Patents Examined by Robert J Eom
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Patent number: 11079339Abstract: The present invention relates to a biosensor (1) which enables the concentration of a desired molecule inside a liquid in the medium, and essentially comprises at least one metallic plate (2) which functions as a ground plate, and which is preferably manufactured from aluminum, at least one dielectric substrate (3) which is located on top of the metallic plate (2), at least one split-ring resonator (4) which is realized on top of the dielectric substrate (3), and which is coated with a dielectric layer, at least two symmetrical antennas (5) which are realized on the same plane with the split-ring resonator (4) on the substrate (3), at least two ports (6) where a network analyzer is connected with the antennas (5) via SMA (SubMiniature Version A) connectors.Type: GrantFiled: June 5, 2018Date of Patent: August 3, 2021Assignee: BOGAZICI UNIVERSITESIInventors: Hamdi Torun, Arda Deniz Yalcinkaya, Gunhan Dundar
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Patent number: 11059043Abstract: A microfluidic system includes a microfluidic chip including a channel layer and a fluid control layer operatively connected to the channel layer, the channel layer having one or more fluid channels. The one or more channels are configured to contain a plurality of droplets. A valve control system is provided to control flow of fluid through the one or more fluid channels in the channel layer. The microfluidic system also includes a droplet impedance detection and feedback control system operatively connected to the valve control system. The droplet impedance detection and feedback control system is configured to detect at least a position of at least one droplet in a fluid channel and to send a signal to the valve control system to operate a particular valve at a particular time based on the detected position of the at least one droplet.Type: GrantFiled: April 19, 2017Date of Patent: July 13, 2021Assignees: The Johns Hopkins University, Pioneer Hi-Bred International, Inc.Inventors: Tza-Huei Wang, Brant Axt, Yi-Fan Hsieh, Helena C. Zec, Aniruddha Kaushik, Kuangwen Hsieh, Yue Yun
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Patent number: 11041828Abstract: The invention relates to a measuring arrangement comprising: a coil arrangement for creating a magnetic field to measure a sample to be arranged in connection with it including at least one flat coil, the coil geometry of which is arranged to be changed in the direction of the plane defined by the coil arrangement, in order to create a spatially changing magnetic field having a known distance dependence for measuring the sample; and electronics connected to the coil arrangement for creating a magnetic field using the coil arrangement; and means for changing the position of the sample and the coil arrangement relative to each other in order to change the magnetic field affecting the sample and having the known distance dependence. In addition, the invention also relates to a method for measuring a sample.Type: GrantFiled: March 20, 2015Date of Patent: June 22, 2021Assignee: MAGNASENSE TECHNOLOGIES OYInventor: Markus Savonen
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Patent number: 11035794Abstract: An optode has a planar radiation guiding medium having a first planar surface and a second planar surface and one or more perimeter surfaces bounded by the first and second planar surfaces. An excitation energy source of the optode is configured to output into the radiation guiding medium first energy at a wavelength selected to excite a fluorophore. The optode also includes a photodetector configured to image at least a portion of the first planar surface of the radiation guiding medium by detecting second energy transmitted through the radiation guiding medium.Type: GrantFiled: September 28, 2018Date of Patent: June 15, 2021Assignees: UCHICAGO ARGONNE, LLC, THE UNIVERSITY OF CHICAGO, THE MARINE BIOLOGICAL LABORATORYInventors: Xufeng Zhang, Supratik Guha, Zoe G. Cardon
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Patent number: 11029288Abstract: A sensor apparatus includes: an element substrate; a detecting section disposed on an upper surface of the element substrate, the detecting section including a reaction section having an immobilization film to detect an analyte; a first IDT electrode configured to generate an acoustic wave which propagates toward the reaction section, and a second IDT electrode configured to receive the acoustic wave which has passed through the reaction section; and a protective film located on the upper surface of the element substrate so as to cover the first IDT electrode, the second IDT electrode, and at least part of the immobilization film, the protective film extending between and contacting with the immobilization film and at least one of the first IDT electrode and the second IDT electrode.Type: GrantFiled: October 30, 2015Date of Patent: June 8, 2021Assignee: KYOCERA CORPORATIONInventor: Kyohei Kobayashi
