Abstract: Methods for preparing a supramolecular therapeutic agent delivery assembly are provided. A hydrophilic precursor, a hydrophibic precursor, and an aromatic diamine precursor may be combined to form an amphiphilic block co-polymer. The block co-polymer may undergo a cross-linking polymerization process and a therapeutic agent may be incorporated into the resulting supramolecular assembly. The supramolecular assembly may comprise HT, PHT, HA, and/or PHA materials.
Type:
Grant
Filed:
June 20, 2014
Date of Patent:
May 31, 2016
Assignee:
INTERNATIONAL BUSINESS MACHINES CORPORATION
Inventors:
Dylan J. Boday, Jeannette M. Garcia, James L. Hedrick, Rudy J. Wojtecki
Abstract: The present invention relates to a nutritional composition for infants and/or toddlers comprising a lipid component which has a lipid globules coated with polar lipids. The composition can be used to prevent obesity and/or improve body composition later in life. Said liquid comprises 10-50 wt % vegetable liquids based on the dry weight of the composition, and (i) 0.5-20 wt % phospholipids based on total weight or (ii) 0.6-25 wt % of polar lipids based on total lipids, wherein polar lipids are the sum of phospholipids, glycosphingolipids and cholesterol, and said composition comprises lipid globules with a core comprising said vegetable lipids and a coating comprising said phospholipids or polar lipids.
Type:
Grant
Filed:
September 2, 2009
Date of Patent:
May 24, 2016
Assignee:
N.V. Nutricia
Inventors:
Eline Marleen van der Beek, Marieke Abrahamse-Berkeveld, Günther Boehm, Antonie van Baalen
Abstract: This invention relates to an aqueous ophthalmic composition comprising (A) polyoxyethylene castor oil and (B) sesame oil. According to the aqueous ophthalmic composition of the present invention, defoaming time is reduced, preservative efficacy is enhanced and photostability is improved.
Abstract: The present invention relates to a particular class of biodegradable linkers, ensuring transiently stable conjugation of building blocks and/or bioactive compounds into drug delivery systems (DDS), such as DDS based on polymeric micelles or hydrogels. In addition, the present invention relates to compounds, comprising said linkers, such compounds preferably being prodrugs. Further, the invention is directed to the use of said linkers, and especially said biodegradable linkers, in a drug delivery system. Moreover, the invention relates to controlled release system comprising a polymer matrix, capable of releasing an active ingredient, wherein the active ingredient is covalently linked to the polymer molecules of the polymer matrix through said linkers, as well as to a method of synthesizing these linkers and preparing such controlled release systems.
Type:
Grant
Filed:
July 14, 2011
Date of Patent:
May 17, 2016
Assignee:
CRISTAL DELIVERY B.V.
Inventors:
Cristianne Johanna Ferdinand Rijcken, Wilhelmus Everhardus Hennink, Cornelis Franciscus van Nostrum, Isil Altintas, Steffen van der Wal, Robertus Matthias Joseph Liskamp, Johannes Anna Wilhelmus Kruijtzer
Abstract: This invention relates to an aqueous ophthalmic composition comprising (A) polyoxyethylene castor oil in which the average number of moles of added ethylene oxide is 2 to 12 and (B) terpenoid. According to the present invention, an aqueous ophthalmic composition having an improved foam disappearance speed can be obtained.
Type:
Grant
Filed:
April 10, 2015
Date of Patent:
April 26, 2016
Assignee:
ROHTO PHARMACEUTICAL CO., LTD.
Inventors:
Chinatsu Furumiya, Takayuki Miyano, Atsuko Nakata, Eri Matsumoto
Abstract: A solid oral controlled-release oral dosage form of hydrocodone is disclosed. The dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and a sufficient amount of a controlled release material to render the dosage form suitable for twice-a-day administration to a human patient, the dosage form providing a C12/Cmax ratio of 0.55 to 0.85, said dosage form providing a therapeutic effect for at least about 12 hours.
Type:
Grant
Filed:
March 30, 2015
Date of Patent:
April 26, 2016
Assignee:
Purdue Pharma L.P.
