Abstract:
The invention relates to novel compounds derived from pentaerythrite compounds of formula (XII) and (XVI), which can be used as pharmaceutically active substances, specially in the treatment of cardiac and circulatory diseases.
Abstract: Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of picornaviral 3C proteases. These compounds, as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses. Several novel methods and intermediates can be used to prepare the novel picornaviral 3C protease inhibitors of the present invention.
Type:
Grant
Filed:
October 13, 2000
Date of Patent:
March 26, 2002
Assignee:
Agouron Pharmaceuticals, Inc.
Inventors:
Stephen E. Webber, Peter S. Dragovich, Thomas J. Prins, Siegfried H. Reich, Thomas L. Little, Jr., Ethel S. Littlefield, Joseph T. Marakovits, Robert E. Babine, Ted M. Bleckman
Abstract: A granular detergent composition containing a secondary (2,3) alkyl sulfate surfactant and a bleach/bleach activator system which has improved cleaning performance is provided. The detergent composition comprises: (a) from about 1% to about 40% of a secondary (2,3) alkyl sulfate surfactant; (b) from about 0.005% to about 5% of an enzyme; (c) from about 0.5% to about 20% of a peroxygen bleaching agent; and (d) from about 0.5% to about 20% of a bleach activator. The peroxygen bleaching compound and the bleach activator are in a molar ratio from about 1:1 to about 9:1. The detergent composition is stable, exhibits superior cleaning and contains a more biodegradable surfactant.
Type:
Grant
Filed:
November 18, 1997
Date of Patent:
March 26, 2002
Assignee:
The Procter & Gamble Company
Inventors:
Todd Edmund Wichmann, Edward Eugene Getty
Abstract: The present invention provides a novel compound represented by the general formula I;
wherein R is H or COR3;
R1 is H, R2, phenyl, or COR3, wherein R2 is C1-C5 lower alkyl and R3 is R2 or phenyl;
Z is CH2 or O;
Y is OH, OCOR3 or ═O;
x is 0 or 1; and
X is C1-C5 n-alkyl, C3-C7 cycloalkyl, phenyl, furanyl, thienyl or substituted derivatives thereof, wherein the substituents maybe selected from the group consisting of C1-C5 alkyl, halogen, CF3, CN, NO2, NR42, CO2R4 and OR4 wherein
R4 is hydrogen or C1-C5 alkyl and dotted lines represent the presence or absence of a double bond and wavy lines represent a cis or trans bond. These novel compounds are especially useful for treating elevated intraocular pressure (ocular hypertension) and glaucoma.
Type:
Grant
Filed:
July 26, 2001
Date of Patent:
March 19, 2002
Assignee:
Allergan Sales, Inc.
Inventors:
Robert M. Burk, Mark Holoboski, Mari F. Posner
Abstract: The present invention relates to carboxylic acid derivatives of the formula I
the substituents having the meanings explained in the description, preparation and use as endothelin receptor antagonists.
Type:
Grant
Filed:
April 27, 2000
Date of Patent:
March 19, 2002
Assignee:
Abbott Laboratories
Inventors:
Wilhelm Amberg, Rolf Jansen, Heinz Hillen, Stefan Hergenröder, Manfred Raschack, Liliane Unger
Abstract: Novel compounds and pharmaceutical compositions useful as EGFR tyrosine kinase inhibitors. Methods of the invention include administration of the EGFR TK inhibitors to treat diseases characterized by enhanced expression of EGF, including cancers, particularly breast cancer. Additionally, a homology model representing the structure of EGFR kinase domain is provided, which model is useful for the rationally design and screening of compounds predicted to bind favorably to EGFR and to inhibit EGFR TK.
Type:
Grant
Filed:
March 19, 1999
Date of Patent:
March 12, 2002
Assignee:
Parker Hughes Institute
Inventors:
Fatih M. Uckun, Yaguo Zheng, Sutapa Ghosh
Abstract: This invention provides a substituted isoxazolylthiophene compound represented by the formula
wherein R1 and R2 individually represent an alkyl group of 1-5 carbon atoms, R3 represents a cyano group or a group CONR5R6 (in which R5 and R6 individually represent a hydrogen atom or an alkyl group of 1-10 carbon atoms), R4 represents an alkyl group of 1-5 carbon atoms or a phenyl group, and n is an integer of 0-2, or a salt thereof.
The compounds of the invention are useful for the treatment or prevention of various bone diseases or nerve diseases, because they specifically enhance the action of the cell differentiation induction factors found in a living body.
Abstract: The present invention comprises small molecular weight, non-peptidic inhibitors of formula I and II of Protein Tyrosine Phosphatase 1 (PTP1) which are useful for the treatment and/or prevention of Non-Insulin Dependent Diabetes Mellitus (NIDDM).
Type:
Grant
Filed:
August 24, 1998
Date of Patent:
March 5, 2002
Assignee:
Pharmacia & Upjohn Company
Inventors:
Scott D. Larsen, Paul D. May, John E. Bleasdale, Charlotta Liljebris, Heinrich Josef Schostarez, Tjeerd Barf
Abstract: This invention provides new thiazolindinedione derivatives and new arylacetic acid derivatives. These compounds are useful for the treatment of cardiovascular diseases, certain endocrine diseases, certain inflammatory diseases, certain neoplastic (malignant) and non-malignant proliferative diseases, certain neuro-psychiatric disorders, certain viral diseases, and diseases associated with these viral infections as discussed herein.
Type:
Grant
Filed:
March 7, 2000
Date of Patent:
March 5, 2002
Assignee:
University of Mississippi
Inventors:
Harrihar A. Pershadsingh, Mitchell A. Avery
Abstract: This invention provides compounds and their pharmaceutically-acceptable salts, pharmaceutical formulations of said compounds, and methods for treating hyperglycemia associated with non-insulin dependent diabetes and for treating hyperlipidemia.
