Patents Examined by Samuel P. Siefke
  • Patent number: 11454581
    Abstract: The molecule detecting apparatus of an embodiment includes a light source 31, a fluorescent layer 42 emitting different fluorescence depending on the kind of a target molecule 60 captured when being irradiated with light from the light source 31, a photodetector 32 configured to detect fluorescence, and the photodetector 32 is an array of avalanche photodiodes operating in Geiger mode.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: September 27, 2022
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Honam Kwon, Ikuo Fujiwara, Kazuhiro Suzuki, Keita Sasaki, Yuki Nobusa, Yasushi Shinjo
  • Patent number: 11453000
    Abstract: A flow cell and a method for connecting components of a microfluidic flow cell, in particular for integrating component parts into a carrier structure of the flow cell, in which a gap is formed between the components to be connected. The gap is filled with a solvent. The material of at least one component bordering the gap dissolves in the solvent and the material completely fills the width of the gap and partially fills the height thereof after evaporation of the solvent.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: September 27, 2022
    Inventor: Lutz Weber
  • Patent number: 11454570
    Abstract: In one embodiment, a sample probe has a cap and a base, wherein the cap includes a grip portion and a projection portion. The projection portion fits within a hollow portion of a filter such that the filter is disposed on the outside of the projection portion and the filter and the cap form a cap assemblage. The base comprises a base recess that receives a portion of the cap assemblage including the filter. The cap and base include corresponding media transfer regions adjacent and connected to the filter that reduces flow resistance and chances of blockage and/or contamination during dissolution-testing sampling using the sample probe.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: September 27, 2022
    Assignee: Distek, Inc.
    Inventors: Jeffrey Brinker, Shawn Craig, Peter K. Schultz, Timothy John Nadolski
  • Patent number: 11442055
    Abstract: The invention relates to a method for detecting an analyte present in a liquid specimen, including: injecting the liquid specimen into a detection chamber, the detection chamber having a non-zero volume enclosing polymeric beads covered with a reagent suitable for the analyte to be detected; capturing at least one image of at least one region of the detection chamber using a sensor; processing the image acquired by the sensor, which includes determining a texture level of the acquired image; and determining a concentration of the analyte depending on the texture level determined for the image.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: September 13, 2022
    Assignee: Commissariat a l'Energie Atomique et aux Energies Alternatives
    Inventors: Myriam-Laure Cubizolles, Thomas Bordy, Frederic Revol-Cavalier
  • Patent number: 11440013
    Abstract: A device is provided comprising a receiving chamber for receiving a patient's sample, a first reagent reservoir and a second reagent reservoir. The receiving chamber may be configured for receiving at least an end portion of a sample collecting element, with the patient's sample being collected by that sample collecting element. The first reagent reservoir may generally be configured to accommodate a liquid reagent which may include a lysing agent, i.e. the liquid may be a kind of a lysis buffer. Likewise, the second reagent reservoir may generally be configured to accommodate a dry reagent which may include magnetic particles. The device may further comprise at least one of the following two actuators, a first actuator for supplying a first reagent from the first reagent reservoir to the sample and a second actuator for supplying a second reagent from the second reagent reservoir to the resulting mixture.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: September 13, 2022
    Assignee: Koninklijke Philips N.V.
    Inventors: Matthias Irmscher, Toon Hendrik Evers, Marlieke Joan Overdijk, Thomas Johannes Van Gijsel, Stefan Johannes Hendrikus Toonen
  • Patent number: 11442015
    Abstract: The present invention is directed to sample test cards having an increased sample well capacity for analyzing biological or other test samples. In one embodiment, the sample test cards of the present invention comprises a fluid channel network disposed in both the first surface and the second surface and connecting the fluid intake port to the sample wells, the fluid channel network comprising at least one distribution channels, a plurality of fill channels operatively connected to the at least one distribution channel, a plurality of through-channels operatively connected to one or more of the fill channels and a plurality of horizontally orientated fill ports operatively connecting the fill channels to the sample wells.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: September 13, 2022
    Assignee: bioMerieux, Inc.
    Inventors: Raymond O'Bear, Brian Livingston, David Hertlein, Richard Scott Remes, Stanley Philipak
  • Patent number: 11433393
    Abstract: A microfluidic flow cell including an electrode or sensor device which is located inside the flow cell and from which at least one connecting conductor leads to an externally accessible terminal contact. The electrode or sensor device is arranged on an insulated substrate member. The connecting conductor is embedded in the substrate member. The substrate member can be inserted into an opening in the flow cell such that the electrode or sensor device is placed in the flow cell.
