Patents Examined by Samuel P. Siefke
  • Patent number: 11971360
    Abstract: An optochemical sensor for determining a measurement signal, which correlates with a concentration of an analyte of a measuring fluid, comprises: a sensor cap including a sensor spot, wherein the sensor spot contains at least one analyte-sensitive indicator dye and a state description indicator which reflects the aging state of the sensor spot; a radiation source to radiate excitation radiation onto the sensor spot and to excite a luminescence of the indicator dye; a radiation receiver to receive reception radiation emitted by the sensor spot; and a sensor circuit electrically connected to the radiation source and the radiation receiver and configured to control the radiation source and to generate, based on an intensity of luminescence and/or a phase angle of luminescence, a measurement signal representing the concentration of the analyte in the measuring fluid in contact with the sensor spot.
    Type: Grant
    Filed: April 8, 2021
    Date of Patent: April 30, 2024
    Assignee: Endress+Hauser Conducta GmbH+Co. KG
    Inventor: Andreas Löbbert
  • Patent number: 11971405
    Abstract: In one aspect, molecular sensors and methods of making molecular sensors are described herein. In some embodiments, such a sensor comprises a first layer having a dual nanohole structure and a second layer having at least one nanopore. In some embodiments, the first and second layer define a chip of the sensor. In another aspect, methods of sensing are described herein, which in some embodiments comprise (i) providing a test sample comprising complexed and/or non-complexed biomolecules; (ii) contacting the test sample with the first layer of the molecular sensor; (iii) irradiating the dual nanohole structure of the sensor with a beam of electromagnetic radiation; (iv) optically trapping the biomolecules in the dual nanohole structure and measuring a surface plasmon resonance; (v) applying an electric field across the nanopore of the sensor; and (vi) measuring change in current across the nanopore during one or more translocation events of the biomolecules.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: April 30, 2024
    Inventors: Georgios Alexandrakis, Jon Weidanz, Muhammad Usman Raza, Sai Santosh Sasank Peri
  • Patent number: 11964274
    Abstract: A liquid handling device having an axis of rotation about which the device can be rotated to drive liquid flow in the device. The device includes an upstream chamber having an outlet, a downstream chamber including a proximal portion radially inwards of a distal portion and including a first port disposed in the distal portion and a first conduit which connects the outlet of the upstream chamber to the first port of the downstream chamber. The first conduit extends radially inwards to a crest and radially outwards from the crest to the first port of the downstream chamber. A distance between the axis of rotation and the crest is greater than or equal to a distance between the axis of rotation and the outlet of the upstream chamber.
    Type: Grant
    Filed: March 31, 2020
    Date of Patent: April 23, 2024
    Assignee: BIOSURFIT, SA
    Inventors: Nuno Alexandre Esteves Reis, Tania Moura Pires De Andrade Tenreiro, Miguel Joao Marques Barreiros
  • Patent number: 11964268
    Abstract: The present invention provides a detecting apparatus, including a storage chamber containing a treating fluid; wherein, the detecting apparatus is internally provided with a sharp-pointed portion; the storage chamber may make a movement relative to the sharp-pointed portion; the storage chamber will be pierced by the sharp-pointed portion during the moving process, such that the treating fluid in the storage chamber is released. The detecting apparatus further includes a collecting chamber; the released treating fluid may flow into the collecting chamber; the collecting chamber is disposed inside a first shell and used to contain a sample; an opening is disposed at an upper position of the first shell; the collecting chamber is internally provided with a testing element for detecting an analyte; the testing element is disposed on a carrier, and the carrier has a specific matching form with the collecting chamber.
    Type: Grant
    Filed: January 14, 2022
    Date of Patent: April 23, 2024
    Inventors: Siyu Lei, Lili Shen, Jianqiu Fang
  • Patent number: 11953382
    Abstract: A system comprising a device or the device itself for measuring temperatures, comprising a sensor array plate, comprising on a first surface at least one temperature sensor arranged on at least one tongue that is surrounded by a cut-out leaving a bridge to the sensor array plate, wherein the at least one sensor has on both sides' spacer and a second surface opposite the first surface for connection to at least one operating plate of a thermocycler; and a pressure plate, comprising fins at the side for connection to the sensor array plate that align with the spacer of the sensor array plate when a pressure plate is arranged onto a sensor array plate.
