Patents Examined by Rosalynd Keys
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Patent number: 11731927Abstract: The present invention relates to a cocrystal of ubiquinol and a hydrogen bond donor coformer, to a process for the preparation thereof, and to its use as a medicament or a dietary supplement. The invention also relates to compositions comprising the cocrystal.Type: GrantFiled: February 22, 2019Date of Patent: August 22, 2023Assignee: CENTER FOR INTELLIGENT RESEARCH IN CRYSTAL ENGINEERING, S.L.Inventors: Rafel Prohens López, Rafael Barbas Cañero, Lidia Bofill Herrera, Dafne De Sande López
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Patent number: 11708316Abstract: Method for hydrogenating an ester with molecular hydrogen to the corresponding alcohols in the presence of a ruthenium complex (I), wherein said complex comprises a tridentate ligand L of the general formula (II) n and m are each independently 0 or 1, and the solid-dashed double lines represent a single or double bond, with the proviso that in the case of n=1 both solid-dashed double lines represent a single bond and m is 1, and in the case of n=0 one solid-dashed double line represents a single bond and the other solid-dashed double line represents a double bond, wherein in the case of a double bond on the side facing the phenyl ring m=1, in the case of a double bond on the side facing the pyridyl ring m=0, or both solid-dashed double lines represent a single bond and m is 1.Type: GrantFiled: June 24, 2020Date of Patent: July 25, 2023Assignee: BASF SEInventors: Mathias Schelwies, Jonas Schwaben, Rocco Paciello
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Patent number: 11708383Abstract: An organic borane complex contains, as a component, triarylborane having an enhanced bonding between a boron atom and a carbon atom on an aryl group. The organic borane complex contains, as a component, triarylborane having a structure represented by the following general formula (1), wherein X1 and X2 each independently represent an oxygen atom or a sulfur atom; X3 and X4 each independently represent a hydrogen atom or a substituent, or X3 and X4 are linked together to be a single atom; R1 to R3 each independently represent a hydrogen atom or a substituent; and p, q and r each independently represent an integer of 1 to 3. Also disclosed are a composition containing organic borane, and an organic electroluminescent element.Type: GrantFiled: September 28, 2017Date of Patent: July 25, 2023Assignee: KONICA MINOLTA, INC.Inventors: Takatugu Suzuki, Hiroshi Kita, Yuichi Kitamoto, Shuichi Oi
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Patent number: 11697635Abstract: Disclosed are methods of purifying the compound (22E)-(24R)-2-methylene-22-dehydro-1?,24,25-trihydroxy-19-nor-vitamin D3 to obtain the compound in crystalline form. The methods typically include the steps of dissolving (22E)-(24R)-2-methylene-22-dehydro-1?,24,25-trihydroxy-19-nor-vitamin D3 in a solvent comprising ethyl acetate and hexane to form a solution, allowing crystals of (22E)-(24R)-2-methylene-22-dehydro-1?,24,25-trihydroxy-19-nor-vitamin D3 to form and precipitate from the solution, and recovering the crystals of (22E)-(24R)-2-methylene-22-dehydro-1?,24,25-trihydroxy-19-nor-vitamin D3 from the solution.Type: GrantFiled: October 16, 2018Date of Patent: July 11, 2023Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATIONInventors: Hector F. Deluca, Margaret Clagett-Dame, Lori Plum, Agnieszka Flores, James Thoden, Hazel Holden
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Patent number: 11697631Abstract: A process can be used for recovering 1-methoxy-2-propanol and 2-methoxy-1-propanol from an aqueous effluent stream by liquid-liquid-extraction, followed by extractive distillation, distillation of methoxypropanols from the extraction solvent, and distillative separation of the methoxypropanol isomers. Recovered extraction solvent is recycled to the extraction and extractive distillation. Heat transfer from recovered extraction solvent to the extract fed to the extractive distillation reduces energy demand of the process. A facility for this process contains a countercurrent extraction column, an extractive distillation column, a solvent recovery distillation column, an isomer separation distillation column, and a heat exchanger for transferring heat from recovered extraction solvent to the extract fed to the extractive distillation.Type: GrantFiled: March 23, 2021Date of Patent: July 11, 2023Assignees: Evonik Operations GmbH, thyssenkrupp Industrial Solutions AGInventors: Michael Kleiber, Willi Hofen
