Patents Examined by Robert J Eom
  • Patent number: 11674916
    Abstract: A gas sensing device comprising a substrate comprising an etched cavity portion and a substrate portion, a dielectric layer disposed on the substrate, wherein the dielectric layer comprises a dielectric membrane, wherein the dielectric membrane is adjacent to the etched cavity portion of the substrate, a heater located within the dielectric layer; a material for sensing a gas; and one or more polysilicon electrodes coupled with the material for sensing a gas.
    Type: Grant
    Filed: November 12, 2018
    Date of Patent: June 13, 2023
    Assignee: Sciosense B.V.
    Inventors: Florin Udrea, Syed Zeeshan Ali
  • Patent number: 11662337
    Abstract: This productivity evaluation method is for evaluating productivity of a chemical substance in a process comprising a first step of obtaining gas from a waste material and a second step of synthesizing a chemical substance from the gas obtained in the first step in the presence of a catalyst, said method including: a first carbon mass calculation stage of calculating mass of carbon contained in the waste material, a second carbon mass calculation stage of calculating mass of carbon contained in the chemical substance produced in said process, and a productivity evaluation stage of evaluating the productivity of the chemical substance based on values of the mass of carbon which are calculated in the first carbon mass calculation stage and the second carbon mass calculation stage.
    Type: Grant
    Filed: May 4, 2020
    Date of Patent: May 30, 2023
    Inventors: Yoji Fujimori, Akio Shokaku
  • Patent number: 11662329
    Abstract: Disclosed herein are compositions for permeable outer diffusion control membranes for creatinine and creatine sensors and methods of making such membranes.
    Type: Grant
    Filed: June 3, 2019
    Date of Patent: May 30, 2023
    Inventor: Xiaoxian Xu
  • Patent number: 11650192
    Abstract: A device for measuring the total organic carbon content (TOC) of a sample fluid comprises a measuring cell (2) defining a volume (3) for containing a sample fluid and an excimer lamp (20) arranged to cause an oxidation reaction of the sample fluid by emitting radiation onto the sample fluid in the volume (3). A pair of electrodes is arranged to measure the conductivity of the sample fluid during the oxidation reaction and at least one temperature senor (31) is arranged on the measuring cell (2) to measure a temperature that is related to the sample fluid. The total organic carbon content (TOC) of the sample fluid is determined on the basis of the measured conductivity compensated by the temperature related to the sample fluid.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: May 16, 2023
    Inventors: Pascal Rajagopalan, Julien Gross, Pierre Caruso
  • Patent number: 11630094
    Abstract: Described is an oxygen permeable layer for detection of molecular oxygen, wherein the layer has a carrier material in which at least one particle is comprised, wherein the carrier material is polyvinylidene fluoride or a copolymer of polyvinylidene fluoride, and the particle comprises a polymer or a copolymer, wherein the polymer or copolymer of the particle has a chemically covalently bonded indicator compound for detection of molecular oxygen. In addition, a multilayer system for detection of molecular oxygen is described. Also described are a method for producing the layer, and the use of the layer or of the multilayer system for detection of molecular oxygen.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: April 18, 2023
    Assignee: Hamilton Bonaduz AG
    Inventors: Claudius-Michael Ortega Schulte, Dirk Schönfuss, {hacek over (S)}pela Willi, Sara Simonato
  • Patent number: 11609223
    Abstract: A device for analysis of cells comprises: an active sensor area (104) presenting a surface for cell growth; a microelectrode array (102) comprising a plurality of pixels (110) in the active sensor area (104), wherein each pixel (110) comprises at least one electrode (120) at the surface, wherein each pixel (110) is configured to control the configuration of the pixel circuitry and set a measurement modality of the pixel; recording circuitry having a plurality of recording channels (130), wherein each pixel (110) is connected to a recording channel (130), wherein each recording channel (130) comprises a reconfigurable component (131), which is selectively controlled between being set to a first mode, in which the reconfigurable component (131) is configured to amplify a received pixel signal, and being set to a second mode, in which the reconfigurable component (131) is configured to selectively pass a frequency band of the received pixel signal.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: March 21, 2023
    Assignee: IMEC VZW
    Inventor: Carolina Mora Lopez
  • Patent number: 11596942
    Abstract: A microfluidic device may include an inlet, an outlet, first and second channels arranged in parallel, a first sensor pair positioned along the first channel, and a second sensor pair positioned along the second channel. The first channel may include a first upstream zone, a first downstream zone, and a first constriction zone. The second channel may include a second upstream zone, a second downstream zone, and a second constriction zone. The first sensor pair may include a first entry sensor configured to detect a first cell flowing through the first upstream zone, and a first exit sensor configured to detect the first cell flowing through the first downstream zone. The second sensor pair may include a second entry sensor configured to detect a second cell flowing through the second upstream zone, and a second exit sensor configured to detect the second cell flowing through the second downstream zone.