    Type: Grant
    Filed: August 9, 2020
    Date of Patent: April 9, 2024
    Assignee: STRATEC SE
    Inventors: Manuel Künz, Daniel Ahr, Martin Trump, Rüdiger Retzlaff
  • Patent number: 11946068
    Abstract: A system for seeding therapeutic active ingredients (TAIs) onto a porous scaffold includes a first chamber for accommodating the scaffold, a TAI storage device for storing TAIs, at least one second chamber for storing TAI media, and a gas inlet for receiving gas from a compressed source. A flow circuit is coupled to the first chamber, the TAI storage device, the second chamber and the gas inlet for delivering the TAIs, the TAI media and the gas to the scaffold. A pump pumps at least one of the TAIs, the TAI media and the gas in the flow circuit. The system also includes a processor that regulates the delivery of the TAIs, the TAI media and the gas to the scaffold via a plurality of valves.
    Type: Grant
    Filed: February 12, 2021
    Date of Patent: April 2, 2024
    Assignee: EpiBone, Inc.
    Inventors: Sarindr Bhumiratana, Keith Yeager
  • Patent number: 11940381
    Abstract: Methods for calibrating a multispectral analysis system include calibrating the system to detect fluorescence emission from a first fluorescent entity in a biological sample that includes the first fluorescent entity and a second fluorescent entity using a calibration sample, where the calibration sample features a first concentration of the first fluorescent entity and a second concentration of the second fluorescent entity, and where the first concentration is larger than the second concentration.
    Type: Grant
    Filed: June 10, 2019
    Date of Patent: March 26, 2024
    Assignee: Revvity Health Sciences, Inc.
    Inventors: Rongcong Wu, Daniel Schoener
  • Patent number: 11913064
    Abstract: An optical gene biosensor is disclosed. The optical gene biosensor includes a substrate; a molecular beacon anchored to the substrate, wherein the molecular beacon includes an oligonucleotide specifically binding to a target nucleic acid molecule and a first compound bound to a first terminal of the oligonucleotide; an optical marker specifically binding to the first compound, wherein the optical marker is configured to retro-reflect irradiated light; a light source for irradiating the optical marker with light; and a light-receiver for receiving light retro-reflected from the optical marker. The optical gene biosensor may perform accurate quantitative analysis of a target nucleic acid molecule using both non-spectral and spectral light sources.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: February 27, 2024
    Inventors: Hyun-Chul Yoon, Jae-Ho Kim, Yong-Duk Han, Hyeong-Jin Chun
  • Patent number: 11896974
    Abstract: A microfluidic device system includes a channel having an entrance and an exit, a height at the entrance being greater than a height at the exit. The height of the channel may decrease continuously from the height at the entrance to the height at the exit. Cells or particles or beads traveling through the channel become trapped based on their size and/or deformability. A visual sensor captures images of the trapped cells or particles or beads, and image software analyzes the captured images to provide size and/or deformability and/or fluorescence information. A method of fabricating such a microfluidic device includes introducing a glass wafer to an etching solution at a specific rate such that a first end of the glass wafer is etched longer than other portions of the glass wafer.
    Type: Grant
    Filed: July 7, 2022
    Date of Patent: February 13, 2024
    Inventors: Mark A. Burns, Alyse D. Krausz, Sarah Elizabeth Mena, Martin Patrick De Beer, Kevin R. Ward, Frederick Korley
  • Patent number: 11896971
    Abstract: A fluid ejection head and a method of detecting the presence of fluid in an ejection chamber. The ejection head includes a semiconductor substrate having an elongate fluid supply via etched therethrough. An array of fluid ejectors is disposed adjacent to the fluid supply via, wherein the elongate fluid supply via provides fluid to the array of fluid ejectors for ejection of fluid from the ejection head. Fluid sense cells for the array of fluid ejectors are disposed at each end of the fluid supply via, wherein each of the fluid sense cells has a fluid ejector, an electrode disposed in a fluid chamber for the fluid ejector, and an electrode disposed in a fluid channel associated with a fluid chamber. A fluid detection circuit is provided in electrical communication with each of the fluid sense cells for detecting the presence or absence of fluid in the fluid chamber.
