Patents Examined by Sean Basquill
  • Dry eye treatment
    Patent number: 9044388
    Abstract: This invention relates to an emulsion composition for the formation of an artificial tear film over the ocular surface of the eye capable of providing mechanical lubrication for the ocular surface while reducing evaporation of fluid therefrom. The emulsion is desirably in the form of a meta stable emulsion and is characterized by the use of a surfactant comprising a combination of a primary and secondary surfactant where the primary surfactant permits formation of the emulsion and the secondary surfactant permits autoclaving of the surfactant. The invention also includes a method for the formation of such an emulsion.
    Type: Grant
    Filed: November 5, 2008
    Date of Patent: June 2, 2015
    Assignee: Ocular Research of Boston, Inc.
    Inventors: Donald R. Korb, Chris J. Brancewicz
  • Wound care products with peracid compositions
    Patent number: 9044527
    Abstract: Methods have been developed for incorporation of a peracid compound into or on wound application matrices, such as bandages or dressings, and other matrices which will favorably impact wound healing and help eliminate microbial infection. The peracid compound comprises a base compound that is metabolically pertinent to wound healing, the oxidized form of the base compound (a peracid), and an appropriate oxidizer, such as hydrogen peroxide. In addition, other excipients with wound healing potential, such as esters of the base compound, may be added to the peracid compound. The combination peracid-wound application matrices can be used to disinfect and heal various wound types with designed time release of the peracid compound.
    Type: Grant
    Filed: August 14, 2013
    Date of Patent: June 2, 2015
    Assignee: CHD Bioscience, Inc.
    Inventors: Edwin D. Neas, Michael K. Handley, Kevin S. Marchitto, Stephen T. Flock
  • Cosmetic compositions containing phenolic compounds
    Patent number: 9044416
    Abstract: A method of photoprotecting a keratinous substrate comprising applying a composition onto the keratinous substrate, the composition comprising at least one phenolic compound chosen environmental at least one ortho-diphenol, at least one phenolic compound having a carboxylic acid moiety, and mixtures thereof, —a compound chosen from at least one pelyarn!ne, at least one water solvable metal salt, and mixtures thereof; and a cosmetically acceptable carrier. The present disclosure also relates to photoprotective compositions for application onto hair and skin, the compositions comprising at least one phenolic compound chosen from at least one ortho-diphenol, at least one phenolic compound having a carboxylic acid moiety, and mixtures thereof; a compound chosen from at least one polyamine, at least one water soluble metal salt, and mixtures thereof; and a cosmetically acceptable carrier.
    Type: Grant
    Filed: June 7, 2011
    Date of Patent: June 2, 2015
    Assignee: L'OREAL
    Inventors: Nghi Van Nguyen, Sawa Hashimoto
  • Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor
    Patent number: 9040483
    Abstract: Provided are prophylactic and therapeutic methods of treatment of subjects for the purpose of inhibiting vaso-occlusive events, including embolism, by administering agents, including anagrelide and anagrelide derivatives, which reduce the number of circulating platelets to low normal or to below normal levels. Methods and pharmaceutical preparations comprising such agents are provided.
    Type: Grant
    Filed: July 17, 2012
    Date of Patent: May 26, 2015
    Assignee: BIOVASCULAR, INC.
    Inventors: Paul F. Glidden, Alison J. Pilgrim, Stephen R. Hanson
  • Crystallization of (20R) 19-nor-24-difluoro-1?,25-dihydroxyvitamin D
    Patent number: 9040728
    Abstract: Disclosed are methods of purifying the compound (20R)-19-nor-24-difluoro-1?,25-dihydroxyvitamin D3 to obtain the compound in crystalline form. The methods typically include the steps of dissolving a product containing the compound in a solvent comprising hexane and 2-propanol, cooling the solvent and dissolved product below ambient temperature for a sufficient amount of time to form a precipitate of crystals, and recovering the crystals.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: May 26, 2015
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Agnieszka Flores, James B. Thoden, Hazel M. Holden
  • Product based on conjugated linoleic acid and a method for the manufacture thereof
    Patent number: 9034385
    Abstract: A product based on conjugated linoleic acid (CLA) comprises an inner core in which the conjugated linoleic acid is substantially concentrated as well as a coating for covering and protecting the inner core; the coating in turn comprises a fraction greater than 80% by weight relative to the coating of a lipid matrix formed by glycerides of C16, C18, C20 and C22 saturated fatty acids.
    Type: Grant
    Filed: January 11, 2008
    Date of Patent: May 19, 2015
    Assignee: SILA S.R.L.
