Patents Examined by S. P. Williams
  • Patent number: 3994921
    Abstract: Iminoisoindolenine pigments of the formula ##SPC1##Wherein R represents a phenylene or diphenylene radical, X represents a hydrogen or halogen atom, Y represents an alkyl, alkoxy, alkanoylamino or alkylsulphonyl group containing 1 to 4 carbon atoms, a nitro group, a phenyl, benzoylamino, phenoxy or phenylsulphonyl group which may be substituted by halogen atoms, alkyl or alkoxy groups of 1 to 4 carbon atoms, X.sub.1 represents a hydrogen or halogen atom, an alkyl or alkoxy group of 1 to 4 carbon atoms, an alkoxycarbonyl group of 2 to 6 carbon atoms, a nitro, trifluoromethyl, carbamoyl or cyano group, Y.sub.1 represents a halogen atom, an alkyl or alkoxy group of 1 to 4 carbon atoms or a trifluoromethyl group, Z represents a --NHCO or NHCONH group, m is 1 to 4, n is 0 to 2, and p is 0 to 1, the sum of m + n being 4, are useful for coloring plastics and lacquers in yellow shades of excellent fastness properties.
    Type: Grant
    Filed: October 21, 1975
    Date of Patent: November 30, 1976
    Assignee: Ciba-Geigy Corporation
    Inventor: Jost Von der Crone
  • Patent number: 3993617
    Abstract: Certain 2-substituted phthalimidines of the formula: ##SPC1##Wherein Ar is 3,4-dichlorophenyl and 2-naphthyl possess activity as antifungal agents.
    Type: Grant
    Filed: October 30, 1975
    Date of Patent: November 23, 1976
    Assignee: Morton-Norwich Products, Inc.
    Inventor: Thomas James Schwan
  • Patent number: 3993662
    Abstract: New dicarboximides of the formula ##SPC1##WhereinR represents a phenyl mono- to trisubstituted, identically or differently, by fluorine, chlorine, bromine, iodine, trifluoromethyl, nitro, cyano, C.sub.1 --C.sub.4 -alkyl, methoxy or methylthio, or monosubstituted by a methylenedioxy group, andZ.sub.1 and Z.sub.2 each represent hydrogen, or together with the carbon atoms to which they are bound they represent a carbon-carbon bondAnd their use for controling insects are disclosed.
    Type: Grant
    Filed: October 28, 1975
    Date of Patent: November 23, 1976
    Assignee: Ciba-Geigy Corporation
    Inventors: Hans U. Brechbuhler, Jean Claude Petitpierre
  • Patent number: 3992406
    Abstract: Aromatic bisimides can be prepared by effecting reaction between a 3- or 4-nitro-N-substituted phthalimide with an aromatic dihydroxy compound in the presence of a certain class of solid alkali-metal fluorides and using a dipolar aprotic compound as a solvent.
    Type: Grant
    Filed: April 14, 1976
    Date of Patent: November 16, 1976
    Assignee: General Electric Company
    Inventor: Ronald L. Markezich
  • Patent number: 3992450
    Abstract: Compounds of the general formula: ##SPC1##Wherein m = 0 or 1;Ar is an arylene or lower alkyl substituted arylene radical;R.sub.1 and R.sub.2, which may be the same or different, are lower alkyl or hydroxyalkyl groups, or ##EQU1## R.sub.3 is H, lower alkyl, benzyl, R.sub.4, or ##EQU2## R.sub.4 is ##SPC2##Alkyl group, an aryl group, ##EQU3## wherein n=2-6; and R.sub.6 is a lower alkyl group or an aryl group. Where m = 1, the formula represents a colorless leuco compound; where m = 0, the formula represents the yellow dye derivative of the leuco. These compounds are particularly useful in photosensitive compositions.
