Abstract: A sample staining device, comprising a staining platform provided with a staining solution and cleaning solution supply part; glass slide support structures located on either side of the staining platform and forming a certain clearance between a glass slide and the staining platform; and a glass slide driving mechanism that enables the glass slide to move while maintaining a certain clearance from the staining platform. When said device works, a staining solution is supplied to the staining platform, and a convex liquid surface is formed due to surface tension; when the glass slide moves to the convex liquid surface of the staining solution, the staining solution infiltrates and diffuses in the clearance formed between the staining platform and the glass slide to cover the glass slide so as to stain a sample; and after the glass slide is stained, a cleaning solution is supplied to clean the residual staining solution.
Abstract: A sensor device is provided to sample data from a fluid in a sealed environment. The sensor comprises a housing and a diamond within the housing. The housing is formed such that the device is reversibly insertable into the sealed environment so that the diamond directly interfaces with the sealed environment.
Type:
Grant
Filed:
March 3, 2017
Date of Patent:
November 22, 2022
Assignee:
UCL Business LTD
Inventors:
Richard B. Jackman, Ralph Jennings-Moors, Alexander C. Pakpour-Tabrizi, William Parfitt, Joseph O. Welch
Abstract: [Task] To provide an automatic analysis apparatus including a photomultiplier tube which controls a sensitivity of the photomultiplier tube without adjusting a high voltage value. [Solution] An automatic analysis apparatus according to the present invention includes a photomultiplier tube which detects light from a reaction vessel; a determination unit which determines an output signal of the photomultiplier tube in a case where the photomultiplier tube is irradiated with first light; and a control unit which irradiates the photomultiplier tube with second light to lower a sensitivity of the photomultiplier tube in accordance with a determination result by the determination unit.
Abstract: An analyzing system is provided. The analyzing system includes a fluid container defining a sample chamber where a sample is contained in the sample chamber, and a sensor including a transparent body with a reverse face and an obverse face where the obverse face having a nanostructured surface. The nanostructured surface includes a plurality of elongate nanostructures having a respective longitudinal axis that is disposed substantially perpendicularly to the obverse face. The analyzing system includes an excitation and detection apparatus that includes an excitation source for generating a beam of polarized radiation and a corresponding radiation detector where the sensor is coupled to the fluid container such that the nanostructured surface is exposed to the sample chamber, to the sample located therein.
Type:
Grant
Filed:
February 8, 2019
Date of Patent:
November 15, 2022
Assignee:
Causeway Sensors Limited
Inventors:
Robert Pollard, Antony Murphy, Breandan Hill, Danny O'Connor
Abstract: A hydrogen gas sensor with a substrate and a zinc oxide nanostructured thin film deposited on the substrate, wherein the zinc oxide nanostructured thin film has a lattice structure with a weight ratio of low binding energy O2? ions to medium binding energy oxygen vacancies in a range of 0.1 to 1.0, and a method of fabricating a gas sensor by thermally oxidizing a metal thin film under low oxygen partial pressure. Various combinations of embodiments of the hydrogen gas sensor and the method of fabricating the gas sensor are provided.
Type:
Grant
Filed:
October 29, 2019
Date of Patent:
November 8, 2022
Assignee:
KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS
Inventors:
Qasem Ahmed Drmosh, Zain Hassan Yamani, Mohammad Kamal Hossain
Abstract: A microfluidic group includes a female connector and a male needle connector. The female connector has a connector chamber in a containment body; a duct extending in the containment body to a duct opening on a first face of the connector chamber; a needle entry hole extending from a lateral face of the containment body to a second face, not facing the first face of the connector chamber; and a gasket arranged in the connector chamber. The gasket has a side wall internally delimiting a cavity and extending in part adjacent to the second face of the connector chamber. The cavity of the gasket faces the first face of the connector chamber.