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Patent number: 11021785Abstract: A microfluidic device for use with a microfluidic delivery system, such as an organic vapor jet printing device, includes a glass layer that is directly bonded to a microfabricated die and a metal plate via a double anodic bond. The double anodic bond is formed by forming a first anodic bond at an interface of the microfabricated die and the glass layer, and forming a second anodic bond at an interface of the metal plate and the glass layer, where the second anodic bond is formed using a voltage that is lower than the voltage used to form the first anodic bond. The second anodic bond is formed with the polarity of the voltage reversed with respect to the glass layer and the formation of the first anodic bond. The metal plate includes attachment features that allow removal of the microfluidic device from a fixture.Type: GrantFiled: December 13, 2017Date of Patent: June 1, 2021Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, UNIVERSAL DISPLAY CORPORATIONInventors: Stephen Forrest, Gregory McGraw, Siddharth Harikrishna Mohan, Diane L. Peters
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Patent number: 11013823Abstract: A chromogenic absorbent material for detecting a detectable substance in a water-containing medium, such as animal urine, is provided. The detectable substance may be indicative of a disease or condition, and the water-containing medium may be an excretion, blood, plasma, an aqueous solution or a solid impregnated with an aqueous solution. The chromogenic absorbent material may include a trigger agent, a chromogenic indicator convertible into a chromogenically active substance in the presence of the trigger agent and the detectable substance, and an absorptive material which is porous, for absorbing the water-containing medium. The absorptive material may include a water-absorbing polysaccharide providing absorptive properties to the chromogenic absorbent material. The trigger agent, the chromogenic indicator and the detectable substance are preferably unreactive to the absorptive material.Type: GrantFiled: September 1, 2016Date of Patent: May 25, 2021Assignee: 7905122 CANADA INC.Inventors: Paul Jollez, Isabelle Bolduc, Stéphane Chevigny, Olivier Sigouin
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Patent number: 11002704Abstract: Biosensor devices and methods of forming the same are provided. A cavity is formed in a substrate and is configured to receive one or more charged molecules. A transistor is formed in the substrate and includes a source region, a drain region, and a channel region that are spatially separated from the cavity in a lateral direction. A gate of the transistor is disposed below the cavity and extends between the cavity and the source, drain, and channel regions. A voltage potential of the gate is based on a number of the charged molecules in the cavity.Type: GrantFiled: August 31, 2016Date of Patent: May 11, 2021Assignee: Taiwan Semiconductor Manufacturing Company LimitedInventors: Tung-Tsun Chen, Chien-Kuo Yang, Jui-Cheng Huang, Mark Chen, Ta-Chuan Liao, Cheng-Hsiang Hsieh
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Patent number: 10996188Abstract: The present disclosure relates to a device in particular, a sensor for determining a measurand correlated with a concentration of an analyte in a measuring medium, including a housing that has a region provided for contacting the measuring medium, a fluid line arranged in the housing, an interface that is arranged within the region provided for contacting the measuring medium and has a first side which is in contact with the fluid line and a second side which is in contact with an environment of the housing in particular, with the measuring medium in contact with the housing, a first reservoir that is arranged in the housing and fluidically connected to the fluid line and which contains a reagent intended for contacting and/or interacting with the analyte, and a transport mechanism that is designed to transport reagent from the first reservoir into the fluid line.Type: GrantFiled: December 14, 2017Date of Patent: May 4, 2021Assignee: Endress+Hauser Conducta GmbH+Co. KGInventors: Torsten Pechstein, Thomas Wilhelm, Michael Hanko
