Patents Examined by S. Jiang
  • Patent number: 6720340
    Abstract: The present invention features methods for recruitment of bone marrow-derived stem cells (e.g., endothelial cell precursors, hematopoietic stem cells) by administration of nicotine or other nicotine receptor agonist. The methods of the invention can be used in, for example, treatment of conditions amenable to treatment by recruitment of bone marrow-derived stem cells (e.g., neutropenia).
    Type: Grant
    Filed: July 28, 2000
    Date of Patent: April 13, 2004
    Assignee: The Board of Trustees of the Leland Stanford, Jr. Unversity
    Inventors: John Cooke, Frances Lauri Johnson, Anjali Pathak, James Jang, Phillip Tsao, Christopher Heeschen
  • Patent number: 6683192
    Abstract: A compound represented in general formula (X) and (XI):
    Type: Grant
    Filed: September 26, 2001
    Date of Patent: January 27, 2004
    Assignee: Curis, Inc.
    Inventors: Anthony David Baxter, Edward Andrew Boyd, Oivin M. Guicherit, Jeffrey Porter, Stephen Price, Lee Rubin, John Harry Alexander Stibbard
  • Patent number: 6682750
    Abstract: The invention relates to surfactant-free cosmetic, dermatological and pharmaceutical compositions, comprising at least one copolymer consisting essentially of a1) 1 to 50% by weight of the repeat structural unit of the formula (1)  where n is an integer from 2 to 9, or a2) 1 to 50% by weight of a mixture of the repeat structural unit of the formula (1) and the repeat structural unit of the formula (2)  where R, R1 and R2 may be identical or different and are hydrogen or a linear or branched alkyl or alkenyl group having in each case 1 to 30 carbon atoms and b) 49.99 to 98.99% by weight of the repeat structural unit of the formula (3)  in which R3 is hydrogen, methyl or ethyl, Z is (C1-C8)-alkylene, n is an integer from 2 to 9 and X is an ammonium, alkali metal or alkaline earth metal ion and c) 0.01 to 8% by weight of crosslinking structures which originate from monomers having at least two olefinic double bonds.
    Type: Grant
    Filed: February 28, 2002
    Date of Patent: January 27, 2004
    Assignee: Clariant GmbH
    Inventors: Matthias Löffler, Roman Morschhäuser, Michael Hornung
  • Patent number: 6683108
    Abstract: The present invention makes available methods and reagents for inducing activation of a hedgehog pathway in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as a small molecule, in a sufficient amount to achieve a therapeutic result. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: January 27, 2004
    Assignee: Curis, Inc.
    Inventors: Anthony David Baxter, Edward Andrew Boyd, Oivin M. Guicherit, Jeffrey Porter, Stephen Price, Lee Rubin
  • Patent number: 6664283
    Abstract: This invention relates to pharmaceuticals for neuropathic pains comprising an mGluR1 receptor antagonist for systemic administration. Drugs efficacious in treating various neuropathic pain can be provided by the invention.
    Type: Grant
    Filed: May 15, 2002
    Date of Patent: December 16, 2003
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Masamichi Okada, Yukinori Nagakura, Tetsuo Kiso, Takashi Toya, Satoshi Hayashibe
  • Patent number: 6656960
    Abstract: A method for indirectly stimulating a vagus nerve of a patient includes the steps of positioning one or more electrodes in the vicinity of the vagus nerve and then actuating the electrode(s) to create an electrical field for stimulating the vagus nerve. Disclosed embodiments include positioning one or more electrodes in the esophagus, trachea, or jugular vein, on the neck of the patient, and combinations thereof.
    Type: Grant
    Filed: January 17, 2002
    Date of Patent: December 2, 2003
    Assignee: Emory University
    Inventor: John D. Puskas
  • Patent number: 6653318
    Abstract: The present invention relates to pyrimidine nucleoside compounds and their use to treat viral infections of Varicella Zoster virus and Epstein Barr Virus, as well as cancers which are complications of Epstein Barr virus.
