Patents Examined by Robert J Eom
  • Patent number: 12103003
    Abstract: Analysis systems with a housing having a chamber sized and configured to receive at least one microfluidic device. The systems also include an optic system coupled to the housing in optical communication with the at least one microfluidic device, a controller coupled to the optic system, a heat source coupled to the optic system and thermally coupled to the at least one microfluidic device held in the housing, and a sub-array selection module in communication with the controller. The sub-array selection module is configured to select a sub-set of sets of microwells of at least one fluid channel of the microfluidic device for imaging by the optic system after a reaction step (e.g., one thermocycle) during an assay.
    Type: Grant
    Filed: November 5, 2019
    Date of Patent: October 1, 2024
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: William Hampton Henley, Adam D. Pfefferle, John Michael Ramsey, Ellen Foot Perkowski
  • Patent number: 12100290
    Abstract: A method includes transmitting, by a set of drive-sense circuits of a plurality of drive-sense circuits of a test system, a set of electrode signals on a set of test container electrodes of a test container of a test container array of the test system. The test container contains a content. The method further includes generating, by the set of drive-sense circuits, a set of sensed signals. The method further includes interpreting, by a processing module of the test system, the set of sensed signals as a plurality of impedance values and generating an impedance map based on the plurality of impedance values and with respect to positioning of the set of test container electrodes. The impedance map is representative of electrical characteristics of the content.
    Type: Grant
    Filed: April 29, 2021
    Date of Patent: September 24, 2024
    Assignee: SIGMASENSE, LLC.
    Inventors: Daniel Keith Van Ostrand, Richard Stuart Seger, Jr., Gerald Dale Morrison, Patrick Troy Gray, Phuong Huynh, Timothy W. Markison, Patricia M. Healy
  • Patent number: 12097308
    Abstract: The present invention relates to a bio-electrode having improved conductivity, flexibility and bio-compatibility, and a method of manufacturing the same. Specifically, the present invention relates to a conductive polymer bio-electrode including nano-porous permeable membrane, based on a bio-compatible polymer material having a plurality of pores and an improved surface area based on a PDMS device having a low mechanical strength and an excellent bio-compatibility, bio-signal transmission patterning, and a gold coating layer and has an excellent bio-compatibility and low rejection response while having a conductivity similar to that of a bio-electrode configured with a metal material of the related art. Therefore, the conductive polymer bio-electrode of the present invention is expected to be able to replace a bio-electrode configured with a metal material by which the bio-signal transmission efficiency is degraded due to a high bio-incompatibility.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: September 24, 2024
    Assignee: KNU-Industry Cooperation Foundation
    Inventor: Kwang Ho Lee
  • Patent number: 12099052
    Abstract: A method for detecting ingestion times comprises the following steps: obtaining hair samples or nail samples; sampling hair samples or nail samples per unit length, and judging whether the target ingested substance and its metabolites are present in each sample; and counting times of detected target ingested substance and its metabolites as the ingestion times.
    Type: Grant
    Filed: March 1, 2020
    Date of Patent: September 24, 2024
    Assignee: XIAMEN LISI TECH SERVICE CO., LTD.
    Inventors: Zhiyin Zeng, Kongtao Zhu, Hui Wu, Jiansheng Zeng
  • Patent number: 12100291
    Abstract: A test system includes a test container array including a plurality of test containers, and a plurality of electrodes integrated into the test container array. The test system further includes a plurality of drive-sense circuits coupled to the plurality of electrodes. When enabled, and when the test container contains a content, the set of drive-sense circuits transmit a set of electrode signals on the set of electrodes and generate a set of sensed signals. The test system further includes a processing module that includes a bandpass filter circuit operable to convert a sensed signal of the set of sensed signals to a filtered signal of a set of filtered signals and a frequency interpreter operable to convert the set of filtered signals into a set of impedance values, where the set of impedance values are representative of electrical characteristics of the content.
    Type: Grant
    Filed: May 31, 2021
    Date of Patent: September 24, 2024
    Assignee: SIGMASENSE, LLC.