Abstract: A device for storing, incubating or manipulating biological samples, in particular incubating device or shaking device, comprising a sample chamber, an irradiation chamber, and a holder with a UV light source, wherein a sidewall of the irradiation chamber comprises a first mounting member and wherein the holder comprises a second mounting member configured to interact with the first mounting member for pre-mounting the holder to the sidewall.
Abstract: Disclosed is a microorganism inoculation device, which comprises a workbench, wherein support columns are provided on the upper surface of the workbench, a limiting plate is provided in the middle part of the supporting column, an injection head is provided in the middle part of the limiting plate, an air cylinder is provided in the middle part of the lower surface of the workbench, a piston rod of the air cylinder is fixedly connected with the middle part of the upper surface of a lifting plate, guide rods are provided on the upper surface of the lifting plate, the upper end of the guide rod is fixedly connected with a tray, the left and right sides of the upper surface of the tray are fixedly connected with the lower part of a fixed bracket, the middle part of the injection head is slidably connected with the limiting plate.
Abstract: A specimen measurement device which detects a measurement object material according to the present embodiment, includes: a magnetic field applicator configured to apply a magnetic field to a measurement cartridge including a substrate, a first substance fixed on the substrate and specifically reacting with the measurement object material, a magnetic particle, and a substance fixed on the magnetic particle and specifically acting with the measurement object material; a detector configured to detect light passing through the substrate; and a controller configured to control the magnetic field applicator to perform a first operation to apply a first magnetic field in a direction to move the magnetic particle away from the substrate when a specimen solution containing the measurement object material is introduced into the measurement cartridge, and then perform a second operation to apply a second magnetic field in a direction to move the magnetic particle toward the substrate.
Abstract: An instrument for detecting signal from a biological sample includes a pipettor module configured to hold a plurality of pipettes in respective pipette positions, to hold liquid in one or more pipette tips, and to pipette liquid in and out of the one or more pipette tips. Each of the one or more pipette tips has a pipette tip point. The instrument further includes one or more magnets positioned such that each of the one or more pipette tips is adjacent one of the one or more magnets.
Abstract: A sample assembly includes a vial, a vial insert, and a sealing arrangement. The vial insert could be any combination of a sample chamber, a matrix, or a swab breaker configured to be positioned within the vial. The sealing arrangement includes a coupling portion and a cap assembly. The coupling portion defines a mounting channel sized to receive a portion of the vial. The coupling portion is configured to slidably couple to the vial. The cap assembly includes a desiccant cap. The desiccant cap is configured to couple to the vial to selectively form a sterile barrier between the sealing arrangement and the vial.
Abstract: Embodiments of the present disclosure provide for methods of detecting, sensors (e.g., chromogenic sensor), kits, compositions, and the like that related to or use tunable macroporous polymer. In an aspect, tunable macroporous materials as described herein can be used to determine the presence of a certain type(s) and quantity of liquid in a liquid mixture.
Type:
Grant
Filed:
May 17, 2018
Date of Patent:
October 11, 2022
Assignee:
University of Florida Research Foundation, Inc.
Abstract: Provided is a porous pellet for inclusion into an operating fluid of a fluid system for detecting sites of fluid leakage. The porous pellet comprises a solid matrix formed by at least one fluorescent dye which is solid at room temperature. The matrix has a porosity of from about 10% to about 90%. Methods of installing the porous pellets into fluid system for detection of leaks is also provided.
Type:
Grant
Filed:
June 15, 2017
Date of Patent:
October 11, 2022
Assignee:
Spectronics Corporation
Inventors:
Jonathan Daniel Cooper, Limin Chen, John Thomas Duerr, Jennifer Marie Hunt
Abstract: Automated cell staining systems and methods are disclosed herein. In particular, the staining systems disclosed herein provide low-volume, automated bench top staining systems for staining biological samples contained on a cytological slide.