    Type: Grant
    Filed: April 30, 1971
    Date of Patent: November 16, 1976
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: John Fred Neumer
  • Patent number: 3992408
    Abstract: Phthalimides of the Formula ##SPC1##Wherein X is NH.sub.2, N(CH.sub.3).sub.2, Cl or Br and R.sub.0 and R.sub.1 are hydrogen, methyl or ethyl are disclosed as intermediates in the preparation of benzodiazepines.
    Type: Grant
    Filed: August 6, 1975
    Date of Patent: November 16, 1976
    Assignee: The Upjohn Company
    Inventor: Martin Gall
  • Patent number: 3992189
    Abstract: This invention relates to herbicidal isoindol-1-one derivatives. These compounds have the general formulae: ##SPC1##WhereinR.sub.1 is hydrogen or methyl;R.sub.2 is hydrogen or alkyl of 1 to 4 carbons;X is fluorine, chlorine or bromine;Y is hydrogen or fluorine;Z is hydrogen or fluorine, provided that when Y and Z are both fluorine, X must also be fluorine; andA is --(CH.sub.2).sub.4 -- or --CH=CH--CH=CH--, provided that when A is --CH=CH--CH=CH-- and Y is hydrogen, Z must be fluorine.Both geometric isomers, Formulae IIa and IIb, are encompassed by this invention.In particular, these compounds have demonstrated that they are active pre- and post-emergence herbicides and tend to do minimal damage to certain desirable crops, e.g., corn and wheat.
    Type: Grant
    Filed: October 31, 1975
    Date of Patent: November 16, 1976
    Assignee: E. I. Du Pont de Nemours & Company
    Inventor: Steven Jerome Goddard
  • Patent number: 3992407
    Abstract: Aromatic bisimides can be prepared by effecting reaction between a 3- or 4-fluoro-N-substituted phthalimide with an aromatic dihydroxy compound in the presence of a certain class of solid alkali-metal fluorides and using a dipolar aprotic compound as a solvent.
    Type: Grant
    Filed: April 14, 1976
    Date of Patent: November 16, 1976
    Assignee: General Electric Company
    Inventor: Ronald L. Markezich
  • Patent number: 3991074
    Abstract: A process for the catalytic conversion of o-ethylaniline to indole in a gaseous phase and in the presence of hydrogen or steam and an SiO.sub.2 -containing catalyst modified by chromium dioxide and copper, wherein said conversion is conducted at about 400.degree. - 700.degree. C.; said catalyst comprising at least about 15% by weight copper and at least about 8% by weight of a chromate of a metal of Group IIA of the Periodic Table. A catalyst for use in the invention is provided.
    Type: Grant
    Filed: November 15, 1974
    Date of Patent: November 9, 1976
    Assignee: Rutgerswerke Aktiengesellschaft
    Inventors: Georg Grigoleit, Gerd Collin, Rudolf Oberkobusch
  • Patent number: 3988349
    Abstract: Racemic organic carboxylic acids are efficiently resolved into their enantiomers with antipodes of .alpha.-methyl-p-nitrobenzylamine.
    Type: Grant
    Filed: May 15, 1975
    Date of Patent: October 26, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Clark William Perry, Sidney Teitel
  • Patent number: 3987059
    Abstract: Highly branched .alpha.-substituted indoles, e.g., 2-(1-methylcyclohexyl)-indole, are prepared by treating N-(.alpha.-branched carbonyl) toluidines with alkyl lithium.
    Type: Grant
    Filed: August 25, 1975
    Date of Patent: October 19, 1976
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • Patent number: 3987057
    Abstract: This invention relates to herbicidal 2-(substituted aryl)-3a,4,5,6,7,7a-hexahydro-1H-isoindole-1,3(2H)-diones. These compounds may be used for selective weed control for certain crops or for total vegetation control. In particular, the compounds may be utilized as rice herbicides and have the formula ##SPC1##Wherein X is Cl, Br or F, and Y is H or F, provided that when Y is F, X is F.
