Patents Examined by Samuel Wei Liu
  • Paramagnetic and active analogue (EMP-2) of melanocyte stimulating hormone containing amino acid-type stable free radical
    Patent number: 6582968
    Abstract: The present invention relates to an &agr;-melanocyte stimulating hormone (&agr;-MSH) analogue, labeled with an amino acid-type paramagnetic spin probe, for example, Toac, or 2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid, and methods for the synthesis thereof. The preferred analogue of the invention, acetyl-Toac0-&agr;-MSH (abbreviated as EPM-2) is the first such analogue that maintains entirely the natural &agr;-MSH activity.
    Type: Grant
    Filed: August 24, 2001
    Date of Patent: June 24, 2003
    Assignee: Conselho Nacional de Desenvolvimento Cientifico e Technologico PROJUR/CNPq/AC
    Inventors: Clóvis Ryuichi Nakaie, Eduardo Maffud Cilli, Maria Tereza Lamy-Freund, Simone dos Reis Barbosa
  • Short gastrointestinal peptides
    Patent number: 6420521
    Abstract: The present invention is directed to polynucleotides, polypeptides, peptides, variants and uses thereof for novel peptide fragments which have homology to motilin. Tissue distribution of the mRNA for the novel polypeptide fragment is specific to the stomach, small intestine and pancreas. Binding of the peptide fragment has been shown in kidney and small intestine. The present invention further includes agonists, antagonists, variants, antibodies and host cells expressing the cDNA encoding the novel Short Gastrointestinal Peptides (SGIP) peptide.
    Type: Grant
    Filed: June 30, 2000
    Date of Patent: July 16, 2002
    Assignee: Zymogenetics, Inc.
    Inventors: Paul O. Sheppard, Stephen R. Jaspers, Theresa A. Deisher, Paul D. Bishop