Patents Examined by Robert T. Crow
  • Biological sample preparation for testing
    Patent number: 10371604
    Abstract: In one embodiment, a method for processing a sample includes selecting a selected sample from a biological specimen, the selected sample being in contact with a first surface of a first substrate. The method also includes transferring the selected sample directly from the first surface to a container comprising an internal volume. The method also includes forming or providing a sample solution within the internal volume of the container by contacting the selected sample with a lysis mixture using a protocol. The method further includes performing an assay, experiment, or test on the sample solution while the sample solution disposed is within the internal volume of the container. In another embodiment, a method for processing a sample includes providing a selected sample comprising one or more cells. The method also includes transferring the selected sample into an internal volume of a container.
    Type: Grant
    Filed: August 10, 2016
    Date of Patent: August 6, 2019
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Mousumi Rath, Mark Shannon, Jason La
  • Antigen-loaded chitosan nanoparticles for immunotherapy
    Patent number: 10369217
    Abstract: The present invention is directed to nanoparticles comprising chitosan and an antigen, whereby the chitosan has a degree of deacetylation of about 90% and a molecular weight from 5 kDa to 80 kDa, to microparticles containing such nanoparticles as well as to a process for preparation of such particles. The particles are usable for vaccination.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: August 6, 2019
    Assignee: MERCK PATENT GMBH
    Inventors: Andrea Hanefeld, Markus Weigandt, Michael Wolf, Percy Knolle, Matthias Schroeder, Regina Scherliess, Peter Walden, Andrea Diedrich, Hartwig Steckel, Renato Brito Baleeiro
  • Method for manufacturing nanoparticle array, surface plasmon resonance-based sensor and method for analyzing using same
    Patent number: 10359362
    Abstract: The present invention relates to a method for manufacturing a nanoparticle array, a surface plasmon resonance-based sensor, and a method for analyzing using the same. According to one embodiment of the present invention, after a mixed solution of an ionized binder and conductive nanoparticles is prepared, a substrate is dipped into the mixed solution. Thereafter, by applying an electric field to the mixed solution into which the substrate is dipped so as to induce coating of the conductive nanoparticles on the substrate, it is possible to manufacture, by a wet method, a nanoparticle array in which the conductive nanoparticles are quickly coated on the substrate with high density.
    Type: Grant
    Filed: September 10, 2013
    Date of Patent: July 23, 2019
    Assignee: Plexense, Inc.
    Inventor: Gibum Kim
  • Magnetic flux density based DNA sequencing
    Patent number: 10344326
    Abstract: In an approach to magnetic flux density based DNA sequencing, a static magnetic field is provided. A chain of nucleotides is passed through the magnetic field. A change in magnetic flux density of the static magnetic field due to an ionic voltage associated with an individual nucleotide or base pair of the chain of nucleotides is measured. An identity of the nucleotide is determined based on the change in magnetic flux density.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: July 9, 2019
    Assignee: International Business Machines Corporation
    Inventors: Samuel Mathew Jawaharlal, Arunachalam Narayanan, Sathya Santhar, Balamurugaramanathan Sivaramalingam
  • Films for biologic analyte collection and analysis and methods of production and use thereof
    Patent number: 10346671
    Abstract: Compositions, films, collection devices, apparatuses, kits and methods related to biologic analyte collection and analysis include thin films of modified polycaprolactone. Methods of production and use thereof are described herein. The films, compositions, collection devices, kits and methods can be used for collection of fingerprints for both image capture and nucleic acid extraction and analysis.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: July 9, 2019
    Assignee: Diomics Corporation
    Inventors: Beverly Lynn Wolgast, John F. Steel, Thomas J. Kindt, Ryan B. Lamer
  • Compositions and methods for treating ectoparasite infestation
    Patent number: 10334853
    Abstract: Compositions suitable for topical use to treat ectoparasite infestations are described. The compositions are suitable for use on the hair of humans or animals, without the need for pharmaceuticals or medicaments. The compositions are essentially nonaqueous and non-Newtonian, such that the compositions can be controllably delivered either manually or through use of a dispensing means. One such exemplary dispenser/applicator is described. Although the compositions are otherwise substantially free of water, they exhibit good risibility characteristics and pseudoplastic rheology. Methods for the use of the nonaqueous compositions and kits containing the compositions are also presented.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: July 2, 2019
    Assignee: Larada Sciences
    Inventors: Gregory van Buskirk, Kelly J. Brodbeck
  • Inhibition of central nervous system effects from smoking and sensory effects from smoking
    Patent number: 10335378
    Abstract: Pharmaceutical compositions and methods of use therefor for reducing the desire to engage in smoking are disclosed. More specifically, the pharmaceutical composition utilizes an active ingredient to reduce the side effects of smoking cessation and to limit the molecular feedback caused by nicotine-mediated activation of acetylcholine receptors.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: July 2, 2019
    Assignee: Altria Client Services LLC
    Inventors: Gerd Kobal, Justin Heynekamp, Peter Reeh, Munmaya K. Mishra, Tetyana Kichko
  • Selection of biological objects
    Patent number: 10338068
    Abstract: Provided herein are molecular automaton systems for identification, isolation, or elimination of a target biological object. Some embodiments include modules specific for a target biological object having a first biological object surface marker and a second biological object surface marker. Some embodiments include modules specific for a target biological object having a first biological object surface marker but not a second biological object surface marker.