    Type: Grant
    Filed: March 18, 2021
    Date of Patent: February 13, 2024
    Inventors: Steven W. Bergstedt, Patricia A. Clore
  • Patent number: 11892460
    Abstract: A method for determining fatty acid level in case of acute or chronic medical conditions, and diagnosing medical conditions associated with increased fatty acid level in a biological sample containing albumin is provided. The method includes incubation of patient's sample and high surface area carbon-based electrode together in a holder. Due to attractive hydrophobic interaction between the albumin's surface fatty acids and the carbon-based material, the electrode self-extracts fatty acids from the albumin. The method eventually includes adsorption/accumulation with subsequent monolayer formation of extracted fatty acids over the carbon-based electrode. Accumulation of the fatty acid monolayer changes already existing electrode-electrolyte (sample) interfacial construct, which in turn changes also the interfacial states, such as electrical double layer capacitance.
    Type: Grant
    Filed: May 7, 2019
    Date of Patent: February 6, 2024
    Inventor: Ismail Oran
  • Patent number: 11879119
    Abstract: Disclosed herein is a bioreactor system that allows perfusive flow through a porous support medium enabling 3D growth of biological samples. In some embodiments, the system comprises a sample well filled with a three-dimensional (3D) cell growth medium. The system can further comprises a liquid medium reservoir fluidly connected to the sample well by a first filter material. The system can further comprises a medium collection chamber fluidly connected to the sample well by a second filter material. The system can further comprise an absorbant material that creates an osmotic pressure gradient to produce perfusive flow. In some embodiments, osmotic pressure draws fluid from the liquid medium reservoir, through the first filter material, into the sample well where it permeates the three-dimensional cell growth medium, through the second filter material, and finally into the medium collection chamber.
    Type: Grant
    Filed: August 1, 2019
    Date of Patent: January 23, 2024
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Thomas Ettor Angelini, Tapomoy Bhattacharjee, Wallace Gregory Sawyer, Cameron Morley
  • Patent number: 11867633
    Abstract: Nano-structured anodic aluminum oxide ceramic films and membranes doped with chelated metals for fluorescence enhancement. Controlled doping during production steps results in the inclusion of traces of ions in the finished materials while maintaining high control over the film structure. This approach yields products suitable for optical applications, including fluorescence enhancement.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: January 9, 2024
    Assignee: Nanopec, Inc.
    Inventor: Mario Blanco
  • Patent number: 11865543
    Abstract: An apparatus for forming a plurality of microdroplets from a droplet includes a substrate, a dielectric layer on the substrate and having a plurality of hydrophilic surface regions spaced apart from each other by a hydrophobic surface, and a plurality of electrodes covered by the dielectric layer. The electrodes are configured to form an electric field across the droplet in response to voltages provided by a control circuit to move the droplet across the dielectric layer in a lateral direction while leaving portions of the droplet on the hydrophilic surface regions to form the plurality of microdroplets on the hydrophilic surface regions.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: January 9, 2024
    Assignee: MGI Tech Co., Ltd.
