Patents Examined by Robert T. Crow
  • Accelerating muscle recovery after immobilization-induced muscle atrophy
    Patent number: 9867391
    Abstract: The present invention generally relates to the field of medical nutrition. For example, the present invention provides a composition that can be used to treat, prevent and/or reverse muscle atrophy related to immobilization and its consequences. One embodiment of the present invention concerns a composition comprising a leucine and antioxidants that can be used in accelerating muscle recovery after muscle atrophy.
    Type: Grant
    Filed: October 11, 2012
    Date of Patent: January 16, 2018
    Assignee: Nestec S.A.
    Inventors: Dominique Dardevet, Isabelle Savary-Auzeloux, Didier Remond, Lydie Combaret, Gary Williamson, Magali Faure, Denis Breuille
  • Wound dressing materials incorporating anthocyanins derived from fruit or vegetable sources
    Patent number: 9855364
    Abstract: A wound dressing composition, such as gauze, bandages, and surgical tapes comprising a substrate material impregnated with a pH sensitive dye composition comprising at least one anthocyanin derived from fruit or vegetable sources, and methods of use thereof.
    Type: Grant
    Filed: October 15, 2014
    Date of Patent: January 2, 2018
    Inventor: Allison Coomber
  • Small conditional RNAs
    Patent number: 9856472
    Abstract: The present subject matter relates to the use conditional hairpins, such as, but not limited to shRNAs. The conditional formation of these structures can allow for further events, such as gene silencing (in some embodiments).
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: January 2, 2018
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Niles A. Pierce, Lisa Hochrein
  • Molecular code systems
    Patent number: 9850531
    Abstract: The present invention relates to a method for protecting and. recovering nucleic acids. This method may be applied in a verification method of products using molecular code systems or it may be applied in a storage method for nucleic acids. The invention further provides specific particles, their use in secure marking; products suitable for such verification method, to processes for manufacturing such products and methods for reading the information.
    Type: Grant
    Filed: March 26, 2013
    Date of Patent: December 26, 2017
    Assignee: ETH Zurich
    Inventors: Robert N. Grass, Wendelin Jan Stark
  • Compositions and methods for administration to subjects with dysphagia
    Patent number: 9849093
    Abstract: Provided are novel methods and compositions for administration of pharmaceuticals to subjects with dysphagia. Pharmaceuticals are associated with beads and administered with food, beverage or cosmetic to provide ease of administration to subjects with dysphagia. Environmental indicators are associated with beads for Quality Assurance.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: December 26, 2017
    Assignee: Cape Spear Pharmaceuticals, Ltd.
    Inventors: David Barnes, Jonathan Barker, Stephen Haggerty
  • Metabolomics-based biomarkers for lung function
    Patent number: 9823204
    Abstract: Chronic obstructive pulmonary disease (COPD), characterized by chronic airflow limitation, is a serious and growing public health concern. The major environmental risk factor for COPD is cigarette smoking, but the biological mechanisms underlying COPD are not well understood. Herein, proton nuclear magnetic resonance (1H-NMR) spectroscopy is used in methods to identify metabolites and biomarkers associated with lung function in COPD.
    Type: Grant
    Filed: July 3, 2012
    Date of Patent: November 21, 2017
    Assignee: Lineagen, Inc.
    Inventors: Joseph Louie McClay, Barbara K. Zedler, Edward Lenn Murrelle, Edwin J. C. G. van den Oord, Thomas O'Connell, Daniel Adkins
  • Method for immobilizing nucleic ligands
    Patent number: 9803184
    Abstract: The invention relates to a method for immobilizing nucleic ligands including at least one reactive amine function, by grafting on an activated solid substrate, including a step of coupling said nucleic acids on said activated solid substrate having a pH of less than 6.
