Patents Examined by Robert J Eom
  • Patent number: 10605767
    Abstract: A high data rate integrated circuit, such as an integrated circuit including a large sensor array, may be implemented using clock multipliers in individual power domains, coupled to sets of transmitters, including a transmitter pair configuration. Reference clock distribution circuitry on the integrated circuit distributes a relatively low speed reference clock. In a transmitter pair configuration, each pair comprises a first transmitter and a second transmitter in a transmitter power domain. Also, each pair of transmitters includes a clock multiplier connected to the reference clock distribution circuitry, and disposed between the first and second transmitters, which produces a local transmit clock.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: March 31, 2020
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Keith G. Fife, Jungwook Yang
  • Patent number: 10598723
    Abstract: In one implementation, a method for operating an apparatus is described. The method includes applying a bias voltage to place a transistor of a reference sensor in a known state, the reference sensor in an array of sensors that further includes a chemical sensor coupled to a reaction region for receiving at least one reactant. The method further includes acquiring an output signal from the reference sensor in response to the applied bias voltage, and determining a defect associated with the array if the output signal does not correspond to the known state.
    Type: Grant
    Filed: August 19, 2015
    Date of Patent: March 24, 2020
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventor: Mark Beauchemin
  • Patent number: 10591433
    Abstract: A gas sensor, having: a substrate; a heatable membrane configured on a substrate front side of the substrate; at least three electrodes disposed on a membrane surface of the membrane; a first coating configured on an area of the membrane surface, at least two of the at least three electrodes contacting the first coating; a second coating configured on the first coating and on an area of the membrane surface, at least two of the at least three electrodes contacting the second coating, and at least one of the at least two electrodes that contact the second coating being different from the at least two electrodes that contact the first coating.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: March 17, 2020
    Assignee: Robert Bosch GmbH
    Inventor: Andreas Krauss
  • Patent number: 10591454
    Abstract: Disclosed is a gas sensing material for methylbenzene detection. Specifically, the gas sensing material includes a nanocomposite of Cr2O3 and ZnCr2O4. The content of Cr in the nanocomposite is from 67.0 at. % to 90.0 at. %, based on the sum of the contents of Cr and Zn atoms. The gas sensing material is highly selective to methylbenzenes over other gases and is highly sensitive to methylbenzenes. Also disclosed are methods for preparing the gas sensing material. The methods facilitate control over the composition of the gas sensing material and enable rapid synthesis of the gas sensing material at low temperature. Also disclosed is a gas sensor including the gas sensing material.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: March 17, 2020
    Assignee: Korea University Research and Business Foundation
    Inventors: Jong-Heun Lee, Jae-Hyeok Kim, Hyun-Mook Jeong, Tae-Hyung Kim, Hyung-Sik Woo
  • Patent number: 10578573
    Abstract: A combustible gas sensor for detecting a combustible analyte includes a first sensing element including a first conductive element in electrical connection with an electronic circuitry, a first support structure in operative connection with the first conductive element, a catalyst supported on the first support structure for catalyzing a reaction of the analyte, and a system for measuring a variable related to the reactance of the first sensing element. Changes in the measured variable over time provide an indication of an operational status of the first sensing element.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: March 3, 2020
    Assignee: MSA TECHNOLOGY, LLC
    Inventor: Mark F. Zanella, Sr.
  • Patent number: 10578526
    Abstract: A method for providing in situ chemical transformation and ionization of a portion (e.g., inorganic oxidizer) of a sample via an analyte detection system is disclosed herein. The method includes introducing a gas into an ionization source of the analyte detection system via an inlet. The method further includes generating ions within the ionization source and directing the gas and generated ions through and out of the ionization source and to the sample. The sample is located proximal to the ionization source in an ambient environment. The ions chemically react with the sample and desorb and ionize an analyte from the sample, the analyte being generated from the inorganic oxidizer, the desorbed analyte having a lower melting point and/or better desorption kinetics than the inorganic oxidizer. The method further includes receiving the desorbed analyte via an analyzer of the analyte detection system.
    Type: Grant
    Filed: July 24, 2014
    Date of Patent: March 3, 2020
    Assignee: SMITHS DETECTION MONTREAL INC.
