Abstract: A fluid connection device is provided for biological analysis apparatuses, intended to simultaneously connect a plurality of fluid conduits and at least one fluidic component including a connecting surface with a plurality of fluid ports, the device having: (i) a holding plate, (ii) removable attachment structure capable of pressing the holding plate against the connecting surface, (iii) connectors suitable for being fixed to the ends of the fluid conduits and provided with a seal suitable for allowing a sealed connection to be made between the connectors and the fluid ports, holding plate including through-openings opposite the fluid ports and being shaped in such a way as to be able to receive the connectors in through-openings and to hold them pressed against the connecting surface. A biological analysis apparatus implementing the device is also provided.

Abstract: A lateral flow device for use in a mainframe or point-of-care clinical analyzer, in which the lateral flow device includes a planar support having at least one sample addition area and at least one reaction area disposed thereon. The sample addition area and reaction area are fluidly interconnected to one another and form at least one lateral fluid flow path. The lateral flow device is sized for retention within a storage cartridge of the analyzer defined by a hollow interior and having a plurality of lateral flow assay devices retained in stacked relation therein.

Abstract: A fluid specimen collection, storage, transport, and testing cup contains a chromatographic strip-carrying caddy which moves between an initial position allowing a deposited liquid specimen to contact the test strips, and a second, sealed position where the strips are hermetically isolated from a remainder portion of the specimen stored for later confirmatory testing. The caddy is moved between the two positions by screwing a threaded lid onto the top opening of the cup. The axial range of the screw is limited by a removable obstruction collar. The caddy can include a liquid specimen containing chamber having a lower opening sealed by a frangible barrier. The strips can be loaded in a cartridge mountable to the caddy. An adulteration panel having a transparent adhesive backed fronting can secure adulteration patches to the caddy.

Abstract: In a housing configured to mount thereon a biosensor in an attachable and detachable manner in which the biosensor is configured to have a liquid sample of a biological object deposited thereon, the medial measuring device includes a measuring component operable to measure biological information from the liquid sample of the biological object, a recording component operable to store a result measured by the measuring component, and an information protection component operable to determine an access limitation to personal information data stored in the recording component. With this configuration of the device, it is possible to properly protect personal information stored in the device.

Abstract: An array chip useful for biochemical assays is provided wherein the chip includes a field region arranged with attachment sites according to a first pitch and at least one track region having a one-dimensional spot pattern arranged according to a second pitch that is less dense and is a non-integer multiple of the first pitch so that one-dimensional Moiré averaging may be applied in the track region, thereby to attain alignment of the chip to the optical instrumentation with a higher density of attachment sites.

Abstract: A lateral flow device for use in a mainframe or point-of-care clinical analyzer, in which the lateral flow device includes a planar support having at least one sample addition area and at least one reaction area disposed thereon. The sample addition area and reaction area are fluidly interconnected to one another and form at least one lateral fluid flow path. The lateral flow device is sized for retention within a storage cartridge of the analyzer defined by a hollow interior and having a plurality of lateral flow assay devices retained in stacked relation therein.

Abstract: A test strip module includes a case, a test strip in the case, and a position anchor extending down past a mating surface to a face of a mobile computing device. The position anchor has a shape matching a feature on the face of the mobile computing device.

Abstract: An operating and reading instrument for performing an assay employing a portable microfluidic assay cartridge, the instrument comprising a translatable table under automated control, the translatable table carrying a receiving region for the portable cartridge and carrying a port system connectable to the cartridge that includes at least one remotely automated valve carried by the translatable table, the valve arranged to apply pressurized flowable substance at selected times to the cartridge while the cartridge is on the translatable table.

Abstract: A biosensor includes a detection element having an analyte detecting portion which is monotonically increased in mass in response to detection of an analyte; a reference element having a reference measuring portion which exhibits no reactivity to the analyte; a mixer which mixes a detection signal responsive to mass variations in the analyte detecting portion from the detection element and a reference signal from the reference element; a measurement which calculates two candidate phase-change values of a positive value and a negative value, from a signal mixed by the mixer in accordance with a heterodyne system, and determines a phase-change value from the two candidate phase change value by judging whether the phase is positive or negative based on temporal changes in signal strength; and a detection amount calculation portion which calculates a detection amount of the analyte based on the phase change value determined by the measurement portion.

Abstract: A method for performing an assay to determine the presence or concentration of an analyte contained in a sample of body fluid by using a device comprising at least one analyte quantification member and a sensor associated therewith, the method includes: applying a first sample to the analyte quantification member; and detecting the presence or absence of an adequate sample volume; wherein upon detection of the absence of an adequate sample volume, initiating a finite timed period, and signaling the user to introduce a second sample of body fluid to the analyte quantification member. Associated arrangements and devices are also disclosed.

