Patents Examined by S. P. Williams
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Patent number: 4014897Abstract: Cyclicdicarboximido-substituted phosphonothioates corresponding to the formula ##EQU1## WHEREIN R represents phthalimido, monomethyl substituted phthalimido, 4-cyclohexene-1,2-dicarboximido or monomethyl substituted 4-cyclohexene-1,2,-dicarboximido are prepared by a method which comprises reacting an appropriate O,O-diloweralkyl phosphorochloridothioate with an appropriate N-alkali metal cyclicdicarboximide reactant in the presence of a catalytic amount of a 1-(loweralkyl)imidazole and an inert tertiary alcohol as a reaction medium.Type: GrantFiled: October 7, 1974Date of Patent: March 29, 1977Assignee: The Dow Chemical CompanyInventor: Ian McLachlan
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Patent number: 4006161Abstract: Thio-substituted 2-oxoindolines have the formula ##SPC1##In which one of R or R.sub.1 is hydrogen and the other is R.sub.2 --S--, in which R.sub.2 is C.sub.1 -C.sub.3 alkyl, benzyl, halobenzyl, nitrobenzyl, C.sub.1 -C.sub.3 alkylbenzyl, or phenyl. These compounds are active in relieving a condition associated with anxiety, tension, or like emotional disturbances.Type: GrantFiled: December 26, 1973Date of Patent: February 1, 1977Assignee: Eli Lilly and CompanyInventors: Richard E. Holmes, Glen P. Jourdan
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Patent number: 4006162Abstract: Iminoisoinolinone pigments of the formula ##STR1## wherein R denotes an alkyl group containing 1-4 C atoms, or an aryl group, the W's denote H atoms or, conjointly denote a direct bond, the X's denote halogen atoms, the Y's and Z's denote halogen atoms, alkoxy or alkylmercapto groups containing 1-6 atoms, cycloalkoxy groups containing 5-6 C atoms, or aralkoxy, aryloxy or arylmercapto groups, which are useful for pigmenting high molecular organic material.Type: GrantFiled: May 6, 1975Date of Patent: February 1, 1977Assignee: Ciba-Geigy CorporationInventors: Ernst Model, Jost VON DER Crone, Andre Pugin
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Patent number: 4001179Abstract: This invention discloses chemical compounds of the formula ##STR1## wherein X is chlorine or bromine and each of Y.sup.1, Y.sup.2, Y.sup.3 and Y.sup.4 are hydrogen, chlorine or bromine. Further disclosed are combustible polymers which have incorporated therein a fire retardant amount of a compound of the foregoing description.Type: GrantFiled: March 21, 1975Date of Patent: January 4, 1977Assignee: Velsicol Chemical CorporationInventors: Sidney B. Richter, Glendon D. Kyker
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Patent number: 4001260Abstract: An improved process is provided for producing an aromatic amine from ammonia and an aromatic compound which comprises reacting the aromatic compound with ammonia at a temperature of from about 150.degree. C. to about 500.degree. C. and at a pressure of from about 10 to about 1000 atmospheres in the presence of a conditioned nickel/nickel oxide/zirconium oxide cataloreactant which has been treated with ammonia prior to introduction of the cataloreactant to the amination reactants.Type: GrantFiled: December 19, 1973Date of Patent: January 4, 1977Assignee: E. I. Du Pont de Nemours and CompanyInventor: Thomas W. Del Pesco
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Patent number: 4001278Abstract: This invention relates to a process of preparing phthalein indicator dyes including phthalides and naphthalides derived from certain hydroxy-substituted carbocyclic aryl compounds, such as phenols, and from certain N-heterocyclic aryl compounds, such as indoles, and to a process of preparing novel intermediates useful therein. According to the present invention, the selected carbocyclic compound or the selected N-heterocyclic compound is reacted with phthalaldehydic or naphthalaldehydic acid to form the corresponding (na)phthalidyl adduct which is treated with an oxidizing agent to yield the subject intermediates. To prepare the indicator dye, the intermediate, i.e., the oxidation product thus obtained is then reacted with a carbocyclic or heterocyclic aryl compound to yield the corresponding indicator dye. The oxidation products comprising the novel intermediates of the present invention may be dehydro or hydrated (na)phthalidyl adducts.Type: GrantFiled: September 29, 1975Date of Patent: January 4, 1977Assignee: Polaroid CorporationInventor: Alan L. Borror