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: March 7, 2023
    Inventors: Ali Fatih Sarioglu, A K M Arifuzzman, Norh A. Asmare
  • Patent number: 11596704
    Abstract: The present disclosure relates to an article for detecting a disinfectant via visual feedback. The article have a first substrate with a first major surface and opposite ends. The article also comprises a process indicator disposed on at least a portion of the first major surface. The process indicator reacts with at least one liquid disinfectant selected from the group consisting of glutaraldehyde, ortho-phthalaldehyde, hydrogen peroxide, peroxyacetic acid, and combinations thereof. The process indicator can be formed from a synthetic amine-containing polymer derived from polyethylenimine (PEI). The article can have a flow channel that is formed by a portion of the process indicator and that extends between the opposite ends. The disclosure also relates to a kit containing the article as well as a method of using the article in a disinfection process. The article is used to diagnose issues in an automated endoscope reprocessors (AERs).
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: March 7, 2023
    Assignee: 3M Innovative Properties Company
    Inventors: Timothy J. Nies, G. Marco Bommarito, Christopher J. Claypool
  • Patent number: 11592016
    Abstract: A low-voltage microfluidic valve device and system for regulating the flow of fluid. One low-voltage microfluidic valve device for regulating the low of fluid includes a nano-textured dendritic metallic filament configured to grow and retract in response to a voltage. The low-voltage microfluidic valve device also includes a microfluidic channel configured to allow fluid flow, wherein the fluid flow is selectively interrupted by the growth of the nano-textured dendritic metallic filament. The low-voltage microfluidic valve device also includes a membrane positioned proximate to the fluid and configured to alter shape in response to the growth of the nano-textured dendritic metallic filament.
    Type: Grant
    Filed: July 14, 2020
    Date of Patent: February 28, 2023
    Inventors: Michael N. Kozicki, Junseok Chae
  • Patent number: 11585787
    Abstract: A detection device, a detecting method for the detection device, and a detecting system are provided. The detection device includes: a first interdigital transducer and a second interdigital transducer, wherein the first interdigital transducer is arranged opposite to the second interdigital transducer, and a surface wave of the first interdigital transducer is transmitted in a direction toward the second interdigital transducer; and a reaction layer arranged between the first interdigital transducer and the second interdigital transducer.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: February 21, 2023
    Inventor: Yingyi Li
  • Patent number: 11585777
    Abstract: The present disclosure provides a biosensor for detecting the presence of and/or the amount of at least one fungal plant pathogen in a sample, comprising: a support structure; at least two interdigitated electrodes coupled to the support structure, wherein at least one of the interdigitated electrodes is functionalized with a linker coupled to at least one biological component that recognizes the at least one fungal plant pathogen; and an impedance measurement circuit coupled to the at least two interdigitated electrodes. The present disclosure also provides methods of detecting the presence of and/or the amount of at least one fungal plant pathogen in a sample, methods of making the biosensor described herein, as well as methods and uses of using the herein described biosensor for detecting the presence of and/or amount of at least one fungal plant pathogen.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: February 21, 2023
    Assignees: InnoTech Alberta Inc., The Governors of the University of Alberta
    Inventors: Xiujie Li, Jie Chen, Jian Yang, Scott Mackay, Lian C. T. Shoute
  • Patent number: 11573184
    Abstract: One embodiment of the present invention provides an apparatus for analyzing substances included in a sample. The apparatus includes a physical enclosure for holding the sample and one or more sensors positioned on an inner surface of the physical enclosure. The sensors are configured to provide information associated with the substances included in the sample. The apparatus further includes electrical conductive traces positioned on the inner surface and coupled to the one or more sensors, thereby facilitating transmission of outputs of the sensors.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: February 7, 2023
    Assignee: Palo Alto Research Center Incorporated
    Inventors: Michael Kuniavsky, Siqi Wang
  • Patent number: 11549959
    Abstract: The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within microfluidic channels, and detect those nucleotides. The technology still more particularly relates to automated devices for carrying out pipetting operations, particularly on samples in parallel, consistent with sample preparation and delivery of PCR-ready nucleotide extracts to a cartridge wherein PCR is run.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: January 10, 2023
    Assignee: HandyLab, Inc.