Abstract: A system for deforming and analyzing a plurality of particles carried in a sample volume includes a substrate defining an inlet, configured to receive the sample volume, and an outlet; and a fluidic pathway fluidly coupled to the inlet and the outlet.

Abstract: A drug test device for bodily fluids, such as urine, includes a cup and a removable lid which houses one or more test strips. The lid is releasably locked onto the cup so as to align dipping ends of the test strips exposed through an underside of the lid with a position stabilizer, thereby causing the dipping ends to be located downwardly and submerged in fluid when the device is placed on its side in a reactive position. The position stabilizer may comprise a sidewall indentation that reduces the internal volume of the cup and keeps the cup from rolling when placed on its side.

Abstract: A detection system of a test substance, includes: a magnetic body that is modified by a first substance capable of being bound to the test substance at a first binding site of the test substance; a marker that is modified by a second substance capable of being bound to the test substance at a second binding site of the test substance, the second coupling site being a different site from the first binding site; a development medium that has a flow passage into which liquid, in which the magnetic body and the marker is dispersed, flows due to a capillary phenomenon, the development medium having a detection position for detecting the marker in a portion of the flow passage, the development medium having light transparency at least in the detection position; and a magnetic force generating portion that is equipped in the development medium.

Abstract: To provide a sample analyzer capable of accurately obtaining the number of analyzable samples. When analyzing a sample collected from a subject, a CPU of the sample analyzer calculates the number of analyzable samples based on a remaining number of tests of a reagent set in a reagent holding section and the number of tests of the reagent to be consumed in measurement of a control, and causes a output section to display the number of analyzable samples. When creating a calibration curve, the CPU calculates the number of analyzable samples based on a remaining number of tests of the reagent set in the reagent holding section, the number of tests of the reagent to be consumed in measurement of the control, and the number of tests of the reagent to be consumed in measurement of a calibrator, and causes the output section to display the number of analyzable samples.

Abstract: A test instrument for analyzing body fluids such as blood or urine. The instrument includes a wound test tape which can be transported from a storage space into a waste space by advancing the tap. The test tape has a plurality of test sections to which body fluid can be applied at a receiving position and also includes a measuring unit for detecting a constituent of the body fluid on an active test section. In order to carry out auxiliary instrument functions, in addition to the test sections, the test tape has one or more functional sections which can be brought into a functional position by advancing the tape.

Abstract: An analysis device is proposed for detecting an analyte in a liquid sample, in particular for detecting glucose in a bodily fluid. The analysis device comprises at least one control element, which is configured to provide a function menu with at least two menu items. The analysis device further comprises at least one adjustable selector element, in particular a mechanically adjustable selector element, which can be adjusted by a user to at least two different selection positions. The selector element is configured to remain in the adjusted selection position after being adjusted. The control element is configured to select a menu item corresponding to the adjusted selection position. The analysis device further comprises at least one operating element. At least one parameter in the selected menu item can be influenced by the user via the operating element.

Abstract: A method for dynamic enhancement of chemical reactions by nanomaterials under hard X-ray irradiation. The nanomaterials were gold and platinum nanoparticles, and the chemical reaction employed was the hydroxylation of coumarin carboxylic acid. The reaction yield was enhanced 2000 times over that predicted on the basis of the absorption of X-rays only by the nanoparticles, and the enhancement was found for the first time to depend on the X-ray dose rate. The maximum turnover frequency was measured at 1 16×10-4 s-1 Gy-1. We call this process chemical enhancement, which is defined as the increased yield of a chemical reaction due to the chemical properties of the added materials. The chemical enhancement described here is believed to be ubiquitous and may significantly alter the outcome of chemical reactions under X-ray irradiation with the assistance of nanomaterials.

Abstract: A biological sample measurement device comprising a main body case including a sensor mounting component; a measurement component including an input side; a controller connected to the measurement component, the controller including a measurement preparation mode and a measurement mode, the controller configured to determine whether there is an abnormality in the measurement component; a memory component connected to the controller; a switching component connected to the input side of the measurement component, a first reference resistor, and to the sensor mounting component; the switching component configured to switch between at least two states.

Abstract: A biological fluid sample analysis cartridge is provided. The cartridge includes a housing, a fluid module, and an analysis chamber. The fluid module includes a sample acquisition port and an initial channel, and is connected to the housing. The initial channel is sized to draw fluid sample by capillary force, and is in fluid communication with the acquisition port. The initial channel is fixedly positioned relative to the acquisition port such that at least a portion of a fluid sample disposed within the acquisition port will draw into the initial channel. The analysis chamber is connected to the housing, and is in fluid communication with the initial channel.

Abstract: A sensor includes a substrate that includes an upper substrate and a lower substrate, and an electrode that is provided on the lower substrate, and the upper substrate, the lower substrate, and the electrode are formed by an optically transparent member.