Abstract: Embodiments related to methods and wearable medical detecting systems for detecting disease states and/or treatment states of a subject are described. In one embodiment, a wearable structure may include one or more radiation detectors use to detect a time varying radiation signal emitted from a labeled compound within a body portion of interest. The radiation signal may be analyzed to determine one or more signal characteristics that may be compared to one or more predetermined standard characteristics associated with known disease and/or treatment states to determine a current disease and/or treatment state of a subject.

Abstract: A surface of the tissue is illuminated with light having a known wavelength spectrum capable of materially penetrating the tissue. The light remitted from the tissue in response to the illumination is separated into at least two distinguishable polarization components. The intensity of the illumination light remitted from the tissue is measured over a hyperspectral range of wavelengths for the at least two distinguishable polarization components. Based on the preceding measurements and a degree of linear polarization of the remitted light, data representative of the three-dimensional location and one or more characteristics of an abnormal portion of the tissue are produced. Further, the masking effect of melanin may be eliminated to obtain accurate estimations of an anomaly.

Abstract: An intraluminal ultrasound imaging device includes a flexible elongate member configured to be inserted into a body lumen of a patient, the flexible elongate member comprising a proximal portion and a distal portion. The device includes an ultrasound scanner assembly disposed at the distal portion of the flexible elongate member. The ultrasound scanner assembly includes a flexible substrate comprising a longitudinal width extending from an inner edge to an outer edge; a control region embedded in the flexible substrate; a transducer region embedded in the flexible substrate; and a window region disposed between the outer edge of the flexible substrate and the transducer region, and wherein the window region, the transducer region, and the control region are radially arranged relative to one another. Associated devices, systems, and methods are also described.

Abstract: The present disclosure provides methods and apparatuses for identifying and/or analyzing a muscle tissue of a subject. An apparatus for identifying and/or analyzing muscle tissue of the present disclosure may comprise an optical element comprising an excitation probe and a collection probe. A method for identifying or analyzing muscle tissue of the present disclosure may comprise the generation of images of a muscle tissue using signals generated from the tissue by a beam of light directed towards the muscle tissue from the excitation probe and collected by the collection probe. Signals collected by the collection probe may include forward second harmonic generation signals.

Abstract: A method of detecting injury to the brain such as stroke, concussion and cognitive dysfunction using a contrast agent and light source. The blood ocular barrier is disrupted when said injury occurs, allowing the entry of contrast agent into the aqueous and vitreous humor. An exemplary method comprises injecting a contrast agent into a peripheral location and then testing for leakage of contrast agent into the eye cavity by observing for light reflection, when a beam of light incidents on the contrast agent in the eye.

Abstract: The invention relates to a system for assisting in navigating a medical device (1) in a region of a patient body, such as a cardiac chamber. The system comprises a unit (5) for providing a three-dimensional model of the region and an ultrasound probe (2) for acquiring image signals of the region of the patient body. At least one an ultrasound sensor (6) is attached to the medical device (1) for sensing ultrasound signals emitted by the 5 ultrasound probe (2) and a tracking unit (7) determines a relative position of the at last one ultrasound sensor (6) with respect to the live images and/or the ultrasound probe (2) on the basis of the sensed ultrasound signals. Further, a mapping unit (8) maps the determined relative position of the at least one ultrasound sensor (6) onto the model to generate a visualization of region of the patient body.

Abstract: Embodiments of the invention provide a guided surgical tool assembly with a guide tube including a sensor, a surgical instrument including a detectable feature moveable within the guide tube, and the sensor capable of detecting the detectable feature when the surgical instrument is inserted in the guide tube. Some embodiments include a sensor pad, a guide stop coupled to the surgical instrument, a plunger mechanism including a compressible spring mechanism coupled to the guide tube, and a wiper capable of being sensed by the sensor pad. Some embodiments include a guided surgical tool assembly system comprising a tool sensor system including a processor and at least one data input/output interface. Some embodiments include a medical robot system with a guided surgical tool assembly and including a robot coupled to an effectuator element configured for controlled movement and positioning along one or more of an x-axis, a y-axis, and a z-axis.

Abstract: Disclosed are a method of measuring concentration distribution of boron for boron neutron capture therapy (BNCT) using magnetic resonance imaging (MRI) alone and a treatment planning method for BNCT. The methods include (a) acquiring an anatomical image of a patient and measuring a boron concentration from magnetic resonance (MR) data, (b) extracting a boron concentration change prediction parameter of the patient and predicting the concentration over time, (c) calculating and verifying a boron distribution prediction value estimated by boron imaging and spectral analysis, and (d) deriving an optimal time for BNCT based on the verified results.

Abstract: An insertion system having a processor including hardware, configured to: determine, for each of a plurality of times, one or more positions of an insertion section configured to be inserted into an insertion subject; determine, for the each of the plurality of times, state of the insertion section relative to the insertion subject based on the one or more positions for the each of the plurality of times; determine, for the each of the plurality of times, whether an attention state of the insertion section that restricts insertion of the insertion section into the insertion subject has occurred, based on the state of the insertion section relative to the insertion subject determined; and control a monitor to display attention state information indicating the one or more positions of the insertion section at which the occurrence of the attention state of the insertion section is determined over the plurality of times.

Abstract: A navigation, tracking and guiding system for the positioning of operatory instruments inside the body of a patient. The system includes a control unit, a viewer and detecting means for determining the spatial position of the viewer. The system further includes a sensor associated to an operatory instrument and insertable inside the internal portion of the body of the patient. The control unit is configured to project on the viewer an image of the state of the internal portion.

