Abstract: An EWOD device includes a first substrate assembly and a second substrate assembly; wherein one of said substrate assemblies includes electrowetting electrodes, and the first substrate assembly and the second substrate assembly are spaced apart to define a channel between the substrate assemblies; and a housing for receiving the first substrate assembly and the second substrate assembly, the housing comprising an alignment feature for locating at least one of the first and second substrate assemblies within the housing. The device further includes a fixing feature for fixing the first and second substrate assemblies within the housing. The second substrate assembly is located within the housing such that the second substrate assembly is an outer component of the EWOD device. The device further may include a spacer that spaces apart the first substrate assembly from the second substrate assembly to define the channel between the first and second substrate assemblies.

Abstract: A system that includes a sensor for measuring a resonant impedance spectral response of an inductor-capacitor-resistor (LCR) resonator and correlating the measured response of one or more spectral parameters to one or more characteristics of the fluid. Such characteristics may be the age or health of the fluid and/or the identification of and concentration of components in the fluid.

Abstract: A semiconductor biosensor includes a central reaction unit of an inspection equipment. The central reaction unit includes a plurality of first conducting wires, a plurality of second conducting wires, a common electrode source, a plurality of sense-amplifiers, a plurality of non-volatile memory type transistors, and a first oxide film. Each sense-amplifier is connected to a respective second conducting wire. The non-volatile memory type transistors are respectively formed on the second conducting wires. Each non-volatile memory type transistor includes a control gate, a third oxide film, a floating gate, and a second oxide. The first oxide film wraps or covers the first conducting wires. Receptors are fixed on a surface of the first oxide film. A portion of the targets couples with a portion of the receptors to form composite bodies. The sense-amplifiers are configured to detect a change in a current signal based on the charges of the composite bodies.

Abstract: A device for the detection of a target analyte in solution is provided. The device comprises a gate-keeper membrane made of a substrate having a first receptor surface for exposure to the target analyte and a second opposing surface exposed to a detector, wherein the substrate is adapted to incorporate pores sufficient to permit passage of a reporter through the membrane from exposure to the first receptor surface to the second opposing surface; one or more receptors anchored on the first surface of the substrate which bind with the target analyte, wherein binding of the receptor with the target analyte alters the passage of the reporter through the pores of the membrane; and one or more detectors which interact with reporter that passes through the membrane and emits a detectable signal that permits quantification of reporter in the detection reservoir.

Abstract: The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within microfluidic channels, and detect those nucleotides.

Abstract: The present disclosure provides methods for detecting biological print(s) or biological fluid(s) or target low molecular weight analyte(s) therein comprising contacting the suspected print(s) or fluid(s) with porous semiconductor substrates or microparticles (MPs) under conditions to allow said semiconductor substrates or microparticles to adhere to the print(s) or fluid(s) or analyte(s) therein, and analysing the adhered porous semiconductor substrates or MPs to detect the print(s), fluid(s) or analytes when present. The disclosure also includes method for making porous semiconductor substrates.

Abstract: A bioFET device includes a semiconductor substrate having a first surface and an opposite, parallel second surface and a plurality of bioFET sensors on the semiconductor substrate. Each of the bioFET sensors includes a gate formed on the first surface of the semiconductor substrate and a channel region formed within the semiconductor substrate beneath the gate and between source/drain (S/D) regions in the semiconductor substrate. The channel region includes a portion of the second surface of the semiconductor substrate. An isolation layer is disposed on the second surface of the semiconductor substrate. The isolation layer has an opening positioned over the channel region of more than one bioFET sensor of the plurality of bioFET sensors. An interface layer is disposed on the channel region of the more than one bioFET sensor in the opening.

Abstract: A device and a method for measuring small voltages and potentials on biological, chemical and other samples. The device comprises at least one field effect transistor including a source, a drain, a gate that is in contact with the sample and insulated by a gate dielectric from the conducting channel of the field effect transistor, means for applying a voltage between the source and the drain, and means for applying a bias voltage to the gate. The gate dielectric includes at least one attachment site in the interior thereof, which is able to trap charge carriers from the channel and, conversely, to release these to the channel.

Abstract: The present disclosure provides a method of fabricating a nanoporous thin film device comprising depositing a template on a substrate to form a nanoporous insulating layer, the template comprising one or more polymers capable of forming pores when polymerized and at least one cross-linking agent, and depositing a second layer (e.g. organic semiconductor, semiconductor, insulator) on the nonporous insulating layer to form a thin film having a plurality of isolated nanopores on the surface. Nanoporous semiconductor thin films made by these methods is provided. Sensors and devices comprising the nanoporous thin film is also disclosed.

Abstract: A chemical sensor and a system and method for sensing a chemical species. The chemical sensor includes a plurality of nanofibers whose electrical impedance varies upon exposure to the chemical species, a substrate supporting and electrically isolating the fibers, a set of electrodes connected to the plurality of fibers at spatially separated points to permit the electrical impedance of the plurality of fibers to be measured, and a membrane encasing the fibers and having a thickness ranging from 50 ?m to 5.0 mm. The system includes the chemical sensor, an impedance measuring device coupled to the electrodes and configured to determine an electrical impedance of the plurality of fibers, and an analyzer configured to identify the chemical species based on a change in the electrical impedance.

