Abstract: A portable biosensor for detecting and quantifying a target molecule in a biological sample and method of use include a biosensor fabricated with a recognition layer with an imprinted polymer, an electrode electrically coupled to the recognition layer, and a logic circuit that may include a processor and non-transitory memory with computer executable instructions embedded thereon, wherein the imprinted polymer is shaped to have a profile that substantially matches a profile of the target molecule, such that the target molecule can form-fit and bind to the imprinted polymer, thus changing an electrical property of the polymer layer that may be detected to identify the presence of the target molecule.

Abstract: Described herein are methods for evaluating polymer compositions comprising polymers modified with a small molecule compound (e.g., afibrotic compound), including methods for determining the concentration levels of said compounds.

Abstract: Various embodiments of an interconnect device and modules and systems that utilize such interconnect device are disclosed. In one or more embodiments, the interconnect device can include a printed circuit board (PCB). The PCB can include a substrate forming a resiliently deflectable element, a conductive material disposed on the substrate, and an electrical contact disposed on the resiliently deflectable element and electrically coupled to the conductive material. The interconnect device can also include a connector that includes a connecting pin configured to electrically couple with the electrical contact of the resiliently deflectable element of the PCB and cause the resiliently deflectable element to deflect when the element contacts the connecting pin.

Abstract: A system and a method for multi-gas sensing using dielectric excitation of a single sensing material at multiple operating temperatures. By measuring dielectric excitation responses of the gas sensing material, enhanced multi-gas differentiation and differentiation can be achieved using fewer operating temperatures than would be used by the same MOS gas sensing material configured to perform multi-gas differentiation based on resistance responses alone. The disclosed gas sensors and gas sensing techniques enable improved response linearity, improved dynamic range, and reduced computational resource consumption for multi-gas quantitation relative to traditional resistance-based gas sensing methods.

Abstract: Described are an intelligence system and process for material blending in the gasification. The system includes a subsystem for material blending in the gasification, wherein the subsystem for material blending in the gasification includes a raw material property rapid analysis module, for obtaining raw material property parameters of raw materials according to characteristic spectral line intensities of in-furnace raw materials; a blended material property prediction module, for establishing a prediction model, and predicting blended material property parameters by means of the prediction model according to raw material property parameters and raw material proportions; a blending scheme optimization module, for establishing an optimization model, and obtaining an optimized blending scheme by means of the optimization model according to blended material property parameters; a blending scheme economy evaluation module, for outputting a blending scheme with the optimum technical economy.

Abstract: The present invention relates to the electrochemical detection of an analyte by capacitance spectroscopy using a redox active polymer-coated electrode such as a polyaniline-coated electrode.

Abstract: The present disclosure relates to a sensor device, comprising: a measurement chamber having at least a first wall, the measurement chamber including a plurality of analyte sensors; wherein the measurement chamber allows a fluid to be analyzed to interact with each of the plurality of analyte sensors when the fluid is accommodated within the measurement chamber; the measurement chamber having an inlet configured to receive the fluid to be analyzed and an outlet configured to allow the fluid to exit the measurement chamber after having interacted with the plurality of analyte sensors; the measurement chamber defining a sample volume for accommodating the fluid to be analyzed, the sample volume extending at least between the inlet and the outlet; a heating element configured to heat the fluid accommodated within the measurement chamber.

Abstract: A fluidic cartridge and methods of operation are described. The fluidic cartridge includes a substrate having a plurality of contact pads designed to electrically couple with an analyzer, a semiconductor chip having a sensor array, and a reference electrode. The fluidic cartridge includes a first fluidic channel having an inlet and coupled to a second fluidic channel, the second fluidic channel being aligned such that the sensor array and the reference electrode are disposed within the second fluidic channel. A first plug is disposed at the first inlet. The first plug includes a compliant material configured to be punctured by a capillary without leaking fluid through the first plug.

Abstract: Provided are methods and devices for the label free detection of analytes in solution, including analytes suspended in a biological fluid. A field effect transistor (FET) is positioned in close proximity to a paired set of reference electrodes and the reference electrodes electrically biased to provide desalting and a stable gate voltage to the FET. In this manner, charged ions are depleted in the sensing region of the sensor and device sensitivity to analyte detection improved by the removal of charge that otherwise interferes with measurement. Also provided are methods and systems providing increased in reference electrode surface area and/or decrease in droplet volume to further improve label-free detection of analytes.

Abstract: A method of live monitoring of long-term and/or multi-channel reactions may include: controlling a chemical reaction apparatus via a modular control system, collecting reaction data via the digital and analog input ports, logging the reaction data via a data logging module configured to transmit the reaction data to a remote data server for data storage, periodically querying a remote interlock server for an emergency stop instruction via an emergency stop controller, inputting the emergency stop instruction into the remote interlock server via a remote user interface, executing, in response to receiving the emergency stop instruction, one or more emergency stop actions. The modular control system may include: a digital control module in electrical communication with digital input and output ports; an analog control module in electrical communication with analog input and output ports; and a pneumatic control module in pneumatic communication with pneumatic output ports.

Abstract: Methods and systems are provided for accurate and efficient identification and quantification of proteins. In an aspect, disclosed herein is a method for identifying a protein in a sample of unknown proteins, comprising receiving information of a plurality of empirical measurements performed on the unknown proteins; comparing the information of empirical measurements against a database comprising a plurality of protein sequences, each protein sequence corresponding to a candidate protein among a plurality of candidate proteins; and for each of one or more of the plurality of candidate proteins, generating a probability that the candidate protein generates the information of empirical measurements, a probability that the plurality of empirical measurements is not observed given that the candidate protein is present in the sample, or a probability that the candidate protein is present in the sample; based on the comparison of the information of empirical measurements against the database.

