Patents Examined by Rex R Holmes
-
Patent number: 12042250Abstract: In alternative embodiments, provided are compositions, medical devices or products of manufacture, systems, diagnostic tools, and methods, including computer implemented methods, for predicting the response of patients with dyssynchronous heart failure (DHF) to cardiac resynchronization therapy (CRT), comprising: measuring or determining the fraction of the LV/septum performing negative work (MNW); and measuring or determining the coefficient of variation of external work density (COVW), wherein the MNW fraction performing negative work and coefficient of variation COVW (sd/mean) correlated strongly with observed reduction in end-systolic volume after CRT.Type: GrantFiled: November 14, 2014Date of Patent: July 23, 2024Assignee: The Regents of the University of CaliforniaInventors: Andrew D. McCulloch, Adarsh Krishnamurthy, Christopher Villongco, David Krummen, Sanjiv Narayan, Jeffrey Omens, Roy Kerckhoffs
-
Patent number: 12035206Abstract: A wearable electronic fabric comprises a woven fabric formed from a plurality of interlaced threads. The plurality of interlaced threads comprise a plurality of warp threads interlaced with a plurality of weft threads. The woven fabric has a top face and a bottom face. A plurality of conductive threads is included among the plurality of interlaced threads at predetermined intervals and interlacing angles to provide a pattern of connection locations. The connection locations are located at regular intervals on at least one of the top face and the bottom face of the woven fabric.Type: GrantFiled: January 8, 2020Date of Patent: July 9, 2024Inventors: John J Daniels, Joseph A. Curcio
-
Patent number: 12023480Abstract: In an implanted medical device system, an internal controller, external power transmitter and methods for monitoring and dynamically managing power in an implanted medical device system are disclosed. According to one aspect, an internal controller is configured to provide power to a motor of an implanted medical device, the power being drawn from at least one of an internal battery and an internal coil, the at least one of the internal battery and the internal coil providing a supplied voltage. The internal controller includes processing circuitry configured to switch to one of the internal battery, the internal coil and a combination of the internal battery and the internal coil, based on a comparison of the supplied voltage to a threshold.Type: GrantFiled: December 22, 2020Date of Patent: July 2, 2024Assignee: Medtronic, Inc.Inventors: Joel B. Artmann, Jacob A. Roe, Jonathan P. Roberts, David J. Peichel
-
Patent number: 12023479Abstract: A tubular pulsatile ventricular assist device (PVAD) system for providing forward flow of blood in a pulsatile, peristaltic, and non-hemolytic manner to help reduce the amount of blood clotting associated with current ventricular devices on the market. The system can encircle a portion of a blood vessel, and the system can sequentially apply a pressure through each port in a particular pre-determined patter so as to selectively occlude the lumen, thereby creating a pulsatile, peristaltic movement along a length of system. Said movement causes blood to flow through the portion of the blood vessel.Type: GrantFiled: June 12, 2019Date of Patent: July 2, 2024Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONAInventors: Zain I. Khalpey, Zachary David Frankman, Marvin J. Slepian
-
Patent number: 12023497Abstract: An improved stimulus coil for use in wireless stimulation of biological tissue (e.g., nerves, muscle tissue, etc.) and, in one exemplary implementation, to glaucoma therapy based on the wireless administration of energy to the eye of a mammalian subject (e.g., human, rodent, etc.) to reduce an elevated intraocular pressure (IOP) involving the use of an improved stimulus coil. The improved stimulus coil may be implanted in the eye of a mammalian subject or positioned on the exterior of the eye, such as (by way of example) by being disposed within a contact lens worn by a mammalian subject.Type: GrantFiled: December 6, 2021Date of Patent: July 2, 2024Assignee: Purdue Research FoundationInventors: Pedro P. Irazoqui, Gabriel Simon, Gabriel O. Albors, Jack Williams, Quan Yuan
-