    Inventors: Daniel Keith Van Ostrand, Richard Stuart Seger, Jr., Gerald Dale Morrison, Patrick Troy Gray, Phuong Huynh, Timothy W. Markison, Patricia M. Healy
  • Patent number: 12055543
    Abstract: In one aspect, a method of detecting tetrahydrocannabinol (THC) in a sample is disclosed, which comprises bringing the sample into contact with a graphene layer functionalized with an antibody exhibiting specific binding to THC, applying a time-varying electric field to said antibody-functionalized graphene layer, monitoring electrical resistance of said graphene layer in response to interaction with said sample, and detecting presence of THC in the sample by detecting a change in said electrical resistance indicative of interaction of THC with said anti-body functionalized graphene layer.
    Type: Grant
    Filed: April 10, 2020
    Date of Patent: August 6, 2024
    Assignee: Graphene-DX, Inc.
    Inventors: Mohammed Fotouhi, Mehdi Abedi, Edward Alvin Greenfield, Reza Mollaaghababa, Mohammad E. Taslim
  • Patent number: 12042277
    Abstract: A blood detection method and a blood detection device are disclosed. When a count number of platelet in a blood sample is less than a predetermined value, a detection solution of the blood sample is prepared. A cell statistical amount of the detection solution of the blood sample is increased to obtain the platelet detection result. The cell statistics amount of the detection solution of the blood sample may be increased in an impedance detection area to perform PLT-I detection, or in an RET detection area; or performing both of RET detection and PLT-O detection simultaneously. Thus, the accuracy of platelet detection can be improved when the number of platelets in the blood sample is low.
    Type: Grant
    Filed: December 27, 2019
    Date of Patent: July 23, 2024
    Assignee: SHENZHEN MINDRAY BIO- MEDICAL ELECTRONICS CO., LTD.
    Inventors: Xuerong Li, Huilin Shi, Jianchao Liu, Bo Ye
  • Patent number: 12025624
    Abstract: A device for detecting cotinine includes (a) a film that includes a plurality of molecularly-imprinted-polymer (MIP) coated conductive nanoparticles having specific affinity for binding with cotinine, and (b) two electrodes in contact with the film for passing electrical current through the film to detect binding with cotinine as a change in electrical conductivity of the film. A MIP coated conductive nanoparticle for detecting cotinine includes (a) a conductive nanoparticle, (b) a silicon dioxide coating formed on the conductive nanoparticle and forming a first shell around the conductive nanoparticle, and (c) an MIP coating formed on the silicon dioxide coating and forming the second shell, wherein the MIP coating includes a polymer molecularly imprinted with cotinine to provide specific affinity for binding of cotinine to the MIP coated conductive nanoparticle such that the cotinine is detectable as a change in electrical conductivity of the MIP coated conductive nanoparticle.
    Type: Grant
    Filed: October 25, 2021
    Date of Patent: July 2, 2024
    Assignee: THE TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Joseph J. Belbruno, Ziyi Chai
  • Patent number: 12024426
    Abstract: The present disclosure discloses a device for producing hydrogen through photothermal coupling of solar energy based on a frequency division technology, including a photothermal coupling reactor and a liquid storage tank and so on; during operation, a test sample containing a photothermal catalyst is placed in the photothermal coupling reactor, a light source is divided into an infrared light part and an ultravioiet light part through the solid-state frequency divider, energy of the infrared light part is finally transferred to the photothermal coupling reactor, and the ultraviolet light part is projected onto the photothermal catalyst. The present disclosure is used for an experiment for producing hydrogen through photothermal coupling of catalyst particles, and has advantages of environmental protection, high efficiency, simple and convenient operation and the like.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: July 2, 2024
    Assignee: XI'AN JIAOTONG UNIVERSITY
    Inventors: Liejin Guo, Dengwei Jing, Zilong Zeng, Lijing Ma, Maochang Liu
  • Patent number: 12018243
    Abstract: The present invention provides a device for adipose tissue processing, microfragmentation and facilitation of mechanical separation of adipose derived stem cells (“ADSCs”), methods of using the device to generate a stromal vascular fraction (“SVF”) and methods of the SVF.