Abstract: In one aspect, the inventive concepts disclosed herein are directed to a sensor assembly which contains a first planar substrate and a second planar substrate which respectively support opposing sensor arrays and contains an integrated flow path extending between the first and second substrates. Sensor assembly contains a first planar substrate having a base layer, and a conductive layer formed on a first planar surface of the base layer. Base layer may be made from, for example, ceramic, polymer, foil, or any other type of material known to someone of ordinary skill in the art. Conductive layer contains at least at least two electrically isolated electrical contacts made, for example, using a thick film approach (e.g., screen printing, rotogravure, pad printing, stenciling conductive material such as carbon, Cu, Pt, Pd, Au, and/or Nanotubes, etc.) or a thin firm approach (e.g., by sputtering, thermal spraying, and/or cold spraying conductive material).

Abstract: Provided here are cell detection systems, fluidic devices, structures and techniques related to particle and cell sorting and detection in fluid, for example sorting specific subpopulations of cell types. A method for verification of sorting of particles includes receiving a first detection signal that is associated with optical characteristics of a particle in a first channel. A sorting channel of a plurality of second channels is determined based on the first detection signal, thereby determining the sorting of the particle into the sorting channel based on the optical characteristics of the particle. A sorting signal for sorting the particle from the first channel into the sorting channel is transmitted. A second detection signal is received that is associated with the presence of the particle in the sorting channel. The sorting of the particle from the first channel into the sorting channel is verified based on the second detection signal.

Abstract: A bulk acoustic wave MEMS resonator device includes at least one functionalization (e.g., specific binding or non-specific binding) material arranged over a top side electrode, with at least one patterned enhanced surface area element arranged between a lower surface of the top side electrode and the functionalization material. The at least one patterned enhanced surface area element increases non-planarity of the at least one functionalization material, thereby providing a three-dimensional structure configured to increase sensor surface area and reduce analyte diffusion distance, and may also promote fluid mixing. Methods for biological and chemical sensing, and methods for forming MEMS resonator devices and fluidic devices are further disclosed.

Abstract: A sensor component includes a sensor including a sensor surface and a reaction site in cooperation with the sensor and exposing the sensor surface. The reaction site including a reaction site surface. A surface agent is bound to the reaction site surface or the sensor surface. The surface agent includes a surface active functional group reactive with Bronsted base or Lewis acid functionality on the reaction site surface or the sensor surface and including distal functionality that does not have a donor electron pair.

Abstract: A gas measurement system for measuring the concentration of gaseous and/or vaporous components of a gas mixture by means of the color change of at least one reaction substance on a reaction support unit in which the at least one reaction substance is arranged on the reaction support unit separately within at least two light permeable channels is provided in such a manner that data can be read out reliably at low technical expense. The data reading device can be designed as a digital camera and/or as a reading apparatus for an electronic data storage device.

Abstract: Microfluidic devices having an electrowetting configuration and an optimized droplet actuation surface are provided. The devices include a conductive substrate having a dielectric layer, a hydrophobic layer covalently bonded to the dielectric layer, and a first electrode electrically coupled to the dielectric layer and configured to be connected to a voltage source. The microfluidic devices also include a second electrode, optionally included in a cover, configured to be connected to the voltage source. The hydrophobic layer features self-associating molecules covalently bonded to a surface of the dielectric layer in a manner that produces a densely-packed monolayer that resists intercalation and or penetration by polar molecules or species.

Abstract: An integrated circuit (IC) with an impedance sensor fabricated on a surface of the substrate is disclosed. The impedance sensor includes a bottom conductive plate formed on the substrate. A sensing membrane is formed on the bottom conductive plate. A top conductive plate is formed on the sensing membrane, in which the top conductive plate is a fusion of conductive nanoparticles having a random three dimensional porosity that is permeable to a reagent.

Abstract: Multimodal biosensor devices are disclosed. A device may include at least two sensors selected from: (i) a nanomechanical resonator; (ii) plasmonic nanodisk antennae; and (iii) a field effect transistor. The biosensor device is capable of transducing the adsorption of biomolecules onto the biosensor device into optical, electrical and/or mechanical signals.

Abstract: A processing and detection system for detecting presence of at least one gluten protein in a food sample comprises a food processor including: a reservoir containing a process liquid for processing the food sample; a body that comprises a chamber configured to receive the food sample; and a pressing surface configured to press on the reservoir to cause the process liquid to exit the reservoir and mix with the food sample, thereby generating a processed food liquid; and an exit port configured to conduct the processed food liquid out of the food processor; and a cartridge including: at least one sensor configured to receive the processed food liquid and to generate an electrical signal in response to interaction with the at least one gluten protein in the processed food liquid, and an analyzer in electrical communication with the at least one sensor for detecting the electrical signal and determining the presence of the at least one gluten protein in the food sample based on the detected electrical signal.

Abstract: The present disclosure provides a semiconductor hydrogen sensor and a manufacturing method thereof. The semiconductor hydrogen sensor comprises: a substrate; a gas-sensitive material pattern and a metal electrode pattern arranged in a same layer and distributed alternatingly on a side of the substrate; and a two-dimensional material filter layer arranged on a side surface of the gas-sensitive material pattern and the metal electrode pattern facing away from the substrate.