    Type: Grant
    Filed: November 4, 2015
    Date of Patent: July 2, 2019
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Milan N. Stojanovic, Sergei Rudchenko, Maria Rudchenko, Steven Taylor
  • Compositions and processes for improved mass spectrometry analysis
    Patent number: 10329612
    Abstract: The invention provides a novel additive for improved analysis by mass spectrometry. More specifically, ascorbic acid has been found to reduce or eliminate the presence of adducts commonly present in mass spectra. The improved processes and compositions of the invention allow for increased accuracy, sensitivity and throughput for samples analyzed by mass spectrometry.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: June 25, 2019
    Assignee: Agena Bioscience, Inc.
    Inventor: Thomas Becker
  • Method for isolating RNA including small RNA with high yield
    Patent number: 10329553
    Abstract: The present invention provides a method for isolating RNA including small RNA having a size of 200 nt or less from a sample, comprising the following steps: a) providing a composition comprising RNA and a chaotropic agent; b) adding alcohol; c) incubating the mixture for at least 2 min; d) adding additional alcohol to the mixture to adjust the overall alcohol concentration in the mixture to ?50%; e) binding RNA contained in the mixture to a nucleic acid binding solid phase; f) optionally washing the bound RNA; g) optionally eluting RNA from the solid phase. Due to the step-wise addition of alcohol, the overall RNA yield and the yield of small RNA is improved.
    Type: Grant
    Filed: September 3, 2013
    Date of Patent: June 25, 2019
    Assignee: QIAGEN GmbH
    Inventors: Martin Schlumpberger, Stefanie Schröer, Vera Holländer
  • Systems comprising non-immunogenic and nuclease resistant nucleic acid origami devices for molecular computation
    Patent number: 10316320
    Abstract: Systems acting as logic gates and systems exhibiting quorum sensing are provided, wherein said systems comprise at least one effector nucleic acid origami device, at least one regulator nucleic acid origami device, at least one input and at least one output, and the nucleic acid origami devices are non-immunogenic and/or resistant to nucleases.
    Type: Grant
    Filed: April 13, 2014
    Date of Patent: June 11, 2019
    Assignee: BAR ILAN UNIVERSITY
    Inventors: Ido Bachelet, Almogit Abu-Horowitz, Eldad Ben-Ishay, Yaniv Amir, Joel De Beer, Shmulik Ittah
  • Diagnostic and sample preparation devices and methods
    Patent number: 10301666
    Abstract: Contemplated methods and devices are drawn to preparation and analysis of analytes from biological samples. In a preferred embodiment the analytes are nucleic acids that are both released from biological compartments present in the sample and fragmented through the use of a voltage potential applied to a pair of electrodes. The nucleic acids thus prepared are subsequently characterized.
    Type: Grant
    Filed: January 17, 2017
    Date of Patent: May 28, 2019
    Assignee: General Atomics
    Inventors: Shana O. Kelley, Susan Bortolin, Reginald James McKenzie Orton, Stefan Christopher Wiechula
  • Immune stimulating composition comprising an extract of sp. in combination with selenium and/or zinc
    Patent number: 10293014
    Abstract: Disclosed is a composition which comprises a combination of Aronia extract in an amount of at least about 10 ?g/mg and seleniumin in an amount from about 0.0001 ?g/mg to about 2.0 ?g/mg. The composition may further comprise zinc as additional micronutrient. The composition may be formulated as a pharmaceutical or a nutraceutical composition.
