Abstract: A plethysmograph is constructed with a base including parallel, horizontal guide rails; an open-ended, moveable enclosure section having a horizontal central axis slidable on the guide rails between open and closed positions; a fixed enclosure section mounted on the base transverse to the horizontal pathway, the fixed enclosure section including an inner face toward the open end of the enclosure section adapted for sealing engagement with the open end of the moveable enclosure section when the moveable enclosure section is in its closed position; and a support table attached to the fixed section, the table projecting into the moveable enclosure section when the moveable enclosure section is in the closed position, the table being vertically adjustable and having an angularly adjustable longitudinal axis.

Abstract: An apparatus for assessing the brain state of a patient comprises at least one sensor to monitor at least one physiological variable, which provides at least one output signal. In addition, the apparatus for assessing the brain state of a patient comprises a computer processor for receiving the at least one output signal, wherein the computer processor filters the at least one output signal and applies pattern recognition techniques in evaluating the brain state of the subject. The computer processor comprises a first filtering module, which removes transient events not indicative of a brain state, and a second filtering sub-module, which groups together multiple modalities on the basis of classification techniques and incorporates additional information regarding mental states.

Abstract: Apparatuses and methods for medical monitoring physiological characteristic values such as blood glucose levels for the treatment of diabetes, are presented. The apparatuses and methods provide for preventing any negative consequence in the operation of a monitor and/or infusion device as a result of disorientation that may occur from waking from slumber with a low blood glucose level. In addition, a graphical display is disclosed incorporating a variety of enhancements which readily conveys to the user historical as well as real time information regarding the measured characteristic value.

Abstract: A method and apparatus of assessment of relative changes in the cross sectional area of a limb artery. The method includes applying to the artery an external pressure, which causes the cross-sectional area of the artery to change between systole and diastole much more than if the pressure is not applied, determining, over one or more cardiac cycles, a baseline value for a parameter related to the cross-sectional area of the artery, while the pressure is applied, applying a stimulus to the artery, determining, over one or more cardiac cycles, a stimulus-affected value for the parameter related to the cross-sectional area of the artery, while the pressure is applied and while the artery is in a dilated state affected by the stimulus and evaluating the artery based on a comparison of the determined stimulus-affected and baseline values, the baseline value is determined while the artery is substantially not affected by the stimulus.

Abstract: A device for directly measuring a person's respiratory exchange ratio (RER) utilizes a Zn-air battery cell and a constant current load circuit as an O2 pump capable of drawing oxygen from expired air. A thermistor located in the flow path forms a leg of a bridge circuit whose output is proportional to oxygen concentration in the expired air and, therefore, to oxygen uptake. The thermistor flowmeter circuit utilizes the thermal conductivity differences between O2 and CO2 to provide a measure at the relative ratio of the two gases present.

Abstract: A peak flow meter is described with a body having a sample channel and at least one bypass channel. One of at least two flow range scales may be selected using a flow range selector to adjust the sensitivity of the peak flow meter. A flow range selection indicator provides visual reference as to which flow range scale has been selected. A peak flow calculator used in cooperation with zone indicators on the peak flow meter permits a user to customize the peak flow meter for that user's predicted personal best exhalation range.

Abstract: This document discusses, among other things, a cardiac rhythm management device or other implantable medical device that uses thoracic impedance to determine how much fluid is present in the thorax, such as for detecting or predicting congestive heart failure, pulmonary edema, pleural effusion, hypotension, or the like. The thoracic fluid amount determined from the thoracic impedance is compensated for changes in blood resistivity, which may result from changes in hematocrit level or other factors. The blood-resistivity-compensated thoracic fluid amount can be stored in the device or transmitted to an external device for storage or display. The blood-resistivity-compensated thoracic fluid amount can also be used to adjust a cardiac pacing, cardiac resynchronization, or other cardiac rhythm management or other therapy to the patient. This document also discusses applications of the devices and methods for predicting or indicating anemia.

Abstract: Disclosed herein is a method of measuring an absolute lung volume. In the method, concentrations of oxygen and carbon dioxide gases are measured and analyzed in respiratory gas, consisting of nitrogen (N2), oxygen (O2), and carbon dioxide (CO2), to indirectly measure a concentration of nitrogen, thereby achieving measurement of absolute lung volume, such as a functional residual capacity.

Abstract: Systems and methods obtain information that allows detection of whether a patient suffers from congestion by monitoring a response of the patient to a recumbent position of the patient's body. The patient may be monitored to determine a respiration pattern for a non-recumbent position such as standing and a respiration pattern for a recumbent position such as lying down. The two patterns may be compared, either by a processing device or a physician, to determine a difference in the two respiration patterns. Furthermore, the congestion may be inferred from detecting an amount of time that the patient spends in a recumbent position or from detecting the recumbent angle that the patient obtains, either of which is presumed to indicate whether a recumbent position presents discomfort to the patient due to the presence of congestion.

Abstract: A system and method for calibrating a sensor. The method may include, without limitation, compiling an array of data relating to the sensor; adjusting a sensor parameter a first time based on data in the array; adjusting a curve representing the sensor output based on data in the array; and adjusting the sensor parameter a second time based on data in the array. The sensor may be an in vivo glucose sensor and the sensor parameter adjusted may be a current. The array may include historical as well as recent data, such as, for example, blood glucose readings and sensor electrode readings.

