Patents Examined by Sean Basquill
  • Patent number: 8834856
    Abstract: A novel three-component synergistic preservative system has zinc oxide, a phenoxyethanol component, and caprylyl glycol. The preservative system provides sufficient preservative activity without the use of other preservatives such as parabens. It provides broad spectrum activity against yeast and molds, and remains effective long term.
    Type: Grant
    Filed: February 15, 2012
    Date of Patent: September 16, 2014
    Assignee: Eveready Battery Company, Inc.
    Inventors: Laura A. Spaulding, Alissa R. Frontauria, Vincent R. La Iaconna
  • Patent number: 8822547
    Abstract: A hydroalcoholic gel composition includes greater than about 40 weight percent of an alcohol, based upon the total weight of the alcoholic composition, a polyacrylate thickener, and an ester plug-preventing agent. The composition is suitable for use in dispensers, and exhibits reduced mis-directed output when the dispenser is actuated.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: September 2, 2014
    Assignee: GOJO Industries, Inc.
    Inventors: Marcia Snyder, Carol A. Quezada
  • Patent number: 8815772
    Abstract: Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, wherein L is —C(R12a)R12b—C(R13a)R13b—, wherein the carbon atom bonded to R12a and R12b is also bonded to the carboxamide nitrogen atom in Formula 1; or 1,2-phenylene optionally substituted with up to 4 substituents independently selected from halogen and C1-C2 alkyl; and A, Z, R1, R2, n, G and Q are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention. Also disclosed are methods for controlling a phytophagous nematode comprising contacting the nematode or its environment with a nematocidally effective amount of a compound of Formula 1 wherein L is —C(R12a)R12b—C(R13a)R13b; and A, Z, R1, R2, n, G and Q are as defined in the disclosure.
    Type: Grant
    Filed: June 19, 2013
    Date of Patent: August 26, 2014
    Assignee: E I du Pont de Nemours and Company
    Inventors: James Francis Bereznak, Steven Gutteridge, Ravisekhara P Reddy, Andrew Edmund Taggi, Matthew James Campbell, Moumita Kar, Johan A. J. Desaeger
  • Patent number: 8802075
    Abstract: The invention contemplates a copolymer which is a graft or block copolymer useful to change wettability and surface characteristics of biological surfaces. Methods for use of these formulations and coatings to change wettability and sterically stabilize, and lubricate biological surfaces in a subject, for example, in the treatment of dry eye syndrome, and to prevent adherence of unwanted proteins, for example in the treatment of contact lens intolerance, are provided.
    Type: Grant
    Filed: February 18, 2010
    Date of Patent: August 12, 2014
    Assignee: Eyeon Particle Sciences LLC
    Inventors: Eugene R. Cooper, David M. Kleinman, Andrew Loxley, Mark Mitchnick
  • Patent number: 8796476
    Abstract: Pest controlling compositions exhibiting enhanced pesticidal activity levels and methods for preparing the same are disclosed. In one embodiment, a method includes providing a liquid composition that includes at least one pesticide and at least one co-ingredient that enhances pesticidal activity of the composition compared to a composition dissimilar only in not having the at least one co-ingredient. The at least one co-ingredient may include at least one metal oxide, a combination of at least one transition metal salt and at least one proteinaceous material or a combination of at least one proteinaceous material and at least one polymeric material. The method further includes spray drying the liquid composition to provide a solid composition. In one aspect of this embodiment, the solid composition provided by the spray drying exhibits enhanced pesticidal activity compared to the liquid composition.
    Type: Grant
    Filed: April 27, 2010
    Date of Patent: August 5, 2014
    Assignee: Dow AgroSciences, LLC
    Inventors: Stephen L. Wilson, Lei Liu, James D. Thomas, Raymond E. Boucher, Jr., James E. Dripps, Margaret S. Kempe, Martin C. Logan, Douglas J. Linscott, John M. Atkinson
  • Patent number: 8785379
    Abstract: Pest controlling compositions exhibiting enhanced pesticidal activity levels are disclosed. In one embodiment, a composition includes at least one pesticide, at least one transition metal salt and at least one proteinaceous material. In this embodiment, the composition exhibits enhanced pesticidal activity levels compared to a composition dissimilar only in not having the at least one transition metal salt and the at least one proteinaceous material.
    Type: Grant
    Filed: April 27, 2010
    Date of Patent: July 22, 2014
    Assignee: Dow AgroSciences, LLC.
