Abstract: Systems and methods are provided for continuously monitoring a user to determine when cardiovascular events are likely occurring and to responsively provide a prompt to a user to engage in additional physiological assessment of the putative cardiovascular event. Additional assessment can include the user engaging an additional sensor to provide signals that are more accurate, lower noise, or otherwise improved relative to a continuously-monitoring sensor used to initially detect the cardiovascular event. Detection of cardiovascular events includes using a cardiovascular classifier to determine, based on the output of such a continuously-monitoring sensor, whether the event is likely occurring. Such a classifier can be received from a cloud computing service or other remote system based on sensor outputs sent to such a system.

Abstract: There is disclosed a hearing prosthesis comprising a first housing containing a primary signal processor that receives signals output by a microphone; and a second housing removably connectable to the first housing; wherein a user interface is provided on the second housing that provides control of one or more features of the operation of the primary signal processor.

Abstract: A method is provided that includes implanting (a) a parenchymal electrode in or in contact with an outer surface of brain parenchyma of a subject identified as at risk of or suffering from a disease, and (b) a cerebrospinal fluid (CSF) electrode in a CSF-filled space of a brain of the subject, the CSF-filled space selected from the group consisting of: a ventricular system and a subarachnoid space. A midplane treatment electrode is disposed in or over a superior sagittal sinus. Control circuitry is activated to drive the parenchymal electrode and the CSF electrode to drive a substance from the brain parenchyma into the CSF-filled space of the brain, and apply a treatment current between the CSF electrode and the midplane treatment electrode to drive the substance from the CSF-filled space of the brain to the superior sagittal sinus. Other embodiments are also described.

Abstract: A variety of charging circuits and current control techniques are described that are well suited for use in portable medical devices to enable such devices to be powered by a mobile communication device such as a smart phone, tablet computer, etc. The described current regulating and charging circuitry and techniques are well suited for use in portable medical devices such as defibrillators, X-ray machines and other imaging machines, as well as a variety of other devices (both medical and non-medical).

Abstract: A multi-lead stimulation lead connector for facilitating electrical and mechanical connectivity between one or more stimulation leads and a pulse generator, e.g., an EPG used in a test stimulation system. One or more cam lock assemblies are disposed in a housing, each cam lock assembly comprising a cam knob and a cam shaft and having a longitudinal channel defined therein for accepting a proximal end of a respective stimulation lead, the proximal end having a plurality of terminal contact electrodes. By actuating a rotational movement of the cam knob, the cam lock assembly is unlocked in a first direction for guiding the proximal end and locked in a second direction for securely holding the proximal end and effectuating electrical connectivity with a plurality of conductors encapsulated in a cable for interfacing with the EPG.

Abstract: Embodiments of the present disclosure provide for catheters for use in electrical neuromodulation. The catheter of the present disclosure includes an elongate body having a first end and a second end. The elongate body includes a longitudinal center axis that extends between the first end and the second end. The elongate body further includes three or more surfaces that define a convex polygonal cross-sectional shape taken perpendicularly to the longitudinal center axis. The catheter further includes one or more electrodes on one surface of the three or more surfaces of the elongate body, where conductive elements extend through the elongate body. The conductive elements can conduct electrical current to combinations of the one or more electrodes.

Abstract: A vital signs sensor includes an identifier storage device that stores an identifier of a subject, and a signal processing device that acquires a vital sign from the subject, and that wirelessly transmits the vital sign and the identifier that is stored in the identifier storage device, with correlating the vital sign with the identifier, wherein the identifier storage device has a structure where the identifier storage device is attachable to and detachable from the signal processing device.

Abstract: A laser therapy apparatus having a diode-based continuous emission laser source, a diode-based pulsed emission laser source, and a terminal handpiece. The laser therapy apparatus further includes a bundle of optic fibers for coupling between individual diodes of the diode-based pulsed emission laser source, which is interfaced with a single optic fiber which terminates in the handpiece.

Abstract: A wearable cardioverter defibrillator (WCD) system includes a support structure that the patient may wear, and one or more sensors that may acquire patient physiological signals, such as ECG and others. A processor of the WCD system may determine diagnostics from the patient physiological signals. These diagnostics include a six-second ECG portion, heart rates as histograms, heart rates against QRS width, heart rate trends, clinical event counters, diagnostics relating to heart rate variability and about the atrial arrhythmia burden of the patient. In some embodiments, the WCD system includes a user interface with a screen that displays these diagnostics. In some embodiments, the WCD system exports these diagnostics for viewing by a different screen. When viewed, these diagnostics permit more detailed analysis of the state of the patient.

Abstract: A method includes receiving an input mesh representation of a cardiac chamber, a set of measured locations on a wall tissue of the cardiac chamber, and a respective set of local activation times (LATs) measured at the locations. The input mesh is re-meshed into a regular mesh including regularized polygons. The set of measured locations and respective LATs is data fitted to the regularized polygons. Respective LAT values are iteratively calculated for the regularized polygons, so as to obtain a cyclic EP activation wave solution over the regular mesh that take account of reentry of an EP wave. An electroanatomical map including the cyclic EP activation wave overlaid on the regular mesh is presented.

Abstract: A method is provided that includes implanting (a) a parenchymal electrode in or in contact with an outer surface of brain parenchyma of a subject identified as at risk of or suffering from a disease, and (b) a cerebrospinal fluid (CSF) electrode in a CSF-filled space of a brain of the subject, the CSF-filled space selected from the group consisting of: a ventricular system and a subarachnoid space. A midplane treatment electrode is disposed in or over a superior sagittal sinus. Control circuitry is activated to drive the parenchymal electrode and the CSF electrode to drive a substance from the brain parenchyma into the CSF-filled space of the brain, and apply a treatment current between the CSF electrode and the midplane treatment electrode to drive the substance from the CSF-filled space of the brain to the superior sagittal sinus. Other embodiments are also described.