Abstract: A method of sensing the concentration level of at least one particular electrolyte in the sweat fluid of a subject, includes providing a sweat sensor system having sweat fluid absorbing material, measuring apparatus for sensing the electrical conductivity of sweat fluid absorbed by the absorbing material and producing ionic concentration data for said at least one particular electrolyte, and a user interface connected to the measurement apparatus for interpreting the data to a user. The absorbing material is applied to the skin of the subject to cause sweat fluid thereon to be absorbed by the absorbing material whereby the measurement apparatus produces ionic concentration data for the sweat fluid absorbed and the user interface interprets the data for a user.

Abstract: One embodiment is a microprobe. An example of the microprobe comprises a housing having an aperture. This example of the microprobe also comprises an ISFET attached to the housing. The ISFET may have a gate located proximate the aperture. This example of the microprobe further comprises a reference electrode attached to the housing proximate the aperture. Another embodiment is a microsensor system. Another embodiment is a method for measuring a characteristic of tissue. Yet another condition embodiment is a method for monitoring tissue pH.

Abstract: The invention relates to an apparatus for collection of airway gases from a subject comprising a first means for producing closure of the velum of the subject, and a second means for collection of the airway gases, wherein the first and second means need not be integral with each other.

Abstract: In one embodiment, a method includes but is not limited to: conditioning an inhalent environment; exposing a first organism to the inhalent environment for a first-organism duration of time; and exposing a second organism to the inhalent environment for a second-organism duration of time. In one embodiment, a method includes but is not limited to: conditioning an inhalent environment; exposing a first organism to the inhalent environment until a calculated first-organism delivered dosage meets or exceeds a predefined first-organism target dosage; and exposing a second organism to the inhalent environment until a calculated second-organism delivered dosage meets or exceeds a predefined second-organism target dosage. In one embodiment, a method includes but is not limited to: detecting a first organism via a first-organism biochip device implanted in the first organism; and controlling a first-organism dosage in response to the first-organism biochip device.

Abstract: A system and method of deception detection is disclosed wherein T trials are combined with P and I trials. Denoted as the complex trial (CT) protocol, in one embodiment, the beginning of each trial is indicated by the onset of a stimulus which is either a P or I, which remains on the display terminal for particular random (unpredictable to the subject) time period. At the expiration of the period, the stimulus remains on the screen, but is altered/augmented in some way, such as by color change. The subject has been instructed that if the color change is to green, for example, the trial is a target trial, and the subject should make a “yes” (target) response. If the color is anything else (e.g., red, blue, yellow), the subject must give a “no” (non-target) response. Accordingly, in the CT protocol, the subject must attend even more intensely than in prior 3-stimulus protocols to the probe-irrelevant attribute (i.e.

Abstract: The method and the apparatus serve for non-invasively determining the blood pressure of a patient. An electrical cardiac potential measurement signal and a pulse-pressure-wave measurement signal are detected which, starting from the heart, propagate within the blood vessels as far as to a pulse-feeling location. A pulse-pressure-wave propagating time between the heart and the pulse-feeling location is determined, based on the electrical measurement signal and the pulse measurement signal. The blood pressure is determined by the aid of a function interrelationship on the basis of the propagating time, with the function interrelationship comprising a first portion that specifies the active elasticity behaviour of the blood vessels, and a second portion that specifies the passive electricity behaviour of the blood vessels. In this way, especially accurate blood pressure determination is rendered possible.

Abstract: A method of determining endothelial dependent vasoactivity of a subject, the method is effected by recording pressure-related signals of a plurality of locations adjacent to at least one blood vessel; extracting at least one parameter from the pressure-related signals; and using the at least one parameter to determine a change of at least one characteristic of the at least one blood vessel, the change being representative of endothelial functioning; thereby determining the endothelial dependent vasoactivity of the subject.

Abstract: To improve measurement accuracy of blood pressure. A wrist sphygmomanometer comprises a cuff spring formed in a curved shape to fit the semicircle on the side of the pulsation part of the wrist, having a mount portion formed outside; a cuff band including the cuff spring as a core material, having an air bag inside, and wound around a wrist; and a sphygmomanometer main body mounted on the mount portion of the cuff spring, having a pressure pump for supplying air to the air bag, wherein the cuff spring has a protrusion protruding inward formed in a nearly central position in a peripheral direction.

Abstract: Techniques are provided for detecting the onset of an episode of apnea/hypopnea substantially in real-time. A moving threshold is generated based on recent respiration cycles and differences are accumulated between amplitudes of new respiration cycles and the moving threshold. Apnea/hypopnea is then detected based upon a comparison of the accumulated differences against a fixed threshold. The technique exploits the fact that many episodes of hypopnea begin with a sharp drop in respiration and many episodes of apnea are preceded by a sharp drop in respiration. By accumulating differences between new respiration amplitudes and a short term moving average, any sharp drop in respiration is thereby promptly detected. In many cases, by the time the amplitudes of individual respiration cycles drop to levels directly indicative of apnea/hypopnea, the episode of apnea/hypopnea will have already been detected based upon the sudden sharp drop in respiration amplitude and therapy will have already been initiated.

Abstract: A method and apparatus to monitor the neurologic state of a patient undergoing general anesthesia is provided. Previous automated systems to monitor the neurologic state of a patient undergoing general anesthesia involve a significant time delay between the patient's true hypnotic state and the computed indices. The present invention reduces this time delay by using a different analysis technique applied to spontaneous EEG. A wavelet decomposition and statistical analysis of the observed EEG is conducted and compared to reference data to provide a numerical indicator. In addition, this indicator is more consistent with the patient's loss of consciousness indicated by the loss of count event than previous systems.