    Inventors: Jan Hendrikse, Vladimir Romanov
  • Patent number: 10562022
    Abstract: A mechanically-actuated vacuum-controlled fluid collection system includes a mechanically-actuated vacuum controller (MA VC) to draw fluid into a chamber through the opening to the chamber. The system may include a releasable seal to seal the opening, and the MAVC may include a spring-loaded plunger to create a vacuum within the chamber when sealed. The system includes multiple fluid chambers, and may further include a single actuator or multiple corresponding actuators. The system may be configured to add a pre-loadable reagent to fluid drawn into the one or more chambers, and may be configured to add the reagent in proportion to a volume of the fluid. The system may be controllable to release collected fluid to another device, such as for assay and/or transport. The system may be configured to draw a liquid biological sample such as urine, and may include a fluid interface to draw fluid from a biological sample container.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: February 18, 2020
    Inventors: Brandon T. Johnson, Kate E. Christian, Glenn H. Verner
  • Patent number: 10551371
    Abstract: Devices and methods for performing extracellular recording of cells, such as excitable cells, cardiomyocytes, and cardiomyocyte precursor cells is provided. An exemplary device includes a nonconductive substrate forming or provided as a base of one or more wells; a recording electrode positioned on the substrate within the well, wherein the recording electrode is accessible to cells when a cell sample is added to the device; and a reference electrode positioned within the well in a cell-free zone, the cell-free zone characterized as free from contact with cells when the cell sample is added to the device, thereby preventing contact between cells and the reference electrode.
    Type: Grant
    Filed: May 5, 2010
    Date of Patent: February 4, 2020
    Assignee: ACEA Biosciences, Inc.
    Inventors: Xiaobo Wang, Wei Ouyang, Nan Li, Biao Xi, Yama A. Abassi, Xiao Xu
  • Patent number: 10551338
    Abstract: The subject matter of the present disclosure generally relates to systems and methods for sensing analytes with a high selectivity and low responses to interferences in an environment. In one embodiment, a sensor was developed which comprises a sensor electrode, a coupling element operationally coupled to a discrete segment of the sensor electrode, and an activation material in operational contact with the coupling element and configured to induce an irreversible sensor response for a selected sensing application.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: February 4, 2020
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Radislav Alexandrovich Potyrailo, Zhexiong Tang, Igor Tokarev, Binil Itty Ipe Kandapallil
  • Patent number: 10539523
    Abstract: Devices, systems and methods for monitoring excitable cells, such as cardiomyocytes, on microelectrode arrays that couple the electro-stimulation of excitable cells to induce or regulate cardiomyocyte beating and the simultaneous measurement of impedance and extracellular recording to assess changes in cardiomyocyte beating, viability, morphology or electrophysical properties in response to a plurality of treatments.
    Type: Grant
    Filed: November 28, 2013
    Date of Patent: January 21, 2020
    Assignee: ACEA Biosciences, Inc.
    Inventors: Xiaobo Wang, Wei Ouyang, Nan Li, Tianxing Wang, Xiaoyu Zhang, Xiao Xu, Yama A. Abassi
  • Patent number: 10533987
    Abstract: The inventive concepts relate to a member for a gas sensor, a gas sensor using the same, and a method of manufacturing the same. More particularly, the inventive concepts relate to a gas sensor member using a porous semiconductor metal oxide complex nanofiber functionalized by uniformly distributing porous first metal oxide particles, including metal nanoparticle catalysts synthesized using a metal-organic framework, in the inside and on a surface of a second metal oxide nanofiber, a gas sensor using the same, and a method of manufacturing the same.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: January 14, 2020
    Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Il-Doo Kim, Wontae Koo, Jisu Jang
  • Patent number: 10526696
    Abstract: A molecular sensor includes a substrate defining a substrate plane, and a plurality of pairs of electrode sheets above or below the substrate at an angle to the substrate plane. The molecular sensor further includes a plurality of inner dielectric sheets between each electrode sheet in each pair of electrode sheets of the plurality of pairs, and an outer dielectric sheet between each pair of electrode sheets of the plurality of pairs.
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: January 7, 2020
    Assignee: ROSWELL BIOTECHNOLOGIES, INC.
