Patents Examined by Richard Moerschell
  • Patent number: 11067568
    Abstract: Described are embodiments of an invention for detecting target antigens in a biological sample using a sample assembly. Detection may be accomplished by performing a method comprising: sweeping a head module over the sample assembly, wherein said head module includes at least one magneto-resistive read sensor configured to detect target antigens via nanoparticles within the sample assembly; and detecting at least one particular antigen among the target antigens. Preferably, detecting the target antigens via the nanoparticles is based at least in part on detecting unique magnetic properties of particular nanoparticles specifically associated with different types of the target antigens. Detection using a magnetic read/write head in the sample assembly facilitates automation of sample detection with high speed and fidelity. Corresponding systems are also disclosed.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: July 20, 2021
    Assignee: International Business Machines Corporation
    Inventors: Dylan J. Boday, Stephen L. Schwartz, Anna W. Topol, Sandra L. Waters, Daniel J. Winarski
  • Patent number: 11047859
    Abstract: The invention relates to a method for normalization of a label-free system for calibration-free concentration analysis. The method comprises (1) providing a solution containing a control macromolecular particle of a known concentration at a pH lower than the pI of the macromolecular particle and a low ionic strength; (2) contacting the solution with a negatively charged optical sensor surface at a first flow rate to allow electrostatic binding of the macromolecular particle to the surface and obtaining a first sensorgram; (3) contacting the solution with the optical sensor surface at a second flow rate to allow electrostatic binding of the macromolecular particle to the surface and obtaining a second sensorgram; and (4) fitting the sensorgrams to a binding equation to determine a measured concentration of the control; wherein the optical sensor surface is not immobilized with a ligand for the control and the contacting steps are performed under mass transport limitations.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: June 29, 2021
    Assignee: CYTIVA SWEDEN AB
    Inventor: Olof Karlsson
  • Patent number: 10989651
    Abstract: A molecular sensor that utilises dichroism can be used to identify the presence of specific molecules in a substance. The molecular sensor includes a sensor element comprising (i) a scaffold moiety and (ii) one or more receptor molecules for the target molecule attached to the scaffold moiety to form a scaffold/receptor complex, wherein the scaffold/receptor complex is modified to incorporate a chromophore and the modified scaffold/receptor complex has a high aspect ratio.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: April 27, 2021
    Assignee: The University of Birmingham
    Inventors: Timothy Dafforn, Matthew Hicks
  • Patent number: 10883923
    Abstract: This invention relates a biomarker detection system, for detecting cancer biomarkers using optical heterodyning. The system includes a tunable laser configured to produce a plurality of laser beams of at least two frequencies, a pair of optical fibers coated with gold nanoparticles and functionalized with an antibody is configured to undergo a change of fiber surface of each optical fiber by adsorbing molecules of an analyte on a surface of the antibody, modify a reflection of the plurality of laser beams inside a fiber core of the each optical fiber when the each optical fiber is bent, and create an audible beat frequency; and perform spectral analysis. A frequency spectrum analyzer configured to provide a composition information of the adsorbed molecules based on a spectral analysis of the beat frequency.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: January 5, 2021
    Assignee: M.I.S. Electronics Inc.
    Inventor: Mohammad E Khosroshahi
  • Patent number: 10871436
    Abstract: The invention relates to a new type of element encoded particles suitable for the attachment of bio molecules to enable massively multiplex bio-analytical methods, and to calibrate and tune the elemental flow cytometer mass spectrometer (FC-MS).
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: December 22, 2020
    Assignee: Fluidigm Canada Inc.
    Inventors: Mitchell A. Winnik, Cedric Van-Caeyzeele, Vladimir I. Baranov
  • Patent number: 10732191
    Abstract: An automatic analysis device, an analysis method, and an analysis system are provided. The automatic analysis device comprises an incubation unit.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: August 4, 2020
    Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Zhen Zhang, Peng Zhou, Jun Wang, Chuan-Fen Xie
  • Patent number: 10695036
    Abstract: Provided herein is a magnetic apparatus for collecting superparamagnetic particles from a subject. The superparamagnetic particles are previously injected into the subject and have ligands bound thereto that are specific for one or more non-cell biomarkers. In one embodiment, the superparamagnetic particles are injected into and retrieved from a cavity such as a joint cavity. These compositions and methods allow for the sequestration and removal of inflammatory mediators, as both a diagnostic of the local immune response and a therapeutic that can reduce inflammation in the local disease environment.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: June 30, 2020
    Inventors: Kyle Douglas Allen, Jon Paul Dobson, Elena Georgina Yarmola, Zachary Kaufman, David P. Arnold
  • Patent number: 10663466
    Abstract: A portable rapid diagnostic test reader system includes a mobile phone having a camera and one or more processors contained within the mobile phone and a modular housing configured to mount to the mobile phone. The modular housing including a receptacle configured to receive a sample tray holding a rapid diagnostic test. At least one illumination source is disposed in the modular housing and located on one side of the rapid diagnostic test. An optical demagnifier is disposed in the modular housing interposed between the rapid diagnostic test and the mobile phone camera.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: May 26, 2020
    Inventors: Aydogan Ozcan, Onur Mudanyali, Stoyan Dimitrov, Uzair Sikora, Swati Padmanabhan, Isa Navrus
  • Patent number: 10658072
    Abstract: The present invention relates to a method of evaluation of molecular binding interactions at a sensing surface, and more particularly to a method for evaluation of screening data obtained from an interaction between an analyte in a fluid sample and a ligand immobilized on a sensor surface of a biosensor that is independent of interaction models. Preferably the biosensor is a SPR biosensor. The invention also relates to a biosensor system arranged to perform the method and a computer program arranged to control the operation of the biosensor system.
    Type: Grant
    Filed: February 9, 2017
    Date of Patent: May 19, 2020
    Assignee: GE Healthcare Bio-Sciences AB
    Inventor: Robert Karlsson
  • Patent number: 10627400
    Abstract: Successful application of an engineered protein as therapeutics or in other industries would require the protein to have good expression level, good biophysical properties and often desired affinity to its target. The present invention provides s method of screening large numbers of protein candidates (PCs) in all three aspects simultaneously. PCs are fused to a protein anchor, which is captured by the target/antigen. The captured PCs are evaluated for their expression levels, biophysical properties and affinities using conventional methods.
    Type: Grant
    Filed: October 5, 2016
    Date of Patent: April 21, 2020
    Assignee: National Research Council of Canada
    Inventors: Jianbing Zhang, Tomoko Hirama
  • Patent number: 10539561
    Abstract: There is disclosed a process and an array for assaying for binding of target molecules to capture molecules on micro array devices, wherein the microarray devices contain electrodes. Specifically, there is disclosed a binding (including nucleotide hybridization) process to detect binding on a microarray wherein the microarray contains electronically addressable electrode devices. There is further disclosed an enzymatically catalyzed oxidation/reduction reaction to take place within a “virtual flask” region of a micro array wherein the reaction is detected by current changes detected on the addressable electrode.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: January 21, 2020
    Assignee: CustomArray, Inc.
    Inventor: Kilian Dill
  • Patent number: 10539580
    Abstract: Compositions and methods for detecting the presence and/or amount of one or more analytes, including analytes such as drugs of abuse, are provided. The compositions include two or more analytes associated with a solid phase, e.g., a particle or a multiwell plate. The compositions and methods also allow the simultaneous, tandem, or serial determination of the presence and/or amount of two or more analytes of interest in a sample.
    Type: Grant
    Filed: April 29, 2009
    Date of Patent: January 21, 2020
    Assignee: Psychemedics Corporation
    Inventors: Virginia Hill, Mohammad Atefi, Michael I. Schaffer
  • Patent number: 10481164
    Abstract: The invention provides a method for controlling contaminants in biopharmaceutical purification processes by using light scattering and UV absorbance to establish a determinant. The invention makes use of multi-angle light scattering (MALS) and UV as a continuous monitoring system to provide information about the elution peak fractions in real-time instead of conventional pooling methods that rely on a predetermined percent UV peak max value to initiate the pooling process; regardless of product quality.
    Type: Grant
    Filed: March 26, 2013
    Date of Patent: November 19, 2019
    Assignee: AMGEN INC.
    Inventors: Arthur C. Hewig, III, Duke H. Phan, Yinges Yigzaw, Robert Bailey
  • Patent number: 10378043
    Abstract: Devices and methods are provided for electrically lysing cells and releasing macromolecules from the cells. A microfluidic device is provided that includes a planar channel having a thickness on a submillimeter scale, and including electrodes on its upper and lower inner surfaces. After filling the channel with a liquid, such that the channel contains cells within the liquid, a series of voltage pulses of alternating polarity are applied between the channel electrodes, where the amplitude of the voltage pulses and a pulsewidth of the voltage pulses are effective for causing irreversible electroporation of the cells. The channel is configured to possess thermal properties such that the application of the voltage produces a rapid temperature rise as a result of Joule heating for releasing the macromolecules from the electroplated cells. The channel may also include an internal filter for capturing and concentrating the cells prior to electrical processing.
    Type: Grant
    Filed: January 9, 2017
    Date of Patent: August 13, 2019
    Inventors: Samad Talebpour, Aye Aye Khine, Robert Maaskant, Tino Alavie
  • Patent number: 10317398
    Abstract: A sample assembly includes an outer layer with at least one sample trench. The sample trench includes a first set of antibodies that are bonded on a first surface of a base layer. Target antigens are bonded with the first set of antibodies, and a second set of antibodies are bonded to the target antigens. Further, the sample trench includes nanoparticles that are bonded to the second set of antibodies.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: June 11, 2019
    Assignee: International Business Machines Corporation
    Inventors: Dylan J. Boday, Stephen L. Schwartz, Anna W. Topol, Sandra L. Waters, Daniel J. Winarski
  • Patent number: 10317403
    Abstract: The present invention provides an immunoassay analyzer capable of discriminating between normal coloring due to a specific immunoreaction and abnormal coloring due to a cause other than the specific immunoreaction in a measurement region of a sample analysis tool. An immunoassay analyzer 1 of the present invention includes an optical detection unit 4 and a determination unit 5. The optical detection unit 4 includes an optical signal measurement unit for measuring an optical signal at each of two or more different wavelengths including a main wavelength for detecting color change due to the specific immunoreaction and a sub-wavelength(s) other than the main wavelength. The determination unit 5 includes a discrimination unit for comparing the respective optical signals at the two or more different wavelengths and discriminating between the color change due to the specific immunoreaction and color change due to a cause other than the specific immunoreaction based on a comparison criterion determined previously.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: June 11, 2019
    Assignee: ARKRAY, Inc.
    Inventor: Kyouichi Ohshiro
  • Patent number: 10209252
    Abstract: A substrate comprising a microporous microstructure, an interlayer over at least a portion of the microstructure and a functional layer attached to the interlayer, the functional layer having functional sites with a density of at least 50 nanomoles/cm2.
    Type: Grant
    Filed: March 1, 2011
    Date of Patent: February 19, 2019
    Assignee: W.L. Gore & Associates, Inc.
    Inventors: Anit Dutta, Heidi Flannery, William P. Mortimer, Jr.
  • Patent number: 10191054
    Abstract: A device for full blood count includes first channel and second channels separated from each other. The device further includes a first inlet configured to provide a whole blood sample to the first and second channels, a second inlet configured to provide a lysis agent for white blood cell count in to the first channel, a third inlet configured to provide a quench solution to the first channel, and a fourth inlet configured to provide a lysis agent for hemoglobin measurement to the second channel.
    Type: Grant
    Filed: January 26, 2010
    Date of Patent: January 29, 2019
    Inventors: David M. Pettigrew, James D. Gwyer
  • Patent number: 10190986
    Abstract: A method for analyzing the results of a ligand-receptor binding assay comprising the steps of: (a) providing the results of a ligand-receptor binding assay; and (b) qualifying the results of a ligand-receptor binding assay. More particularly, the ligand-receptor binding assay involves the steps of combining appropriate reagents in which receptors attached to a solid support, a sample suspected of containing a ligand, and a conjugate comprising a label form a complex in which the label is present at a concentration that is directly proportional to the amount of ligand present in the sample. Alternatively, the ligand-receptor binding assay involves the steps of combining appropriate reagents to perform a ligand-receptor binding assay in which receptors attached to a solid support, a sample suspected of containing a ligand, and a conjugate comprising a label form a complex in which the label is present at a concentration that is inversely proportional to the amount of analyte present in the sample.
    Type: Grant
    Filed: June 6, 2011
    Date of Patent: January 29, 2019
    Assignee: Abbott Laboratories
    Inventors: Qiaoqiao Ruan, Sylvia C. Saldana, Joseph P. Skinner, Sergey Y. Tetin
  • Patent number: 10173216
    Abstract: A particle capture system that can be used in the context of a lab-on-a-chip platform for particle- and cell-based assays is described. The system comprises a capture chamber comprising a plurality of capture sites, the capture sites defining a capture area configured to receive individual particles travelling within the capture chamber. By rotating the chamber, the individual particles are biased towards the capture sites where they may be captured.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: January 8, 2019
    Inventors: Jens Ducree, Robert Burger