    Type: Grant
    Filed: December 28, 2016
    Date of Patent: September 6, 2022
    Inventor: Lutz Weber
  • Patent number: 11435340
    Abstract: Materials and manufacturing techniques to produce test strips in high volume at low-cost for the measurement of gas in various industries and environments are disclosed. The test strip is generally comprised of a substrate, at least one electrical connection, at least one sensing chemistry and at least one additional layer. The test strip may provide a quantitative and/or a qualitative read out. A method for collecting and analyzing data to monitor and manage patients with chronic respiratory disease is disclosed. Implementations include software applications, connected medical devices, web servers and electronic catalogs. A method for identifying treatment trends from a population combining medical, biological and environmental data is disclosed. A method for proactively alerting and patients, caregivers and medical providers to trends in health by using the implementations of the invention are disclosed.
    Type: Grant
    Filed: June 9, 2015
    Date of Patent: September 6, 2022
    Assignee: Biometry Inc.
    Inventors: Thomas T. Morgan, Bryan Nolan, David L. Carnahan
  • Patent number: 11435295
    Abstract: A sensor element is used to collect environment information on a surface of the earth or a surface layer of the earth by being scattered in a target region where the environment information is collected. At least one of reflection properties, transmission properties, absorption properties, or luminescence properties with respective to an electromagnetic wave with a specific wavelength, or light emitting properties changes in accordance with an environment.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: September 6, 2022
    Assignee: Yokogawa Electric Corporation
    Inventors: Koichi Taniguchi, Mitsuhiro Iga
  • Patent number: 11427661
    Abstract: The present invention provides a fluorescent polymer comprising a fluorophore perylene bisimide (PBI) and oligo (p-phenylene vinylene) (OPV) functionalized with carboxy and amine functionality groups and a polystyrene (PS) backbone for the detection of volatile organic compound, a process for the detection and a kit thereof.
    Type: Grant
    Filed: February 18, 2019
    Date of Patent: August 30, 2022
    Assignee: Council of Scientific & Industrial Research
    Inventors: Sarabjot Kaur Makkad, Asha Syamakumari
  • Patent number: 11426722
    Abstract: A specimen collection, storage, transport, and testing device can include an outer vessel containing an internal cup having an openable drain having a brim raised above the bottom floor of the cup. Once opened the drain allows a portion of liquid specimen to flow from the cup into a lower chamber of the vessel containing a number of chromatographic assay strips. A lid sealing the vessel can include a downwardly projecting guide tube having first barrier sealing a bottom aperture. An oblong initiator can axially engage the guide tube, break the first barrier and open the drain to initiate the test while retaining a pool of liquid specimen in the cup for subsequent confirmatory testing.
    Type: Grant
    Filed: June 5, 2019
    Date of Patent: August 30, 2022
    Inventors: Phuong Nguyen, John D. Buchaca
  • Patent number: 11428681
    Abstract: A sensor can include a conductive region in electrical communication with at least two electrodes, the conductive region including a conductive material and an alkene-interacting metal complex.
    Type: Grant
    Filed: November 4, 2019
    Date of Patent: August 30, 2022
    Assignee: Massachusetts Institute of Technology
    Inventors: Timothy M. Swager, Sophie Liu, Graham Sazama, Alexander R. Petty, Jan M. Schnorr
  • Patent number: 11428690
    Abstract: A plasmonic photoconductor sensing platform is provided. The plasmonic photoconductor sensing platform includes an insulating substrate; a semiconducting film placed on top of the insulating substrate; two metal contacts placed at least in part on the semiconducting film to enforce an electric field; a plurality of plasmonic nanostructures deposited on the semiconducting film and physically separated from metal contacts; an insulating layer, the insulating electrically isolating the plasmonic nanostructures from semiconductor; at least one energy source; and at least one microfluidic channel disposed on the insulating layer.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: August 30, 2022
    Assignee: University of Miami
    Inventors: Xu Han, Hossein Shokri Kojori, Roger M. LeBlanc, Sung Jin Kim
  • Patent number: 11428700
    Abstract: A method of operating a tissue processor for processing tissue samples. The tissue processor includes at least one retort for receiving tissue samples, at least one container for storing a reagent, and at least one sensor arranged for fluid communication with one or both of the at least one container and the at least one retort for measuring a measured purity level of a reagent. The method includes conducting reagent from the at least one container or the at least one retort to the at least one sensor, automatically measuring a measured purity level of the reagent, checking whether the measured purity level meets a predetermined purity level of the reagent associated with the at least one container, and thereby automatically determining whether the reagent is suitable for processing tissue samples in the tissue processor. Also, a tissue processor for processing tissue samples and a container for storing tissue samples.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: August 30, 2022