Abstract: An electronic endoscope processor includes a converting means for converting each piece of pixel data that is made up of n (n?3) types of color components and constitutes a color image of a biological tissue in a body cavity into a piece of pixel data that is made up of m (m?2) types of color components, m being smaller than n; an evaluation value calculating means for calculating, for each pixel of the color image, an evaluation value related to a target illness based on the converted pieces of pixel data that are made up of m types of color components; and a lesion index calculating means for calculating a lesion index for each of a plurality of types of lesions related to the target illness based on the evaluation values calculated for the pixels of the color image.

Abstract: A photoacoustic apparatus includes a light source configured to generate a plurality of pulsed lights in different wavelengths, an irradiation optical system configured to irradiate an object with the pulsed light from the light source and configured to irradiate the object in different irradiation positions along a rotational trajectory during a rotational scanning period in a corresponding wavelength, and a probe configured to receive photoacoustic wave from the object in response to each pulsed light irradiation in the different irradiation positions and to convert the received photoacoustic wave into an electric signal. The irradiation optical system is moved to irradiate the object with a first wavelength in a plurality of times during a first rotational scanning period and irradiate the object with a second wavelength in a plurality of times during a second rotational scanning period after the first rotational scanning period.

Abstract: Systems and methods are provided for detecting the flow of blood or other fluids in biological tissue by illuminating the biological tissue with two or more beams of coherent light and detecting responsively emitted light. A difference in wavelength, coherence length, beam divergence, or some other property of the beams of illumination causes the beams to preferentially scatter from, be absorbed by, or otherwise interact with respective elements of the biological tissue. Flow properties in one or more regions of the biological tissue (e.g., a region with which both beams of light preferentially interact, a region with which only one of the beams preferentially interacts) could be determined based on detected responsively emitted light from the biological tissue. Variations in speckle patterns over time and/or space, Doppler shifts, or some other properties of the detected light could be used to determine the flow properties.

Abstract: The invention relates to a system for determining blood flow within a blood vessel (18). A fluid infusion unit (4, 10, 11) continuously infuses a fluid into the blood vessel, and a temperature values determining unit (14, 21) determines simultaneously a first temperature value at a first location and a second temperature value at a second location such that the first temperature value is indicative of the temperature of the fluid and the second temperature value is indicative of the temperature of a mixture of the fluid and the blood. The blood flow is determined based on the measured first and second temperature values and the infusion rate. This kind of determining the blood flow leads to an increased accuracy and is less cumbersome than known techniques requiring a movement of a temperature sensor for measuring temperatures at different locations.

Abstract: A registration fixture or plate is configured for use with a medical imaging system. The registration fixture may be an optical magnetic registration plate including a plurality of fiducial markers in arranged in a predefined unique pattern. The pattern can be unambiguously detected on 2D image of the plate produced by the medical imaging system. Association of the 2D imaged pattern of fiducial markers with the actual 3D pattern on the optical magnetic registration plate allows for accurate calculation of projection matrices and co-registration of the 3D and 2D coordinate systems.

Abstract: An ultrasound diagnosis apparatus according to an embodiment includes processing circuitry. The processing circuitry is configured to speculate saturation of reflected-wave signals observed before a phased addition process performed by using the reflected-wave signals, in accordance with an intensity of reflected-wave data generated through the phased addition process, the reflected-wave signals being generated by transmitting an ultrasound wave with respect to mutually the same scanning line, and the processing circuitry is configured to output a result of the speculation. The processing circuitry is configured to cause a display to display data based on the result of the speculation.

Abstract: A surgical instrument assembly may include a processor, a surgical instrument configured to operate on an anatomical structure, and a display coupled to the processor and attached to the surgical instrument. The processor can be configured to determine a position of the medical imaging device, from which the medical imaging device can generate an X-ray image that includes holes of an intramedullary nail shown as circles, for instance perfect circles. In an example, the processor identifies the intramedullary nail, so as to determine an intramedullary nail identity, and determines the position of the medical imaging device based on a portion of at least two locking holes of the intramedullary nail and based on the intramedullary nail identity.

Abstract: Ultrasound methods provide for the motion tracking of both vessel wall motion and blood flow (e.g., with use of high frame rate ultrasound pulse echo data and speckle tracking both wall motion and flow can be tracked simultaneously). Ultrasound systems provide for the motion tracking of both vessel wall motion and blood flow (e.g., with use of high frame rate ultrasound pulse echo data and speckle tracking both wall motion and flow can be tracked simultaneously).

Abstract: A method for localizing gingival inflammation using an oral care device, comprising: emitting (520) light by one or more light emitters (42) of the oral care device; obtaining (530), at a first rate by one or more light detectors (40), reflectance measurements for a plurality of locations to generate first reflectance data; determining (540), by a controller (30) of the oral care device using the first reflectance data, whether the location comprises gingiva; obtaining (550), at a second rate by the one or more light detectors, reflectance measurements for each location determined to comprise gingiva to generate gingiva reflectance data, wherein the second rate is faster than the first rate; and determining (560), by the controller using the gingiva reflectance data, whether gingiva at that location is inflamed.

Abstract: A magnetometer system for medical use comprises one or more induction coils for detecting a time varying magnetic field. Each coil has a maximum outer diameter of 10 cm or less, and a configuration such that the ratio of the coil's length to its outer diameter is 0.9 or more, and the ratio of the coil's inner diameter to its outer diameter is 0.6 or more. Each induction coil comprises a magnetic core. The magnetometer system further comprises a detection circuit coupled to each coil and configured to convert a current or voltage generated in the coil by a time varying magnetic field to an output signal for use to analyse the time varying magnetic field.