    Type: Grant
    Filed: November 3, 2020
    Date of Patent: June 25, 2024
    Assignee: The Duke Limited
    Inventor: Marcos Sforza
  • Patent number: 12019051
    Abstract: A sensor apparatus includes: an element substrate; a detecting section disposed on an upper surface of the element substrate, the detecting section including a reaction section having an immobilization film to detect an analyte; a first IDT electrode configured to generate an acoustic wave which propagates toward the reaction section, and a second IDT electrode configured to receive the acoustic wave which has passed through the reaction section; and a protective film located on the upper surface of the element substrate so as to cover the first IDT electrode, the second IDT electrode, and at least part of the immobilization film, the protective film extending between and contacting with the immobilization film and at least one of the first IDT electrode and the second IDT electrode.
    Type: Grant
    Filed: May 3, 2021
    Date of Patent: June 25, 2024
    Assignee: KYOCERA CORPORATION
    Inventor: Kyohei Kobayashi
  • Patent number: 12017229
    Abstract: Assay cartridges are described that have a plurality of chambers and a fluidic network that includes fluidic conduits and a multi-port valve designed to selectively connect the valve inlet and one valve outlet through a fluidic connector in the valve as the remaining valve outlets are sealed.
    Type: Grant
    Filed: October 1, 2021
    Date of Patent: June 25, 2024
    Assignee: MESO SCALE TECHNOLOGIES, LLC.
    Inventors: Eli N. Glezer, Bandele Jeffrey-Coker, Kenneth Page, Sandor Kovacs, Sudeep Kumar, Kristian Roth
  • Patent number: 12013411
    Abstract: Devices and methods for rapidly and incrementally or continuously, measuring rheological properties of polymers under different shear rates. The device includes a pump configured to accept a continuous stream of sample solution during an interval of time, an injector configured to inject a flow of the sample solution through two or more viscometers, and a computing and processing device configured to monitor and measure rheological properties of the solution under at least two shear rates simultaneously in the two or more viscometers.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: June 18, 2024
    Assignees: YOKOGAWA FLUENCE ANALYTICS, INC., THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
    Inventors: Wayne Frederick Reed, Alex Reed, Michael Felix Drenski
  • Patent number: 12000826
    Abstract: The present invention provides for methods and compositions for detecting the presence of a food allergy or food intolerance in a subject. In one aspect, the present invention provides for methods and compositions for detecting the presence of a food allergy or food intolerance in a subject without risk of adverse reactions in the test subject. Furthermore, if a subject has multiple allergies, a single test can determine if there is any allergic component in a food composition or mixture, as opposed to doing multiple individual test for each allergen. In an additional aspect, the present invention provides for methods that do not require identification of any particular allergen of interest. In one or more embodiments, a single test can determine if there is any allergic component in a food composition or mixture without needed to identify the particular allergen itself.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: June 4, 2024
    Inventor: Anant Ramji
  • Patent number: 11986824
    Abstract: A system and method for determining a trajectory parameter of particles, comprising receiving a plurality of particles at a microfluidic channel, applying a force to each particle of the microfluidic channel, acquiring a dataset of each particle, measuring a trajectory of the particle, and determining a trajectory parameter of the particles.
    Type: Grant
    Filed: August 13, 2021
    Date of Patent: May 21, 2024
    Assignee: CytoVale Inc.
    Inventors: Henry Tat Kwong Tse, Ajay M. Shah, Lionel Guillou, Roya Sheybani, Christopher Dahlberg, Anne E. Jensen
  • Patent number: 11988662
    Abstract: Methods and sensors for the detection, identification, and quantification of one or more gas species, including volatile organic compounds, in a test sample are described. Methods employ gas sensors comprising a diffusion matrix present on the sensor surface. A gas analyte in a test sample diffuses through the matrix and is detected upon interaction of the analyte with the sensor. A response profile of a gas sensor to a gas analyte in the test sample is compared to a control gas sensor response profile determined in a similar manner for a known gas species. Comparisons of test sample and control sample sensor response profiles enable detection, identification, and quantification of a gas species analyte in a test sample.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: May 21, 2024
    Assignee: Nanohmics, Inc.