    Type: Grant
    Filed: January 30, 1975
    Date of Patent: October 19, 1976
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Steven Jerome Goddard
  • Patent number: 3984435
    Abstract: A.DELTA..sup.1 - tetrahydrophthalic anhydride is reacted with an amine in the presence of lower fatty acid. Alternatively N-(4-hydroxyphenyl)-.DELTA..sup.1 -tetrahydrophthalimide or a salt thereof is reacted with an aralkyl halide. A N-substituted-.DELTA..sup.1 -tetrahydrophthalimide compound having herbicidal activity is produced. This compound has the formula ##EQU1## wherein R' is naphthyl; phenyl; phenyl substituted by 1-3 substituents selected from the group consisting of halogen, nitro, cyano, thiocyano, carboxyl, haloalkyl, lower alkyl and alkylthio; --CH.sub.2 Y wherein Y is phenyl, naphthyl or phenyl substituted by 1-5 substituents selected from the group consisting of halogen, nitro, lower alkyl and lower alkoxyl; or ##SPC1##Wherein Z is phenyl, naphthyl, or phenyl substituted by at least one substituent selected from the group consisting of halogen, nitro, lower alkyl and lower alkoxyl.
    Type: Grant
    Filed: February 10, 1975
    Date of Patent: October 5, 1976
    Assignee: Mitsubishi Chemical Industries Ltd.
    Inventors: Kazuo Matsui, Hiroshi Kasugai, Kuni Matsuya, Hiroyasu Aizawa
  • Patent number: 3984563
    Abstract: Compounds with antiinflammatory, analgesic and CNS depressant activity having the following general formula ##SPC1##WhereinR represents hydrogen or methoxy;R.sub.1 represents hydrogen; lower alkyl; lower alkyl substituted with a group carboxy, carbo(lower alkoxy) or carbamyl; phenyl; benzyl, lower aliphatic acyl; benzoyl; benzoyl substituted with a halo group;R.sub.2 represents hydrogen; lower alkyl; carbo(lower alkoxy); carbamyl; phenylcarbamyl; lower aliphatic acyl; benzoyl; benzoyl substituted with a halo group,R.sub.3 represents halo; lower alkyl; lower alkyl substituted with a group selected from carboxy, carbo(lower alkoxy), carbamyl, halo, amino, mono and di-lower alkylamino, phthalimido and morpholino; phenyl; phenyl substituted with a group selected from lower alkoxy, halo, nitro, amino and acetamido;R.sub.4 represents hydrogen or lower alkyl; with the proviso that when simultaneously R.sub.1 represents hydrogen, methyl, phenyl, benzyl, acetyl or benzoyl, R.sub.
    Type: Grant
    Filed: September 9, 1974
    Date of Patent: October 5, 1976
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Giorgio Winters, Nunzio Di Mola
  • Patent number: 3983137
    Abstract: This invention is concerned with a novel class of protonated compounds, namely, 3-(indol-3-yl)dehydronaphthalide hydrochlorides, with their synthesis by the reaction of a 3-(indol-3-yl)naphthalide and a high-potential quinone in an inert anhydrous aprotic solvent in the presence of a carboxylic acid catalyst, and with the synthesis of indole naphthalide indicator dyes by reacting the said dehydronaphthalide hydrochlorides and an indole in an aromatic hydrocarbon solvent in the presence of a carboxylic acid catalyst.
    Type: Grant
    Filed: September 4, 1975
    Date of Patent: September 28, 1976
    Assignee: Polaroid Corporation
    Inventor: Yunn H. Chiang
  • Patent number: 3983242
    Abstract: 3-Alkylsulfinyl-2-indolinones, of the formula ##SPC1##E.g., 3-methylsulfinyl-5-trifluoromethyl-2-indolinone, are useful as minor tranquillizers, muscle relaxants and sedative-hypnotics and are obtainable by oxidizing corresponding 3-alkylthio-2-indolinones.
