Abstract: Various oxime derivatives are provided, which do not cause any chemical damage to plants and which exhibit sufficient effectiveness against various plant diseases. The oxime derivatives are expressed by two general chemical formulas (1) and (2), as follows. Agricultural chemicals and plant disease control chemicals are also provided which contain the above mentioned oxime derivatives as active ingredients. Test results of these agricultural chemicals and the plant disease control chemicals are proved to be very effective for downey mildews and late blights or Phytophthora rot etc.

Abstract: Objects of the present invention are compounds of a peptido-mimetic character having the capacity of acting as inhibitors of metalloproteinases produced by venom of snake, and of other metalloproteinases of human origin which have been put in relation with various pathologies in man, including tumoral growth and metastatization, aterosclerosis, multiple sclerosis, Alzheimer's disease, osteoporosis, hypertension, rheumatoid arthritis and other inflammatory diseases. Object of the present invention is also the procedure for the production of diethylester of (1)-phosphotryptophan, as an initial product necessary to synthesize all compounds mentioned above.

Abstract: The novel compounds of formula I: wherein Het represents an optionally substituted, optionally benzofused nitrogen containing 5- or 6-membered heteroaromatic group; R1 represents an alkyl, alkoxyalkyl or cycloalkyl group; R2 each independently represent an alkyl or alkenyl group, and m is 0 or an integer from 1 to 6, and herbicidal compositions containing such compounds as active ingredients can be utilized in various agricultural methods.

Abstract: A composition comprising (a) a metal complex of a cyclic thiohydroxamic acid such as the 2:1 zinc complex of 3-hydroxy-4-methylthiazol-2(3H)-thione and (b) a salt of the metal such as zinc chloride, acetate or oxide. The presence of component (b) gives enhanced microbiological activity.

Abstract: The invention relates to new fluoromethoxyacrylic acid derivatives, a process for their preparation and their use as pesticides, as well as to new intermediates and a plurality of processes for their preparation. It has already been disclosed that certain fluoromethoxyacrylic acid derivatives which are similar in constitution to the compounds described below have fungicidal properties (compare, for example, WO 9517376). The fungicidal action of these compounds, however, is unsatisfactory in many cases.

Abstract: A 1,2,3-thiadiazole derivative represented by general formula (I) or a salt thereof: wherein R1 is H, (halo) C1-C4 alkyl, 5- or 6-membered heterocycle containing 1 to 3 same or different O, N or S or the like, A is a group of the following formulas: wherein R2 and R3 are H, halogen, cyano, formyl, alkylthio, alkoxycarbonyl, substituted or unsubstituted phenyl, or the like, or R2 and R3, taken conjointly, may form a 3- to 7-membered ring including a C2-C6 alkylene group which may be intercepted by —O—, —S(O)n— (n is 0-2), —CO— or —NR8— (R8 is H, halogen or the like), B is cyano or an unsubstituted or substituted 5- or 6-membered heterocycle containing 1-3 hetero atoms selected from O, N and S, and m is 0-4; salts thereof; an agrohorticultural disease controller containing said derivative or salt; and method for using said disease controller.

Abstract: There is provided a process for preparing a pharmacologically acceptable salt of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-amino acid which comprises condensing an amino acid and N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine.N-carboxyanhydride under basic condition, carrying out decarboxylation under between neutral and acidic condition to obtain N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-amino acid, and forming a pharmacologically acceptable salt thereof, wherein the production of a by-product (3): is suppressed by carrying out in an aqueous liquid a series of operations till formation of the pharmacologically acceptable salt or till isolation of the pharmacologically acceptable salt. The present invention enables to prepare the pharmacologically acceptable salt of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-amino acid having high quality, in a commercial scale with high yield and economical efficiency.

Abstract: A process for preparing a 2-acylamino alcohol derivative which comprises (A) reacting an aminopropanol derivative represented by the following formula (1): Y—CH2—C*H (NHP1)—C*H(OH)—R1   (1) with an amine represented by R2H to synthesize an amino alcohol derivative represented by the following formula (2): R2—CH2—C*H(NHP1)—C*H(OH)—R1   (2) (B) leaving P1 from said amino alcohol derivative represented by formula (2) to synthesize an amino alcohol derivative represented by the following formula (3): R2—CH2—C*H(NH2)—C*H(OH)—R1   (3) (C) reacting said amino alcohol derivative represented by formula (3) with a carboxylic acid represented by R11COOH or a reactive derivative thereof to prepare a 2-acylamino alcohol derivative represented by the following formula (4): R2—CH2—C*H(NHCOR11)—C*H(OH)—R1   (4 ) wherein * represents an asymmetric carbon atom, and P1, R1, R2 and R

Abstract: Compounds of formula (I), wherein X and Y are independently carbon or nitrogen but not both simultaneously carbon, R1 is a group (II) and R2 is a group (III), R5 being a carbonate, carbamate or phosphate residue, are useful as anti-gestative, immuno-suppressant and anti-tumor agents