    Type: Grant
    Filed: July 21, 1999
    Date of Patent: November 25, 2003
    Assignees: Yale University, The University of Georgia Research Foundation, Inc.
    Inventors: Yung-Chi Cheng, Chung K. Chu, Ling Li, Yongseok Chai
  • Patent number: 6653353
    Abstract: Cosmetic or personal care compositions comprise: a hair styling polymer having one or more groups selected from acidic functional groups, anionic groups derived from the acidic functional groups or a mixture of said groups; a partially or fully fluorinated compound having one or more groups selected from amino groups, acid salts of the amino groups or a mixture of said groups, wherein the partially or fully fluorinated compound comprises an aromatic ring; and a cosmetically acceptable diluent or carrier. The compositions are particularly effective under high humidity conditions.
    Type: Grant
    Filed: March 13, 2002
    Date of Patent: November 25, 2003
    Assignee: Unilever Home & Personal Care USA, division of Conopco, Inc.
    Inventors: Gerald Adams, Ezat Khoshdel
  • Patent number: 6649644
    Abstract: This invention relates to a method of treating human immunodeficiency virus (HIV) infection in a mammal comprising administering to the mammal a therapeutically effective amount of a combination of: (i) at least one cytotoxic agent and (ii) at least one non-nucleoside reverse transcriptase HIV inhibitor (NNRTI). This invention also relates to a method of treating chronic viral infections comprising administering to the mammal a therapeutically effective amount of a combination of: (i) at least one cytotoxic agent and (ii) at least one antiviral agent.
    Type: Grant
    Filed: October 12, 1999
    Date of Patent: November 18, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventor: Bruce D. Korant
  • Patent number: 6646013
    Abstract: The instant invention provides a combination of multiple nutrients useful to reduce colon rectal cancer in a mannalian or human subject. Further, the combination provides synergistic ratios of the useful nutrients.
    Type: Grant
    Filed: June 15, 2000
    Date of Patent: November 11, 2003
    Assignee: Nutri-Logics
    Inventors: Anna D. Barker, Robert W. Day, Anthony J. Dennis, Norman R. Farnsworth, Julie A. Haack, Joseph M. McCord, John D. Potter
  • Patent number: 6642219
    Abstract: An estrogen-free contraceptive is provided which does not have the bleeding-related drawbacks of conventional progestogen-only pills. Thus the invention is a contraceptive kit comprising a combined means for the simultaneous daily administration of a progestogen as the sole contraceptively effective ingredient and an anti-progestogen. Said combined means preferably is in the form of tablets having a normal contraceptive dose of the progestogen and low dose of the anti-progestogen.
    Type: Grant
    Filed: June 26, 2000
    Date of Patent: November 4, 2003
    Assignee: Akzo Nobel N.V.
    Inventor: Herman Jan Tijmen Coelingh Bennink
  • Patent number: 6638957
    Abstract: The invention relates to the use of compounds of the general formula (I) wherein Y is a C1-3-alkenylene group, wherein B is selected from the group, which consists of C1-26-alkenylene groups, wherein one C-atom is replaced by an oxygen atom and one C-atom is replaced by a sulphur atom or two C-atoms may be replaced by a S-heterocycle, and wherein X represents the organo phosphorous group. or the amino group for inhibition of the 1-deoxy-D-xylulose-5-phosphate-(DOXP)-metabolic pathway, use there of as a herbicide and for the preparation of a pharmaceutical preparation as well as a method for the therapeutic and prophylactic treatment of infections in humans and animals, caused by viruses, bacteria, fungi and parasites.
    Type: Grant
    Filed: November 2, 2001
    Date of Patent: October 28, 2003
    Assignee: Jomaa Pharmaka GmbH
    Inventor: Hassan Jomaa
  • Patent number: 6632838
    Abstract: The use of bissulfonamides for producing medicines for the treatment of hyperlipidemia. The invention relates to the use of bissulfonamides and their salts for producing medicines for the treatment of hyperlipidemia. The use of compounds of formula I in which the radicals have the stated meanings, and of their salts for producing a medicine for the treatment of hyperlipidemia is described.