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Patent number: 4001277Abstract: This invention relates to a class of indicator dyes useful as optical filter agents in photographic processes to protect a selectively exposed photosensitive material from further exposure during processing in the presence of incident light. Such dyes comprise 3,3-disubstituted phthalides and 3,3-disubstituted naphthalides wherein one of the 3,3-substituents is an indol-3-yl radical substituted with hydrogen on the heterocyclic N atom and the other of said 3,3 substituents is a p-hydroxycarbocyclic aryl radical selected from a 4'-hydroxy-1'-phenyl radical and a 4'-hydroxy-1'-naphthyl radical.Type: GrantFiled: April 1, 1974Date of Patent: January 4, 1977Assignee: Polaroid CorporationInventors: Eva R. Karger, Paul T. MacGregor
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Patent number: 4001273Abstract: Continuous manufacture of phthalimide by reaction of phthalic anhydride with ammonia and washing the offgas with a melt containing phthalimide. The product is a starting material for the manufacture of dyes, pesticides and pigments, especially copper phthalocyanines.Type: GrantFiled: July 8, 1974Date of Patent: January 4, 1977Assignee: BASF AktiengesellschaftInventors: Eckhard Hetzel, Ludwig Vogel, Gerhard Rotermund, Hans Christoph Horn
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Patent number: 4001275Abstract: This invention relates to a process of preparing phthalein indicator dyes including phthalides and naphthalides derived from certain hydroxy-substituted carbocyclic aryl compounds, such as phenols, and from certain N-heterocyclic aryl compounds, such as indoles, and to a process of preparing novel intermediates useful therein. According to the present invention, the selected carbocyclic compound or the selected N-heterocyclic compound is reacted with phthalaldehydic or naphthalaldehydic acid to form the corresponding (na)phthalidyl adduct which is treated with an oxidizing agent to yield the subject intermediates. To prepare the indicator dye, the intermediate, i.e., the oxidation product thus obtained is then reacted with a carbocyclic or heterocyclic aryl compound to yield the corresponding indicator dye. The oxidation products comprising the novel intermediates of the present invention may be dehydro or hydrated (na)phthalidyl adducts.Type: GrantFiled: September 29, 1975Date of Patent: January 4, 1977Assignee: Polaroid CorporationInventor: Alan L. Borror
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Patent number: 4001276Abstract: As a novel compound, an .alpha.-alkyl(or aryl)thio-5-hydroxytryptophan derivative and the preparation process thereof are disclosed. Said novel compound is readily convertible to 5-hydroxytryptophan having a versatile utilization.Type: GrantFiled: February 26, 1974Date of Patent: January 4, 1977Assignee: Sagami Chemical Research CenterInventors: Genichi Tsuchihashi, Katsuyuki Ogura
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Patent number: 4001272Abstract: This invention relates to herbicidal 2-fluoro-4-halo-phenyl-4,5,6,7-tetrahydro-2H-isoindole-1,3-diones. These compounds may be used for selective weed control in certain crops or for total vegetation control.Type: GrantFiled: December 24, 1974Date of Patent: January 4, 1977Assignee: E. I. Du Pont de Nemours and CompanyInventor: Steven Jerome Goddard
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Patent number: 4001271Abstract: Isoindolin-1-one derivatives carrying on the nitrogen atom in the 2-position a phenyl or pyridyl radical, optionally carrying one or two substituents selected from halogen, alkyl (C.sub.1 -C.sub.4), alkoxy (C.sub.1 -C.sub.4), cyano and trifluoromethyl, and in the 3-position a grouping --O--T--NR.sub.1 R.sub.2 wherein T is alkylene (C.sub.2 -C.sub.6), and R.sub.1 and R.sub.2 represent hydrogen or alkyl (C.sub.1 -C.sub.4), are new compounds possessing pharmacodynamic properties and are useful as anti-arrhythmic agents.Type: GrantFiled: February 7, 1974Date of Patent: January 4, 1977Assignee: Rhone-Poulenc S.A.Inventors: Claude Cotrel, Claude Jeanmart, Mayer Naoum Messer
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Patent number: 4000307Abstract: Alkanoyl isoindolinylmethyl alkylphenones of the formula, ##STR1## e.g. 4'-(5-pivaloyl-2-isoindolinylmethyl)-pivalophenone, are prepared by reacting a 3',4'-bis(bromomethyl)alkylphenone with a 4'-(aminomethyl)alkylphenone-(2,2-dimethyl-1,3-propanediyl)cyclic ketal and hydrolyzing the ketal formed, and are useful as hypolipidemic agents.Type: GrantFiled: November 19, 1975Date of Patent: December 28, 1976Assignee: Sandoz, Inc.Inventor: Jeffrey Nadelson