Abstract: A process for the preparation of a purified monomer is disclosed which comprises the steps of reacting an impure monomer wherein R1 and R2 are independently hydrogen or alkyl groups containing from 1 to about 6 carbon atoms, with (B) a substantially aqueous solution of an oxide or hydroxide of the structure MO or MOH wherein M is a Group IA or Group IIA metal, or an amine of the structure NR3R4R5 wherein R3, R4 and R5 are independently hydrogen or alkyl, alkanol or alkoxy groups containing from 1 to about 12 carbon atoms, wherein the molar ratio of (A):(B) is from about 1:1-2 for Group IA metals, 2:1-2 for Group IIA metals or ratio of moles of (A) to nitrogens of (B) is from about 1:1-2 nitrogens to form a salt, wherein in order to prevent polymerization of (A), the purified monomer or both or prevent undesired side reactions, the reaction of (A) and (B) occurs at a temperature of between about −20 to 75° C. and at a pH between about 7 to about 12.

Abstract: A pyrrolesulfonamide compound having formula (I) wherein the ring P represented by &agr; is a pyrrole ring having structure &bgr; or &psgr; wherein A represents alkylene, alkenylene or alkynylene; and Y represents a group &dgr; in which W represents CH, C═ or N; m stands for 0 or 1 when W is CH or N, or m stands for 1 when W is C═; B represents a specific divalent group; E1 and E2 each independently represents H or lower alkyl; and D represents an aromatic hydrocarbon group or heterocyclic group; l stands for 0 or 1; the dashed line indicates the presence or absence of a bond; and, when the bond is present, Z2 is not present and Z1 represents H but, when the bond is absent, Z1 represents H and Z2 represents OH or Z1 and Z2 are combined together to represent O or a group NOR5, in which R5 represents H, or alkyl, aralkyl or aryl; and R represents H, alkyl, cycloalkyl, cycloalkyl-alkyl or aralkyl.

Abstract: The invention relates to an amine derivative represented by the general formula (1): wherein R1 is a C1-C30 hydrocarbon group which may be interrupted by an ether linkage, with the proviso that phenyl and benzyl groups are excluded; one of A and B is and the other of them is —OR4; R2 and R3 are individually H, amidino group, alkanoyl group, C1-C20 hydrocarbon group, or the like; R4 and R5 are individually H, phosphoryl group, or the like, and an external skin care composition containing the same. The external skin care composition exhibits excellent preventing effects on aging of the skin, etc.

Abstract: A heterocyclic halide represented by a general formula (I): T—CH2—Y  (I) (wherein T denotes a heterocyclic group, and Y denotes a chlorine atom, bromine atom or iodine atom), is reacted with ammonia in the presence of an aromatic aldehyde represented by a general formula (II): A—CHO  (II) (wherein A denotes an aromatic group), to thereby produce an aminomethyl-heterocyclic derivative represented by a general formula (III): T—CH2—N═CH—A  (III) (wherein T denotes a heterocyclic group, and A denotes an aromatic group).

Abstract: Compounds of the formula I wherein X, Y, Z, R1 and R2 are as defined in claim 1, and their salts and solvates, can be used as integrin inhibitors in particular for the prophylaxis and treatment of circulatory disorders, for thrombosis, cardiac infarction, coronary heart diseases, arteriosclerosis, for pathological processes which are maintained or propagated by angiogenesis and in tumour therapy.

Abstract: This invention relates to compounds of formula which inhibit Factor Xa, to pharmaceutical compositions containing the compounds, and to the use of the compounds for the treatment of patients suffering from conditions which can be ameliorated by the administration of an inhibitor of Factor Xa.

Abstract: Compounds of formula I wherein R1, R1-R3, R4′, R4″ and R5 are as defined in the description, have valuable pharmaceutical properties and are effective especially as NK1 and NK2 antagonists. They are prepared in a manner known per se.

Abstract: The present invention relates to compositions and methods for reversing advanced glycosylation end product-mediated cross-linking and protein aging. Accordingly, compositions are described which comprise thiazolium compounds substituted with heterocyclic groups which are capable of reversing the formation of advanced glycosylation end product cross-links. Both industrial and therapeutic applications for the invention are disclosed, as food spoilage and animal protein aging can be treated. Such compounds have particular application in the treatment of protein aging such as is responsible for the complications of aging and diabetes.

Abstract: Novel 2-thio-thiazolidine-5-one compounds useful as intermediates for fungicidal 2-imidazoline-5-ones are disclosed.

Abstract: The present invention relates to compounds of Formula (I) that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.

Abstract: Compounds of formula (I), their salts and prodrugs thereof, where the substituents are as defined herein are disclosed as opiate binding agents useful in the treatment of opiate-mediated conditions. Also described are processes for making such substances.