Patents Examined by Rosalynd Keys
  • Patent number: 11655201
    Abstract: The present invention relates to a stable crystal form, i.e. form A, of 2-tert-butyl-4-methoxyphenol, and to a new preparation method for the 2-tert-butyl-4-methoxyphenol; and the use of the 2-tert-butyl-4-methoxyphenol and the stable crystal form thereof, i.e. form A, in preparing antitumor drugs or immunomodulator drugs. The stable crystal form, i.e. form A, as expressed by a powder X-ray diffraction pattern in an angle of 2?, using Cu-K? radiation, has at least 3 absorption peaks selected from the following positions: 6.27±0.10, 6.94±0.10, 12.27±0.10, 13.36±0.10, 14.01±0.10, 14.79±0.10, 15.31±0.10, 17.05±0.10, 18.30±0.10, 19.00±0.10, 20.47±0.10, 20.98±0.10, 22.37±0.10, 23.68±0.10, 24.55±0.10, 25.37±0.10, 30.83±0.10, 33.12±0.10, 40.50±0.10, 42.81±0.10.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: May 23, 2023
    Inventors: Xuemin Zhang, Xinhua He, Tao Zhou, Zhenggang Liu, Tao Li, Shengming Wu
  • Patent number: 11649200
    Abstract: The present invention discloses an integrated process and an apparatus for production of various alcohols and Oligomerization of Olefinic feed stocks comprising butylenes and mixture thereof. In this process the combined light olefinic hydrocarbon feedstock is divided into two streams and contacted in two different reaction zones, viz. hydration and oligomerization. The mixture of alcohols and oligomer product from hydration reaction is separated and the bottom stream from separator is routed to oligomerization reaction zone in a controlled quantity as selectivity enhancer. Both the reaction zones are operated at different conditions. The product from oligomerization zone is further separated in to lighter and heavier components. Each reaction zone may comprise series of reactors filled with acidic catalysts comprising ion exchange resins.
    Type: Grant
    Filed: September 7, 2021
    Date of Patent: May 16, 2023
    Inventors: Saravanan Subramani, Pushkar Varshney, Reshmi Manna, Madhusudan Sau, Gurpreet Singh Kapur, Sankara Sri Venkata Ramakumar
  • Patent number: 11637250
    Abstract: The present invention addresses the problem of providing a polycyclic aromatic compound which has improved solubility in solvents, film formability, wet coatability and in-plane orientation. The above-described problem is solved by a composition for forming a light emitting layer, which contains, as a first component, at least one compound selected from the group consisting of compounds represented by general formula (A-1) and compounds represented by general formula (A-2), as a second component, at least one compound that has a triplet energy (ET) of 1.8-3.0 eV, and as a third component, at least one organic solvent. In the formulae, R represents a hydrogen atom, an aryl group, a heteroaryl group, a diarylamino group, a diheteroarylamino group or an aryl heteroarylamino group.
    Type: Grant
    Filed: April 28, 2020
    Date of Patent: April 25, 2023
    Assignees: Kwansei Gakuin Educational Foundation, SK Materials JNC Co., Ltd.
    Inventors: Takuji Hatakeyama, Yasuhiro Kondo, Keiichi Nakamoto, Motoki Yanai
  • Patent number: 11623904
    Abstract: Provided is a process in which a cyclobutanediol compound having a high cis:trans ratio can be stably obtained. The cyclobutanediol compound having a cis:trans ratio of 1.5:1 to 5000:1 is produced by using at least one compound selected from a group consisting of a cyclobutanedione compound, a cyclobutane ketol compound, and a cyclobutanediol compound as a raw material, and performing a catalytic hydrogenation reaction and an isomerization reaction in the cyclobutanediol compound in a solid phase state in the presence of a metal catalyst without adding a solvent.