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Patent number: 10994274Abstract: An EWOD device includes a first substrate assembly and a second substrate assembly; wherein one of said substrate assemblies includes electrowetting electrodes, and the first substrate assembly and the second substrate assembly are spaced apart to define a channel between the substrate assemblies; and a housing for receiving the first substrate assembly and the second substrate assembly, the housing comprising an alignment feature for locating at least one of the first and second substrate assemblies within the housing. The device further includes a fixing feature for fixing the first and second substrate assemblies within the housing. The second substrate assembly is located within the housing such that the second substrate assembly is an outer component of the EWOD device. The device further may include a spacer that spaces apart the first substrate assembly from the second substrate assembly to define the channel between the first and second substrate assemblies.Type: GrantFiled: July 12, 2017Date of Patent: May 4, 2021Assignee: Sharp Life Science (EU) LimitedInventors: Lesley Anne Parry-Jones, Emma Jayne Walton
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Patent number: 10989705Abstract: A micro-electromechanical platform and array system and methods for identifying microbial species with single molecule electrical conductance measurements are provided. The electromechanical platform has a two-tier actuation mechanism with a long stroke provided by a comb drive and a fine stroke provided by an in-plane flexural actuator. The platform is capable of making contact with a single-molecule, applying a bias, measuring the current, and performing a large number of measurements for statistical analysis. The system is capable of detecting any microbial species without requiring enzymatic amplification by detecting specific RNA sequences, for example. With oligonucleotide target molecules, the conductance is extremely sensitive to the sequence so even single-nucleotide polymorphisms can be identified. The system can also discern between subspecies using the same DNA probe.Type: GrantFiled: July 11, 2017Date of Patent: April 27, 2021Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Joshua Hihath, Xiaoguang Liu, Maria Louise Marco
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Patent number: 10989677Abstract: Provided is a fluorescent X-ray analysis apparatus, including: a collecting portion configured to drop a liquid droplet onto a substrate having an object to be measured on a surface thereof and move the dropped liquid droplet on the surface of the substrate to collect the object to be measured into the liquid droplet; a drying portion configured to dry the liquid droplet so that the object to be measured is held onto the surface of the substrate; an analysis portion configured to irradiate the object to be measured with an X-ray and perform quantitative analysis of an element contained in the object to be measured based on a fluorescent X-ray output from the object to be measured; a beam sensor configured to emit a laser having a band shape for detecting an amount of the liquid droplet separated from the collecting portion before the liquid droplet is dried after the object to be measured is collected; and a calculating portion configured to calculate a correction coefficient for correcting the amount of theType: GrantFiled: February 22, 2018Date of Patent: April 27, 2021Assignee: RIGAKU CORPORATIONInventor: Seiitsu Kurita
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Patent number: 10983242Abstract: A subterranean characterization and fluid sampling device for analyzing a fluid from a subterranean formation includes a controller, a tool body, and a probing module. The tool body includes a fluid testing module configured to receive a sample of the fluid from the subterranean formation and a permanent magnet configured to induce a static magnetic field (B0). The probing module is coupled to the tool body and separate from the permanent magnet, and configured to withdraw the fluid from the formation and deliver the fluid to the testing module. The probing module comprises an antenna that generates a radio frequency magnetic field (B1) in response to a signal from the controller.Type: GrantFiled: August 8, 2016Date of Patent: April 20, 2021Assignee: Halliburton Energy Services, Inc.Inventors: Lilong Li, Songhua Chen, Arcady Reiderman
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Patent number: 10976293Abstract: A method and device for processing an agricultural product is provided. The device includes a chamber having an opening, and a heater operative to heat the contents of the chamber. A sensor having an output is coupled to the chamber, the sensor output being processed to provide information about at least one of: a state of decarboxylation, or a quantity of a material in the contents of the chamber. The method includes loading a quantity of the agricultural product in a chamber having an port and applying an elevated temperature to the chamber to increase a rate of decarboxylation. A property of a gas is measured at the port the measurement being processed to determine one of either: a state of decarboxylation, or a quantity of material in the sample.Type: GrantFiled: December 30, 2017Date of Patent: April 13, 2021Inventor: Mark Alan Lemkin