    Inventor: Maurizio Lorenzon
  • Aqueous ophthalmic composition
    Patent number: 9034931
    Abstract: This invention relates to an aqueous ophthalmic composition comprising (A) polyoxyethylene castor oil in which the average number of moles of added ethylene oxide is 2 to 12 and (B) terpenoid. According to the present invention, an aqueous ophthalmic composition having an improved foam disappearance speed can be obtained.
    Type: Grant
    Filed: December 27, 2011
    Date of Patent: May 19, 2015
    Assignee: ROHTO PHARMACEUTICAL CO., LTD.
    Inventors: Chinatsu Furumiya, Takayuki Miyano, Atsuko Nakata, Eri Matsumoto
  • Nanosuspension of a poorly soluble drug via microfluidization process
    Patent number: 9023886
    Abstract: Provided are compositions and methods for preparation and administration of an oral nanosuspension of a poorly soluble drug with improved bioavailability. The method is optimized through microfluidization process with water soluble polymeric excipients in the absence of surfactants.
    Type: Grant
    Filed: November 9, 2010
    Date of Patent: May 5, 2015
    Assignee: Celgene Corporation
    Inventors: Ming J. Chen, Ho-Wah Hui, Thomas Lee, Paul Kurtulik, Sekhar Surapaneni
  • Cross-linked fatty acid-based biomaterials
    Patent number: 9012506
    Abstract: Fatty acid-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.
    Type: Grant
    Filed: December 1, 2008
    Date of Patent: April 21, 2015
    Assignee: Atrium Medical Corporation
    Inventors: Keith M. Faucher, Hui Tang, Joseph Ferraro, Paul Martakos, Steve A. Herweck, Theodore Karwoski, Scott E. Corbeil
  • Bi-functional co-polymer use for ophthalmic and other topical and local applications
    Patent number: 9005596
    Abstract: The invention contemplates a copolymer which is a graft or block copolymer useful to change wettability and surface characteristics of biological surfaces. Methods for use of these formulations and coatings to change wettability and sterically stabilize, and lubricate biological surfaces in a subject, for example, in the treatment of dry eye syndrome, and to prevent adherence of unwanted proteins, for example in the treatment of contact lens intolerance, are provided.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: April 14, 2015
    Assignee: Eyeon Particle Sciences LLC
    Inventors: Eugene Rex Cooper, David Maxwell Kleinman, Andrew Loxley, Mark Mitchnick
  • Composition, method and kit for enhancing hair
    Patent number: 9006291
    Abstract: Compositions for application and methods of application of a composition to modify hair. In one embodiment, a composition includes a compound (molecule) represented by: wherein A and B are individually selected from a hydrogen, a hydroxyl group and a halogen, with the proviso that when one of A and B is a hydroxyl group, the other of A and B is a hydrogen and when one of A and B is a halogen, the other of A and B is a halogen or a hydrogen; wherein Z is, for example, an aryl moiety; and wherein X1 and X2 are, for example, individually selected from a hydrogen and an alkyl moiety, wherein R1 and R2 are individually selected from an oxo, a hydroxyl or an ester group; wherein y is 0 or 1, x is 0 or 1 and x and y are not both 1, or a salt.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: April 14, 2015
    Assignee: Pharma Patent Holding Inc.
    Inventor: Michael C. Brinkenhoff
  • Methods for increasing the stabilization of hypoxia inducible factor-1 alpha
    Patent number: 8999971
    Abstract: Disclosed herein are methods for controlling the activity of hypoxia-inducible transcription factor 1-alpha (HIF-1?) and diseases, conditions, or syndromes related thereto, inter alia, Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, and anemia. Further disclosed are pharmaceutical compositions comprising HIF-1? prolyl hydroxylase inhibitors useful in treating diseases, conditions, and/or syndromes related thereto the activity of HIF-1?.
    Type: Grant
    Filed: August 21, 2014
    Date of Patent: April 7, 2015
    Assignee: Aerpio Therapeutics Inc.
    Inventors: Robert Shalwitz, Joseph H. Gardner
  • Cross-linked fatty acid-based biomaterials
    Patent number: 9000040
    Abstract: Fatty acid-based, pre-cure-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.