    Type: Grant
    Filed: September 8, 1975
    Date of Patent: September 28, 1976
    Assignee: Sandoz, Inc.
    Inventors: Goetz E. Hardtmann, Thomas E. Jackson
  • Patent number: 3980667
    Abstract: Series of 5-endo-benzoyloxy-N-[amino(lower)-alkyl]bicyclo[2.2.2]octane-2,3-di-endo-c arboxylic acid imides, 5-endo-(3-indolecarbonyloxy)-N-[amino-(lower)alkyl]bicyclo[2.2.2]octane-2, 3-di-endo-carboxylic acid imides, 5-endo-n-substituted-carbamoyloxy-N-[amino(lower)alkyl]bicyclo[2.2.2]octan e-2,3-di-endo-carboxylic acid imides and 5-endo-(1-naphthoyloxy)-N-[amino(lower)alkyl]bicyclo[2.2.2]octane-2,3-di-e ndo-carboxylic acid imides have been found to possess unique prophylactic and therapeutic activity as anti-arrhythmia agents. An example of such a compound possessing activity is 5-endo-(3-indolecarbonyloxy)-N-(3-dimethylaminopropyl)bicyclo[2.2.
    Type: Grant
    Filed: March 5, 1975
    Date of Patent: September 14, 1976
    Assignee: Bristol-Myers Company
    Inventors: Richard Anthony Partyka, Henry Michael Holava, Alex Michael Jelenevsky
  • Patent number: 3980641
    Abstract: N-substituted-14-hydroxy-3-substituted-morphinan derivatives have been found to possess potent narcotic agonist or antagonist activity. In particular, the compound 3,14-dihydroxy-N-cyclopropylmethylmorphinan has been found to possess potent agonist-antagonist activity.
    Type: Grant
    Filed: July 31, 1975
    Date of Patent: September 14, 1976
    Assignee: Bristol-Myers Company
    Inventors: Ivo Monkovic, Henry Wong, Gary Lim
  • Patent number: 3980668
    Abstract: A series of 5-endo-(3-indolecarbonyloxy)-N-[amino-(lower)alkyl]bicyclo[2.2.1]heptane-2 ,3-di-endo-carboxylic acid imides having the formula ##SPC1##Wherein R.sup.1 is H, Cl, Br, F or (lower)alkyl, R.sup.7 is H or methyl, R.sup.2 and R.sup.3 are alike or different and each is H, Cl, Br, F, (lower)alkyl, nitro, CF.sub.3, OH or (lower)alkoxy, n is an integer of 2 to 4 inclusive and R.sup.4 and R.sup.5 are alike or different and each is H, (lower)alkyl or when taken together with the nitrogen a radical of the formula ##SPC2##In which R.sup.6 is (lower)alkyl; or a pharmaceutically acceptable acid addition salt thereof have been found to possess unique prophylactic and therapeutic activity as anti-arrhythmia agents. An example of such a compound possessing excellent activity is 5-endo-(3-indolecarbonyloxy)-N-(3-dimethylaminopropyl)bicyclo-[2.2.1]hepta ne-2,3-di-endo-carboxylic acid imide hydrochloride.
    Type: Grant
    Filed: July 10, 1975
    Date of Patent: September 14, 1976
    Assignee: Bristol-Myers Company
    Inventors: Ronald Leslie Buchanan, Alex Michael Jelenevsky
  • Patent number: 3979410
    Abstract: o-nitrobenzylketones are prepared by reacting a trans-.beta.-substituted amino-2-nitrostyrene with a lower alkanoyl halide, halo-lower alkanoyl halide, phthalimido-lower alkanoyl halide, benzoyl halide or substituted benzoyl halide, and subsequently hydrolyzing the resulting product to yield the desired o-nitrobenzylketone.
    Type: Grant
    Filed: September 22, 1975
    Date of Patent: September 7, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Rodney Ian Fryer, Edward Ernest Garcia