Abstract: Visco-supplement compositions derived from a transcellular fluid, such as human amniotic fluid, human aqueous humor fluid, or human vitreous fluid are described. Also described are methods for treating inflammatory conditions of the musculoskeletal system, such as joint inflammation, and methods of lubricating a joint using the described visco-supplement compositions.

Abstract: To develop a novel administration method of a fucoidan-containing hair-growing agent and to provide a means for exerting excellent effects of a fucoidan. A hair-growing agent of the present invention is characterized in that it is composed of a combination of a fucoidan-containing microneedle and a fucoidan-containing liniment. A base of the fucoidan-containing microneedle is preferably a biosoluble polymer. A hair-growing method of the present invention is characterized in that the fucoidan-containing microneedle and the fucoidan-containing liniment are concomitantly used.

Abstract: The present invention is directed to composition comprising Nigella sativa (NS) oil, wherein said oil comprises thymoquinone (TQ) at a concentration of at least 2% (w/w). The composition is further characterized by having a much lower free fatty acid concentration than prior art compositions. The composition, which has anti-inflammatory activity, may be formulated for oral administration to a mammalian subject, for the purpose of preventing or treating inflammatory conditions and other disorders.

Abstract: A method of feeding a non-livestock ruminant animal a feed composition including a phytogenic composition for improving performance during periods of heat stress involves determining the non-livestock ruminant animal is experiencing heat stress during a period of heat stress conditions, and feeding the heat stressed non-livestock ruminant animal the feed composition including an amount of the phytogenic composition that is effective to improve performance. A method of feeding a non-livestock ruminant animal a feed composition including a phytogenic composition for improving performance in anticipation of periods of heat stress involves determining a potential for heat stress is increased based on one or more of historical weather patterns or short-term forecasts, and feeding the non-livestock ruminant animal the feed composition including the phytogenic composition based on the determined potential for heat stress.

Abstract: AC-11® is a federally registered trademark covering a product consisting of an aqueous extract of the botanical Uncaria tomentosa. Applicants have found that administration of AC-11® product in a pharmaceutically effective amount and for a sufficient time period results in enhancement of cognition in people with normal cognition prior to commencing administration. The method of administering the AC-11® product is disclosed and claimed.

Abstract: The present application is directed to the field of implants comprising soft tissue for use in implantation in humans. The soft tissue implants of the present application are preferably obtained from xenograft sources. The present application provides a chemical process that sterilizes, removes antigens from and/or strengthens xenograft implants. The present techniques yield soft tissue implants having superior structural, mechanical, and/or biochemical integrity. The present application is also directed to processes for treating xenograft implants comprising soft tissues such as dermis, and to implants produced by such processes.

Abstract: Disclosed herein is disclosed is a nutritional food product (supplement) comprising creatine, which may be provided in a gummy form. In certain embodiments, the supplement may comprise about 6% to 35% by weight of creatine. In some embodiments, the supplement may comprise a gelling agent, a sweetener, and water.

Abstract: The present invention encompasses oils that have anti-inflammatory or resolution-stimulating activity that contain or are enriched with Specialized Proresolving Mediators (SPM) or SPM precursors, which originate from an oil obtained from organisms containing long chain omega-3 polyunsaturated fatty acids, such as fish, crustaceae, algae, and mollusks. The invention also encompasses a method for the production of these oils, and the utilization of the oils for nutritional supplements, pharmaceutical formulations, and cosmetic formulations, which can be employed for treating an inflammatory condition.

Abstract: The invention relates to a tobacco leaf extract containing, relative to the total weight of the extract, at least 5 wt.-% proteins essentially free of molecules with a molecular mass of less than 10 kDa. The invention also relates to a pharmaceutical composition containing such an extract and to the use thereof in the treatment of tobacco addiction.

Abstract: The present disclosure provides compositions composed of amniotic fluid and/or modified amniotic fluid, a pharmaceutically acceptable carrier, and optionally a placental tissue graft, micronized placental tissue components, or extracts derived therefrom. Also described are systems and apparatuses for administering or storing said compositions, as well as methods of treatment using said compositions.