Inventors:
Benjamin Oshlack, Hua-Pin Huang, John Masselink, Alfred P. Tonelli
Abstract: One aspect of the invention provides polymer conjugated MetAP2 inhibitors. While not being bound by any particular theory, it is believed that coupling the MetAP2 inhibitory core via the linkers described herein provides compounds with superior efficacy to the parent small molecules and superior pharmacokinetic profiles. In one aspect of the invention, the polymer conjugated MetAP2 inhibitors are useful in methods of treating disease, comprising administering to a subject in need thereof a therapeutically effective amount of a polymer conjugated MetAP2 inhibitor.
Abstract: The present invention relates to a nutritional composition for infants and/or toddlers comprising a lipid component which has a large lipid globule size. The composition can be used to prevent obesity and/or improve body composition later in life. Said lipid component comprises 10-50 wt % vegetable lipids, and the lipid globules have a volume-weighted diameter above 1.0 m and/or a diameter of 2-12 m in an amount of at least 45 vol %.
Type:
Grant
Filed:
September 2, 2009
Date of Patent:
April 26, 2016
Assignee:
N.V. Nutricia
Inventors:
Antonie van Baalen, Eline Marleen van der Beek, Christopher Beermann, Günther Boehm
Abstract: The present invention relates to improved ophthalmic solutions that employ select B vitamins; pyridoxine and its salts; and thiamine and its salts in order to more effectively preserve solutions and to reduce the degree to which cationic preservatives will deposit on contact lenses. Ophthalmic solutions are here understood to include contact lens treatment solutions, such as cleaners, soaking solutions, conditioning solutions and lens storage solutions, as well as wetting solutions and in-eye solutions for treatment of eye conditions.
Abstract: The problem of the present invention is provision of a cleansing composition providing good amount and good quality of lather. Using a particular alkenoic acid or a salt thereof, the above-mentioned problem can be solved. In addition, the cleansing composition provided by the present invention is stable in various formulations and also useful for rough skin and damaged hair.
Abstract: A flat self-curling permeable sheet membrane containing a matrix formed of crosslinked biopolymeric fibers. The matrix self-curls into a predetermined shape upon absorption of an aqueous fluid and is permeable to molecules having molecular weights not greater than 1×106 daltons. Also disclosed is a method of preparing such a flat self-curling permeable membrane.
Abstract: The invention contemplates a copolymer which is a graft or block copolymer useful to change wettability and surface characteristics of biological surfaces. Methods for use of these formulations and coatings to change wettability and sterically stabilize, and lubricate biological surfaces in a subject, for example, in the treatment of dry eye syndrome, and to prevent adherence of unwanted proteins, for example in the treatment of contact lens intolerance, are provided.
Type:
Grant
Filed:
July 10, 2014
Date of Patent:
March 29, 2016
Assignee:
Eyeon Particle Sciences LLC
Inventors:
Eugene Rex Cooper, David Maxwell Kleinman, Andrew Loxley, Mark Mitchnick
Abstract: The present invention relates to personal care compositions, especially those personal care compositions in the form of a personal care article that is a porous dissolvable solid substrate. The porous dissolvable solid substrate has a surface resident coating comprising a surface resident coating comprising from about 25% to about 70% of a starch derived material, from about 5% to about 60% of a cationic surfactant conditioner, and from about 5% to about 60% of a perfume, that can provide a consumer benefit.
Type:
Grant
Filed:
December 8, 2010
Date of Patent:
March 29, 2016
Assignee:
The Procter & Gamble Company
Inventors:
Robert Wayne Glenn, Jr., Kathleen Mary Kaufman, Joanne Roberta Willman
Abstract: The invention contemplates a copolymer which is a graft or block copolymer useful to change wettability and surface characteristics of biological surfaces. Methods for use of these formulations and coatings to change wettability and sterically stabilize, and lubricate biological surfaces in a subject, for example, in the treatment of dry eye syndrome, and to prevent adherence of unwanted proteins, for example in the treatment of contact lens intolerance, are provided.
Type:
Grant
Filed:
March 18, 2015
Date of Patent:
March 15, 2016
Assignee:
EYEON PARTICLE SCIENCES LLC
Inventors:
Eugene Rex Cooper, David Maxwell Kleinman, Andrew Loxley, Mark Mitchnick
Abstract: Delivery systems for incorporating functional compounds into substrates for use in various consumer products are disclosed. Specifically, the delivery system includes a carrier component comprising an ultrasonically energized adsorbent and one or more functional compounds. The ultrasonically energized adsorbent can adsorb the desired functional compounds and bind the functional compounds to the surface of the substrate.
Type:
Grant
Filed:
September 8, 2006
Date of Patent:
March 15, 2016
Assignee:
Kimberly-Clark Worldwide, Inc.
Inventors:
Robert Allen Janssen, Earl C. McCraw, Jr., Kimberlee Fay Thompson, John Gavin MacDonald, Thomas David Ehlert, Patrick Sean McNichols
Abstract: A high-efficacy, long-acting, slow-release formulation of the poorly soluble drug, comprising solid dispersion of the poorly soluble drug, silica nanoparticles loaded with the poorly soluble drug, matrix material, and release enhancer, wherein the mass ratio of these components is solid dispersion of the poorly soluble drug: silica nanoparticles loaded with the poorly soluble drug: matrix material: release enhancer=1: 0.5˜1.25: 0.1˜0.3: 0.1˜0.3; the said solid dispersion of the poorly soluble drug contains povidone K30, soybean lecithin, and acrylic resin IV, wherein the mass ratio of the drug and the accessory materials is poorly soluble drug: povidone K30: soybean lecithin: acrylic resin IV=1: 1˜3: 0.3˜0.8: 0.2˜0.5. Compared with the existing formulations, the in vivo half life of the high-efficacy, long-acting formulation of the poorly soluble drug disclosed in this invention is 2.3˜14.8 times longer while the mean residence time (MRT) of which is 7.94˜4.
Type:
Grant
Filed:
November 23, 2009
Date of Patent:
March 15, 2016
Assignee:
JIANGSU UNIVERSITY
Inventors:
Ximing Xu, Jiangnan Yu, Yuan Zhu, Xia Cao
Abstract: The present invention is related to novel oral compositions comprising an irreversible gastric H+/K+-ATPase proton pump inhibitor (PPI) as a gastric acid secretion inhibitor and one or more small carboxylic acid molecules as parietal cell activators in the gastric lumen. Unexpectedly, the compositions of the present invention are capable of enhancing the anti-acid activity of PPI in the stomach. The present invention further relates to a method of using such compositions to reduce gastric acid secretion in a mammal.
Abstract: Disclosed herein are methods for controlling the activity of hypoxia-inducible transcription factor 1-alpha (HIF-1?) and diseases, conditions, or syndromes related thereto, inter alia, Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, and anemia. Further disclosed are pharmaceutical compositions comprising HIF-1? prolyl hydroxylase inhibitors useful in treating diseases, conditions, and/or syndromes related thereto the activity of HIF-1?.
Abstract: A solid oral controlled-release oral dosage form of hydrocodone is disclosed. The dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and a sufficient amount of a controlled release material to render the dosage form suitable for twice-a-day administration to a human patient, the dosage form providing a C12/Cmax ratio of 0.55 to 0.85, said dosage form providing a therapeutic effect for at least about 12 hours.
Type:
Grant
Filed:
March 30, 2015
Date of Patent:
March 8, 2016
Assignee:
Purdue Pharma L.P.
Inventors:
Benjamin Oshlack, Hua-Pin Huang, John Masselink, Alfred P. Tonelli
Abstract: Freshening compositions comprising a malodor binding polymer and an aqueous carrier, wherein the composition is essentially free of any material that would soil or stain fabric; and methods thereof are provided. In some embodiments, the malodor binding polymer comprises a homopolymeric polyethylenimine having a molecular weight of about 1,000 to about 2,000,000. In some embodiments, the freshening composition includes a buffering agent providing a pH of about 6 to about 8. Such freshening compositions may be used to reduce malodor and/or microbes on inanimate surfaces or in the air.
Type:
Grant
Filed:
September 18, 2009
Date of Patent:
March 1, 2016
Assignee:
The Procter & Gamble Company
Inventors:
Kristin Rhedrick Williams, Ricky Ah-Man Woo, Christine Marie Readnour, Shih-Chuan Liou, Lon Montgomery Gray, Cahit Eylem, Carla Jean Colina