Abstract: Compositions and methods are disclosed for the controlled release delivery of polypeptide growth factors. The compositions of the invention are hydrogels which comprise: a polypeptide growth factor having at least one region of positive charge; a physiologically acceptable water-miscible anionic polymer; a physiologically acceptable non-ionic polymeric viscosity controlling agent; and water.

Abstract: A transdermal structure is provided for delivering cannabis chemical(s) to one's bloodstream. The structure comprises a backing layer which carries the cannabis chemical(s). The chemicals are contained in a film on the backing layer or within a cavity formed in the backing layer. Alternatively, an opening in a secondary layer that overlies the backing layer may be used to create the cavity. The structure is applied to one's skin so that the cannabis chemicals are in contact with the skin. A polymer material which is mixed with the cannabis and placed in the cavity or a membrane over the cavity may be used to control the flow of cannabis chemical (s) into the bloodstream. In an alternative embodiment, a porous material impregnated with cannabis chemical (s) may be used to hold the chemical(s) in the cavity.

Abstract: The present invention a method for making nail coverings comprises the steps of scanning a persons fingernail to produce a digitized nail image of the nail top surface and shaping a nail covering material using the digitized nail image such that the nail covering material conforms to the nail top surface thereby producing a nail cover sized to cover substantially the entire nail top surface. The invention preferably includes the step of adhering the nail cover to the nail top surface thereby covering substantially the entire nail top surface with the nail cover. The invention preferably includes the further step of producing a three dimensional digital nail image of the nail top surface.

Abstract: The present invention relates to lipstick compositions which comprise thermodynamically association structures, preferably lamellar liquid crystals and/or reverse hexagonal liquid crystals, which are used to deliver polar solvent/moisturizers through a non-polar (lipophilic) medium. The association structures consist essentially of from about 3% to about 96%, by weight, of polar solvent (e.g. glycerine) and from about 4% to about 97% of surfactant having a Krafft point at or below about ambient temperature.

Abstract: Methods and products for delivering a medicament or agent to an individual are provided as well as methods for producing the product. The product includes a coating having a medicament or agent. The medicament or agent is present within the coating that surrounds a tableted gum center (the water soluble portion and a water insoluble base portion). By chewing the gum, the medicament or agent is released from the product. Continuing to chew the chewing gum creates a pressure within the buccal cavity forcing the agent or medicament directly into the systemic system of the individual through the oral mucosa contained in the buccal cavity. This greatly enhances the absorption of the drug into the systemic system as well as the bioavailability of the drug within the system.

Abstract: The invention concerns topical formulations such as nail varnishes comprising as the active agent the compound of formula I in free base form or in acid addition salt form, together with a polymeric film former and further excipients as appropriate. It also concerns a process of preparation of such preparations by mixing with an appropriate polymeric film former and conventional further excipients as appropriate, and a method of treatment of onychomycosis.

Abstract: A composition containing: a) 5 to 50% by weight relative to the total weight of the composition of a water-dispersible polycondensate containing sulphonate functional groups, b) 0.5 to 20% by weight relative to the total weight of the composition of a water-soluble copolymer containing carboxylic acid functional groups neutralized in a proportion of at least 80% with a nonvolatile basic agent, the weight average molecular weight of said copolymer being between 1,000 and 700,000, and c) 0.01 to 0.5% by weight relative to the total weight of the composition of a nail care active principle, in an aqueous or aqueous-alcoholic medium, provides a nail coating composition which is readily applicable to the nail, dries rapidly and leaves a protective film on the nail.

Abstract: In order to obtain a makeup cosmetic preparation having natural color-rendering property in response to intensity of surrounding light, a light-responding high color-rendering makeup cosmetic preparation of the present invention is characterized in that titanium oxide or titanium oxide compound, which has photochromic property to darken in response to intensity of irradiated ultraviolet ray, is coated on a surface of mica and metal or metal compound exists on a surface and/or inside of said photochromic titanium oxide coated mica and color of said metal or metal compound is observed as an object color, and wherein an observation color of said photochromic titanium oxide coated mica is changed by emphasizing an interference color generated by darkening of titanium oxide layer which is made of titanium oxide or titanium oxide compound in response to irradiation of ultraviolet ray, and wherein at least one of color tone in the cosmetic preparation is given by an observation color of the observation color changea

Abstract: The present invention relates to a dietary product comprising ubiquinone, stabilized vitamin E, phospholipids, selenuim in an organic form and L-methionin, which is effective to combat cell oxidative stress even to the extreme consequences thereof, for example cell decay, acquired and/or congenital immunodeficiency or other alterations in the immune system. The dietary product object of the present invention is also effective as a coadjutant in the treatment of apoptosis, in mutagenesis and/or carcinogenesis, in infectious diseases of viral or bacterial origin or those deriving from other external pathogens, in myelinic and skin diseases, in cardiovascular diseases and in allergies.

Abstract: A plaster preparation comprising a synthetic rubber; a reinforcing agent based on silica or random styrene-butadiene, copolymer; a tackifier; salicylic acid or a pharmaceutically acceptable salt or ester thereof.