    Inventors: Sungho Jin, Barry L. Merriman, Tim Geiser, Chulmin Choi, Paul Mola
  • Patent number: 10527579
    Abstract: Provided are methods and devices for the label free detection of analytes in solution, including analytes suspended in a biological fluid. A field effect transistor (FET) is positioned in close proximity to a paired set of reference electrodes and the reference electrodes electrically biased to provide desalting and a stable gate voltage to the FET. In this manner, charged ions are depleted in the sensing region of the sensor and device sensitivity to analyte detection improved by the removal of charge that otherwise interferes with measurement. Also provided are methods and systems providing increased in reference electrode surface area and/or decrease in droplet volume to further improve label-free detection of analytes.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: January 7, 2020
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Rashid Bashir, Vikhram Vilasur Swaminathan, Bobby Reddy, Jr., Eric M. Salm, Carlos Duarte-Guevara
  • Patent number: 10513922
    Abstract: Methods and systems for monitoring material loss in a downhole environment arising from corrosion and/or erosion include placing a downhole sensor in a borehole. The resistance of the downhole sensor is measured using a four-probe resistance technique in which a power source is provided at two electrodes of the downhole sensor and voltage is measured at two voltage taps. A rise in voltage over time indicates loss of conductive material on the downhole sensor. The conductive material on the downhole sensor may be formed to provide discrete voltage increases for improving reliability of material loss and/or rate of material loss resistance measurements.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: December 24, 2019
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Li Gao, Michael T. Pelletier, Robert S. Atkinson, David L. Perkins
  • Patent number: 10514367
    Abstract: The present disclosure generally relates to a color indicator that signals when the concentration of an antimicrobial solution changes. In some embodiments, the color indicator is specific for changes in the concentration of an antimicrobial quaternary ammonium compound in an antimicrobial solution. The color indicator can be incorporated into a variety of articles including towels, labels, containers, buckets, trays, sinks, spray bottles, liners for containers, buckets, sinks, or spray bottles, indictor wands or strips, and test kits.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: December 24, 2019
    Assignee: Ecolab USA Inc.
    Inventors: Eric Balz, Kim R. Smith, Erik C. Olson, Sherri Tischler
  • Patent number: 10509008
    Abstract: A biological device includes a substrate, a gate electrode, and a sensing well. The substrate includes a source region, a drain region, a channel region, a body region, and a sensing region. The channel region is disposed between the source region and the drain region. The sensing region is at least disposed between the channel region and the body region. The gate electrode is at least disposed on or above the channel region of the substrate. The sensing well is at least disposed adjacent to the sensing region.
    Type: Grant
    Filed: April 29, 2015
    Date of Patent: December 17, 2019
    Assignee: Taiwan Semiconductor Manufacturing Co., Ltd.
    Inventors: Ta-Chuan Liao, Chien-Kuo Yang, Yi-Shao Liu, Tung-Tsun Chen, Chan-Ching Lin, Jui-Cheng Huang, Felix Ying-Kit Tsui, Jing-Hwang Yang
  • Patent number: 10502706
    Abstract: The present disclosure provides a biological field effect transistor (BioFET) and a method of fabricating a BioFET device. The method includes forming a BioFET using one or more process steps compatible with or typical to a complementary metal-oxide-semiconductor (CMOS) process. The BioFET device includes a plurality of micro wells having a sensing gate bottom and a number of stacked well portions. A bottom surface area of a well portion is different from a top surface area of a well portion directly below. The micro wells are formed by multiple etching operations through different materials, including a sacrificial plug, to expose the sensing gate without plasma induced damage.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: December 10, 2019
    Assignee: Taiwan Semiconductor Manufacturing Company, Ltd.
    Inventors: Yi-Hsien Chang, Chun-Ren Cheng, Shih-Wei Lin, Yi-Shao Liu
  • Patent number: 10481068
    Abstract: The present disclosure relates to compositions comprising a hydrogel particle with optical properties substantially similar to the optical properties of a target cell, and methods for their use.
    Type: Grant
    Filed: February 13, 2018
    Date of Patent: November 19, 2019
    Assignee: SLINGSHOT BIOSCIENCES
    Inventors: Jeffrey Kim, Oliver Liu, Jeremy Agresti, Anh Tuan Nguyen
  • Patent number: 10481118
    Abstract: Disclosed are a hydrogen sensor which includes a P-type silicon nanowire array and a hydrogenation catalyst formed on a surface of the nanowire array, and a method of manufacturing the same.
    Type: Grant
    Filed: January 10, 2017
    Date of Patent: November 19, 2019
    Assignee: SHIN SUNG C&T CO., LTD.
    Inventors: Woo Young Lee, Ji Sun Baek, Byung Jin Jang
  • Patent number: 10481120
    Abstract: Disclosed are methods and apparatus for determining the properties of artificial membranes (e.g., artificially prepared lipid bilayers and biomimetic membranes comprising amphiphilic copolymers). Multiple physical properties of the membranes can be determined via a combination of electrical and optical measurements. The optical and electrical measurements can be determined using a single apparatus, which can also be used to prepare the artificial membrane. Methods are also disclosed for determining the effects changes in the composition of the artificial membrane, such as the addition of a drug or a change in lipid content.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: November 19, 2019
    Assignee: University of Tennessee Research Foundation
    Inventors: Stephen Andrew Sarles, Graham Jeffrey Taylor