    Type: Grant
    Filed: March 17, 2021
    Date of Patent: April 11, 2023
    Inventors: Shinichi Furusato, Toshiyuki Kawanabe, Kaori Tsuruoka, Hironao Sajiki, Tsuyoshi Yamada, Kwihwan Park
  • Patent number: 11613717
    Abstract: A method of producing a fuel additive includes passing a feed stream comprising C4 hydrocarbons through a methyl tertiary butyl ether unit producing a first process stream; passing the first process stream through a selective hydrogenation unit producing a second process stream; passing the second process stream through an isomerization unit producing a third process stream; and passing the third process stream through a hydration unit producing the fuel additive and a recycle stream.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: March 28, 2023
    Inventors: Guillermo Leal, Kareemuddin Mahaboob Shaik, Mohammed Bismillah Ansari, Hiren Shethna, Zhonglin Zhang
  • Patent number: 11591280
    Abstract: The invention relates to new intermediates in the synthesis of Eldecalcitol and to processes for the preparation of said intermediates and of Eldecalcitol.
    Type: Grant
    Filed: May 12, 2020
    Date of Patent: February 28, 2023
    Inventors: Gonzalo Hernández Herrero, Neftalí García Domínguez, Tatiana María Suárez Cortés, Tania González García, Generosa Gómez Pácios, Yagamare Fall Diop, Hugo Santalla García, Fátima Garrido Fernández
  • Patent number: 11578038
    Abstract: The embodiments relate to a process for preparing a polythiol composition, which comprises reacting a halogen compound or an alcohol compound with thiourea to prepare a thiouronium salt solution; and adding a basic solution to the thiouronium salt solution to hydrolyze it. The hydrolysis reaction is terminated when the area of peak A in the graph measured by gel permeation chromatography of the reactant in the hydrolysis step under certain conditions is 0.5% to 8% based on the total peak area. A tetrafunctional polythiol composition having high purity can be obtained. Thus, an optical lens having excellent color, transparency, and refractive index can be obtained.
    Type: Grant
    Filed: December 10, 2020
    Date of Patent: February 14, 2023
    Assignee: SKC CO., LTD.
    Inventors: Jaeyoung Pai, Seung Mo Hong, Hyeon Myeong Seo, Junghwan Shin, Jeongmoo Kim, Jung Hwan Myung, Hyuk Hee Han
  • Patent number: 11578026
    Abstract: A process for dehydrating C2+ alcohols to ether products in the presence of a catalyst and promoter, wherein the catalyst is at least one aluminosilicate zeolite catalyst which is a medium pore zeolite having a 3-dimensional framework structure, and the promoter is one or more organic carbonyl compounds or derivatives thereof, and wherein and the molar ratio of promoter to C2+ alcohols is maintained at less than 1.
    Type: Grant
    Filed: February 14, 2020
    Date of Patent: February 14, 2023
    Assignee: BP P.L.C.
    Inventors: Benjamin James Dennis-Smither, John Glenn Sunley, Fiona Jackson
  • Patent number: 11565990
    Abstract: A more environmentally friendly synthesis method of 4-bromo-2-(4?-ethoxyphenyl)-1-chlorobenzene with simplified steps provides a more effective synthetic strategy for producing key intermediates of SGLT-2 inhibitors such as dapagliflozin, sotagliflozin, and ertugliflozin. In the presence of trifluoroacetic anhydride, 5-bromo-2-chlorobenzoic acid and phenetole are selected to complete a direct acylation reaction under the catalysis of boron trifluoride diethyl etherate, and triethylsilane is added thereinto without treatment for one-pot reaction to obtain a target compound 4-bromo-2-(4?-ethoxyphenyl)-1-chlorobenzene.
    Type: Grant
    Filed: June 9, 2021
    Date of Patent: January 31, 2023
    Inventors: Lin Hu, Tao Xu, Xiaolong Qiu, Xiaoyue Li, Zhiwei Zuo, Wenbo Liu, Lingling Chu, Ximeng Yuan, Ping Zou
  • Patent number: 11560347
    Abstract: A method for synthesizing a fluorovinyl ether compound from a fluorine-containing vinyl compound. Specifically, a method for producing a compound represented by formula (1), comprising step A of reacting a compound represented by formula (2) with a compound represented by formula (3) in the presence of a transition metal catalyst: wherein the substituents are defined in the disclosure.