Patent number: 12023504Abstract: Methods, devices and program products are provided for managing a pacing therapy using an implantable medical device (IMD). The methods, devices and program products sense cardiac activity (CA) signals at electrodes located proximate to multiple left ventricular (LV) sites and a right ventricular (RV) site of the heart and utilizing one or more processors to measure activation times between the multiple LV sites and the RV site based on the CA signals. The processors program an order of activation for the multiple LV sites based on the activation times and identify an RV activation time and a septum activation time based on the CA signals. The processors calculate a septum to RV activation time (SRAT) based on the RV and septum activation times and program an AVSRAT delay based on the SRAT.Type: GrantFiled: June 28, 2022Date of Patent: July 2, 2024Assignee: Pacesetter, Inc.Inventors: David Muller, Raffaele Corbisiero
-
Patent number: 12016618Abstract: A tissue resection device comprises inner and outer coaxial sleeves. The outer sleeve has a cutting window formed therein, and the inner sleeve has a distal cutting end that can be reciprocated past the cutting window. The sleeves comprise electrodes to provide electrosurgical cutting, and an edge portion of the window includes a dielectric material.Type: GrantFiled: January 28, 2022Date of Patent: June 25, 2024Assignee: MINERVA SURGICAL, INC.Inventors: Aaron Germain, Kyle Klein, Michael D. Walker, Benedek Orczy-Timko
-
Patent number: 12017067Abstract: A device for electrifying perineal tissue, including: a housing shaped and sized to be attached to a perineum surface of a subject between a posterior aspect of the scrotum and the anus of the subject; at least two electrodes in the housing configured to deliver an electric field to a perineal tissue, wherein the electrodes are positioned entirely between the scrotum and the anus; a pulse generator in the housing electrically connected to the at least two electrodes, wherein the pulse generator generates an electric field with parameter values selected to affect at least one selected target within the perineal tissue; a control circuitry in the housing electrically connected to the pulse generator; a readable and writable memory circuit in the housing electrically connected to the control circuitry, wherein the readable and writable memory stores indications of at least one electric field parameter and/or at least one treatment program.Type: GrantFiled: December 27, 2018Date of Patent: June 25, 2024Assignee: Virility Medical Ltd.Inventors: Tal Gollan, Gideon Meiri, Oded Shlomo Kraft-Oz
-
Patent number: 12011584Abstract: Disclosed are methods, devices, and systems for treatment of an abnormal wound healing response. The methods, devices, and systems can be used to treat solid ulcerated tissue, such as diabetic foot ulcers (DFUs), arthritic tissue, muscle soreness, joint pain, varicose veins, obesity, and peripheral artery disease. Additionally, the methods, devices, and systems can promote the healing of xenograft, allograft, autograft, or engineered tissue following reconstruction surgery. The methods, devices, and systems include the ability to determine an optimal set of pulse parameters that are specific to wound healing. In embodiments, the methods, devices, and systems include components for guiding the user on electrode placement based on anatomical or electrical measurements, delivering a custom series of electric pulses, applying heat, and using feedback from physiologic measurements to control the device.Type: GrantFiled: May 19, 2021Date of Patent: June 18, 2024Assignee: Adlore, Inc.Inventors: Daryl Lawson, Christopher Brian Arena
-
Patent number: 12005246Abstract: A system configured to be at least partially implanted along an aorta includes an inelastic, static member and a pinching member. The pinching member is configured to receive an activation signal at an activation rate and in response to the activation signal, repeatedly compress the aorta at the second location at the activation rate to pump fluid within the aorta in a desired pumping direction. The system is configured to selectively control wave reflections in order to achieve both improved wave dynamics to reduce cardiac load and increased (or at least non-diminished) blood flow to targeted organs within the cardiovascular system.Type: GrantFiled: January 6, 2021Date of Patent: June 11, 2024Assignee: California Institute of TechnologyInventors: Niema M. Pahlevan, Morteza Gharib, Marie Csete
-
