Abstract: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.

Abstract: Mercaptoalkylalkoxysilane is obtained by reacting at least one sulfide of the general formula MHS wherein M is an alkali metal or ammonium with a haloalkyl silane in an aqueous reaction medium in the presence of an acidic gas to maintain the pH of the reaction medium at or below about 10, and in the additional presence of alkylguanidinium salt phase transfer catalyst to provide mercaptoalkylalkoxysilane, the alkylguanidinium salt phase transfer catalyst being represented by the general formula: wherein each of R1-5 is a primary alkyl radical and R6 is a primary alkyl or bis(primary alkylene) radical, or at least one of the R1–R2, R3–R4 and R5–R6 combinations with the respective connecting nitrogen atom forms a heterocyclic radical; X is an anion; and n is 1 or 2.

Abstract: The present invention concerns a process for producing silylalkylboranes containing the structural feature Si—C—B, new molecular silylalkylboranes, new molecular silyalkylborazines, new oligoborocarbosilazanes and polyborocarbosilazanes, a process for their production and their use as well as silicon boron carbide nitride ceramics and a process for their production.

Abstract: Continuous hydrosilylation of compounds (A) bearing C—C multiple bonds by means of silicon compounds (B) having Si—H groups, in which the reaction components (A) and (B) are reacted continuously in an integrated loop-tube reactor, with reaction mixture being conveyed from the tube into the loop and back again so that a section of the tube is part of the loop circuit, provides a highly controllable reaction process with high product yields.

Abstract: A process for alkylation of a diphenylamine compound in an ionic liquid. The use of an ionic liquid permits convenient separation of the alkylated reaction product from the reaction mixture.

Abstract: Disclosed is a process for the preparation of a compound of formula wherein R1 is hydrogen, hydroxyl, or unsubstituted or substituted alkyl or alkoxy, R2 is hydrogen or a substituent which can be converted to hydrogen, and n is 0, 1 or 2, comprising hydrogenating a compound of formula wherein R1, R2 and n are as defined above, in the presence of a nickel or cobalt catalyst.

Abstract: A composition of matter is disclosed that comprises at least one silane coupling agent for coupling an elastomer and a filler wherein said silane comprises at least one hydrolyzable group that, upon compounding said silane with said elastomer and filler, is released to yield a compound that improves downstream processability of the compounded composition or the properties of the final rubber product or both.

Abstract: A method of synthesizing a polynucleotide which can, for example, be used during fabrication of an array. A second nucleoside is coupled to a first nucleoside through a phosphite linkage, with the second nucleoside having a hydroxyl protecting group that is a non-carbonate protecting group. The product of the foregoing step is exposed to a composition which both oxidizes the formed phosphite to a phosphate and deprotects the protected hydroxyl of the coupled nucleoside. The method has particular application to fabricating an addressable array of polynucleotides on a substrate which carries substrate bound moieties each with a hydroxyl group.

Abstract: A process for the preparation of trifluoromethyl iodide is provided. The process includes the step of contacting in a reactor a compound represented by the formula: CF3—W and a compound represented by the formula: IFn wherein W can be H, Br, Cl, COOH, COCl, COOCH3, COOC2H5, COCH3, COPh, CF3, Si(CH3)3, SPh, SCH3, SSCF3, SSPh, SSCH3, or SO2Cl, wherein n is 1, 3, 5, or 7, and wherein the step of contacting is carried out, at a temperature, pressure and for a length of time sufficient to produce trifluoromethyl iodide. The contacting step can be carried out in the presence or absence of a catalyst and the contacting step can be carried out in the presence or absence of air.

Abstract: Disclosed are compounds produced by a process comprising the step of reacting an amine reactant with an epoxide reactant to form a hydrolytically stable carbon-nitrogen bond therebetween, wherein at least one of the amine or epoxide reactants comprises a terminal alkoxysiyl group. Also disclosed are curable compositions comprising the compounds of the present invention and the cured products derived therefrom.

Abstract: The invention discloses novel series of silicone esters, which are useful as antioxidants on skin. The products are produced using for a variety of hydroxyl containing actives such as vitamin A (retinol), vitamin A-2, and vitamin E. Compounds of the invention are prepared by the esterification of (a) a specific silicone methyl ester and (c) a hydroxyl functional active. The esters of the present invention allow for the formulation of personal care products in which the “active” can be formulated into a variety of solvents without the loss of activity.

Abstract: There is disclosed a process for producing bisphenol A by subjecting phenol and acetone to condensation reaction in the presence of a catalyst composed of an acid type ion exchange resin which is modified in part with a sulfur-containing amine compound, wherein the ion exchange resin having a modification rate of 10 to less than 20 mol % is used for a methanol concentration in acetone of lower than 250 ppm by weight, and the ion exchange resin having a modification rate of 20 to 65 mol % is used for a methanol concentration in acetone of 250 to 8000 ppm by weight. The above process is capable of producing bisphenol A at high conversion and selectivity by suppressing deterioration of catalytic activity due to methanol as an impurity in acetone.

Abstract: The object of the present invention is to provide a new kind of silicon compound having an ester-type organic functional group and a new method for providing a T8-silsesquioxane compound having a hydroxyl group by using said silicon compound as the starting material. A silicon compound represented by formula (1) is obtained through the production process characterized by using a silicon compound represented by formula (2). wherein: in formula (1), each of seven R1 group is independently selected from the group consisting of hydrogen, alkyl, substituted or unsubstituted aryl, and substituted or unsubstituted arylalkyl and A2 is a hydroxyl-terminal organic functional group, and in formula (2), each of R1 group is the same as R1 in formula (1), and A1 is an organic functional group containing an acyloxy group.