    Inventors: Stephen L. Wilson, Lei Liu, James D. Thomas, Raymond E. Boucher, Jr., James E. Dripps, Margaret S. Kempe
  • Patent number: 8784773
    Abstract: The various embodiments herein provide hydrogel nanocomposite wound dressing comprising a polymeric basal matrix, a reinforcing agent, a biological sensor and an antibiotic for a slow release in a wound when applied. The polymeric basal matrix is made up of polyvinyl alcohol polymer with an amount of 1-15% by weight. The reinforcing agent comprises clay nanoparticles to inhibit a sudden drug release. The clay nanoparticles comprise montmorillonite nano particles with an amount of 0-2% by weight. The biological sensor is a peptide chain. The peptide chain is thrombin sensitive with an amount from 50 to 200 mg. The antibiotic is gentamycine with an amount of 1-3% by weight. The embodiments herein also provide a method of synthesizing the hydrogel nanocomposite wound dressing.
    Type: Grant
    Filed: February 25, 2012
    Date of Patent: July 22, 2014
    Inventors: Mohammad Mojmeli Renani, Mehran Solati Hashjin, Mohammad Rabiee, Yasaman Ganji, Leila Parsa, Masoomeh Mojmeli Renani
  • Patent number: 8778412
    Abstract: Disclosed herein are methods for controlling the activity of hypoxia-inducible transcription factor 1-alpha (HIF-1?) and diseases, conditions, or syndromes related thereto, inter alia, Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, and anemia. Further disclosed are pharmaceutical compositions comprising HIF-1? prolyl hydroxylase inhibitors useful in treating diseases, conditions, and/or syndromes related thereto the activity of HIF-1?.
    Type: Grant
    Filed: November 5, 2010
    Date of Patent: July 15, 2014
    Assignee: Aerpio Therapeutics Inc.
    Inventors: Robert Shalwitz, Joseph H. Gardner
  • Patent number: 8772284
    Abstract: A pharmaceutical composition for treating cancer, in particular drug resistant cancer, comprising an effective amount of bifunctional alkylating agent, an effective amount of a DNA repair inhibitor, and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: October 27, 2010
    Date of Patent: July 8, 2014
    Assignee: Academia Sinica
    Inventors: Te-Chang Lee, Tsann-Long Su, Ting-Chao Chou
  • Patent number: 8765724
    Abstract: A topical ophthalmic composition comprised of povidone-iodine 0.01% to 10.0% combined with a steroid or non-steroidal anti-inflammatory drug. This solution is useful in the treatment of active infections of at least one tissue of the eye (e.g., conjunctiva and cornea) from bacterial, mycobacterial, viral, fungal, or amoebic causes, as well as treatment to prevent such infections in appropriate clinical settings (e.g. corneal abrasion, postoperative prophylaxis, post-LASIK/LASEK prophylaxis). Additionally the solution is effective in the prevention of infection and inflammation in the post-operative ophthalmic patient.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: July 1, 2014
    Assignee: CLS Pharmaceuticals, Inc.
    Inventors: C. Michael Samson, Bo Liang, Joseph A. Capriotti
  • Patent number: 8754122
    Abstract: Disclosed herein is a method comprising administering a compound to a mammal suffering from an inflammatory bowel disease for the treatment of said disease, said compound having a structure according to Formula I wherein X, Y, B, R2, R3, R4, R5, R6 and n have the meanings found herein.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: June 17, 2014
    Assignee: Allergan, Inc.
    Inventors: Yariv Donde, Jeremiah H. Nguyen, Karen M. Kedzie, Daniel W. Gil, John E. Donello, Wha-Bin Im
  • Patent number: 8754123
    Abstract: The present invention is directed to the provision of pharmaceutical compositions. The compositions include a therapeutic agent and a relatively low amount of surfactant for providing higher bioavailability of the therapeutic agent. The compositions are particularly desirable as ophthalmic compositions in which the therapeutic agent is a prostaglandin such as travoprost and the surfactant is a vegetable oil such as castor oil.
    Type: Grant
    Filed: April 9, 2012
    Date of Patent: June 17, 2014
    Assignee: Alcon Research, Ltd.
    Inventor: Bhagwati P. Kabra
  • Patent number: 8742133
    Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
    Type: Grant
    Filed: August 13, 2008
    Date of Patent: June 3, 2014
    Assignee: Synta Pharmaceuticals Corp.
    Inventors: Weiwen Ying, Lijun Sun, Keizo Koya, Dinesh U. Chimmanamada, Shijie Zhang, Teresa Kowalcyzk-Przewloka, Hao Li
  • Patent number: 8734839
    Abstract: The invention relates to liquid compositions for production of soft sustained-release capsules. According to the invention, the sustained release of the active agent is obtained by in situ formation of a matrix, more or less consolidated and biodegradable, by physical modification of the capsule contents on coming into contact with digestive juices on the opening thereof. The above leads to a release time of more than one hour for the active agent previously dissolved or dispersed by means of solvents, said release being modulated by addition of appropriate adjuncts. The invention further relates to a method for production of said liquid compositions. The above finds application in the pharmaceutical, cosmetic and dietary fields.