Abstract: Systems and methods for cooling a datacenter are disclosed. In at least one embodiment, a plurality of in-rack coolant distribution units (IRCDUs) include a first IRCDU and a second IRCDU that are interchangeable within a rack depending on a type of coolant to be provided to a rack from a coolant distribution unit (CDU), so that a first IRCDU that is calibrated to a first coolant can distribute a first coolant and a second IRCDU that is calibrated to a second coolant can distribute a second coolant to a rack manifold of a rack.

Abstract: A method for managing crystallization process in a process control plant is provided. The method includes capturing process parameters of an operating reactor unit in a process control plant. The method includes predicting desired process parameters based on first set of parameters and the captured process parameters. The first set of parameters includes information related to process dynamics and process disturbances associated with the operating reactor unit. Furthermore, the method includes controlling process control loop associated with the operating reactor unit based on the desired process parameters and the first set of parameters.

Abstract: Herein disclosed is configuring a layered receptor with at least one layer comprising graphene oxide and an biomarker binding layer configured to bind with a targeted biomarker, connecting a working electrode comprising carbon nanotubes (CNT) and a reference electrode to the layered receptor, and detecting events comprising the targeted biomarker binding layer with the biomarker binding layer, by measuring changes in impedance to a plurality of frequencies of an alternating current voltage signal applied through a patient's body fluid between the working electrode and the reference electrode. The layered receptor may further comprise a plurality of self-assembled layers, comprising, in sequence, a layer abutting the CNT and comprising a polymer and metal nanoparticles, a layer comprising an organosulfur, the graphene oxide layer and the biomarker binding layer. The biomarker binding layer may comprise Syn-211, LB509 or 5G4. The targeted biomarker may be alpha-synuclein.

Abstract: Biosensor devices and methods of forming the same are provided. A cavity is formed in a substrate and is configured to receive one or more charged molecules. A transistor is formed in the substrate and includes a source region, a drain region, and a channel region that are spatially separated from the cavity in a lateral direction. A gate of the transistor is disposed below the cavity and extends between the cavity and the source, drain, and channel regions. A voltage potential of the gate is based on a number of the charged molecules in the cavity.

Abstract: A method for enhanced mud gas logging includes receiving a gas stream; separating the gas stream into a first gas stream, a second gas stream, and a third gas stream; directing the first gas stream to a gas chromatography configuration including a gas chromatography column and a photoionization detector; detecting, by the photoionization detector, gas species in the first gas stream; separating, by a first separation component, water vapor from the second gas stream to produce a processed second gas stream; detecting, by a first mass spectrometer, gas species in the processed second gas stream; separating, by a second separation component, water vapor and other gas species from the third gas stream to produce a processed third gas stream; and detecting, by a second mass spectrometer, gas species in the processed third gas stream.

Abstract: A random access automated molecular testing system and method is used with a planar polymerase chain reaction (PCR) chip to provide molecular detection covering a wide variety of assays/tests in a small footprint. An automated transport mechanism moves the PCR chip between a pipette loading station, a sealing station and an amplification and detection module to provide batchless and random-access amplification and detection of a biological sample fluid. The PCR chip a planar rectangular body, a U-shaped channel for receiving sample fluid from an inlet port and a gripping feature laterally extending from an upper surface of the body above the inlet port for use by the automated transport mechanism. An amplification and detection module includes a heating block, a clip with a viewing window for retaining the PCR chip and a detection platform for identifying a content characteristic of interest of the sample fluid.

Abstract: Disclosed herein are devices, wound dressings and methods for determining the pH of fluid or a wound exudate at a wound. Example devices include a device comprising a surface configured to contact the fluid or wound and a pH indicator covalently bound thereto or applied to the surface, wherein the pH indicator has a first colour prior to contact with the fluid or the wound exudate and changes colour as a function of the pH of the fluid or wound exudate. Example devices include a device which indicates wound exudate loading within a wound dressing and wound dressing comprising an absorbent layer and a moisture indicator which indicates would exudate loading within the dressing, wherein the visibility of the moisture indictor changes as a result of a physical transformation of a first material within the dressing. Systems, devices, and methods are provided for monitoring wound status and progression by measuring pH levels indicated by pH-sensitive wound dressings.

Abstract: An application-analysable bodily fluid testing equipment (100, 200, 300) is provided. The application-analysable bodily fluid testing equipment comprises at least one testing region (109, 209, 309) sensitive to an indicator of a bodily condition in bodily fluid from which image data is capturable and analysable by an associated application on a device. The bodily fluid testing equipment further comprises a handling indicator (107, 207, 307) indicating an area of the equipment for a user to hold during the application of a bodily fluid to the at least one testing region, and during capture of the image data for analysis of the bodily fluid applied to the at least one testing region using the application on the device.

Abstract: A gas detection device and process detect a combustible target gas. A detector chamber (6) encloses a detector (10), and a modulator chamber (5) encloses a modulator (15). The target gas can flow from an area to be monitored through into the modulator chamber and from the modulator chamber into the detector chamber. An electrical voltage is applied to the modulator and to the detector to heat them, oxidizing the target gas in the modulator chamber and in the detector chamber. Heat energy is released bringing about an increase of the temperature of the detector. A detector sensor measures a detection variable which depends on the detector temperature. The voltage is applied to the modulator such that the temperature of the modulator oscillates. An analysis unit checks whether the detection variable oscillates synchronously with the modulator temperature, indicating the target gas is present.