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Patent number: 10968421Abstract: A method is provided for measuring parameters of state of a fluid contained in a container (10, 10?) that has a sensor carrier plate with plural sensors (S01-S10, S01?-S10?). Each sensor has a sensor head in operative contact with the interior of the container (10, 10?) and in operative contact with an external control unit (12). The external control unit (12) receives measurement data generated by the sensor heads of active sensors via their communication link and processes the data. An activation data record (24, 24?) is assigned to each sensor (S01-S10, S01?-S10?) and is recorded in a manner that is accessible for the external control unit (12). The external control unit (12) first accesses the activation data records (24, 24?), then classifies the sensors (S01-S10, S01?-S10?) as activatable or nonactivatable sensors, and subsequently activates only those sensors classified as activatable sensors.Type: GrantFiled: April 27, 2016Date of Patent: April 6, 2021Inventors: Mario Becker, Gerhard Greller, Christian Grimm, Thorsten Adams, Lars Boettcher, Henry Weichert
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Patent number: 10955412Abstract: The specification provides an assay electrode including a composite containing a matrix and a multiplicity of graphene particles dispersed therein.Type: GrantFiled: May 8, 2015Date of Patent: March 23, 2021Assignee: MESO SCALE TECHNOLOGIES, LLC.Inventors: Mark Billadeau, Paul Freese, Alan Kishbaugh, Gisbert Spieles, Nicholas Fox-Lyon
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Patent number: 10942109Abstract: The present disclosure relates to compositions comprising a hydrogel particle with optical properties substantially similar to the optical properties of a target cell, and methods for their use.Type: GrantFiled: November 15, 2019Date of Patent: March 9, 2021Assignee: Slingshot Biosciences, Inc.Inventors: Jeffrey Kim, Oliver Liu, Jeremy Agresti, Anh Tuan Nguyen
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Patent number: 10942191Abstract: There is provided a sensor and the like which can detect a first substance with high accuracy. A sensor for detecting whether an analyte contains a first substance, includes a base and a detection section including a second substance immobilized on a surface of the base. The second substance includes an amino acid, a bond which can be cleaved by a reaction with an enzyme, and a first compound which is bonded to the amino acid by the bond and includes a first group capable of bonding to other substances, and the analyte is configured to be introduced to the detection section by being contacted with a third substance which generates the enzyme by a reaction with the first substance.Type: GrantFiled: December 27, 2013Date of Patent: March 9, 2021Assignees: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION, KYOCERA CORPORATIONInventors: Hiroyasu Tanaka, Hideharu Kurioka, Shinsuke Sando
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Patent number: 10942110Abstract: A system and method for detecting particles in a fluidic medium using a microfluidic sensor is described. The system utilises microfluidic channels though which the fluidic medium is passed. On one section of the microfluidic channel, an array of non-flexible electrodes are coupled with uniform spacing therebetween. On the opposing section of the channel, a flexible electrode is coupled and all electrodes are connected to an electrical analyser which is used to generate an electrical field inside the microfluidic channel with the flexible electrode acting as ground. The flexible electrode is actuated by different means to narrow the width of the microfluidic in the section of interest and to capture the particle between the section, where sectional scans of the particles are obtained and electrical properties of the particle are measured, thereby detecting the particles in the fluidic medium.Type: GrantFiled: June 15, 2017Date of Patent: March 9, 2021Assignee: UNITED ARAB EMIRATES UNIVERSITYInventor: Mahmoud F. Y. Al Ahmad
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Patent number: 10926263Abstract: Methods and apparatus to mitigate bubble formation in a liquid are disclosed. An example apparatus disclosed herein includes a bottom wall, a first baffle cantilevered from the bottom wall, and a second baffle cantilevered from the bottom wall. The first baffle is spaced apart from the second baffle, and the first baffle and the second baffle are positioned radially relative to an axis of rotation of the apparatus.Type: GrantFiled: August 21, 2018Date of Patent: February 23, 2021Assignee: Abbott LaboratoriesInventors: Robert Paul Luoma, II, Brian Ochranek, Cheryl L. Davidson, Bradley C. Weston