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Patent number: 11697629Abstract: Certain embodiments are directed to methods of purifying methanol comprising fractionating a feed source into methanol and heavy alcohol or fusel alcohol fractions and further recovering methanol from the fusel alcohol fraction.Type: GrantFiled: August 10, 2018Date of Patent: July 11, 2023Assignee: SABIC GLOBAL TECHNOLOGIES B.V.Inventors: Ali Al-Hammad, Ijaz Chaudary
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Patent number: 11685704Abstract: A method of producing THB with improved efficiency is provided. Provided is a method of producing trihydroxybenzene (THB), the method comprising a step of heating a bacterial culture liquid comprising deoxy-scyllo-inosose (DOI) at a high temperature of no lower than 80° C. to obtain a product solution comprising trihydroxybenzene (THB).Type: GrantFiled: October 24, 2019Date of Patent: June 27, 2023Assignee: MITSUI CHEMICALS, INC.Inventors: Osamu Yoshikawa, Masaki Yabe, Mitsufumi Wada, Yusuke Ito, Hideki Ouchi
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Patent number: 11673851Abstract: A process the dehydration of methanol to dimethyl ether in the presence of a solid Brønsted acid catalyst selected from aluminosilicate zeolites which have a maximum free sphere diameter of greater than 3.67 Angstroms and heteropolyacids and a promoter selected from methyl formate, dimethyl oxalate and dimethyl malonate and the molar ratio of promoter to methanol is maintained at less than 1.Type: GrantFiled: August 24, 2018Date of Patent: June 13, 2023Assignees: BP p.l.c., BP (China) Holdings LtdInventors: Benjamin James Dennis-Smither, Neil Sainty, John Glenn Sunley
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Patent number: 11667653Abstract: The invention relates to a continuous method for the production of Grignard adducts, in which the magnesium chips are activated mechanically in situ. Furthermore, the invention relates to a device for implementation of the method according to the invention.Type: GrantFiled: March 29, 2017Date of Patent: June 6, 2023Assignee: Fraunhofer-Gesellschaft zur förderung der angewandten Forschung e.V.Inventors: Gabriele Menges-Flanagan, Christian Hofmann
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Patent number: 11655201Abstract: The present invention relates to a stable crystal form, i.e. form A, of 2-tert-butyl-4-methoxyphenol, and to a new preparation method for the 2-tert-butyl-4-methoxyphenol; and the use of the 2-tert-butyl-4-methoxyphenol and the stable crystal form thereof, i.e. form A, in preparing antitumor drugs or immunomodulator drugs. The stable crystal form, i.e. form A, as expressed by a powder X-ray diffraction pattern in an angle of 2?, using Cu-K? radiation, has at least 3 absorption peaks selected from the following positions: 6.27±0.10, 6.94±0.10, 12.27±0.10, 13.36±0.10, 14.01±0.10, 14.79±0.10, 15.31±0.10, 17.05±0.10, 18.30±0.10, 19.00±0.10, 20.47±0.10, 20.98±0.10, 22.37±0.10, 23.68±0.10, 24.55±0.10, 25.37±0.10, 30.83±0.10, 33.12±0.10, 40.50±0.10, 42.81±0.10.Type: GrantFiled: March 23, 2018Date of Patent: May 23, 2023Assignee: BIOMEDICAL ANALYSIS CENTER, ACADEMY OF MILITARY MEDICAL SCIENCESInventors: Xuemin Zhang, Xinhua He, Tao Zhou, Zhenggang Liu, Tao Li, Shengming Wu