Abstract: A process for preparing amino-functional organopolysiloxanes comprising (i) mixing aminosilanes of the general formula RaQbSi(OR1)4?(a+b), where R and R1 are hydrogen or optionally substituted hydrocarbyl, a is 0, 1 or 2, b is 1, 2 or 3, and a+b is ?3, Q is —R5—[NR6(CH2)n]eN(R6)2, where R5 is a hydrocarbyl diradical and R6 is hydrogen, hydrocarbyl, or acyl, e is 0, 1, 2, 3 or 4, n is 2, 3, 4, 5 or 6, with organosilicon compounds selected from siloxanes comprising units R d ? ( O ? R 1 ) f ? SiO 4 - ( d + f ) 2 ? ? and ? ? R c ? SiO 4 - c 2 or silanes RcSi(OR1)4?c, where c is 0, 1, 2 or 3, d is 0, 1 or 2, f is 1, 2 or 3, with the proviso that d+f is ?3, basic catalysts selected from alkali metal hydroxides, alcoholates and siloxanolates, and optionally, alcohols H—[O(CHR2)p]mOR3, where R2 and R3 are hydrogen or hydrocarbyl, p is 2, 3 or 4, and m is 0 or an integer from 1 to 100, (ii) reacting by heating to 70–100° C.

Abstract: This invention provides a method of preparing amine stereoisomers, which comprises stereoselectively reducing a sulfinylimine that bears on the sulfinyl group a residue of an alcohol, thiol or amine, or reacting a sulfinylimine stereoisomer that bears on the sulfinyl group a residue of an alcohol, thiol or amine with a source of a nucleophile, to afford a sulfinylamine stereoisomer, followed by contacting the sulfinylamine stereoisomer with a reagent suitable for the cleavage of a sulfur-nitrogen bond, to afford an amine stereoisomer. It also provides novel intermediates useful in the method, and the use of certain of the intermediates in the preparation of sulfoxide and sulfinylamine stereoisomers.

Abstract: Compounds of formula (Ia) as potent, ?1-specific beta blockers with a short duration of action in the systemic circulation, wherein R is 3?,4?-dimethoxyphenyl, R1 is hydrogen, and R2 is selected from methyl, ethyl, propyl, isobutyl and isopropyl; or R is 3?,4?-dimethoxyphenyl, R1 is selected from fluorine, chlorine and bromine, and R2 is selected from methyl, ethyl, propyl, isopropyl, isobutyl and cyclopropylmethyl; of R is 4?-methoxyphenoxy, R1 is selected from hydrogen, fluorine, chlorine and bromine, and R2 is selected from methyl, ethyl, propyl, isopropyl, isobutyl and cyclopropylmethyl; or R is 3?,4?-dimethoxyphenyl, R1 is cyano, and R2 is cyclopropylmethyl; or R is 4?-methoxyphenoxy, R1 is cyano, and R2 is isobutyl; and physiologically acceptable hydrolysable derivatives thereof having the hydroxy group in the 2-position of the 3-aminopropoxy side chain in esterified form, in their racemic and optically active forms, and their pharmaceutically acceptable acid addition salts.

Abstract: The present invention relates to a process for isomerizing reactant allyl alcohols to product allyl alcohols in the presence of a catalyst, wherein the reactant allyl alcohol is rearranged to product allyl alcohol in semicontinuous or continuous mode in a catalyst-containing suitable reactor. In particular, the process according to the invention is used to prepare linalool from Geraniol and/or nerol.

Abstract: Process for preparing highly viscous organopolysiloxanes by reacting siloxanes (1) composed of units of the general formula A a ? R c ? ( OR 1 ) d ? SiO 4 - ( a + c + d ) 2 ( I ) where A is a nitrogen-containing Si—C-bonded radical, R is a C1-18 hydrocarbon radical R1 is hydrogen or a C1-8 alkyl radical, a and d are 0 or 1, c is 0, 1, 2 or 3, a+c+d is <3 and one A and one R1 where of R1 is hydrogen atom are present, optionally siloxanes (2) R c ? ( OR 1 ) d ? SiO 4 - ( c + d ) 2 ( II ) where c+d is ?3 and one R1 radical is hydrogen is present, with silanes (3) BReSi(OR3)3?e??(III) where B is a radical —CR22—Y, R2 is hydrogen or C1-4 alkyl, Y is halogen, a monosubstituted O and S atom, or a substituted N or P atom, R3 is C1-8 alkyl, and e is 0, 1 or 2.

Abstract: Aromatic amines are produced from aromatic hydrocarbons by a) reacting the aromatic hydrocarbon(s) with a mixture of nitric acid and sulfuric acid to generate a two-phase reaction mixture, b) separating the reaction mixture into an aqueous acid phase and an organic phase containing the nitroaromatic compounds c) washing the organic phase to purify the nitroaromatic compound(s), d) hydrogenating the nitroaromatic compound(s) in the presence of a catalyst to produce the aromatic amine(s) and water of reaction, and e) separating the water of reaction formed in step d) from the aromatic amine(s), in which the water of reaction separated in step e) is used to wash the organic phase containing the nitroaromatic compounds in step c).

Abstract: Novel 3,3-diphenylpropylamines of the formula and stereoisomers and physiologically acceptable acid addition salt thereof; wherein R1, R2, R3, R4, R5, and R6 are as defined herein; methods of use thereof; and pharmaceutical compositions thereof.