    Type: Grant
    Filed: June 26, 2019
    Date of Patent: January 24, 2023
    Inventors: Naoyuki Hoshiya, Akihiro Gotou, Yosuke Kishikawa
  • Patent number: 11535590
    Abstract: The present invention provides a sulfonium salt photoinitiator, a preparation method therefor, a photocurable composition comprising sulfonium salt photoinitiator, and use thereof. The sulfonium salt photoinitiator has a structure represented by formula (I). By modifying the structure of an existing sulfonium salt photoinitiator, a sulfonium salt photoinitiator having a new structure is obtained, which can exhibits a higher photosensitivity and an excellent as well as characteristics of low odor and low toxicity, when being used in a photocurable composition. This is significantly superior to existing similar photoinitiators.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: December 27, 2022
    Assignees: Changzhou Tronly New Electronic Materials Co., Ltd., Changzhou Tronly Advanced Electronic Materials Co., Ltd.
    Inventor: Xiaochun Qian
  • Patent number: 11524936
    Abstract: A chemical compound of formula (I), and specific compositions including 3-methylthiopropionaldehyde, 3-methylthiopropane-1,1-diol, a compound of formula I and water, and processes for producing same and also the use of same may be used for the production of 2-hydroxy-4-(methylthio)butyronitrile, methionine hydantoin, methionine. Protected forms may be used for the storage and/or transport of 3-methylthiopropionaldehyde.
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: December 13, 2022
    Assignee: Evonik Operations GmbH
    Inventors: Judith Hierold, Andrea Kopp, Stephan Rautenberg, Christian Renner
  • Patent number: 11505518
    Abstract: The present invention describes a process for the production of (?)-cannabidiol (CBD) from industrial hemp by means of an extraction followed by two alternative working processes: a process A which provides extraction with solvents first to an alkaline pH and then to acidic pH to isolate the carboxyl form of the CBD which is then subjected to decarboxylation and a process B which provides the elimination of waxes and pitches and then purification by chromatography. At the end of both alternative working processes the CBD is crystallized obtained in high purity crystalline form.
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: November 22, 2022
    Assignee: INALCO S.R.L.
    Inventors: Giovanni Cipolletti, Luana Vagnoli, Marina Matulli, Barbara Febbruari, Jacopo Chini
  • Patent number: 11492319
    Abstract: A biomass-based long-chain alcohol ether oxygenated additive and a preparation method and application thereof are disclosed. The additive used agricultural and forestry wastes as raw materials, and has a general chemical formula of R—(O—C1-3)n—R—OH. The preparation method includes the following steps: step 1, performing drying pretreatment on biomass raw materials, performing rapid pyrolysis under an inert atmosphere to obtain a pyrolysis product containing water, gases, water-phase bio-oil and oil-phase bio-oil, separating out the water-phase bio-oil and performing catalytic hydrogenation on the water-phase bio-oil to obtain polyols; step 2, performing catalytic dehydration on the polyols obtained in step 1 under a basic catalyst system to obtain epoxyalkane; and step 3, making the epoxyalkane obtained in step 2 and methanol undergo a reaction under a molecular sieve catalyst and removing the solid catalyst by separation to obtain the long-chain alcohol ether oxygenated additive.
    Type: Grant
    Filed: September 29, 2020
    Date of Patent: November 8, 2022
    Inventors: Shiliang Wu, Rui Xiao, Yuan Liu, Ziwei Wang
  • Patent number: 11485694
    Abstract: Processes of producing cresols from a phenols containing feed are described. The processes involve a combination of dealkylation and transalkylation processes. The dealkylation process converts the heavy alkylphenols in an alkylphenols stream to phenol and olefins. The olefins produced in the dealkylation process are separated out. The methylphenols, which are not converted in the dealkylation process, and phenol react in the transalkylation process to generate cresols.
