Abstract: A portable, disposable in-vitro diagnostic apparatus and method of performing a point-of-care invitro-diagnostic test is provided. The method includes disposing a specimen to be analyzed in a disposable diagnostic apparatus. Then, channeling a first fluid through a first channel into a first chamber and causing an actuator member to expand upon contact with the fluid from a compressed, deactivated state to an expanded, activated state, thereby causing a second fluid to be pumped outwardly from the first chamber under bias of the actuator to a second chamber for analysis.

Abstract: An apparatus for analyzing a test liquid includes an inlet chamber, a preparation chamber and an analysis element. The inlet chamber receives the test liquid. Test liquid is configured to be brought from the inlet chamber via the preparation chamber onto the analysis element. A volume of the preparation chamber is capable of being increased, the test liquid being sucked into the preparation chamber from the inlet chamber due to an increase of the volume of the preparation chamber. A fixed quantity of test liquid is thus sucked into the preparation chamber, which enables precise analysis results possible.

Abstract: The disclosure provides three-dimensional crosslinked polymer networks comprising one or more channels extending from the surface and/or near the surface of the network into the interior of the network, arrays comprising the networks, processes for making the networks, and uses of the networks and arrays.

Abstract: A disposable, point-of-care diagnostic cartridge and method of performing an invitro diagnostic test on a specimen are provided. The cartridge includes a base having a mixing chamber is formed thereon. The mixing chamber has a mixing chamber inlet and a mixing chamber outlet. A detection chamber is formed downstream from the mixing chamber in fluid communication therewith. The mixing chamber includes a mixing reservoir bounded at least in part by a flexible upper member. The flexible upper member is expandable to accommodate an increase in volume of fluid and collapsible to dispense fluid outwardly from the mixing reservoir. The mixing chamber inlet has an inlet valve member that provides one way flow of fluid into the mixing reservoir. The mixing chamber outlet has an outlet valve member that provides one way flow of fluid outwardly from the mixing reservoir to the detection chamber.

Abstract: The present invention provides a device for nucleic acid extraction using a magnetic bead method. The device includes a disc turntable, an arc arch bridge base, a supporting column, and a magnet structural unit and a sample reaction unit both arranged on the disc turntable. The disc turntable includes a top plate; the arc arch bridge base includes a bottom plate arranged at the lowermost portion and an arc supporting plate arranged on the bottom plate, and the arc supporting plate corresponds to the guide rod insertion holes in position in a radial direction of the disc, and the arc supporting plate includes raised regions used for jacking up a guide rod and a magnet and groove regions used for allowing the guide rod and the magnet to fall. The device provided by the present invention can realize the automatic nucleic acid extraction in a stream-lining manner.

Abstract: The invention relates inter alia to an automated stainer for staining, in particular for hemalum-eosin (HE) staining, of a histological sample, the automated stainer exposing the sample to the action of at least one stain using at least one staining parameter. The automated stainer is notable for the fact that the automated stainer comprises an input means with which a staining parameter is definable, in particular is inputtable or is selectable from a plurality of possible staining parameters; and that a control apparatus is present which, upon application of the defined staining parameter, ascertains the prospectively expectable outcome of an action and displays it to the user with a display apparatus, before the automated stainer actually stains the sample.

Abstract: A self-contained sample processing cartridge, is disclosed. The sample processing cartridge includes a first member that includes a receiver to receive a sample specimen slide. The cartridge may also include a second member that closes on the first member to form a chamber inside the cartridge. The sample specimen slide forms a surface of the chamber. Placing the slide in the cartridge effectively completes the chamber of the cartridge. In one embodiment, the receiver of the first member includes an open region adjacent which the specimen slide is received. The second member includes a plurality of fluid inputs and at least one fluid output. The plurality of fluid inputs couples to the chamber by a plurality of channels respectively therebetween. In one embodiment, at least one of the plurality of channels may include a reagent reservoir and at least one of the plurality of channels includes a dissolvable blocking reservoir.

Abstract: A system reduces and/or prevents the risk of spontaneous ignition and/or explosion of an explosive atmosphere which uses a bag, sealable couplings, automated valves, an explosive gas detector operably disposed inside the bag and in communication with a processor which when the explosive gas detector detects gas levels of an explosive type gas and of a second predetermined molecular weight different than the first predetermined molecular weight and at level to present a risk, the processor causes actuation of the automatically controlled valve to open and release the inert gas into the bag which in turn drives the explosive gas out through one way check valve by means of the different molecular weights.

Abstract: The present invention provides a method of using a two-stage nucleic acid reaction and detection tube. First, a reaction and detection tube is provided. Then a reaction is performed by using a liquid in the storing space of the second tube, following by putting the dipstick into the dipstick fixing space of the connector. The first tube, the second tube and the connector is assembled together, wherein the dipstick is placed both in the dipstick fixing space of the connector and the detection space of the first tube. The reaction and detection tube is rotated from bottom to top, thus making the liquid in the storing space of the second tube flow into the liquid collection space through the diversion unit and then contact the dipstick in the dipstick fixing space. A detection result is then observed from the dipstick.

