Abstract: The present invention provides a new method for producing Engineered Heart Muscle (EHM) under chemically fully defined conditions all compatible with GMP regulations. The resulting human myocardium generates force and shows typical heart muscle properties.
Abstract: Methods for culturing filamentous fungi, in which the filamentous fungi are grown in a colloid of air and a fermentation medium, are provided. The methods result in more rapid and prolific growth of the filamentous fungus than has been achieved by previous methods. Biomats produced by the methods and air-medium colloids for use in the methods are also provided.
Type:
Grant
Filed:
October 15, 2021
Date of Patent:
October 11, 2022
Assignee:
The Fynder Group, Inc.
Inventors:
Michael John Harney, Richard Eugene Macur, Yuval Charles Avniel
Abstract: A production method of microencapsulated probiotics with chitosan-alginate polymers, the microcapsules loaded with probiotics obtained by this method and their use in food, agriculture and cosmetics. The microcapsules do not make alterations in the color and appearance of the product in which they are applied and have antifungal and anti-mycotoxin features.
Abstract: The problem of detecting whether a urine sample is true human urine or a counterfeit urine product is solved by the use of reagent systems that detect two markers normally present in human urine. The markers acid phosphatase and alkaline phosphatase catalyze the substrates thymolphthalein monophosphate and p-nitrophenol phosphate, respectively. These substrates are formulated as spot tests on a dip stick or as reagents for use in automated chemical analyzers. The presence of the markers can be qualitatively detected by color-changes in the sample, formed by the pH-specific chromogens that result from catalysis of the substrates with the markers. The control reagent can further indicate whether a counterfeit urine product contains one or both of the chromogens.
Abstract: Methods for culturing filamentous fungi, in which the filamentous fungi are grown in a colloid of air and a fermentation medium, are provided. The methods result in more rapid and prolific growth of the filamentous fungus than has been achieved by previous methods. Biomats produced by the methods and air-medium colloids for use in the methods are also provided.
Type:
Grant
Filed:
October 15, 2021
Date of Patent:
October 4, 2022
Assignee:
The Fynder Group, Inc.
Inventors:
Michael John Harney, Richard Eugene Macur, Yuval Charles Avniel
Abstract: The present invention relates to an enzyme-carrier complex, and more particularly to the adsorption and stabilization of an enzyme on the surface of a carrier, and an enzyme-carrier complex with secured enzyme stability so that an enzyme immobilized by a hydrophobic interaction exhibits long-term enzymatic activity.
Type:
Grant
Filed:
December 11, 2020
Date of Patent:
September 13, 2022
Assignee:
Korea Univercity Research and Business Foundation
Abstract: The present invention relates to Siphoviridae bacteriophage Vib-ANP-1(accession number KCTC 13075BP) having the ability to specifically kill Vibrio anguillarum bacteria and a genome represented by SEQ ID NO: 1 and isolated from nature, and a method for prevention or treatment of Vibrio anguillarum bacterial infection by using a composition containing the same bacteriophage as an effective ingredient.
Type:
Grant
Filed:
August 21, 2017
Date of Patent:
September 13, 2022
Inventors:
Seong Jun Yoon, Soo Youn Jun, An Sung Kwon, Soon Hye Hwang, Hyun Min Song, Ji In Jung, Sang Hyeon Kang
Abstract: Intensification techniques are described for enhancing biocatalytic CO2 absorption operations, and may include the use of a rotating packed bed, a rotating disc reactor, a zig-zag reactor or other reactors that utilize process intensification. Carbonic anhydrase can be deployed in the high intensity reactor free in solution, immobilized with respect to particles that flow with the liquid, and/or immobilized to internals, such as packing, that are fixed within the high intensity reactor.
Type:
Grant
Filed:
March 30, 2016
Date of Patent:
August 23, 2022
Assignee:
SAIPEM S.P.A.
Inventors:
Mausam Verma, Louis Fradette, Sylvie Fradette, Sylvain Lefebvre, Vincent Sylvestre-Laurence
Abstract: Methods are provided for cultivating fungi for scaled-up production of microbe-based products. Specifically, cultures of fungi, such as, e.g., Pisolithus tinctorius, are grown by aerobic submerged fermentation in liquid medium containing a particulate anchoring carrier to increase mycelial biomass.
Type:
Grant
Filed:
January 10, 2019
Date of Patent:
August 16, 2022
Assignee:
LOCUS IP COMPANY, LLC
Inventors:
Sean Farmer, Ken Alibek, Sharmistha Mazumder, Tyler Dixon
Abstract: Methods for culturing filamentous fungi, in which the filamentous fungi are grown in a colloid of air and a fermentation medium, are provided. The methods result in more rapid and prolific growth of the filamentous fungus than has been achieved by previous methods. Biomats produced by the methods and air-medium colloids for use in the methods are also provided.
Type:
Grant
Filed:
October 15, 2021
Date of Patent:
August 9, 2022
Assignee:
The Fynder Group, Inc.