    Type: Grant
    Filed: February 4, 2019
    Date of Patent: November 1, 2022
    Assignees: China Petroleum & Chemical Corporation, UOP LLC
    Inventors: Shuguang Zhang, Lubo Zhou
  • Patent number: 11453643
    Abstract: According to one embodiment, in producing polythiols in a manner similar to a conventional method, a polythiol having improved storage stability may be produced in a convenient manner by adjusting reaction conditions so as to prevent thiourea from remaining within products. In particular, the equivalent weight of thiourea to be used in a reaction may be adjusted to a predetermined range, thereby reducing the amount of unreacted thiourea, and thiourea may be removed once more in a sub sequent process, thereby effectively removing remaining thiourea while achieving a high yield. The polythiol thus produced does not contain residual thiourea, and thus does not show discoloration or cloudiness caused by precipitates even under prolonged storage or high-temperature conditions.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: September 27, 2022
    Assignee: SKC CO., LTD.
    Inventors: Seung Mo Hong, Hyeon Myeong Seo, Junghwan Shin, Jeongmoo Kim
  • Patent number: 11453633
    Abstract: Provided is a production method capable of efficiently producing a reduced coenzyme Q10 Form II crystal. The method for producing a reduced coenzyme Q10 Form II crystal includes: adding a reduced coenzyme Q10 Form II crystal as a seed crystal to a solution with a temperature of 32° C. to 43° C., the solution containing fa) at least one organic solvent selected from the group consisting of an alcohol, a hydrocarbon, an aliphatic acid ester and a nitrogen compound, and (b) reduced coenzyme Q10, to prepare a mixture, and precipitating the reduced coenzyme Q10 from the mixture, in the form of the reduced coenzyme Q10 Form II crystal.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: September 27, 2022
    Inventors: Takao Yamaguchi, Koichi Kinoshita
  • Patent number: 11447450
    Abstract: The subject of the present invention is a process for producing a sulfonic acid which is sparingly corrosive, or even non-corrosive, with respect to stainless steels, said process comprising at least the steps of adding at least one nitrite to a sulfonic acid, curing, with stirring, with sparging of the mixture and recovering the low-corrosion sulfonic acid obtained. The invention also relates to the low-corrosion sulfonic acid obtained according to the process of the invention, and also to the use thereof as low-corrosion sulfonic acid.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: September 20, 2022
    Assignee: ARKEMA FRANCE
    Inventors: Jean-Alex Laffitte, Bernard Monguillon
  • Patent number: 11427537
    Abstract: The present disclosure relates to a method for preparing L-cysteine hydrochloride hydrate crystals, and L-cysteine hydrochloride hydrate crystals prepared by the method. Through the method for preparing L-cysteine hydrochloride hydrate crystals of the present disclosure, L-cysteine hydrochloride hydrate crystals can be obtained from a natural L-cysteine fermentation broth with a high recovery rate and/or purity without a chemical reaction or the use of an artificial synthetic compound.
    Type: Grant
    Filed: January 30, 2019
    Date of Patent: August 30, 2022
    Inventors: Jun-Woo Kim, Jung Min Lee, Se-Hee Jo, Il Chul Kim, In Sung Lee, Jun Young Jung
  • Patent number: 11407694
    Abstract: In a process of decomposing byproducts of a phenol production process using a reactive distillation column in which a reactor and a distillation column are integrated, since acetophenone is mixed with tar recovered to a lower part of the reactive distillation column and transferred, viscosity of the tar may be lowered so that the tar may be transferred at room temperature, and since the reactive distillation column may be operated at 0.5 to 3 bar, an operating temperature of the reactive distillation column is low as compared with a method of separating acetophenone by pressurization with high pressure, significantly reducing an operation cost of a heater required for a reaction. Also, since acetophenone is separately recovered at a position of 25 to 90% of a total number of stages in the reactive distillation column, recovery of an active ingredient may be enhanced.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: August 9, 2022
    Assignee: LG CHEM, LTD.
    Inventors: Min Suk Kang, Sang Beom Lee, Sung Ho Lee, Joon Ho Shin, Chul Han Park