Abstract: With the increase in the speed of operation of a device, it is necessary to perform washing to drying for a wide range of a probe in a short time. A probe, a washing nozzle which ejects a washing liquid, a vacuum nozzle which sucks air, a washing tank, which is connected to the washing nozzle and the vacuum nozzle, and in which washing and drying of the probe is performed by ejecting the washing liquid from the washing nozzle and then sucking air by the vacuum nozzle, a waste liquid flow path, which is connected to the washing tank, and into which the washing liquid is discharged, and a shielding member 100 which shields a flow path between the washing tank and the waste liquid flow path after the washing liquid is ejected from the washing nozzle.

Abstract: A measurement device includes a sensor attached to a biosensor which includes a reagent that selectively responds to a specific analyte in a biological fluid, an analyte measurer that measures a concentration of the specific analyte with a biosensor, and a motion measurer that measures a motion level of the measurement device. A recorder records the concentration of the analyte and motion information, and a controller connects the analyte measurer and the motion measurer and controls the analyte measurer and the recorder based on the controller motion information. The controller includes a damage determiner that judges whether or not the measurement device is damaged, based on the motion level.

Abstract: Fluidic cartridge including a liquid container having a reservoir configured to hold a liquid. The liquid container includes an interior surface. The fluidic cartridge also includes a transfer tube that extends from the interior surface to a distal end. The distal end includes a fluidic port that is in flow communication with the reservoir through the transfer tube. The transfer tube has a piercing segment that includes the distal end. The fluidic cartridge also includes a movable seal that is engaged to the piercing segment of the transfer tube and configured to slide along the piercing segment from a closed position to a displaced position during a mating operation. The movable seal blocks flow of the liquid through the fluidic port when in the closed position. The piercing segment extends through the movable seal when in the displaced position.

Abstract: An electrophoresis running tank assembly uses two opposed rows of LEDs to illuminate DNA-containing gel on a transparent tray positioned between the rows. A respective cylindrical lens is positioned horizontally between each row and a respective edge of the tray. The optical axis of the illumination light is midway between a bottom surface of the gel tray and a top surface of the gel.

Abstract: Some embodiments of the invention provide a disposable cartridge for rapidly metering a sample for measuring a property of the sample. The cartridge can receive a sample when it is in an unsealed configuration, and a cap is used to facilitate metering of the sample and sealing the cartridge. When the cartridge is in a sealed configuration, pressurised air is used to push the metered sample into a chamber containing at least one reagent, and subsequently into a detection chamber for measuring the property of the sample.

Abstract: Disclosed is a filtration device for liquid samples as well as a close and push-through device for said filtration device.

Abstract: The present invention discloses a two-stage reaction and detection tube comprises a first tube, a second tube and a connector. The first tube comprises a detection space for placing a dipstick and a detection space for the test result. The second tube comprises a storing space for the PCR or RT-PCR reagents and the target gene segments. The connector comprises a first portion and a second portion which connect to the first tube and the second tube respectively. The connector further comprises a diversion unit, a liquid collection space, and a dipstick fixing space, where the liquid collection space is connected to the dipstick fixing space. The target gene amplification and detection could be directly processed in the same tube without any liquid transfer.

Abstract: Apparatus for transferring biological material onto storage media, said apparatus comprising a powered hand held device including a powered hammer arrangement, the apparatus further comprising an anvil arrangement and a storage media accepting area between the hammer and the anvil, the apparatus being operable such that in use the storage media is repeatedly compressed between the hammer and the anvil by blows from the hammer.

Abstract: A portable, disposable in-vitro diagnostic apparatus and method of performing a point-of-care invitro-diagnostic test is provided. The apparatus has a body with at least one chamber containing an actuator member. The chamber is in fluid communication with an upstream first fluid channel and a downstream second fluid channel. The actuator member has a compressed, deactivated state and an expanded, activated state. The actuator member transitions from the compressed, deactivated state to the expanded, activated state upon contact with fluid flowing through the first fluid channel. The actuator member pumps fluid outwardly from the first chamber through the second fluid channel during the transition from its compressed, deactivated state to its expanded, activated state. The pumped fluid can be channeled to other chambers within the body and/or to an analysis chamber within the body for study.

Abstract: Exemplary embodiments of apparatus and method for facilitating an analysis of a sample(s) can be provided. For example, using a first arrangement(s), it can be possible to receive the sample(s) thereon. Further, for example, using a second arrangement(s), it can be possible to cause a force to be applied on a portion(s) of the sample(s) such that a surface(s) of the sample(s) can be flattened against a section(s) of the first arrangement(s).

Abstract: A method for enriching a heterogeneous population of cells includes loading one or more sample chambers containing DEP electrodes therein with a solution containing the heterogeneous population of cells, wherein the heterogeneous population of cells comprises a first subpopulation of cells having a first crossover frequency and a second subpopulation of cells having a second, higher crossover frequency. An AC electrical field is applied to the DEP electrodes, wherein the AC electrical field has an applied frequency that is between the crossover frequency of the first subpopulation of cells and the second subpopulation of cells, wherein the first subpopulation of cells are substantially killed by the applied electrical field and the second subpopulation of cells are substantially not killed by the applied electrical field.