Abstract: The disclosure provides a medical sealant glue capable of promoting wound healing and a preparation method thereof. The medical sealant glue is formed by covalent cross-linking of two components after being physically mixed by a mixing tool, wherein the first component is a nucleophilic component, and the second component is an electrophilic component. The medical sealant glue has a gelation time of 1-10 s, a swelling ratio of 0-100%, a bursting strength of 100-250 mmHg, and a degradation time of 0.5-300 days. The nucleophilic component of the medical sealant glue contains exosome or hyaluronic acid and chitosan, and thus the medical sealant glue not only has the effect of promoting wound healing, but also has antibacterial and anti-infection effects.

Abstract: A method for producing full spectrum hemp extract comprising extracting substances from cannabis-based green material that are soluble in an extraction solvent and collecting an extract that includes the extraction solvent distilling at least a portion of the extraction solvent which results in a concentrate that is not distilled off, removing at least a portion of water soluble substances from the concentrate by partitioning the at least a portion of water soluble substances into an aqueous phase and a remainder of substances from the concentrate into a partitioned concentrate, heating the partitioned concentrate to evaporate the nonpolar solvent and to yield a crude oil, degassing the crude oil by heating it which results in a degassed crude oil, performing a first pass distillation at about 150° C. and collecting a first residue, performing a second and third pass distillation at about 170° C. and about 185° C., and collecting a distillate from same.

Abstract: The present invention relates to a composition comprising an aqueous solvent extract of yuzu seeds and an aqueous solvent extract of brown rice; and a method for treating or suppressing various symptoms of skin problems and allergic skin diseases including atopic dermatitis using the composition.

Abstract: The present disclosure provides a neuron activator that activates neurons. The neuron activator includes at least one selected from the group consisting of a dopamine production promotor that promotes dopamine production of the neurons, a neuron extension promotor that promotes extension of the neurons, and an amyloid ? resistance enhancer that enhances resistance of the neurons against amyloid ?. The neuron activator includes 6-methylsulfinylhexyl isothiocyanates or glycosides thereof, and at least one selected from the group consisting of unsaturated fatty acid and polyphenol.

Abstract: A method for enhancing skin moisture of a subject in need thereof includes administering to the subject a composition including a white roselle (Hibiscus sabdariffa cv.) extract. The white roselle extract is obtained by lysing a cell wall of a white roselle calyx by ice crystals and extracting the lysed white roselle calyx with a solvent.

Abstract: The present disclosure describes methods and compositions for inhibiting fungal growth in food and cosmetic products, as well as food and cosmetic products treated with anti-fungal compositions.

Abstract: The present invention relates to sweetened beverage compositions comprising the steviol glycoside rebaudioside D (Reb D) and combinations of Reb D and rebaudioside M (Reb M). The present invention also relates to methods to reduce the degradation and improve the stability of Reb D.

Abstract: The disclosure describes methods for the purification of protein-enriched extracts to provide concentrates and isolates and methods for incorporation of such materials into products. The purification methods are adapted for removal of nicotine and may have other benefits, e.g., lightening the color of the protein-enriched extracts. The methods generally include treatment with peracetic acid or hydrogen peroxide and filtrations. A protein composition in the form of a concentrate or isolate is provided, the protein composition including RuBisCO, F2 fraction proteins, or combination thereof extracted from a plant of the Nicotiana species, wherein the protein composition is characterized by relatively low nicotine content.

Abstract: Methods for treating knee osteoarthritis in a patient are disclosed. In one embodiment, a method for treating a knee osteoarthritis patient using an oral dried garlic supplement, wherein the treating comprises administering 900 mg of the oral dried garlic supplement on a daily basis. In one embodiment, 1800 mg of the oral dried garlic supplement is used.

Abstract: The use of luteinizing hormone receptor (LHR) binding agents and luteinizing hormone (LH) agonists to enrich for primitive hematopoietic stem cell (pHSC) populations, to target pHSC for ablation, and/or to expand pHSC populations are described. The methods can be used to prepare therapeutic hematopoietic stem cell (HSC) populations, to prepare patients for therapeutic HSC transplants, and/or to treat malignancies, such as those associated with hyperproliferative HSC.