    Type: Grant
    Filed: December 30, 2011
    Date of Patent: October 31, 2017
    Assignee: LABORATOIRE FRANCAIS DU FRACTIONNEMENT ET DES BIOTECHNOLOGIES
    Inventors: Egisto Boschetti, Gérald Perret
  • Composition comprising an internal phase dispersed in a hydrophilic continuous phase
    Patent number: 9789456
    Abstract: The composition, advantageously an emulsion or a foam, includes an internal phase dispersed in a hydrophilic continuous phase, the percentage of the internal phase being higher than 50%. The emulsion composition contains nanocrystals of a polysaccharide other than cellulose, advantageously chitin, that are located at the interface between the internal phase and the hydrophilic continuous phase.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: October 17, 2017
    Assignee: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE—INRA
    Inventors: Isabelle Capron, Herve Bizot, Bernard Cathala
  • Alkaline activation for immobilization of DNA taggants
    Patent number: 9790538
    Abstract: The invention provides methods for stably binding and immobilizing deoxyribonucleic acid onto objects and substrates. The method includes exposing the deoxyribonucleic acid to alkaline conditions, and contacting the deoxyribonucleic acid to the object or substrate. The alkaline conditions are produced by mixing the deoxyribonucleic acid with an alkaline solution having a pH of about 9.0 or higher, and contacting the deoxyribonucleic acid to the substrate. The immobilized DNA can be used as a taggant and can be used in combination with other detectable taggants, such as optical reporters. Methods for authentication of a DNA marked object are also provided.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: October 17, 2017
    Assignee: APDN (B.V.I.) INC.
    Inventors: Abdelkrim Berrada, MingHwa Benjamin Liang, Lawrence Jung, Kurt Jensen
  • High throughput nucleic acid sequencing by expansion and related methods
    Patent number: 9771614
    Abstract: A method for detecting an analyte employing a nanopore substrate positioned between first and second reservoirs by providing an indicator molecule not associated with the analyte and detecting a change in an optical signal emitted from the indicator moiety as the analyte translocates through a nanopore channel of the nanopore substrate.
    Type: Grant
    Filed: January 6, 2015
    Date of Patent: September 26, 2017
    Assignee: Stratos Genomics Inc.
    Inventors: Mark Stamatios Kokoris, Robert N. McRuer
  • DNA origami devices
    Patent number: 9765341
    Abstract: Provided herein are DNA origami devices useful in the targeted delivery of biologically active entities to specific cell populations.
    Type: Grant
    Filed: November 4, 2011
    Date of Patent: September 19, 2017
    Assignee: President and Fellows of Harvard College
    Inventors: Ido Bachelet, Shawn Douglas, George Church
  • Nucleic acid-containing lipid particles and related methods
    Patent number: 9758795
    Abstract: Lipid particles containing a nucleic acid, devices and methods for making the lipid particles, and methods for using the lipid particles.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: September 12, 2017
    Assignee: The University of British Columbia
    Inventors: Pieter R. Cullis, Nathan M. Belliveau, Carl Lars Genghis Hansen, Jens Huft, James Taylor, Andre Wild, Stuart Malcolm, Ismail Hafez, Alex Leung, David Walker
  • Biomaterial and methods of use thereof for the prevention of post-operative adhesions
    Patent number: 9757499
    Abstract: Biofunctional films and methods of use thereof for the prevention of post-operative adhesions are disclosed.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: September 12, 2017
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Noshir Langrana, Devendra Verma, Michelle Previtera
  • Compositions and methods for preparing oligonucleotide solutions
    Patent number: 9745573
    Abstract: The present invention is directed to methods and compositions for generating a pool of oligonucleotides. The invention finds use in preparing a population or subpopulations of oligonucleotides in solution. The pool of oligonucleotides finds use in a variety of nucleic acid detection and/or amplification assays.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: August 29, 2017
    Assignee: Illumina, Inc.
    Inventors: John R. Stuelpnagel, Mark Chee
  • Self-assembled peptide nucleic acids
    Patent number: 9741948
    Abstract: Ordered (e.g., self-assembled) structures, arranged from peptide nucleic acids and/or analogs thereof, are disclosed. The peptide nucleic acids forming the ordered structures comprise from 1 to 10 PNA backbone units, at least one comprising a guanine nucleobase or an analog thereof. Processes of generating the ordered structures, uses thereof and articles-of manufacturing, devices and systems containing same are also disclosed.