Inventors:
Michael John Harney, Richard Eugene Macur, Yuval Charles Avniel
Abstract: The present disclosure relates to stem cells which express high levels of Angeopoetin-1 (Ang1) and uses thereof in inhibiting M1-type macrophage production and treating inflammatory disease such as diabetes.
Type:
Grant
Filed:
March 24, 2020
Date of Patent:
August 9, 2022
Assignees:
MESOBLAST INTERNATIONAL SARL, OAKTREE FUND ADMINISTRATION, LLC
Abstract: The present application relates to probiotic confection-based compositions comprising lactic acid-producing bacteria and oil-based compositions comprising the same.
Abstract: The present invention relates to a method for preventing and/or treating hyperlipemia and its related conditions in a subject, comprising administering a prophylactically and/or therapeutically effective amount of plasminogen to the subject susceptible to hyperlipemia, suffers from hyperlipemia or other diseases accompanied by hyperlipemia. The present invention further relates to a medicament, a pharmaceutical composition, an article of manufacture, and a kit comprising plasminogen which are useful for preventing and/or treating hyperlipemia and its related conditions in a subject.
Abstract: The present invention relates to Lactobacillus salivarius CJLS1511, a composition for animal feed additives comprising the same or its inactivated bacterial cells, and a method for preparing the inactivated bacterial cells.
Type:
Grant
Filed:
August 7, 2017
Date of Patent:
July 12, 2022
Assignee:
CJ CHEILJEDANG CORPORATION
Inventors:
Ji Eun Kim, Kyeong Su Chae, Sung Hun Kim, Seok Woo Chee, Joong Su Lee
Abstract: A medium supplement for high-yield culture of anaerobes is disclosed. The medium supplement includes N-acetylhexosamine, L-aspartic acid, L-cysteine and cobalamin. A culture medium including the supplement and a culture method using the culture medium are also disclosed. It is possible to provide an innovative method which is capable of achieving high-concentration culture of anaerobes that are difficult to culture in high yield. The method is cost-effective, and in particular, is capable of culturing large amounts of fastidious aerobes suitable for use in food and pharmaceutical applications.
Abstract: Methods of analyzing glycosylated biomolecules include the steps of producing a deglycosylation mixture of biomolecules deglycosylated by natural or synthetic enzymatic or chemical techniques; providing a reagent solution having a labeling reagent in a polar aprotic, non-nucleophilic organic solvent; and mixing the deglycosylation mixture with the reagent solution in an excess of labeling reagent to produce derivatized glycosylamines. The method steps can be carried out purposefully without depletion of protein matter. A quenching solution can be added to the reaction mixture so that the pH of the reaction mixture is shifted to above 10. The yield of derivatized glycosylamines can be in an amount of about 80 to about 100 mole percent of the reaction mixture with minimal overlabeling, less than 0.2 mole percent.
Type:
Grant
Filed:
October 28, 2015
Date of Patent:
June 28, 2022
Assignee:
Waters Technologies Corporation
Inventors:
Matthew A. Lauber, Darryl W. Brousmiche, Stephan M. Koza
Abstract: The present disclosure provides methods, systems, compositions, and kits to address the need for microbiome-related treatment of health conditions and disease. The present disclosure provides for treatment of metabolic conditions using microbial compositions.
Type:
Grant
Filed:
August 25, 2021
Date of Patent:
June 21, 2022
Assignee:
Pendulum Therapeutics, Inc.
Inventors:
Colleen Cutcliffe, John S. Eid, James H. Bullard, Marcus F. Schicklberger
Abstract: The disclosure relates to a therapeutic composition for treating L. monocytogenes infection or L. monocytogenes colonization, the composition including at least one, at least two, at least three, or all of an isolated C. saccharogumia bacteria, an isolated C. ramosum bacteria, an isolated C. hathewayi bacteria, and/or an isolated B. producta bacteria in a formulation suitable for administration to a subject. The disclosure further provides similar compositions lacking an isolated C. saccharogumia bacteria. The disclosure additionally provides methods of treating L. monocytogenes infection or colonization using such compositions.
Abstract: The present disclosure relates to an enzyme-immobilized porous membrane and a preparation method of antibiotics using the same, and more specifically, to an enzyme-immobilized porous membrane prepared by immobilizing a specific enzyme through dead-end filtration, and a preparation method of antibiotics with a high yield using the enzyme-immobilized porous membrane. According to various exemplary embodiments of the present disclosure, the enzyme capable of promoting the synthesis reaction of the antibiotic substance is able to be stably immobilized in the porous membrane by passing the solution of enzyme through the membrane. In addition, it is possible to provide antibiotics with a high yield by preparing the antibiotics by passing the reactant solution through the enzyme-immobilized porous membrane.
Type:
Grant
Filed:
October 21, 2019
Date of Patent:
June 14, 2022
Assignee:
GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY