Patents Examined by Sandra Saucier
  • Method of elevating yield of oligosaccharides containing ?-galactosyl and anti-candida compositions
    Patent number: 7491518
    Abstract: A novel method of very efficiently elevating the yield of oligosacchrides containing ?-galactosyl, compared with the conventional methods, which comprises treating galactose or a galactose-containing material with a specific ?-galactosidase and thus performing a dehydrocondensation reaction at a high substrate concentration. Anti-candida compositions originating in foods, having a high safety and excellent anti-candida effect and not being restricted in the supply, which contain as the active ingredient oligosacchrides obtained by treating galactose or a galactose-containing material with an ?-galactosidase and thus performing a dehydrocondensation.
    Type: Grant
    Filed: August 8, 2001
    Date of Patent: February 17, 2009
    Assignees: Amano Enzyme Inc., Bio Research Corporation of Yokohama, Ensuiko Sugar Refining Co., Ltd.
    Inventors: Masamichi Okada, Shigeharu Mori, Hiroyuki Hashimoto, Koki Fujita, Kozo Hara
  • Galenic pectinate formulation for colon-targeted delivery of antibiotic-inactivating enzymes and method of use thereof
    Patent number: 7485294
    Abstract: Forms of colonic delivery suited to be used orally and designed for colonic delivery of active ingredients selected from the group comprising enzymes capable of inactivating macrolide antibiotics and related compounds, enzymes capable of inactivating quinolones, and ?-lactamases.
    Type: Grant
    Filed: August 6, 2003
    Date of Patent: February 3, 2009
    Assignee: Da Volterra
    Inventors: Sandrine Bourgeois, Elias Fattal, Antoine Andremont, Patrick Couvreur
  • Particle/cell separation device and compositions
    Patent number: 7462268
    Abstract: A particle/cell separation device is described which is particularly adapted for neutrophil depletion from a preparation of whole blood or platelet-rich plasma. Also described are blood and platelet rich plasma compositions produced using the device which are neutrophil-depleted.
    Type: Grant
    Filed: August 16, 2005
    Date of Patent: December 9, 2008
    Inventor: Allan Mishra
  • Ambient stored blood plasma expanders containing keratose
    Patent number: 7439012
    Abstract: A liquid plasma expander or resuscitation fluid composition for use in a subject in need thereof, comprising, consisting of, or consisting essentially of: (a) a keratin derivative (preferably alpha keratose, gamma keratose, or combinations thereof, and with basic alpha keratose preferred over acidic alpha keratose); and (b) an electrolyte solution, with the keratin derivative solubilized in the electrolyte solution to form a homogeneous liquid composition. Blood substitutes formed therefrom and methods of making and using the same are also described.
    Type: Grant
    Filed: August 17, 2005
    Date of Patent: October 21, 2008
    Assignee: Wake Forest University Health Sciences
    Inventor: Mark E. Van Dyke
  • Methods of screening for inhibitors of phospholipid synthesis related to glycolipid-storage diseases
    Patent number: 7429460
    Abstract: The present invention discloses methods of screening for identification of compounds that inhibit novel targets in the enzymatic pathway of phospholipid synthesis that are related to glycolipid storage diseases, and use of the compounds for treating patients affected with glycolipid storage diseases, particularly Gaucher disease. Specifically, the compounds of the present invention are intended to inhibit the accumulation of phosphatidylcholine (PC), wherein PC accumulation is increased due to the activation of CTP:phosphocholine cytidylyltransferase (CCT) upon glucosylceramide (GlcCer) accumulation.
    Type: Grant
    Filed: January 15, 2003
    Date of Patent: September 30, 2008
    Assignee: Yeda Research and Development Co., Ltd.
    Inventors: Anthony H. Futerman, Jacques Bodennec, Dori Pelled
  • Method for glucose production with a modified cellulase mixture
    Patent number: 7419809
    Abstract: The present invention pertains to a method of converting cellulose to glucose by treating a pretreated lignocellulosic substrate with an enzyme mixture comprising cellulase enzyme and a modified CBHO, wherein the modified CBHI is present in the enzyme mixture at an amount relative to all CBHI-type enzymes from about 15% to about 100% (w/w),depending upon the modified CBHI used. The pretreated lignocellulosic substrate is selected from the group consisting of agricultural residues, residues after starch or sugar removal dedicated ethanol crops forestry products, and pulp and paper products, or combinations thereof.
    Type: Grant
    Filed: September 25, 2001
    Date of Patent: September 2, 2008
    Assignee: Iogen Energy Corporation
    Inventors: Brian Foody, Theresa C. White, Jeffrey S. Tolan, Jennifer Donaldson
  • Methods and compositions for repairing cartilage
    Patent number: 7416889
    Abstract: Disclosed is a method for inducing repair of a joint tissue in a mammal includes the steps of removing a sample of synovial membrane from a joint of the mammal, isolating type B synoviocytes from the membrane to yield a suspension of enriched type B synoviocytes, and introducing the suspension into an injured joint of the mammal as well as medical devices containing enriched synoviocytes and kits for producing such enriched cell populations.
    Type: Grant
    Filed: April 27, 2006
    Date of Patent: August 26, 2008
    Assignee: Rhode Island Hospital
    Inventors: Deborah McK. Ciombor, Roy K. Aaron
  • Releasable polymeric conjugates based on biodegradable linkers
    Patent number: 7413738
    Abstract: Activated polymeric bicine derivatives such as, as well as conjugates made therewith are disclosed. Methods of making and using the bicine derivatives are also disclosed.
    Type: Grant
    Filed: December 14, 2004
    Date of Patent: August 19, 2008
    Assignee: Enzon Pharmaceuticals, Inc.
    Inventors: Hong Zhao, Susan Adler, legal representative, Richard B. Greenwald
  • Device containing cytophilic islands that adhere cells separated by cytophobic regions
    Patent number: 7410791
    Abstract: The invention provides a device for adhering cells in a specific and predetermined position, and associated methods. The device includes a plate defining a surface and a plurality of cytophilic islands that adhere cells, isolated by cytophobic regions to which cells do not adhere, contiguous with the cytophilic islands. The islands or the regions or both may be formed of a self-assembled monolayer (SAM).
    Type: Grant
    Filed: January 13, 2006
    Date of Patent: August 12, 2008
    Assignees: President and Fellows of Harvard College, Children's Medical Center Corporation, Massachusetts Institute of Technology
    Inventors: Rahul Singhvi, Amit Kumar, George M. Whitesides, Donald E. Ingber, Gabriel P. Lopez, Daniel I. C. Wang, Gregory Stephanopoulos
  • Process of inhibiting cell death in injured cartilage
    Patent number: 7411000
    Abstract: Processes for inhibiting apoptotic cell death and glycosaminoglycan release from injured cartilage is provided. Inhibition is accomplished using caspase inhibitors.
    Type: Grant
    Filed: March 15, 2002
    Date of Patent: August 12, 2008
    Assignee: The Scripps Research Institute
    Inventors: Darryl D'Lima, Martin Lotz, Clifford Colwell
  • Solid dispersions comprising two different polymer matrixes
    Patent number: 7407670
    Abstract: Present invention provides solid dispersions comprising a poorly soluble bioactive compound dispersed in a polymer matrix characterized in that the polymer matrix comprises more than one polymer. Said solid dispersions effectively stabilize the dispersed compound while stimulating the solubilisation of the compound in an aquaeous environment.
    Type: Grant
    Filed: July 1, 2003
    Date of Patent: August 5, 2008
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Karel Six, Geert Verreck, Jozef Peeters, Marcus Eli Brewster, Guy Van Den Mooter
  • Skin substitutes with improved barrier function
    Patent number: 7407805
    Abstract: The present invention relates to in vitro cultured skin substitutes, and in particular to in vitro cultured skin substitutes that have improved barrier function. In some embodiments, improved barrier function is a result of improved culture conditions, while in other embodiments, improved barrier function results from genetic modification of keratinocytes. Improved culture conditions to improve barrier function include organotypic culture in the presence of linoleic acid and/or linoleic acid at about 75% humidity. Suitable genetic modifications for improving barrier function includes transfection with a DNA construct capable of expressing GKLF.
    Type: Grant
    Filed: September 27, 2005
    Date of Patent: August 5, 2008
    Inventors: Allen Comer, Lynn Allen-Hoffmann, Michael Hoffmann
  • Method for the isolation of intact mitochondria from cells
    Patent number: 7407800
    Abstract: Intact mitochondria is isolated from cells by swelling the cells, lysing the swollen cells using a mild detergent such as CHAPS to release the mitochondria, and then recovering the mitochondria.
    Type: Grant
    Filed: April 5, 2005
    Date of Patent: August 5, 2008
    Assignee: Pierce Biotechnology, Inc.