Type:
Grant
Filed:
June 16, 2017
Date of Patent:
October 4, 2022
Assignees:
NanoCytomics, LLC, Northwestern University
Inventors:
Sergey Rozhok, Justin R. Derbas, Jarema Czarnecki, Hariharan Subramanian
Abstract: A method for detecting glutaraldehyde in a water sample in which Au-BSA nanoclusters have been introduced is provided. In the method, the water sample is mixed with the Au-BSA nanoclusters to form a mixture. The mixture is incubated for 2 to 10 minutes, and the glutaraldehyde present in the mixture reacts with the Au-BSA nanoclusters and causes fluorescence quenching of the Au-BSA nanoclusters. Then a fluorescence intensity of the quenched Au-BSA nanoclusters in the mixture is measured at an emission wavelength of 675 nm. A presence and concentration of glutaraldehyde in the water sample is then determined by comparing the measured fluorescence intensity of the quenched Au-BSA nanoclusters at the emission wavelength of 675 nm with fluorescence intensity values of calibration samples comprising Au-BSA nanoclusters and known glutaraldehyde concentrations.
Type:
Grant
Filed:
October 26, 2020
Date of Patent:
October 4, 2022
Assignee:
Saudi Arabian Oli Company
Inventors:
Xiangyang Zhu, Mohammed A. Al-Moniee, Mazen A. Al-Saleh
Abstract: A liquid handling device having an axis of rotation about which the device can be rotated to drive liquid flow. The device includes a vented upstream chamber having an outlet port and an unvented chamber including an inlet port to receive liquid from the outlet port of the upstream chamber and an outlet port radially outward the inlet port. The device further includes a vented downstream chamber having an inlet port to receive liquid from the outlet port of the unvented chamber. A downstream conduit connects the outlet port of the unvented chamber to the inlet port of the downstream chamber and includes a bend radially inward of the outlet port of the unvented chamber. An upstream conduit connects the outlet port of the upstream chamber to the inlet port of the unvented chamber.
Type:
Grant
Filed:
December 10, 2019
Date of Patent:
October 4, 2022
Assignee:
Biosurfit, SA
Inventors:
Nuno Alexandre Esteves Reis, Tania Moura Pires De Andrade Tenreiro, Miguel Joao Marques Barreiros
Abstract: Control of humidity in chemical reactors, and associated systems and methods, are generally described. In certain embodiments, the humidity within gas transport conduits and chambers can be controlled to inhibit unwanted condensation within gas transport pathways. By inhibiting condensation within gas transport pathways, clogging of such pathways can be limited (or eliminated) such that transport of gas can be more easily and controllably achieved. In addition, strategies for purging condensed liquid from chemical reactor systems are also described.
Type:
Grant
Filed:
October 16, 2019
Date of Patent:
October 4, 2022
Assignees:
Sanofi, Massachusetts Institute of Technology
Abstract: A flow cell and a method for connecting components of a microfluidic flow cell, in particular for integrating component parts into a carrier structure of the flow cell, in which a gap is formed between the components to be connected. The gap is filled with a solvent. The material of at least one component bordering the gap dissolves in the solvent and the material completely fills the width of the gap and partially fills the height thereof after evaporation of the solvent.
Abstract: The molecule detecting apparatus of an embodiment includes a light source 31, a fluorescent layer 42 emitting different fluorescence depending on the kind of a target molecule 60 captured when being irradiated with light from the light source 31, a photodetector 32 configured to detect fluorescence, and the photodetector 32 is an array of avalanche photodiodes operating in Geiger mode.
Abstract: In one embodiment, a sample probe has a cap and a base, wherein the cap includes a grip portion and a projection portion. The projection portion fits within a hollow portion of a filter such that the filter is disposed on the outside of the projection portion and the filter and the cap form a cap assemblage. The base comprises a base recess that receives a portion of the cap assemblage including the filter. The cap and base include corresponding media transfer regions adjacent and connected to the filter that reduces flow resistance and chances of blockage and/or contamination during dissolution-testing sampling using the sample probe.
Type:
Grant
Filed:
February 28, 2017
Date of Patent:
September 27, 2022
Assignee:
Distek, Inc.
Inventors:
Jeffrey Brinker, Shawn Craig, Peter K. Schultz, Timothy John Nadolski