohol compositions with selected dimethicone surfactants are disclosed. The dimethicone surfactants are PEG-8 to PEG-12 linear dimethicone surfactants and in particular PEG-10 linear dimethicone surfactant. The compositions are useful as antimicrobial products and in particular handcare or skincare products.
    Type: Grant
    Filed: September 25, 2014
    Date of Patent: August 16, 2016
    Assignee: Ecolab USA Inc.
    Inventors: Joseph R. Wegner, Cheryl A. Littau
  • Piroxicam transdermal composition to treat plantar fasciitis
    Patent number: 9415054
    Abstract: A transdermal composition and method to be used as a treatment for plantar fasciitis is provided. Transdermal composition may include a combination of about 2% w/w to about 5% w/w of piroxicam and about 95% w/w to about 98% w/w of a natural permeation enhancement (NPE) composition. The NPE composition may increase the skin permeability, enhancing the transdermal delivery flux of piroxicam via a single transdermal application, thus, reducing the time of treatment. Transdermal composition may be applied upon an area of treatment, which may include myofascial trigger points linked to pain caused by plantar fasciitis, thus treating this condition more effectively. Moreover, employing a long acting NSAID such as piroxicam, in combination with the NPE composition, may act as a faster and effective treatment for an inflammatory process compared to typical treatments.
    Type: Grant
    Filed: June 13, 2013
    Date of Patent: August 16, 2016
    Assignee: Professional Compounding Centers of America (PCCA)
    Inventor: Andrew B. Glasnapp