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Patent number: 11649200Abstract: The present invention discloses an integrated process and an apparatus for production of various alcohols and Oligomerization of Olefinic feed stocks comprising butylenes and mixture thereof. In this process the combined light olefinic hydrocarbon feedstock is divided into two streams and contacted in two different reaction zones, viz. hydration and oligomerization. The mixture of alcohols and oligomer product from hydration reaction is separated and the bottom stream from separator is routed to oligomerization reaction zone in a controlled quantity as selectivity enhancer. Both the reaction zones are operated at different conditions. The product from oligomerization zone is further separated in to lighter and heavier components. Each reaction zone may comprise series of reactors filled with acidic catalysts comprising ion exchange resins.Type: GrantFiled: September 7, 2021Date of Patent: May 16, 2023Assignee: INDIAN OIL CORPORATION LIMITEDInventors: Saravanan Subramani, Pushkar Varshney, Reshmi Manna, Madhusudan Sau, Gurpreet Singh Kapur, Sankara Sri Venkata Ramakumar
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Patent number: 11637250Abstract: The present invention addresses the problem of providing a polycyclic aromatic compound which has improved solubility in solvents, film formability, wet coatability and in-plane orientation. The above-described problem is solved by a composition for forming a light emitting layer, which contains, as a first component, at least one compound selected from the group consisting of compounds represented by general formula (A-1) and compounds represented by general formula (A-2), as a second component, at least one compound that has a triplet energy (ET) of 1.8-3.0 eV, and as a third component, at least one organic solvent. In the formulae, R represents a hydrogen atom, an aryl group, a heteroaryl group, a diarylamino group, a diheteroarylamino group or an aryl heteroarylamino group.Type: GrantFiled: April 28, 2020Date of Patent: April 25, 2023Assignees: Kwansei Gakuin Educational Foundation, SK Materials JNC Co., Ltd.Inventors: Takuji Hatakeyama, Yasuhiro Kondo, Keiichi Nakamoto, Motoki Yanai
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Patent number: 11623904Abstract: Provided is a process in which a cyclobutanediol compound having a high cis:trans ratio can be stably obtained. The cyclobutanediol compound having a cis:trans ratio of 1.5:1 to 5000:1 is produced by using at least one compound selected from a group consisting of a cyclobutanedione compound, a cyclobutane ketol compound, and a cyclobutanediol compound as a raw material, and performing a catalytic hydrogenation reaction and an isomerization reaction in the cyclobutanediol compound in a solid phase state in the presence of a metal catalyst without adding a solvent.Type: GrantFiled: March 17, 2021Date of Patent: April 11, 2023Assignee: JNC CORPORATIONInventors: Shinichi Furusato, Toshiyuki Kawanabe, Kaori Tsuruoka, Hironao Sajiki, Tsuyoshi Yamada, Kwihwan Park
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Patent number: 11613717Abstract: A method of producing a fuel additive includes passing a feed stream comprising C4 hydrocarbons through a methyl tertiary butyl ether unit producing a first process stream; passing the first process stream through a selective hydrogenation unit producing a second process stream; passing the second process stream through an isomerization unit producing a third process stream; and passing the third process stream through a hydration unit producing the fuel additive and a recycle stream.Type: GrantFiled: July 27, 2018Date of Patent: March 28, 2023Assignees: SABIC GLOBAL TECHNOLOGIES B.V., SAUDI ARABIAN OIL COMPANYInventors: Guillermo Leal, Kareemuddin Mahaboob Shaik, Mohammed Bismillah Ansari, Hiren Shethna, Zhonglin Zhang
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Patent number: 11591280Abstract: The invention relates to new intermediates in the synthesis of Eldecalcitol and to processes for the preparation of said intermediates and of Eldecalcitol.Type: GrantFiled: May 12, 2020Date of Patent: February 28, 2023Inventors: Gonzalo Hernández Herrero, Neftalí García Domínguez, Tatiana María Suárez Cortés, Tania González García, Generosa Gómez Pácios, Yagamare Fall Diop, Hugo Santalla García, Fátima Garrido Fernández