    Inventors: Steve M. Savoy, Kyle W. Hoover, Daniel R. Mitchell, Jeremy J. John, Chris W. Mann, Alexander P. Greis
  • Patent number: 11964275
    Abstract: Microfluidic devices having an electrowetting configuration and an optimized droplet actuation surface are provided. The devices include a conductive substrate having a dielectric layer, a hydrophobic layer covalently bonded to the dielectric layer, and a first electrode electrically coupled to the dielectric layer and configured to be connected to a voltage source. The microfluidic devices also include a second electrode configured to be connected to the voltage source. The hydrophobic layer features self-associating molecules covalently bonded to a surface of the dielectric layer in a manner that produces a densely-packed monolayer that resists intercalation and or penetration by polar molecules or species.
    Type: Grant
    Filed: August 27, 2020
    Date of Patent: April 23, 2024
    Assignee: Berkeley Lights, Inc.
    Inventors: Randall D. Lowe, Jr., Shao Ning Pei, Jian Gong, Alexander J. Mastroianni, Jason M. McEwen, Justin K. Valley
  • Patent number: 11959063
    Abstract: A system and a method is disclosed for adjusting and/or optimizing a fermentation process performed in one U-loop fermenter, the system including a processor and database for repetitively providing a test value of a fermenter parameter and for repetitively entering the test value of the parameter in the database; wherein the database stores multiple test value entries at various points in time and also stores multiple control value entries at various points in time, wherein the processor performs a mathematical analysis of the test value for providing a calculated test value, and/or the control value for providing at least one calculated control value; and selects, on the basis of the calculated test value and/or on the calculated control value, an adjustment to be introduced into at least one other U-loop fermenter to benefit from the change made in the one U-loop fermenter.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: April 16, 2024
    Assignee: UNIBIO A/S
    Inventors: Ib Christensen, Leander Petersen, Andre Kofoed Drejer, John Bagterp Jorgensen, Sten Bay Jorgensen, Jorgen K. H. Knudsen
  • Patent number: 11959846
    Abstract: A method for providing in situ chemical transformation and ionization of a portion (e.g., inorganic oxidizer) of a sample via an analyte detection system is disclosed herein. The method includes introducing a gas into an ionization some of the analyte detection system via an inlet. The method further includes generating ions within the ionization source and directing the gas and generated ions through and out of the ionization source and to the sample. The sample is located proximal to the ionization source in an ambient environment. The ions chemically react with the sample and desorb and ionize an analytic from the sample, the analyte being generated from the inorganic oxidizer, the desorbed analyte having a lower melting point and/or better desorption kinetics than the inorganic oxidizer. The method further includes receiving the desorbed analyte via an analyzer of the analyte detection system.
    Type: Grant
    Filed: March 2, 2020
    Date of Patent: April 16, 2024
    Assignee: Smiths Detection Montreal Inc.
    Inventors: Jan Hendrikse, Vladimir Romanov
  • Patent number: 11946931
    Abstract: Methods, systems and devices for detecting the presence of a pathogen, for example, a virus (e.g., SARS-CoV-2), or its molecular components, in health care-related samples and/or environmental samples are disclosed. An example system for improving detection of a pathogen includes biosensor device comprising a detection chip and at least one probe that specifically recognizes a pathogen, where the detection chip comprises a graphene field-effect transistor (FET) chip and the probe, which comprises an aptamer, specifically binds to a DNA, RNA, or protein associated with the pathogen.
    Type: Grant
    Filed: January 31, 2022
    Date of Patent: April 2, 2024
    Inventors: Deependra Kumar Ban, Ratnesh Lal, Gennadi Glinskii, Prabhakar R. Bandaru, Sunil Srivastava, Scott John, Tyler Bodily, Abhijith Karkisaval Ganapati