    Inventors: Jeff Williams, Kerry Wilson
  • Patent number: 11545234
    Abstract: Methods and systems are provided for accurate and efficient identification and quantification of proteins. In an aspect, disclosed herein is a method for identifying a protein in a sample of unknown proteins, comprising receiving information of a plurality of empirical measurements performed on the unknown proteins; comparing the information of empirical measurements against a database comprising a plurality of protein sequences, each protein sequence corresponding to a candidate protein among a plurality of candidate proteins; and for each of one or more of the plurality of candidate proteins, generating a probability that the candidate protein generates the information of empirical measurements, a probability that the plurality of empirical measurements is not observed given that the candidate protein is present in the sample, or a probability that the candidate protein is present in the sample; based on the comparison of the information of empirical measurements against the database.
    Type: Grant
    Filed: April 2, 2021
    Date of Patent: January 3, 2023
    Assignee: Nautilus Biotechnology, Inc.
    Inventors: Sujal M. Patel, Parag Mallick, Jarrett D. Egertson
  • Patent number: 11534760
    Abstract: A device for the quantification of cellular and non-cellular components in a blood sample including detection electrodes including a first electrode connected with a first input to receive a first signal in input and a second electrode, reference electrodes including a first electrode connected with a second input configured to receive a second signal in input of opposite polarity to the first input signal and a second electrode connected to the second electrode of said detection electrodes, in a common point wherefrom an output signal is picked up, a ferromagnetic concentrator that cooperates with an external magnetic field external to effectuate concentration of said components on said detection electrodes, a substrate configured to house said detection electrodes, reference electrodes, and concentrator; a support configured to collect a blood sample, and a spacer element to confine in the substrate plane the blood sample and to distance said substrate from said support.
    Type: Grant
    Filed: July 17, 2018
    Date of Patent: December 27, 2022
    Assignee: Politecnico Di Milano
    Inventors: Riccardo Bertacco, Daniela Petti, Giorgio Ferrari, Edoardo Albisetti, Marco Giacometti
  • Patent number: 11536688
    Abstract: A high data rate integrated circuit, such as an integrated circuit including a large sensor array, may be implemented using clock multipliers in individual power domains, coupled to sets of transmitters, including a transmitter pair configuration. Reference clock distribution circuitry on the integrated circuit distributes a relatively low speed reference clock. In a transmitter pair configuration, each pair comprises a first transmitter and a second transmitter in a transmitter power domain. Also, each pair of transmitters includes a clock multiplier connected to the reference clock distribution circuitry, and disposed between the first and second transmitters, which produces a local transmit clock.
    Type: Grant
    Filed: March 3, 2020
    Date of Patent: December 27, 2022
    Inventors: Keith G. Fife, Jungwook Yang
  • Patent number: 11534762
    Abstract: A microfluidic device, a method of using a microfluidic device and a micro total analysis system are provided. The microfluidic device includes a first substrate, and the first substrate includes a base substrate and a pixel array. The pixel array includes a plurality of pixels and is on the base substrate, and each of the plurality of pixels includes a driving electrode. Driving electrodes of two adjacent pixels are in different layers.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: December 27, 2022
    Inventors: Yingming Liu, Haisheng Wang, Xiaochuan Chen, Xue Dong, Xiaoliang Ding, Pinchao Gu, Lei Wang, Changfeng Li, Ping Zhang
  • Patent number: 11531024
    Abstract: The invention generally relates to mass tag analysis for rare cells and cell free molecules. In certain embodiments, the invention provides an apparatus including an essentially non-absorbent membrane having at least one pore, a microwell operably associated with the essentially non-absorbent membrane, and an electric field generator. The apparatus may be configured such that an electric field produced by the electric field generator operably interacts with a sample in the microwell and expels a droplet of the sample through the at least one pore in the essentially non-absorbent membrane. In certain embodiments, apparatuses of the invention are used for detection, and optionally quantification, of a target analyte from a heterogeneous sample, such as a rare target analyte (e.g., rare cell) from a biological sample.
    Type: Grant
    Filed: September 24, 2016
    Date of Patent: December 20, 2022
    Assignee: Purdue Research Foundation
    Inventors: Zane Baird, Robert Graham Cooks, Adam Hollerbach, Zheng Ouyang, Michael Pugia
  • Patent number: 11504681
    Abstract: A microfluidic mixing device comprising two bellows pumps (105, 115), microfluidic cartridges comprising the same and methods for use of the same are provided. The disclosed device enables efficient mixing of samples at the microfluidic scale.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: November 22, 2022
    Inventors: Andrew Kolb, Matthew Scott Bragd, C. Frederick Battrell
  • Patent number: 11506580
    Abstract: The present exemplary embodiments provide a sample separation device which applies an electric field to a selective ion permeable layer based on origami to concentrate a target material in a specific area and concentrates a target material and separates a non-target material through a filter layer in which a paper is compressed to adjust a size of micro pore.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: November 22, 2022
    Assignee: CALTH. Inc.
    Inventors: Jeong Hoon Lee, Kyung Jae Lee, Sung Il Han