    Inventors: Jian Gong, Liang Wang, Yan-You Lin, Cheng Frank Zhong
  • Patent number: 11865538
    Abstract: A biological detection chip, a biological detection device, and a detection method thereof are disclosed. The biological detection chip includes a first base substrate and a plurality of detection units arranged in an array along a row direction and a column direction on the first base substrate. Each of the plurality of detection units includes a thin film transistor and an electrode, the thin film transistor is on the first base substrate and includes a gate electrode, a source electrode, and a drain electrode, and the electrode is on a side of the thin film transistor away from the first base substrate and is connected to the drain electrode, and the electrode is configured to carry a biological material to be detected.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: January 9, 2024
    Inventors: Wenliang Yao, Nan Zhao, Peizhi Cai, Fengchun Pang, Yue Geng, Le Gu, Yuelei Xiao, Hui Liao, Yingying Zhao, Bolin Fan
  • Patent number: 11860094
    Abstract: An analysis system includes an analyzer configured to separate a sample including a plurality of components labeled with any of M kinds of fluorescent substances by chromatography and acquire first time-series data of fluorescence signals detected in N kinds (M>N) of wavelength bands in a state in which at least a part of the plurality of components is not completely separated; and a computer configured to compare the first time-series data with the second time-series data, and determine which kind of fluorescent substance of M kinds of fluorescent substances individually labels each of the plurality of components.
    Type: Grant
    Filed: February 20, 2017
    Date of Patent: January 2, 2024
    Inventor: Takashi Anazawa
  • Patent number: 11852640
    Abstract: Instances of the present technology may include a method for operating a hematology analyzer. The method may include passing a control material through a hematology analyzer. The control material may include a first cell population and a second cell population. The method may also include determining a first cell population volume measurement and a second cell population volume measurement. A first value of a first cell population distribution width and a second value of a second cell population distribution width may be calculated. The method may include comparing the first value to a first reference range. The method may also include comparing the second value to a second reference range. Furthermore, the method may include classifying an operational status of the hematology analyzer based on the comparison of the first value to the first reference range and based on the comparison of the second value to the second reference range.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: December 26, 2023
    Assignee: Beckman Coulter, Inc.
    Inventors: Carlos Ramirez, Nery Ortiz, Milton Swaby
  • Patent number: 11850592
    Abstract: A cell sorting device is disclosed, wherein the device includes a sorting magnet and at least one particle manipulation device, wherein the particle manipulation device is formed on a surface of a fabrication substrate. The device may include at least one fluid channel, wherein the sorting magnet and the particle manipulation device are in fluid communication with one another through at least one fluid channel. A method of sorting cells from a first cell suspension is also disclosed, The method may include a) magnetic labeling of first target cells and removal of the non-target cells by applying magnetic fields to obtain a second cell suspension; b) fluorescence-activated labeling of second target cells present in the second cell suspension and separating the fluorescence-activated second target cells from the not labeled cells to obtain a third cell suspension.
    Type: Grant
    Filed: February 11, 2020
    Date of Patent: December 26, 2023
    Assignee: Owl biomedical, Inc.
    Inventors: John S. Foster, Kevin Shields, Mehran Hoonejani
  • Patent number: 11821837
    Abstract: A system for real-time detection of airborne pathogens is disclosed. The system includes: an air intake unit defining an inlet and an air inflow channel; a fan configured to cause air in a sampling environment to flow into the air inflow channel via the inlet; a cooling unit for cooling air in the air inflow channel; a collection chamber for collecting liquid water condensed from air in the air inflow channel, the collection chamber including: an active target substrate having a surface that is coated with bioreceptors; and a reference target substrate that is not coated with bioreceptors, and an optical detection unit that is configured to independently illuminate the active target substrate and the reference target substrate with light for detecting presence of an airborne pathogen.
    Type: Grant
    Filed: November 27, 2020
    Date of Patent: November 21, 2023
    Assignee: Kontrol Energy Corp.
    Inventors: Gary Saunders, Paul Ghezzi
  • Patent number: 11815510
    Abstract: The invention relates to a method for detecting a dengue infection in a patient blood sample, comprising the steps: a) Performing an analysis of prespecified parameters of blood platelets and prespecified types of blood cells in the sample and determining parameter values for the prespecified parameters of the platelets and the prespecified types of cells; b) Obtaining sample parameters from the values determined in step a); and c) Evaluating the sample parameters in relation to a prespecified criterion, wherein, if the criterion is fulfilled, a dengue infection is present.
    Type: Grant
    Filed: December 19, 2022
    Date of Patent: November 14, 2023
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Kieran O'Donoghue, Rory Sobolewski