    Inventors: Margaret Benton, Reinere Ignacio
  • Enzyme for the preparation of 1-amino-4-(hydroxymethyl)-2-cyclopentene derivatives
    Patent number: 7405065
    Abstract: The invention relates to a novel process for the preparation of (1R,4S)- or (1S,4R)-1-amino-4-(hydroxy-methyl)-2-cyclopentene of the formulae and/or of (1S,4R)- or (1R,4S)-amino alcohol derivatives of the general formulae and to novel microorganisms which are able to utilize a cyclopentene derivative of the general formula as sole nitrogen source, as sole carbon source or as sole carbon and nitrogen source.
    Type: Grant
    Filed: July 21, 2004
    Date of Patent: July 29, 2008
    Assignee: Lonza AG
    Inventors: Christine Bernegger-Egli, Olwen M. Birch, Pierre Bossard, Walter Brieden, Frank Brux, Knut Burgdorf, Laurent Duc, Kay-Sarah Etter, Yves Guggisberg, Martin Sauter, Eva Maria Urban
  • Enzymatic process for deacetylation of a phenoxy-alkynyl acetate to the corresponding alcohol
    Patent number: 7402414
    Abstract: A process for preparing the compound of formula II by reacting the compound of formula I with an enzyme that can hydrolyze the ester bond: where * indicates a chiral center, R1 and R2 each independently represent H, C1-C6alkyl, —CN or —CCH, and R3 and R4 each independently represent H or C1-C6alkyl.
    Type: Grant
    Filed: June 7, 2005
    Date of Patent: July 22, 2008
    Assignee: Wyeth
    Inventors: Ramesh V. Matur, Mark E. Ruppen
  • Assay method for measurement of net cholesterol flux
    Patent number: 7402404
    Abstract: The present invention relates to an assay for determining net cholesterol flux from lipid loaded cells in the presence of an acceptor (e.g., serum). The present invention also relates to a method for evaluating efficacy of a therapeutic agent for stimulating or inhibiting net cholesterol flux. Also provided by the present invention are kits that are used to carry out the aforementioned assays and methods.
    Type: Grant
    Filed: April 28, 2005
    Date of Patent: July 22, 2008
    Assignee: The Children's Hospital of Philadelphia
    Inventors: George H. Rothblat, Ginny Kellner-Weibel
  • Process for the extraction of ?-amylase
    Patent number: 7399622
    Abstract: The invention relates to a process for extracting beta-amylase from cereal by means of cellulase. The invention further relates to the use of cellulase in the extraction of ?-amylase.
    Type: Grant
    Filed: August 6, 2003
    Date of Patent: July 15, 2008
    Assignee: Danisco Sugar Oy
    Inventor: Pekka Kekki
  • Method for enriching adherent monocyte populations
    Patent number: 7393628
    Abstract: The present invention provides methods and apparatus for the rapid and efficient collection and purification of activated monocytes. The methods and apparatus of the present invention provide means for effecting the collection and purification in an aseptic environment. The method involves filtering a blood component mixture through a monocyte-adhering filter; washing the blood component mixture; backflushing the filter with a physiological solution; and backflushing the filter with Dextran-40/serum albumin.
    Type: Grant
    Filed: October 7, 2003
    Date of Patent: July 1, 2008
    Assignee: American National Red Cross
    Inventors: Stephen J. Wagner, Andrew Myrup, Christina Celluzzi
  • Monochromatic fluid treatment systems
    Patent number: 7381976
    Abstract: Methods, systems and apparatus for photo-processing of fluids, particularly complex fluids, such as blood products, pharmaceuticals, injectables and vaccines, are provided. The disclosed methods and systems employ non-laser light source(s) to generate monochromatic light energy, preferably in the range of 260 nm to 310 nm, for fluid treatment. Advantageous processing regimens and/or adjunct additives and/or agents may also be used to achieve desired and/or enhanced results, e.g., inactivation of pathogens, bacteria and/or viruses, modulation of immune response, and/or leukoreduction. Particularly preferred embodiments include novel temperature control systems and geometric/structural arrangements that provide enhanced processing results and/or efficiencies.
    Type: Grant
    Filed: March 13, 2001
    Date of Patent: June 3, 2008
    Assignee: Triton Thalassic Technologies, Inc.
    Inventors: John J. Coogan, Jr., Barry Ressler
  • Probiotic containing anhydrous hair care composition
    Patent number: 7374750
    Abstract: This invention concerns nutritive and restorative hair care compositions which are distinctive in that they contain probiotic bacteria and other ingredients found in yogurt. Both water-based and anhydrous embodiments are described. The compositions are designed to moisturize, soften, condition, straighten, strengthen and repair hair in addition to promoting a healthy scalp.
    Type: Grant
    Filed: May 14, 2004
    Date of Patent: May 20, 2008
    Inventor: Jennifer Albano