Abstract: A method of assessing the state of the lining of the small intestine in a mammal or human injesting a suitable labelled test substrate which requires conversion by a brush border enzyme for transport across the small intestinal lining. Suitable substrates include sucrose and maltose. The transport of these can very conveniently be measured by assessing the amount of label present in carbon dioxide expelled in the breath after a period of time. It has been shown that this method has application to assessing damage cause by chemotherapeutic induced mucositis as well as gastroenteritis with an infectious cause.

Abstract: An integrated airway adapter capable of monitoring any combination of respiratory flow, O2 concentration, and concentrations of one or more of CO2, N2O, and an anesthetic agent in real time, breath by breath. Respiratory flow may be monitored with differential pressure flow meters under diverse inlet conditions through improved sensor configurations which minimize phase lag and dead space within the airway. Molecular oxygen concentration may be monitored by way of luminescence quenching techniques. Infrared absorption techniques may be used to monitor one or more of CO2, N2O, and anesthetic agents.

Abstract: In a method and breathing apparatus for assessing pulmonary stress, wherein pressure controlled flow of respiratory gas is generated, an ensuing flow is measured, resistance and compliance are determined based on measured pressure and flow and a stress index value is determined based on pressure, flow, resistance and compliance. The stress index value is 1 when no stress is present, ?1 when there is a risk for overdistension and ?1 when alveolar units are at a risk of being cyclically closed and opened. Implemented in a breathing apparatus the method can be used to assist an operator in diagnostic and therapeutic considerations in relation to a patient.

Abstract: The present invention discloses a method for automatically calibrating an electronic sphygmomanometer, which pumps air at a predetermined air pressure to a testing electronic sphygmomanometer to simultaneously pressurize a set of pressure sensors set for regular use and at least one other set of pressure sensors being interconnected in the electronic sphygmomanometer to detect whether or not the set of pressure sensors used at regular time is normal. The detected change of pressure during the detection is sent to a control module, and the control module will compare the detected value of each pressure sensor. If the comparison is matched, then it means that the set of pressure sensors used at regular time is normal; if the comparison is mismatched, then the pressure sensors are determined as abnormal and the air valve connected to such pressure sensors is shut, such that when a user uses the electronic sphygmomanometer for the next time, another set of pressure sensors will be started.

Abstract: An apparatus for non-invasive detection and quantitation of analytes in a sample, such as blood glucose employs a novel amplifier that uses high-gauss permanent magnets to permit an Rf signal to be transmitted through the sample. The concentration of the analyte can be determined from the magnitude of the reduction in the amplitude of the Rf signal at a characteristic frequency.

Abstract: One method for diagnosing a cardiovascular-related condition in a breathing person comprises interfacing a valve system to the person's airway. The valve system is configured to decrease or prevent respiratory gas flow to the person's lungs during at least a portion of an inhalation event. The person is permitted to inhale and exhale through the valve system. During inhalation, the valve system functions to produce a vacuum within the thorax to increase blood flow back to the right heart of the person, thereby increasing blood circulation and blood pressure. Further, at least one physiological parameter is measured while the person inhales and exhales through the valve system. The measured parameter is evaluated to diagnose a cardiovascular condition.

Abstract: Microprobe device 10 provides an analyte signal from biosensor 12 to an external analyte meter indicating analyte presence in an analyte-containing bodily fluid of a subject (not shown).

Abstract: A method and system for operating a non-invasive blood pressure monitor that utilizes an SpO2 plethysmographic signal to reduce the time required to obtain an estimation of a patient's blood pressure. During operation of the NIBP monitor, the NIBP monitor utilizes the SpO2 plethysmographic signal to determine a timing period and a deflation period for each pulse associated with the patient's heartbeat. Upon receiving an oscillation pulse, the NIBP monitor determines the oscillation amplitude during the timing period and deflates the blood pressure cuff during the deflation period immediately following the timing period. Preferably, the deflation period occurs during the same oscillation pulse used to calculate the oscillation pulse amplitude to decrease the amount of time required to obtain a blood pressure estimate from the patient.

Abstract: Embodiments include methods and apparatus for determining whether a neurological event has occurred in a subject. An apparatus includes at least one sensor adapted to sense electroencephalogram signals from the subject. The apparatus also includes an electroencephalogram acquisition module adapted to receive the electroencephalogram signals from at least one sensor, and a processing and analysis module adapted to receive signals from the electroencephalogram acquisition module and determine changes in neurological function using entropy analysis.

Abstract: A portable, handheld device for measuring lung- and airway-specific respiratory parameters. The device defines a chamber in fluid communication with a mouthpiece. A sensor and/or a flow sensor monitor pressure and/or airflow within the device. A respiratory gas source, e.g., an internal pump, or an external compressor, is also in fluid communication with the chamber and a mouthpiece. The device operates in an active phase and a passive phase. In the active phase, a subject forcibly exhales into the device and the sensors collect spirometric data. In the passive phase, the pump is activated to pump air from the device and inflate the subject's lungs to a specific capacity. The sensors monitor pressure and/or flow as the air is introduced into the subject's respiratory system. The data collected by the sensor is used to determine lung and airway specific parameters, including but not limited to, airway conductance, airway resistance, airway compliance and total lung capacity.