Patent number: 12005251Abstract: The present invention provides materials and methods for using electrical stimulation to treat a mammal having a proteinopathy (e.g., neurodegenerative diseases) or at risk of developing a proteinopathy are provided. For example, the present invention provides materials and methods for modulating glymphatic clearance (e.g., enhancing glymphatic clearance) of pathogenic proteins.Type: GrantFiled: August 10, 2022Date of Patent: June 11, 2024Assignees: Wisconsin Alumni Research Foundation, Mayo Foundation for Medical Education and ResearchInventors: Justin Williams, Kip Ludwig, Erika Ross
-
Patent number: 11998749Abstract: An implantable medical device which performs the following steps during operation: a) performing a detection of whether the implantable medical device is in an implanted state; b) if it is detected that the implantable medical device is in an implanted state, activating a first diagnostic or therapeutic function of the implantable medical device, and subsequently activating a second diagnostic or therapeutic function of the implantable medical device, wherein the second diagnostic or therapeutic function is activated only after the fulfillment of at least one activation criterion selected from the group consisting of an elapse of a first time period from the activation of the first diagnostic or therapeutic function, an elapse of a second time period from the detection that the implantable medical device is in an implanted state, and a passing of a function test.Type: GrantFiled: September 24, 2020Date of Patent: June 4, 2024Assignee: BIOTRONIK SE & Co. KGInventors: Thomas Doerr, Sergey Ershov, Torsten Radtke, Martin Roemer
-
Patent number: 11998340Abstract: The system and method provide for electrocardiogram analysis and optimization of patient-customized cardiopulmonary resuscitation and therapy delivery. An external medical device includes a housing and a processor within the housing. The processor can be configured to receive an input signal for a patient receiving chest compressions and to select at least one filter mechanism and to apply the filter mechanism to the signal to at least substantially remove chest compression artifacts from the signal. A real time dynamic analysis of a cardiac rhythm is applied to adjust and integrate CPR prompting of a medical device. Real-time cardiac rhythm quality is facilitated using a rhythm assessment meter.Type: GrantFiled: October 1, 2020Date of Patent: June 4, 2024Assignee: Physio-Control, Inc.Inventors: Joseph L. Sullivan, Ronald E. Stickney, Robert G. Walker, Daniel W. Piraino, Isabelle Banville, Fred W. Chapman
-
Patent number: 11998347Abstract: A method and system for detecting sleep apnea involves determining the sleep stage, and detecting an apnea event based on a physiological sensor signal using selection of a detection algorithm which is dependent on the determined sleep stage. By taking account of the sleep stage when performing an automated apnea detection process, the accuracy of the apnea detection is improved.Type: GrantFiled: March 6, 2019Date of Patent: June 4, 2024Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Koen Theo Johan De Groot, Pedro Miguel Fonseca, Jenny Margarito
-
Patent number: 11998741Abstract: A pulse current generation circuit (100) for neural stimulation includes an analogue signal receiving device (101) for receiving an analogue signal; an analogue-to-digital converter (102) for converting the analogue signal into a digital control signal; a current signal controller (103) for producing, according to the digital control signal, pulse current parameters for generating bidirectional pulse current signals; and a current generator (104) for generating, according to the pulse current parameters, bidirectional pulse current signals for neural stimulation, and the current generator can generate pulse currents of different precisions according to the pulse current parameters. In addition, the present invention further relates to a charge compensation circuit, a charge compensation method, and an implantable electrical retina stimulator using the pulse current generation circuit or the charge compensation circuit.Type: GrantFiled: August 17, 2021Date of Patent: June 4, 2024Assignee: SHENZHEN SIBIONICS TECHNOLOGY CO., LTD.Inventors: Bin Xia, Yu Zhao, Yu Lin, Zhi Chen
-