    Type: Grant
    Filed: January 20, 2015
    Date of Patent: May 21, 2019
    Assignee: Ursapharm Arzneimittel GmbH
    Inventors: Klaus Eschmann, Josef Beuth
  • Synthesis apparatus and method
    Patent number: 10286399
    Abstract: Apparatus for biochemical synthesis having a reaction vessel, a temperature control device for the reaction vessel, a plurality of reservoirs for reaction components, and supply/withdrawal systems, e.g. reciprocating syringe pumps and switchable valves. Agitation of a reaction mixture is effected by withdrawing a part of the mixture from the reaction vessel and returning it thereto.
    Type: Grant
    Filed: March 4, 2014
    Date of Patent: May 14, 2019
    Assignee: Touchlight IP Limited
    Inventors: Neil Porter, Paul James Rothwell
  • Adenovirus forumations
    Patent number: 10272032
    Abstract: This disclosure provides pharmaceutical adenovirus formulations, in particular, liquid pharmaceutical formulations comprising adenoviruses.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: April 30, 2019
    Assignee: Janssen Vaccines & Prevention B.V.
    Inventor: Janik Adriaansen
  • Use of compounds with thrombopoietic activity to promote bone growth and healing
    Patent number: 10265381
    Abstract: TPO was used to promote the growth of bone in both rats and in mice. Gaps in both mouse and in rat bones were treated with a scaffold sized to fit the gap. Scaffolds that included TPO promoted better outcomes than scaffolds that included BMP-2 or scaffolds that did not include either TPO or BMP-2. These data indicate that compounds that exhibit thrombopoietic activity such a recombinant TPO can be used to promote bone growth and healing in mammals.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: April 23, 2019
    Assignee: Osteofuse, Inc.
    Inventors: Melissa A. Kacena, Tien-Min Gabriel Chu
  • Biosensor
    Patent number: 10261019
    Abstract: Disclosed herein is an apparatus comprising: a plurality of locations configured to have probes attached thereto, wherein interaction between the probes and an analyte generates a signal; an optical system comprising a plurality of collimators; a sensor comprising a plurality of pixels configured to detect the signal; wherein the collimators are configured to essentially prevent light from passing if a deviation of a propagation direction of the light from an optical axis of the collimators is greater than a threshold.
    Type: Grant
    Filed: April 22, 2015
    Date of Patent: April 16, 2019
    Assignee: SHENZHEN GENORIVISION TECHNOLOGY CO., LTD.
    Inventors: Peiyan Cao, Yurun Liu
  • Sodium nitrite-containing pharmaceutical compositions
    Patent number: 10251910
    Abstract: Provided herein are pharmaceutically acceptable sodium nitrite and pharmaceutical compositions thereof. Also provided herein are methods for determining the total non-volatile organic carbon in a sodium nitrite-containing sample. Further provided herein are methods for producing pharmaceutically acceptable sodium nitrite. Still further provided herein are methods of treatment comprising the administration of pharmaceutically acceptable sodium nitrite.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: April 9, 2019
    Assignee: Hope Medical Enterprises, Inc.
    Inventors: Craig Sherman, Anthony James Lepine, Catherine Marie Smith, Kevin Robert Wirtz, Erich Schulze
  • Devices, systems, and methods for magnetic separation
    Patent number: 10240186
    Abstract: Methods, microfluidic devices, and instruments for magnetic separation of particles from a fluid are described. Examples include microfluidic devices having a removable portion. Examples include microfluidic devices having one or more regions of reduced fluid velocity. Examples further including instruments having pneumatic interfaces. Examples further includes instruments having controllable magnets, imaging components, or combinations thereof.
    Type: Grant
    Filed: July 14, 2011
    Date of Patent: March 26, 2019
    Assignee: FLUXION BIOSCIENCES, INC.
    Inventors: Cristian Ionescu-Zanetti, Joshua Tanner Nevill, Michael Schwartz, Carolyn G. Conant, Roger Rudoff
  • Thin film bulk acoustic resonator with signal enhancement
    Patent number: 10234425
    Abstract: Sensitivity of thin film bulk acoustic resonance (TFBAR) sensors is enhanced by mass amplification and operating a high frequency.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: March 19, 2019
    Assignee: QORVO US, INC.
    Inventors: Michael Salvati, Ian Robert Harmon