Abstract: A system and method for detecting and predicting neurological events with an implantable device uses a relatively low-power central processing unit in connection with signal processing circuitry to identify features (including half waves) and calculate window-based characteristics (including line lengths and areas under the curve of the waveform) in one or more electrographic signals received from a patient's brain. The features and window-based characteristics are employed within the framework of a programmable finite state machine to identify patterns and sequences in and across the electrographic signals, facilitating early and reliable detection and prediction of complex spatiotemporal neurological events in real time, and enabling responsive action by the implantable device.

Abstract: Described is a method and system for analyzing a patient's breaths. The arrangement may include a sensor and a processor. The sensor detects data corresponding to a patient's breathing patterns over a plurality of breaths. The processor separates the detected data into data segments corresponding to individual breaths. Then, the processor analyzes the data segments using a pretrained artificial neural network to classify the breaths based on a likelihood that individual ones of the breaths include an abnormal flow limitation.

Abstract: The present invention is a method for analyzing the biological age of a subject. The method analyzes the biological age as it relates to a number of factors indicating levels of health, energy production and metabolism. The method may also be used to calculate a subject's biological age and treat the factors associated with biological age.

Abstract: An apparatus and method for pulse detection based on blood pressure measuring stage is disclosed. Both monitoring of blood pressure and blood vessel pulse are integrated and applied to an apparatus. With the components of the blood pressure monitor, such as an inflatable cuff an air pump and a variable flow valve, with a unique sequential pressure control of reduction and regulation of pressure, not only can blood pressure parameters but also pulse signals under various pressures be measured to provide a complete analysis of blood artery/vessel conditions.

Abstract: The cardiovascular evaluation apparatus of the present invention maintains a pulse wave detection means for detecting pulse wave generated while external pressure is applied to the artery, a pulse wave pattern formulation means for formulating a pulse wave amplitude pattern that indicates the dependency characteristic of the pulse wave amplitude in regard to said external pressure, a pattern shape matching means for matching general polyangular patterns to a pattern portion of said pulse wave amplitude pattern that includes at least a part of the envelope curve where the area of the general pattern, and an index derivation means for deriving a cardiovascular dynamics index related to arterial mechanical characteristics and/or cardiac function.

Abstract: Method for determining, monitoring and updating correction data for correcting measured value distortions and for calibrating liquid-filled transmission systems, via which signals from the patient detected in the body of a patient are transmitted to an external measured value receiver, in particular for invasive pressure measurements in cardiology, intensive care medicine and anaesthesia. The correction data are determined in the frequency range for each frequency from statistics of the signals from the patient measured at this frequency, in particular from the transmission function obtained from the signal from the patient. In the determination of the correction data, empirically checked assumptions about the corresponding statistics of undistorted signals from the patient and general properties of the transmission function are used.

Abstract: Monitoring airflow from a person is accomplished by using a central server arranged to receive and communicate data together with at least one microprocessor-based subsystem. The subsystem includes a microprocessor, a display and a memory. It presents information to the person on the display and processes a digital signal representing airflow from the person. Airflow-related data is communicated to the central server and, in turn, is communicated to at least one health care professional computer. The system can be used to realize systems for self-care monitoring and control of afflictions and physical conditions, such as chronic respiratory afflictions. The system can also be used together with other monitoring devices, such as glucose, blood pressure, pulse and temperature monitors, to monitor the person's condition and to communicate related data to the central server.

Abstract: In a method and device for preparation of a medicament for the treatment of lungs having a surfactant deficiency, a sample from a patient is quantitatively analyzed with regard to at least one of the proteins SP-A, SP-B, SP-C and SP-D, a determination is made as to whether a deficiency of one of the analyzed protein SP-A, SP-B, SP-C or SP-D exists and if that is the case, a determination is made of a therapeutically effective dose of a replacement substance for the analyzed protein SP-A, SP-B, SP-C or SP-D, and a medicament containing the therapeutically effective dose of the replacement substance is prepared.

Abstract: Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette of any one of several disclosed variations is attached to the circulatory flow lines of the catheter, the heat exchange cassette being sized to engage a cavity within one of various described re-usable control units. The control units include a heater/cooler device, a user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and cooling based on polarity. A temperature control scheme for ramping the body temperature up or down without overshoot is provided.

Abstract: A patient's heart condition is monitored by a patient-location based unit. The patient-location based unit includes a receptacle for receiving a cartridge that includes heart condition monitoring information. The patient-location based unit receives information from the patient, monitors the patient's heart condition, and communicates with the patient regarding the patient's heart condition. The patient-location based unit also communicates with a central server. Both the patient-location based unit and central server communicate with a health care professional computer by transferring, to the health care professional computer, information related to the monitored patient's heart condition.