    Inventors: Gordon Sears, Michael Houston Drummond, Donnchadh Oh-Ainle
  • Patent number: 11422125
    Abstract: This disclosure provides a new phagocytosis assay to test the function of RPE cells and photoreceptor progenitors using a pH sensitive fluorescent label.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: August 23, 2022
    Assignee: Astellas Institute for Regenerative Medicine
    Inventors: Irina V. Klimanskaya, Julie Kathryn Carson, Roger Gay, Yordanka Gikova Ivanova
  • Patent number: 11415585
    Abstract: A power off delay system and method is configured to delay termination of electrical power to a digital pathology device in a power off condition. If the apparatus includes a UPS, the power off delay system and method delays termination of electrical power when a power switch is turned off and when a catastrophic power failure occurs. During the delay of the termination of electrical power, the digital pathology device is configured to control the scanning stage system and the glass slide conveyor system and the slide rack conveyor system to place each of these systems into a known state and position all glass slides into a known position prior to the termination of electrical power to the digital pathology device. This allows the digital pathology device to resume normal operation upon power up.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: August 16, 2022
    Assignee: Leica Biosystems Imaging, Inc.
    Inventors: Nicholas Newberg, Benjamin Siehl, Markus Wittmann, Markus Sharpe
  • Patent number: 11415586
    Abstract: An analysis device includes a guide-in section, a piercing member, an airtight member, a gas introduction member, and a measurement member. The guide-in section is configured to guide a rectangular block shaped analysis kit containing a sample. The piercing member pierces a sealing film at an upper face of a liquid reservoir formed in the analysis kit. The airtight member forms an airtight space against the analysis kit at the periphery of a location pierced by the piercing member. The gas introduction member introduces gas into the airtight space. The measurement member measures a component present in the sample in the analysis kit guided into the guide-in section.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: August 16, 2022
    Assignee: ARKRAY, Inc.
    Inventors: Akihiro Yamamoto, Daisuke Matsumoto, Masao Kawano
  • Patent number: 11415503
    Abstract: A method of inseminating an animal including flowing a stream of a population of sperm cells through a channel, differentiating the sperm cells into two subpopulations of X-chromosome containing sperm cells and Y-chromosome containing sperm cells, selecting a desired subpopulation, ablating an undesired subpopulation, and collecting both the subpopulations of sperm cells including the desired subpopulation and the ablated undesired subpopulation together, wherein the collected population of sperm cells is used to fertilize an egg.
    Type: Grant
    Filed: October 7, 2021
    Date of Patent: August 16, 2022
    Assignee: ABS GLOBAL, INC.
    Inventors: David Appleyard, Jeff Betthauser, Marjorie Faust, John Larsen, Guocheng Shao, Zheng Xia, Yu Zhou
  • Patent number: 11408818
    Abstract: A gasket sandwiched between a flow cell and a joint member has, in a main flat surface, an inlet communication hole for communicating between an inlet hole of the flow cell and an inlet flow path of the joint member and an outlet communication hole for communicating between an outlet hole of the flow cell and an outlet flow path of the joint member. Furthermore, a deformation absorbing structure for absorbing deformation of the gasket is provided between the inlet communication hole and the outlet communication hole in the main flat surface of the gasket.
    Type: Grant
    Filed: November 27, 2017
    Date of Patent: August 9, 2022
    Inventor: Masahide Gunji
  • Patent number: 11408879
    Abstract: Provided is a system for centralized water monitoring of a fish farm. the system including a plurality of fish tanks divided into a first and a second subgroup; and a first sample conduit only connected to the first of the subgroups through a first set of pipe connections, and a second sample conduit connected only to the second of the subgroups through a second set of pipe connections; each one of the pipe connections being connected to only one fish tank; the pipe connections being configured for water sampling from a selected fish tank of the first subgroup into the first sample conduit and from a selected fish tank from the second subgroup into the second sample conduit. Water samples are received by a first and second sensor system from the first and second sample conduits for simultaneous measurements of the samples by the sensor system.
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: August 9, 2022
    Assignee: BLUE UNIT A/S
    Inventor: David Alexander Owen