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Patent number: 11578026Abstract: A process for dehydrating C2+ alcohols to ether products in the presence of a catalyst and promoter, wherein the catalyst is at least one aluminosilicate zeolite catalyst which is a medium pore zeolite having a 3-dimensional framework structure, and the promoter is one or more organic carbonyl compounds or derivatives thereof, and wherein and the molar ratio of promoter to C2+ alcohols is maintained at less than 1.Type: GrantFiled: February 14, 2020Date of Patent: February 14, 2023Assignee: BP P.L.C.Inventors: Benjamin James Dennis-Smither, John Glenn Sunley, Fiona Jackson
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Patent number: 11578038Abstract: The embodiments relate to a process for preparing a polythiol composition, which comprises reacting a halogen compound or an alcohol compound with thiourea to prepare a thiouronium salt solution; and adding a basic solution to the thiouronium salt solution to hydrolyze it. The hydrolysis reaction is terminated when the area of peak A in the graph measured by gel permeation chromatography of the reactant in the hydrolysis step under certain conditions is 0.5% to 8% based on the total peak area. A tetrafunctional polythiol composition having high purity can be obtained. Thus, an optical lens having excellent color, transparency, and refractive index can be obtained.Type: GrantFiled: December 10, 2020Date of Patent: February 14, 2023Assignee: SKC CO., LTD.Inventors: Jaeyoung Pai, Seung Mo Hong, Hyeon Myeong Seo, Junghwan Shin, Jeongmoo Kim, Jung Hwan Myung, Hyuk Hee Han
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Patent number: 11565990Abstract: A more environmentally friendly synthesis method of 4-bromo-2-(4?-ethoxyphenyl)-1-chlorobenzene with simplified steps provides a more effective synthetic strategy for producing key intermediates of SGLT-2 inhibitors such as dapagliflozin, sotagliflozin, and ertugliflozin. In the presence of trifluoroacetic anhydride, 5-bromo-2-chlorobenzoic acid and phenetole are selected to complete a direct acylation reaction under the catalysis of boron trifluoride diethyl etherate, and triethylsilane is added thereinto without treatment for one-pot reaction to obtain a target compound 4-bromo-2-(4?-ethoxyphenyl)-1-chlorobenzene.Type: GrantFiled: June 9, 2021Date of Patent: January 31, 2023Assignee: WISDOM PHARMACEUTICAL CO., LTDInventors: Lin Hu, Tao Xu, Xiaolong Qiu, Xiaoyue Li, Zhiwei Zuo, Wenbo Liu, Lingling Chu, Ximeng Yuan, Ping Zou
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Patent number: 11560347Abstract: A method for synthesizing a fluorovinyl ether compound from a fluorine-containing vinyl compound. Specifically, a method for producing a compound represented by formula (1), comprising step A of reacting a compound represented by formula (2) with a compound represented by formula (3) in the presence of a transition metal catalyst: wherein the substituents are defined in the disclosure.Type: GrantFiled: June 26, 2019Date of Patent: January 24, 2023Assignee: DAIKIN INDUSTRIES, LTD.Inventors: Naoyuki Hoshiya, Akihiro Gotou, Yosuke Kishikawa
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Patent number: 11535590Abstract: The present invention provides a sulfonium salt photoinitiator, a preparation method therefor, a photocurable composition comprising sulfonium salt photoinitiator, and use thereof. The sulfonium salt photoinitiator has a structure represented by formula (I). By modifying the structure of an existing sulfonium salt photoinitiator, a sulfonium salt photoinitiator having a new structure is obtained, which can exhibits a higher photosensitivity and an excellent as well as characteristics of low odor and low toxicity, when being used in a photocurable composition. This is significantly superior to existing similar photoinitiators.Type: GrantFiled: August 27, 2018Date of Patent: December 27, 2022Assignees: Changzhou Tronly New Electronic Materials Co., Ltd., Changzhou Tronly Advanced Electronic Materials Co., Ltd.Inventor: Xiaochun Qian