    Type: Grant
    Filed: April 15, 2003
    Date of Patent: May 27, 2014
    Inventor: Laurence Paris
  • Patent number: 8729125
    Abstract: Ophthalmic compositions including compatible solute components and/or polyanionic components are useful in treating eyes, for example, to relieve dry eye syndrome, to protect the eyes against hypertonic insult and/or the adverse effects of cationic species on the ocular surfaces of eyes and/or to facilitate recovery from eye surgery.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: May 20, 2014
    Assignee: Allergan, Inc.
    Inventors: Joseph G. Vehige, Peter A. Simmons, Joan-En Chang-Lin
  • Patent number: 8722735
    Abstract: The present invention is directed to the provision of pharmaceutical compositions. The compositions include a therapeutic agent and a relatively low amount of surfactant for providing higher bioavailability of the therapeutic agent. The compositions are particularly desirable as ophthalmic compositions in which the therapeutic agent is a prostaglandin such as travoprost and the surfactant is a vegetable oil such as castor oil.
    Type: Grant
    Filed: October 4, 2011
    Date of Patent: May 13, 2014
    Assignee: Alcon Research, Ltd.
    Inventors: Bhagwati P. Kabra, Nuria Carreras, Mónica Cuchi, Francisco Javier Galán, Mridvika, Elena González Puig, Nuria Jiménez, Carmen Martinez
  • Patent number: 8715745
    Abstract: The present invention relates to the use of hydrazone compounds and copper for controlling the growth of fungi.
    Type: Grant
    Filed: January 14, 2010
    Date of Patent: May 6, 2014
    Assignee: Dow AgroSciences, LLC.
    Inventors: David H Young, Cruz Avila-Adame, Nneka T Breaux, James M Ruiz, Thomas L Siddall, Jeffery D. Webster, Gerald Shaber
  • Patent number: 8703747
    Abstract: The present invention relates to a compound of the following general formula (I): R1—NH—CH(R2)—P(?O)(OR3)—CH2—C(R4)(R5)—CONH—CH(R6)—COOR7 (I) or a pharmaceutically acceptable salt of the latter, an isomer or a mixture of isomers in any proportions, especially a mixture of enantiomers, and in particular a racemic mixture, for which R1 represents a —C(?O)—O—C(R8)(R9)—OC(?O)—R10 group; R2 represents an optionally substituted hydrocarbon-based chain, an aryl or heteroaryl group or a methylene group substituted by a heterocycle; R3 represents a hydrogen atom or a —C(R12)(R13)—OC(?O)—R14 group; R4 and R5 form, together with the carbon that bears them, a saturated hydrocarbon-based ring or an optionally substituted piperidine ring or R4 represents a hydrogen atom and R5 represents a phenyl or a benzyl that is optionally substituted, a heteroaromatic ring or a methylene group substituted by a heterocycle; R6 represents an optionally substituted hydrocarbon-based chain or a phenyl or a benzyl that is optionally substi
    Type: Grant
    Filed: July 22, 2009
    Date of Patent: April 22, 2014
    Assignee: Pharmaleads
    Inventors: Bernard Roques, Hervé Poras, Marie-Claude Fournie-Zaluski
  • Patent number: 8685985
    Abstract: The present invention relates to the use of selective insecticidal compositions, characterized by an effective amount of an active compound combination comprising (a) (1) at least one haloalkylnicotinic acid derivative of the formula (I) in which AA and R1A are as defined in the description, or (2) at least one phthalic acid diamide of the formula (II) in which XB, R1B, R2B, R3B, L1B, L2B and L3B are as defined in the description, or (3) at least one anthranilamide of the formula (III) in which A1C, A2C, XC,R1C, R2C, R3C, R4C, R5C, R7C, R8Cand R9C are as defined in the description, and (b) at least one crop plant compatibility-improving compound from the group of compounds given in the description, in particular cloquintocet-mexyl, isoxadifen-ethyl and mefenpyr-diethyl for controlling insects and/or arachnids, and a method for controlling insects and/or arachnids using the compositions.
    Type: Grant
    Filed: November 11, 2010
    Date of Patent: April 1, 2014
    Assignee: Bayer CropScience AG
    Inventors: Reiner Fischer, Rüdiger Fischer, Christian Funke, Achim Hense, Wolfram Andersch, Heike Hungenberg, Wolfgang Thielert, Udo Reckmann, Lothar Willms, Christian Arnold
  • Patent number: 8680079
    Abstract: The application relates to novel heterocyclic compounds of the general formula (I) in which R, R1, R2, X, Y, Z and n have the meanings defined in the description, to a process for their preparation and to the use of these compounds as medicaments, in particular as aldosterone synthase inhibitors.
    Type: Grant
    Filed: May 27, 2005
    Date of Patent: March 25, 2014
    Assignee: Novartis AG
    Inventors: Peter Herold, Robert Mah, Vincenzo Tschinke, Christoph Schumacher, Michael Quirmbach