    Type: Grant
    Filed: August 31, 2000
    Date of Patent: October 14, 2003
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Reinhard Kirsch, Hans-Ludwig Schaefer, Eugen Falk, Norbert Krass
  • Patent number: 6627664
    Abstract: The invention is perylenequinones that are both sonosensitizers and photosensitizers, and their therapeutic use.
    Type: Grant
    Filed: January 30, 2001
    Date of Patent: September 30, 2003
    Assignee: Altachem Pharma Ltd.
    Inventors: Gerald G. Miller, J. William Lown
  • Patent number: 6620829
    Abstract: The invention relates to a method of treating non inflammatory cartilage damage by administering a GABA analog of Formula: and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: September 14, 2001
    Date of Patent: September 16, 2003
    Assignee: Warner-Lambert Company
    Inventors: Denis Schrier, Howard Glenn Welgus, David Juergen Wustrow
  • Patent number: 6613798
    Abstract: The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: September 2, 2003
    Assignee: Curis, Inc.
    Inventors: Jeffrey Porter, Oivin M. Guicherit, Lee Rubin, Anthony David Baxter, Edward Andrew Boyd, Stephen Price
  • Patent number: 6610674
    Abstract: The present invention provides methods for treating inflammatory conditions, including but not limited to, inflammatory bowel disease (ulcerative colitis, Crohn's disease, and proctitis), other noninfectious, inflammatory conditions of the GI tract (microscopic colitis, allergic eosinophilic gastroenteritis, food allergies, pill induced esophagitis, celiac disease, recurrent polyps, and hemorrhoids), and psoriasis, using progesterone or progesterone analogs such as medroxyprogesterone acetate.
    Type: Grant
    Filed: September 8, 2000
    Date of Patent: August 26, 2003
    Assignee: University of Pennsylvania
    Inventor: Alan D. Schreiber
  • Patent number: 6608065
    Abstract: The use of (6R, 12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2′,1′:6,1]pyrido[3,4-b]indole -1,4-dione, (3S, 6R, 12aR)-2,3,6,7,12,12a-hexahydro-2,3-dimethyl-6-(3,4-methylenedioxyphenyl)pyrazino[2′, 1′:6,1]pyrido[3,4-b]indole-1,4-dione, and physiologically acceptable salts and solvates thereof, in the treatment of impotence.
    Type: Grant
    Filed: May 18, 2000
    Date of Patent: August 19, 2003
    Assignee: ICOS Corporation
    Inventor: Alain Claude-Marie Daugan
  • Patent number: 6605603
    Abstract: The present invention relates to novel uses of 1-amino-3-(N,N-dimethylamino)-propylidene-1,1-bisphosphonic acid or any of its soluble salts or any of its hydrates, in particular its use for the manufacture of a medicament for selective modulation of osteoblasts.
    Type: Grant
    Filed: July 27, 2001
    Date of Patent: August 12, 2003
    Assignees: Gador, S.A., University of Leiden
    Inventors: Emilio J. A. Roldan, Anibal Perez-Lloret, Guillermo Vazquez, Ricardo Boland, Sokrates E. Papapoulos
  • Patent number: 6605605
    Abstract: Provided herein are medicinal compositions of matter that comprise an estrogenic medication component and a cruciferous indole component (indole 3-carbinol, diindolylmethane, or any derivative thereof. Through use of the compositions of the invention a heretofore unobserved synergy is observed in the treatment of perimenopause, menopause or any other cause of ovarian failure. The invention also provides procedures for administering the composition to a patient who is afflicted with perimenopause, menopause or any other cause of ovarian failure.
    Type: Grant
    Filed: November 10, 2001
    Date of Patent: August 12, 2003
    Inventor: Milton Hammerly