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Patent number: 4000297Abstract: Pharmaceutically active L-tryptophane compounds comprising the compound of the formula: ##STR1## AND ITS CALCIUM, MAGNESIUM AND ALUMINUM SALTS. These compounds exhibit superior pharmacologic activity on the gastroenteric tract.Type: GrantFiled: January 12, 1976Date of Patent: December 28, 1976Assignee: Rotta Research Laboratorium S.p.A.Inventors: Luigi Rovati, Giampaolo Picciola, Francesco Makovec
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Patent number: 3998840Abstract: A method is provided for enhancing the rate of formation of polyetherimides by using either a sodium chloride catalyst, or ferric sulfate catalyst in a mixture of an aromatic bis(ether anhydride) and an organic diamine under melt polymerization conditions.Type: GrantFiled: April 16, 1976Date of Patent: December 21, 1976Assignee: General Electric CompanyInventors: Frank J. Williams, III, Howard J. Klopfer
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Patent number: 3997670Abstract: 1-dioxolanylpropyl-3-indoleacrylic acid esters, e.g., 1-[3-(2-methyl-2-dioxolanyl)propyl]-3-indoleacrylic acid ethyl ester, are prepared by reacting a corresponding 1-dioxolanylpropyl-3-indolecarboxaldehyde with carbalkoxymethylene triphenylphosphorane and are useful as hypolipidemic agents.Type: GrantFiled: February 6, 1975Date of Patent: December 14, 1976Assignee: Sandoz, Inc.Inventor: Marcel K. Eberle
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Patent number: 3997558Abstract: The process is directed to the production of 1-acyl-2-methyl-indolyl-3-alkanoic acids having the general formula ##STR1## wherein R.sub.1 represents hydrogen, halogen, an alkoxy group or an aryloxy group, n is 1, 2 or 3, and R.sub.2 represents an aromatic group. A lactone having the general formula ##STR2## wherein R.sub.1 and n have the meanings stated above, is acylated by being reacted in a polar solvent in the presence of sodium hydride with an acid derivative having the general formula ##STR3## wherein R.sub.2 has the meaning stated above and X represents a halogen, to form a compound having a lactone ring and having the general formula ##STR4## wherein R.sub.1, R.sub.2, and n have the meanings stated above. The last-mentioned compound is hydrogenolyzed in the presence of a hydrogenation catalyst to open the lactone ring.Type: GrantFiled: July 24, 1975Date of Patent: December 14, 1976Inventor: Werner J. Frantsits
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Patent number: 3996241Abstract: New indole derivatives of the formula ##STR1## wherein R.sub.1 and R.sub.2, which may be the same or different, are hydrogen or halogen or lower alkyl or, taken together, represent a --CH=CH-CH=CH- bridge, with the proviso that R.sub.1 and R.sub.2 are not both hydrogen, and wherein, when R.sub.2 is halogen or alkyl, R.sub.1 can also be alkoxy;Are outstandingly effective in blood sugar lowering action in mammals.Type: GrantFiled: October 22, 1974Date of Patent: December 7, 1976Assignee: Boehringer Mannheim G.m.b.H.Inventors: Ruth Heerdt, Manfred Hubner, Felix Helmut Schmidt, Kurt Stach
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Patent number: 3996374Abstract: Isoindole derivatives of the formula ##STR1## wherein R.sub.1 -R.sub.6, A and Z are as hereinafter described. The isoindole derivatives are useful as appetite suppressants.Type: GrantFiled: November 20, 1975Date of Patent: December 7, 1976Assignee: Hoffmann-La Roche Inc.Inventor: Roland Jaunin
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Patent number: 3996373Abstract: 2,3-Dihydro-1H-dibenz[e,g]isoindoles substituted in the 2-position by a lower alkyl or a lower alkenyl, or a lower haloalkyl, or a free or an esterified or etherified lower hydroxyalkyl, or a lower oxoalkyl, or a free or an esterified lower carboxyalkyl group, and therapeutically usable salts thereof, such compounds having an antagonistic action against reserpine as well as against tetrabenazine such pharmacological properties characterizing these new compounds as antidepressants.Type: GrantFiled: March 27, 1975Date of Patent: December 7, 1976Assignee: Ciba-Geigy CorporationInventor: Hans Blattner