    Type: Grant
    Filed: May 1, 2014
    Date of Patent: August 22, 2017
    Assignee: Technology Innovation Momentum Fund (Israel) Limited Partnership
    Inventors: Or Berger, Lihi Adler-Abramovich, Ehud Gazit
  • Tube-in-a-tube electronic sensors
    Patent number: 9739741
    Abstract: The present invention is directed to tube-in-a-tube electronic materials and electronic chemical sensors comprising tube-in-a-tube configurations such as covalently functionalized double-walled carbon nanotubes.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: August 22, 2017
    Assignee: UNIVERSITY OF MARYLAND, COLLEGE PARK
    Inventors: YuHuang Wang, Jia Huang, Allen Ng, Yanmei Piao, Cheng S. Lee
  • Method for sequencing a heteropolymeric target nucleic acid sequence
    Patent number: 9732381
    Abstract: The invention relates to a method for sequencing a heteropolymeric target nucleic acid sequence that involves stochastic sensing. The invention also relates to a method for improving a pore for sequencing a target nucleic acid sequence by modifying one or more sites in the pore.
    Type: Grant
    Filed: March 25, 2010
    Date of Patent: August 15, 2017
    Assignee: OXFORD UNIVERSITY INNOVATION LIMITED
    Inventors: David Stoddart, Andrew John Heron, Giovanni Maglia, John Hagan Pryce Bayley
  • Cell analysis apparatus and cell analysis method
    Patent number: 9733186
    Abstract: A cell analysis apparatus includes an optical detection section that accommodates a flow of a measurement sample obtained from a biological sample and a pigment into a flow cell. A light source irradiates the measurement sample flowing in the flow cell and a fluorescence detector detects fluorescence from the measurement sample. A signal processing circuit acquires a value reflecting the height of a waveform of the signal and a value reflecting the length of a ridge line of the waveform of the signal, and a system control section distinguishes between an aggregating cell formed by aggregation of a plurality of cells and a non-aggregating cell, based on the value of the fluorescence signal obtained by the signal processing circuit.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: August 15, 2017
    Assignee: SYSMEX CORPORATION
    Inventors: Masaki Ishisaka, Kazuki Kishi, Masakazu Fukuda
  • Method of designing addressable array suitable for detection of nucleic acid sequence differences using ligase detection reaction
    Patent number: 9725759
    Abstract: The present invention is directed to a method of designing a plurality of capture oligonucleotide probes for use on a support to which complementary oligonucleotide probes will hybridize with little mismatch, where the plural capture oligonucleotide probes have melting temperatures within a narrow range. The present invention further relates to an oligonucleotide array comprising of a support with the plurality of oligonucleotide probes immobilized on the support, a method of using the support to detect single-base changes, insertions, deletions, or translocations in a plurality of target nucleotide sequences, and a kit for such detection, which includes the support on which the oligonucleotides have been immobilized.
    Type: Grant
    Filed: April 12, 2016
    Date of Patent: August 8, 2017
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Francis Barany, Monib Zirvi, Norman P. Gerry, Reyna Favis, Richard Kliman
  • Biologic sample collection devices and methods of production and use thereof
    Patent number: 9708600
    Abstract: Collection devices and kits for biological sample collection include a biologic sample collection device having a hydrophilic swab matrix that includes a modified polycaprolactone (PCL). Methods of production and use thereof are also described herein. The biologic sample collection devices, kits and methods described herein are used to collect a biologic sample (e.g., blood, buccal cells, etc.) and to enable extraction of nucleic acids (e.g., DNA) from that biologic sample so that the nucleic acids can be analyzed (e.g., sequencing and subsequent analyzes of DNA).
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: July 18, 2017
    Assignee: DIOMICS CORPORATION
    Inventors: Jeff Morhet, Thomas Kindt, Franco Ferrari, Vasana Maneeratana, Frederic Zenhausern, Sean Grandfield, Beverly L. Wolgast