Abstract: Methods and apparatus for assessing the condition of and treating patients for heart failure by the delivery of continuous positive airway pressure are disclosed. Treatment of obstruction due to reflex vocal cord closure often experienced by heart failure patients is distinguished from treatment of upper airway obstruction typically associated with Obstructive Sleep Disorder. Treatment may also be implemented by delivering synchronized cardiac pressure oscillations superimposed on a respiratory pressure level to provide assistance for the heart. Heart treatment pressure dose indicator may be calculated for prescribing and monitoring the delivery of treatment. The apparatus may also generate data to track heart failure condition that may be indicative of the degree of severity of heart failure based upon breathing patterns to assist in the diagnosis and management of heart failure patients.

Abstract: A method includes receiving an input mesh representation of a cardiac chamber, a set of measured locations on a wall tissue of the cardiac chamber, and a respective set of local activation times (LATs) measured at the locations. The input mesh is re-meshed into a regular mesh including regularized polygons. The set of measured locations and respective LATs is data fitted to the regularized polygons. Respective LAT values, and respective probabilities that the wall tissue includes scar tissue, are iteratively calculated for the regularized polygons, so as to obtain an electrophysiological (EP) activation wave over the regular mesh that indicates scar tissue. An electroanatomical map overlaid on the regular mesh, the map including the EP activation wave and the scar tissue, is presented.

Abstract: A method and system for delivering a cardiac pacing therapy that includes a cardiac signal being sensed via electrodes of an atrial lead, and an occurrence of one of an intrinsic and a paced atrial depolarization event of a current cardiac cycle being determined in response to the sensed cardiac signal. A first pacing therapy is delivered during the current cardiac cycle in response to the determined occurrence of the depolarization event, and an amplitude of the cardiac signal within the current cardiac cycle subsequent to the delivered first pacing therapy is compared to a predetermined amplitude threshold. A second pacing therapy is delivered, via a left ventricular lead, within the same cardiac cycle and subsequent to the delivered first pacing therapy in response to the amplitude not being more negative than the predetermined amplitude threshold and is not delivered in response to the amplitude being more negative than the predetermined amplitude threshold.

Abstract: A system for closed-loop pulsed transcranial stimulation for cognitive enhancement. During operation, the system identifies a region of interest (ROI) in a subject's brain and then estimates ROI source activations based on the estimated source of the ROI. It is then determined if a subject is in a bad encoding state based on the ROI source activations. Finally, one or more electrodes are activated to apply a pulsed transcranial stimulation (tPS) therapy when the subject is in a bad encoding state, a predefined external event or behavior occurs, or the subject is in a consolidation state during sleep.

Abstract: The present invention discloses a method for noninvasive imaging of cardiac electrophysiological based on low rank and sparse constraints. This method decomposes the spatio-temporal distribution of endocardial and epicardial potentials into a low-rank matrix representing smooth potential components and a sparse matrix representing the details of potential salience according to the prior condition of spatio-temporal correlation of the endocardial and epicardial potential distribution of the heart. By introducing low rank and sparse constraints, the solution of the ill-conditioned inverse problem of ECG is constrained to the unique optimal solution. The invention combines the individualized three-dimensional heart model of the subject to obtain a three-dimensional dynamic distribution image of the cardiac endocardial and epicardial potential of the subject, which has important practical application value.

Abstract: An optical stimulation system includes a lead, a control module, and a control interface. The lead includes light emitters for emitting light having wavelengths that activate light-sensitive neurons. The light-sensitive neurons generate either an excitatory response or an inhibitory response when activated depending on the wavelength of the emitted light. The control module directs the emission of light from the light emitters using a set of stimulation parameters. The control interface includes user-selectable controls to adjust the stimulation parameters. The user-selectable controls include a graphical representation of a light emitter for each light emitter. Each graphical representation includes one or more user-selectable emitter controls to indicate whether a corresponding light emitter emits light and, if so, whether the emitted light generates an excitatory response or an inhibitory response from activated light-sensitive neurons.

Abstract: In some examples, a medical device system includes a first implantable medical device. The first implantable medical device (IMD) may comprise circuitry configured to at least one of deliver a therapy to a patient or sense a physiological signal from the patient; generate stimulation deliverable to a patient; a first rechargeable power source; and a secondary coil coupled to the first rechargeable power source, the secondary coil configured to charge the first rechargeable power source via inductive coupling with a primary coil of an external charging device. The medical device system may comprise processing circuitry configured to control charging of the first rechargeable power source based on a charge state of a second rechargeable power source of a second IMD.

Abstract: A flexible cable sheath includes an outer sleeve, an inner sleeve, and a flexible cable passing through the inner sleeve. The outer sleeve has a plurality of individual segments which are coupled to bend and have limited axial separation. By tensioning the inner sleeve relative to the outer sleeve, the resulting assembly has improved dimensional stability and torsional rigidity.

Abstract: A medical device is configured to deliver a high-energy electrical stimulation pulse to a patient that produces a post-stimulation polarization signal. A cardiac signal analyzer of the medical device is configured to detect a cardiac electrical signal superimposed on the post-stimulation polarization signal, determine at least one feature of the detected cardiac electrical signal, compare the feature to criteria that differentiate an intrinsic cardiac event during the post-stimulation polarization signal from an evoked response signal and identify the detected cardiac electrical signal as the intrinsic cardiac event if the feature meets the criteria.