Patent number: 11998344Abstract: An implantable medical device is configured to determine a first atrial arrhythmia score from ventricular events sensed by a sensing circuit of an implantable medical device and determine a second atrial arrhythmia score from an intraventricular signal comprising atrial mechanical event signals attendant to atrial systole and produced by a sensor of the implantable medical device. An atrial arrhythmia is detected based on the first atrial arrhythmia score and the second atrial arrhythmia score.Type: GrantFiled: September 14, 2021Date of Patent: June 4, 2024Assignee: Medtronic, Inc.Inventors: Shantanu Sarkar, Wade M. Demmer, Todd J. Sheldon, Vincent E. Splett
-
Patent number: 11992676Abstract: A device for the active fixation of an implantable medical lead includes a housing, a tine assembly, and rotatable shaft. The housing includes a proximal end for connecting to the lead and a distal end opposite the proximal end. The housing defines a housing lumen having a longitudinal axis extending between the proximal end and the distal end. The tine assembly is disposed within the housing lumen. The tine assembly includes at least one tine configured to self-bias from a linear configuration within the housing to a curved configuration outside of the housing. The rotatable shaft extends through the housing lumen. The shaft is configured to engage the tine assembly such that rotation of the shaft transitions the at least one tine between the linear configuration and the curved configuration.Type: GrantFiled: June 29, 2022Date of Patent: May 28, 2024Assignee: Cardiac Pacemakers, Inc.Inventors: Arthur J. Foster, Benjamin J. Haasl, Linda L. Evert, G. Shantanu Reddy
-
Patent number: 11992311Abstract: Systems, methods, apparatuses, and medical devices for harmonizing data from a plurality of non-invasive sensors are described. A physiological parameter can be determined by harmonizing data between two or more different types of non-invasive physiological sensors interrogating the same or proximate measurement sites. Data from one or more first non-invasive sensors can be utilized to identify one or more variables that are useful in one or more calculations associated with data from one or more second non-invasive sensors. Data from one or more first non-invasive sensors can be utilized to calibrate one or more second non-invasive sensors. Non-invasive sensors can include, but are not limited to, an optical coherence tomography (OCT) sensor, a bio-impedance sensor, a tissue dielectric constant sensor, a plethysmograph sensor, or a Raman spectrometer.Type: GrantFiled: May 19, 2021Date of Patent: May 28, 2024Assignee: Willow Laboratories, Inc.Inventors: Jesse Chen, Sean Merritt, Cristiano Dalvi, Ferdyan Lesmana, Hung The Vo, Kevin Hughes Pauley, Jeroen Poeze, Ruiqi Long, Stephen L Monfre
-
Patent number: 11990233Abstract: Systems and methods are disclosed that facilitate providing guidance to a user during performance of a program or routine using a personalized avatar. In an aspect, a system includes a reception component configured to receive biochemical information about a physiological state or condition of a user, including information identifying a presence or a status of one or more biomarkers. The system further includes an analysis component configured to determine or infer one or more characteristics of the physiological state or condition of the user based on the information identifying the presence or the status of the one or more biomarkers, and a visualization component configured to adapt an appearance of an avatar presented to the user based on the one or more characteristics to reflect the one or more characteristics.Type: GrantFiled: July 29, 2021Date of Patent: May 21, 2024Assignee: KC HOLDINGS IInventor: Robert Louis Kaleal, III
-
Patent number: 11975202Abstract: Disclosed are methods to treat patients with AFib by monitoring their heart rhythm to determine the presence and/or the number of episodes of long duration AFib, and optionally the extent of AFib burden. Patients who meet threshold requirements are qualified for the treatment of AFib with a dosage of budiodarone. Patient monitoring is continued in order confirm that the patient is and remains responsive to budiodarone therapy including dose adjusting the patient to achieve such therapy. Subsequently, monitoring is continued to confirm that the patient remains responsive. These methods allow for treatment of the AFib and, correspondingly, reduce or delay the risk of stroke and/or congestive heart failure in the treated patient.Type: GrantFiled: July 17, 2023Date of Patent: May 7, 2024Assignee: Xyra, LLCInventors: Pascal Druzgala, Peter Gerard Milner