Abstract: A fragrant fingernail polish composed of 35.5 wt % ethyl solvent, 20 wt % butyl solvent, 12 wt % acetone, 16.5 wt % cellulose acetate butyrate, 10 wt % acrylic resin, 0.5 wt % whitening-preventive agent, 4.4 wt % artificial pearl powder, 0.55 wt % dye of desired base color, and 0.55 wt % perfume.

Abstract: The invention relates to the use in a cosmetic or dermatological composition which can be applied to the skin, keratin fibres, semi-mucous membranes and/or mucous membranes, of an aqueous dispersion of film-forming polymer particles combined with an antimicrobial protection system, in particular an antibacterial and/or antifungal system, comprising 1,2-pentanediol. The invention relates in particular to a make-up composition for the lips or the body.

Abstract: The invention relates to an antifungal composition for the treatment of human nails containing extracts of walnut hull, pulverized roots of Nardostachys jatamansi or Vetiveria zizanioides or Catharanthus roseus, polyols, fixed oil, non-ionic emulsifiers, thickening agent plasticizer and base. The invention also relates to a process for the preparation of the above synergistic composition.

Abstract: A disposable towelette is provided which includes a flexible substrate such as a cellulosic tissue impregnated with an alpha-hydroxycarboxylic add delivered in a cosmetically acceptable carrier vehicle. There is further provided a method for cleansing skin and simultaneously inhibiting fine lines and wrinkles by wiping the skin with the impregnated towelette.

Abstract: The present invention provides for a composition for bleaching hair consisting essentially of: (a) an oxidizing agent selected from any peroxygen compound, and (b) a linear hydroxy terminated polyoxypropylene oligomer which comprises from 0.5% to 15% by weight relative to the total weight of the composition. The linear hydroxy terminated polyoxypropylene oligomer may comprise an oil like material having a pour point less than 0 degress Fahrenheit. The present invention also provides for a process for the preparation of a composition for bleaching hair which comprises mixing a linear hyroxy terminated polyoxypropylene oligomer into the composition for bleaching hair, spraying the mixture at room temperature to apply a uniform coating of the oligomer on particles of the composition, thereby causing the particles to agglomerate so as to render the composition essentially dust free during handling.

Abstract: A lipstick is provided for freshening the breath and reducing oral malodor. These lipsticks utilize an antibacterial agent in combination with menthol as the active components. Most preferred as the antibacterial agent are zinc salts, especially zinc citrate. Further components of the lipstick include a lipophilic material such as waxes and usually colorants. Water may be included at levels ranging up to about 25% by weight.

Abstract: Methods and products for delivering a medicament or agent to an individual are provided as well as methods for producing the product. The product includes a coating having a medicament or agent. The medicament or agent is present within the coating that surrounds a tableted gum center (the water soluble portion and a water insoluble base portion). By chewing the gum, the medicament or agent is released from the product. Continuing to chew the chewing gum creates a pressure within the buccal cavity forcing the agent or medicament directly into the systemic system of the individual through the oral mucosa contained in the buccal cavity. This greatly enhances the absorption of the drug into the systemic system as well as the bioavailability of the drug within the system.

Abstract: A topical therapeutic preparation includes capsaicin which is an extract of peppers or chiles and which is a potent local pain killer. The ointment also includes a norepinephrine inhibitor and preferably a vasodilator which act to promote blood circulation in the treatment area and thereby promote healing of tissues in the treatment area. The ointment also preferably includes a local pain killer to offset the irritating effects of the capsaicin and a promoter of transcutaneous absorption.

Abstract: The present invention relates to a modified polypeptide which has an enzymatic activity level of greater than about 70% of the parent polypeptide and an allergenic response level of less than about 33% of the parent polypeptide. Embodiments of the present invention relate to modified polypeptides with reduced allergenicity and high enzymatice activity comprising the formula: A-Bn wherein A is an enzyme, and mixtures thereof; B is a twin polymer moiety, having a total molecular weight of from about 0.5 kilodaltons (KD) to about 40 KD, having the formula conjugated to the enzyme; wherein R1 and R2 are essentially straight chain polymers, having a molecular weight ranging from about 0.

Abstract: A method and devices for localized delivery of a chemotherapeutic agent to solid tumors, wherein the agent does not cross the blood-brain barrier and is characterized by poor bioavailability and/or short half-lives in vivo, are described. The devices consist of reservoirs which release drug over an extended time period while at the same time preserving the bioactivity and bioavailability of the agent. In the most preferred embodiment, the device consists of biodegradable polymeric matrixes, although reservoirs can also be formulated from non-biodegradable polymers or reservoirs connected to implanted infusion pumps. The devices are implanted within or immediately adjacent the tumors to be treated or the site where they have been surgically removed. The examples demonstrate the efficacy of paclitaxel and camptothecin delivered in polymeric implants prepared by compression molding of biodegradable and non-biodegradable polymers, respectively. The results are highly statistically significant.