Type:
Grant
Filed:
March 3, 2000
Date of Patent:
March 5, 2002
Assignee:
Eli Lilly and Company
Inventors:
Samuel James Dominianni, Margaret Mary Faul, Russell Dean Stucky, Leonard Larry Winneroski, Jr.
Abstract: Biologically active sultams are disclosed which have potent anti-HIV activity. A combinational method of synthesis, which uses a solid support and variants thereof, are described. Biological compositions and method of treating mammals for viral infections with compositions comprising the sultams of the invention, especially HIV are described.
Type:
Grant
Filed:
May 19, 1999
Date of Patent:
March 5, 2002
Assignee:
The University of Tennessee Research Corporation
Abstract: The present invention relates to novel 2-aminocarbonyl-5(2H)-isoxazolones as selective ligands of a high-affinity binding site of diisopropyl fluorophosphate (DFP) on brain membranes for the prophylaxis and treatment of disorders of the central nervous system, in particular cognitive disorders, depression, schizophrenia and anxiety.
Type:
Grant
Filed:
February 27, 2001
Date of Patent:
February 5, 2002
Assignee:
Bayer Aktiengesellschaft
Inventors:
Stephan Lensky, Bernd Riedl, Chantal Fürstner, Jens Ergüden, Frank Böss, Bernhard Schmidt, Franz-Josef van der Staay, Werner Schröder, Joachim Schuhmacher, Delf Schmidt
Abstract: 1,3-diazolino and 1,3-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.
Type:
Grant
Filed:
August 7, 2000
Date of Patent:
February 5, 2002
Assignee:
G.D. Searle & Co.
Inventors:
Donald W. Hansen, Jr., Arija A. Bergmanis, Timothy J. Hagen, E. Ann Hallinan, Steven W. Kramer, Suzanne Metz, Karen B. Peterson, Barnett S. Pitzele, Foe S. Tjoeng, Mihaly V. Toth, Mahima Trivedi, R. Keith Webber, Sofya Tsymbalov, Rolando E. Gapud
Abstract: Methods of synthesizing 9-Halo-13,14-dihydroprostaglandins useful in the treatment of glaucoma and ocular hypertension are disclosed. Also disclosed are ophthalmic, pharmaceutical compositions comprising such prostaglandins.
Type:
Grant
Filed:
October 31, 1997
Date of Patent:
February 5, 2002
Assignee:
Alcon Manufacturing, Ltd.
Inventors:
Raymond E. Conrow, Paul W. Zinke, Peter G. Klimko, Robert D. Selliah
Abstract: The present invention relates to novel tyrosine alkoxyguanidine compounds that are inhibitors of alpha V (&agr;v) integrins, for example &agr;v&bgr;3 and &agr;v&bgr;5 integrins, their pharmaceutically acceptable salts, and pharmaceutical compositions thereof. The compounds may be used in the treatment of pathological conditions mediated by &agr;v&bgr;3 and &agr;v&bgr;5 integrins, including conditions such as tumor growth, metastasis, restenosis, osteoporosis, inflammation, macular degeneration, diabetic retinopathy, and rheumatoid arthritis. The compounds have the general formula:
where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, m and n are defined herein.
Abstract: The subject of the invention is the compounds of formula:
in which R1, R2, R3, R4, R5 and R6 are as defined in Claim 1.
The compounds have a high affinity for CRF receptors.
Type:
Grant
Filed:
April 2, 1999
Date of Patent:
February 5, 2002
Assignee:
Sanofi-Synthelabo
Inventors:
Evelyne Fontaine, Danielle Gully, Pierre Roger, Camille Georges Wermuth
Abstract: A process for the purification of a compound of general formula I:
wherein:
R1 is hydrogen or C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl (any of which may optionally be substituted with one or more substituents selected from halogen and OH) or COOR4, COR6, CONR4R5 or CONHSO2R4;
R4 and R5 are each independently hydrogen or C1-C4 alkyl optionally substituted with one or more halogen atoms;
R6 is a halogen atom or a group R4;
R2 is hydrogen or halo;
R3 is C1-C4 alkyl, C2-C4 alkenyl or C2-C4 alkynyl, any of which may optionally be substituted with one or more halogen atoms, or halo; or, where appropriate, a salt thereof;
from a mixture containing the compound of general formula I together with one or more isomers or di-nitrated analogues thereof; the process comprising dissolving the mixture in a suitable crystallisation solvent and recrystallising the product from the resulting crystallisation solution;
characterised in that the crystallisation solution contains not more than 25% loadin
Type:
Grant
Filed:
September 11, 1996
Date of Patent:
January 29, 2002
Assignee:
Zeneca Limited
Inventors:
Stephen Martin Brown, Brian David Gott, Thomas Gray, Seyed Mehdi Tavana
Abstract: A superoxide radical inhibitor containing, as an effective ingredient, an azole derivative represented by the general formula (1),
[wherein R1 represents a phenyl group which may have 1-3 lower alkoxy groups as substituent(s) on the phenyl ring, a phenyl group having a lower alkylenedioxy group, or the like; R2 represents a hydrogen atom, a phenyl group, a halogen atom, a lower alkoxycarbonyl group, a lower alkyl group, an amino-lower alkyl group which may have a lower alkyl group as a substituent, a dihydrocarbostyril group, or the like; R3 represents a group of the formula,
(R4B represents a hydroxyl group, a carboxy group, a lower alkenyl group or a lower alkyl group, m represents 0, 1 or 2); X represents a sulfur atom or an oxygen atom] or a salt thereof.