    Type: Grant
    Filed: February 3, 2009
    Date of Patent: April 7, 2015
    Assignee: Atrium Medical Corporation
    Inventors: Keith M. Faucher, Hui Tang, Paul Martakos, Steve A. Herweck, Theodore Karwoski, Allison Sullivan, Greg Melville, Scott E. Corbeil
  • Treatment of protein degradation disorders
    Patent number: 8999289
    Abstract: The invention relates to methods of treating protein degradation disorders, such cellular proliferative disorders (e.g., cancer) and protein deposition disorders (e.g., neurodegenerative disorders). The invention provides methods and pharmaceutical compositions for treating these diseases using aggresome inhibitors or combinations of aggresome inhibitors and proteasome inhibitors. The invention further relates to methods and pharmaceutical compositions for treating multiple myeloma. New HDAC/TDAC inhibitors and aggresome inhibitors are also provided as well as synthetic methodologies for preparing these compounds.
    Type: Grant
    Filed: March 22, 2006
    Date of Patent: April 7, 2015
    Assignees: President and Fellows of Harvard College, Dana-Farber Cancer Institute, Inc.
    Inventors: Kenneth C. Anderson, James E. Bradner, Edward Franklin Greenberg, Teru Hideshima, Nicholas Paul Kwiatkowski, Ralph Mazitschek, Stuart L. Schreiber, Jared Shaw, Stephen J. Haggarty
  • Melatonin tablet and methods of preparation and use
    Patent number: 8992948
    Abstract: The present invention provides a pharmaceutical composition for sublingual or buccal administration of actives with low to poor aqueous solubility, e.g. the indole hormone melatonin, which contains a solution of the active in a pharmaceutically acceptable solvent adsorbed or absorbed onto particles of a pharmaceutically acceptable carrier and methods of preparing and using the pharmaceutical composition.
    Type: Grant
    Filed: October 3, 2012
    Date of Patent: March 31, 2015
    Assignee: Pharmaceuticals Productions, Inc.
    Inventor: John A. McCarty
  • Skin care compositions
    Patent number: 8986663
    Abstract: Described are skin care compositions comprising an aqueous dispersion comprising a metallocene catalyzed polyolefin, an ethylene acrylic acid copolymer, or a combination thereof.
    Type: Grant
    Filed: October 27, 2011
    Date of Patent: March 24, 2015
    Assignees: Rohm and Haas Company, Union Carbide Chemicals & Plastics Technology LLC
    Inventors: Susan L. Jordan, Ying O'Connor
  • Plant disease controlling composition and method for controlling plant disease
    Patent number: 8980885
    Abstract: A plant disease controlling composition comprising, as active ingredients, a compound represented by the formula (I), as well as at least one compound A selected from the group consisting of dimoxystrobin, trifloxystrobin, azoxystrobin, pyraclostrobin, a compound represented by the formula (II) and an agrochemically acceptable salt of the compound represented by the formula (II): wherein, R1, Q, X, Y, Z, M and n are as defined in the description.
    Type: Grant
    Filed: March 24, 2009
    Date of Patent: March 17, 2015
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Masato Soma, Masanao Takaishi
  • Controlled release hydrocodone formulations
    Patent number: 8975273
    Abstract: A solid oral controlled-release oral dosage form of hydrocodone is disclosed. The dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and a sufficient amount of a controlled release material to render the dosage form suitable for twice-a-day administration to a human patient, the dosage form providing a C12/Cmax ratio of 0.55 to 0.85, said dosage form providing a therapeutic effect for at least about 12 hours.
    Type: Grant
    Filed: September 11, 2014
    Date of Patent: March 10, 2015
    Assignee: Purdue Pharma L.P.
    Inventors: Benjamin Oshlack, Hua-Pin Huang, John Masselink, Alfred P. Tonelli
  • Controlled release hydrocodone formulations
    Patent number: 8975271
    Abstract: A solid oral controlled-release oral dosage form of hydrocodone is disclosed. The dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and a sufficient amount of a controlled release material to render the dosage form suitable for twice-a-day administration to a human patient, the dosage form providing a C12/Cmax ratio of 0.55 to 0.85, said dosage form providing a therapeutic effect for at least about 12 hours.
    Type: Grant
    Filed: December 3, 2013
    Date of Patent: March 10, 2015
    Assignee: Purdue Pharma L.P.
    Inventors: Benjamin Oshlack, Hua-Pin Huang, John Masselink, Alfred P. Tonelli
  • Plant disease control composition and its use
    Patent number: 8969393
    Abstract: A composition comprising a carboxamide compound represented by following formula (I), wherein R1 represents a hydrogen atom or a methyl group, and R2 represents a methyl group, a difluoromethyl group or a trifluoromethyl group, and ethaboxam is provided by the present invention. This composition has excellent effect for controlling plant disease.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: March 3, 2015
    Assignee: Sumitomo Chemical Company, Limited
    Inventor: Yuichi Matsuzaki